Volume 36 Issue 2
Mar.  2020
Turn off MathJax
Article Contents
Article Navigation >  Journal of Nanjing University of traditional Chinese Medicine  > 2020  >  36(2): 174-178
YAOWei-feng, ZHAIYuan-yuan, LINLi-li, YANGBin, ZHUANGLi, ZHANGLi, XIETong, ZHAOXia, SHANJin-jun, WANGShou-chuan. Study on Effective Compounds of Qingfei Oral Liquid for Treating COVID-19 Through Integrating 'Compound-Target-Common Pathway' Network and Molecular Docking[J]. Journal of Nanjing University of traditional Chinese Medicine, 2020, 36(2): 174-178.
Citation: YAOWei-feng, ZHAIYuan-yuan, LINLi-li, YANGBin, ZHUANGLi, ZHANGLi, XIETong, ZHAOXia, SHANJin-jun, WANGShou-chuan. Study on Effective Compounds of Qingfei Oral Liquid for Treating COVID-19 Through Integrating "Compound-Target-Common Pathway" Network and Molecular Docking[J]. Journal of Nanjing University of traditional Chinese Medicine, 2020, 36(2): 174-178.
shu

Study on Effective Compounds of Qingfei Oral Liquid for Treating COVID-19 Through Integrating "Compound-Target-Common Pathway" Network and Molecular Docking

  • 1.

    Jiangsu Key Laboratory for Pediatric Respiratory Disease, Nanjing University of Chinese Medicine, Nanjing, 210023, China

  • 2.

    School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China

  • Publish Date: 2020-03-10
    Abstract
  • OBJECTIVE To study on active ingredients of Qingfei Oral Liquid in the treatment of COVID-19， based on network pharmacology and molecular docking. METHODS The Chinese Traditional Medicine System Pharmacology Analysis Platform (TCMSP) was used to search the chemical constituents of medicinal herbs in Qingfei Oral Liquid and the corresponding targets. The "compound-target-common pathway" network of Qingfei Oral Liquid for the treatment of viral pneumonia was built through Cytoscape software. Then the key compounds in the network were docked with the potential drug target protein for treating COVID-19. RESULTS Biological analysis of the target protein of compounds in Qingfei Oral Liquid was carried out to yield a total of 129 KEGG pathways (P<0.05)， and 104 KEGG pathways (P<0.05) were obtained from biological analysis of the disease target proteins of viral pneumonia. Among them，83 common pathways were obtained. The "compound-target-common pathway" network contained 201 components and 2 424 corresponding targets. The docking of 78 core compounds in the network with the potential targets of treatment of COVID-19 drugs， RdRp， 3Clpro， and PLpro， showed that core components such as Phaseol， Dan-shexinkum D， 1，2，5，6-tetrahydrotanshinone had the similar drug affinity to current drugs treatment COVID-19. CONCLUSION This study demonstrates that many key components of Qingfei Oral Liquid might be docked well with multiple potential targets to achieve the purpose of treating COVID-19， reflecting the characteristics of multi-component， multi-target and multi-path of traditional Chinese medicine， and providing a reference for the modern creation of traditional Chinese medicine.

     

    • FullText(HTML)
  • loading
    • References(14)
  • [1]
    卢立伟，张桂菊，季旭明，等.基于中医传承辅助平台的中医药治疗病毒性肺炎用药规律分析[J].中国实验方剂学杂志，2015，21(13):208-211.
    [2]
    新型冠状病毒感染的肺炎诊疗方案(试行第五版)[EB/OL]. (2020-02-04)[2020-02-24]. http://www.gov.cn/zhengce/zhengceku/2020-02/05/5474791/files/de44557832ad4be1929091dcbcfca891.pdf
    [3]
    王维静，宋祯艳，伍建光，等.伍炳彩运用麻杏石甘汤治疗咳嗽经验[J].江西中医药，2019，50(11):26-27.
    [4]
    王昕泰，谢辉辉，徐珊，等.清肺口服液治疗儿童病毒性肺炎疗效及安全性的Meta分析[J].时珍国医国药，2015，26(12):3054-3058.
    [5]
    刘千勇，王晓良.新型冠状病毒（2019-nCoV）的靶向药物研究策略[J/OL].药学学报.（2020-02-12）[2020-02-24].http://kns.cnki.net/kcms/detail/11.2163.R.20200212.1110.002.html.
    [6]
    翟园园，刘其南，徐佳，等.基于网络药理学的二至丸保肝作用机制研究[J].药学学报，2018，53(4):567-573.
    [7]
    徐森楠，庄莉，翟园园，等.基于网络药理学研究二至丸防治骨质疏松症的物质基础与作用机制[J].中国药学杂志，2018，53(22):1913-1920.
    [8]
    ZHU F， HAN BC， KUMAR P， et al. Update of TTD: Therapeutic target database[J]. Nucleic Acids Res， 2010， 38: 787-791.
    [9]
    HARTLEY T， BALC TB， ROJAS SK， et al. The unsolved rare genetic disease atlas? An analysis of the unexplained phenotypic descriptions in OMIM[J]. Am J Med Genet C Semin Med Genet， 2018， 178: 458-463.
    [10]
    BECKER KG， BARNES KC， BRIGHT TJ， et al. The genetic association database[J]. Nature Genetics， 2004， 36(5): 431-432.
    [11]
    SINGH SK， REDDY SM， PLASMODIUM F. Investigation of hub genes and their nonsynonymous single nucleotide polymorphism analysis in Plasmodium falciparum for designing therapeutic methodologies using next-generation sequencing approach[J]. Indian J Pharmacol， 2019， 51(6): 389-399.
    [12]
    宋文杰. 麻杏甘石汤治疗哮喘的作用机制及君臣佐使配伍意义研究[D]. 北京：北京中医药大学，2019.
    [13]
    杨俊姝. 通鼻止鼽方抑制过敏性鼻炎作用的实验和网络药理学研究[D]. 武汉：湖北中医药大学，2016.
    [14]
    庄莉，翟园园，姚卫峰，等.基于网络药理学的二至丸对肾脏保护作用的机制研究[J].药学学报，2019，54(5):877-885.
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索
    Get Citation
    PDF
    XML

    Article Metrics

    Article views (710) PDF downloads(410) Cited by()
    Proportional views
    Related

    Copyright © Journal of Nanjing University of traditional Chinese Medicine

    Sponsored by：Nanjing University of traditional Chinese MedicineAddress：No.138 xianlin Avenue, Qixia District, Nanjing cityChina Pos：210023

    Tel：025-85811935Email：xb@njucm.edu.cn

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return