Citation: | SHI Chen, LIN Li-li, XIE Tong, SHEN Cun-si, JI Jian-jian, ZHAO Xia, WANG Shou-chuan, SHAN Jin-jun. The Role of the Lung-Gut Axis and the Lung and Gut Microorganism in Pulmonary Disease[J]. Journal of Nanjing University of traditional Chinese Medicine, 2020, 36(2): 168-173. |
[1] |
新型冠状病毒感染的肺炎诊疗方案(试行第五版)[EB/OL].(2020-02-04)[2020-02-12].http://www.gov.cn/zhengce/zhengceku/2020-02/05/5474791/files/de44557832ad4be1929091dcbcfca891.pdf
|
[2] |
莫芳芳, 马师雷, 李鸿涛, 等. 基于中医古籍研究的“肺与大肠相表里”理论源流及其内涵探讨[J]. 环球中医药, 2015, 8(2): 165-168.
|
[3] |
RUTTEN EPA, LENAERTS K, BUURMAN WA, et al. Disturbed intestinal integrity in patients with COPD: Effects of activities of daily living[J]. Eur Respir J,2014, 145(2): 245-252.
|
[4] |
ROUSSOS A, KOURSARAKOS P, PATSOPOULOS D, et al. Increased prevalence of irritable bowel syndrome in patients with bronchial asthma[J]. Respir Med, 2003, 97(1): 75-79.
|
[5] |
〖JP2〗LLOYD-PRICE J, ABU-ALI G, HUTTENHOWER C, et al. The healthy human microbiome[J]. Genome Med, 2016, 8(1): 1-11.〖JP〗
|
[6] |
MORGAN XC, SEGATA N, HUTTENHOWER C, et al. Biodiversity and functional genomics in the human microbiome[J]. Trends Genet, 2013, 29(1): 51-58.
|
[7] |
HARTSTRA AV, BOUTER KE, BACKHED F, et al. Insights into the role of the microbiome in obesity and type 2 diabetes[J]. Diabetes Care, 2015, 38(1): 159-165.
|
[8] |
SUBRAMANIAN S, BLANTON LV, FRESE SA, et al. Cultivating healthy growth and nutrition through the gut microbiota[J]. Cell, 2015, 161(1): 36-48.
|
[9] |
RAUTAVA S, LUOTO R, SALMINEN S, et al. Microbial contact during pregnancy, intestinal colonization and human disease[J]. Nat Rev Gastroenterol Hepatol, 2012, 9(10): 565.
|
[10] |
GILL SR, POP M, DEBOY RT, et al. Metagenomic analysis of the human distal gut microbiome[J]. Science, 2006, 312(5778): 1355-1359.
|
[11] |
TREMAROLI V, BACKHED F. Functional interactions between the gut microbiota and host metabolism[J]. Nature, 2012, 489(7415): 242-249.
|
[12] |
WILSON I, NICHOLSON J. The role of gut microbiota in drug response[J]. Curr Pharm Des, 2009, 15(13): 1519-1523.
|
[13] |
EKMEKCIU I, VON KLITZING E, FIEBIGER U, et al. Immune responses to broad-spectrum antibiotic treatment and fecal microbiota transplantation in mice[J]. Front Immunol, 2017, 8:397.
|
[14] |
ABRAHAMSSON T, JAKOBSSON H, ANDERSSON AF, et al. Low gut microbiota diversity in early infancy precedes asthma at school age[J]. Clin Exp Allergy, 2014, 44(6): 842-850.
|
[15] |
METSALA J, LUNDQVIST A, VIRTA L, et al. Prenatal and post-natal exposure to antibiotics and risk of asthma in childhood[J]. Clin Exp Allergy, 2015, 45(1): 137-145.
|
[16] |
GREENHALGH K, MEYER KM, AAGAARD KM, et al. The human gut microbiome in health: establishment and resilience of microbiota over a lifetime[J]. Environ Microbiol, 2016, 18(7): 2103-2116.
|
[17] |
DICKSON RP, ERB-DOWNWARD JR, MARTINEZ FJ, et al. The microbiome and the respiratory tract[J]. Annu Rev Physiol, 2016, 78:481-504.
|
[18] |
PATTARONI C, WATZENBOECK ML, SCHNEIDEGGER S, et al. Early-life formation of the microbial and immunological environment of the human airways[J]. Cell Host Microb, 2018, 24(6): 857-865.
|
[19] |
GOLLWITZER ES, MARSLAND BJ. Impact of early-life exposures on immune maturation and susceptibility to disease[J]. Trends Immunol, 2015, 36(11): 684-696.
|
[20] |
UBAGS ND, MARSLAND BJ. Mechanistic insight into the function of the microbiome in lung diseases[J]. Eur Respir J, 2017, 50(3): 1602467.
|
[21] |
〖JP2〗YANG X, LI H, MA Q, et al. Neutrophilic asthma is associated with increased airway bacterial burden and disordered community composition[J]. BioMed Res Inter, 2018, 2018:1-11.〖JP〗
|
[22] |
GREEN BJ, WIRIYACHAIPORN S, GRAINGE C, et al. Potentially pathogenic airway bacteria and neutrophilic inflammation in treatment resistant severe asthma[J]. PLoS ONE, 2014, 9(6):e100645.
|
[23] |
SIMPSON JL, DALY J, BAINES KJ, et al. Airway dysbiosis: Haemophilus influenzae and Tropheryma in poorly controlled asthma[J]. Eur Respir J, 2016, 47(3): 792-800.
|
[24] |
PROCTOR DM, RELMAN DAJ. The landscape ecology and microbiota of the human nose, mouth, and throat[J]. Cell Host Microbe, 2017, 21(4): 421-432.
|
[25] |
PABST O. New concepts in the generation and functions of IgA[J]. Nat Rev Immunol, 2012, 12(12): 821-832.
|
[26] |
BUNKER JJ, ERICKSON SA, FLYNN TM, et al. Natural polyreactive IgA antibodies coat the intestinal microbiota[J]. Science, 2017, 358(6361): 6619.
|
[27] |
SALZMAN NH, HUNG K, HARIBHAI D, et al. Enteric defensins are essential regulators of intestinal microbial ecology[J]. Nat Immunol, 2010, 11(1): 76.
|
[28] |
MAMANTOPOULOS M, RONCHI F, VAN HAUWERMEIREN F, et al. Nlrp6-and ASC-dependent inflammasomes do not shape the commensal gut microbiota composition[J]. Immunity, 2017, 47(2): 339-348.
|
[29] |
ZMORA N, ZILBERMAN-SCHAPIRA G, SUEZ J, et al. Personalized gut mucosal colonization resistance to empiric probiotics is associated with unique host and microbiome features[J]. Cell, 2018, 174(6): 1388-1405.
|
[30] |
GROVES HT, CUTHBERTSON L, JAMES P, et al. Respiratory disease following viral lung infection alters the murine gut microbiota[J]. Front Immunol, 2018, 9:182.
|
[31] |
WYPYCH TP, MARSLAND BJ. Antibiotics as instigators of microbial dysbiosis: Implications for asthma and allergy[J]. Trends Immunol, 2018, 39(9): 697-711.
|
[32] |
〖JP2〗HANSKI I, VON HERTZEN L, FYHRQUIST N, et al. Environmental biodiversity, human microbiota, and allergy are interrelated[J]. P Natl Acad Sci USA, 2012, 109(21): 8334-8339.〖JP〗
|
[33] |
〖JP2〗FUJIMURA KE, SITARIK AR, HAVSTAD S, et al. Neonatal gut microbiota associates with childhood multisensitized atopy and T cell differentiation[J]. Nat Med, 2016, 22(10): 1187.〖JP〗
|
[34] |
WANG J, LI F, WEI H, et al. Respiratory influenza virus infection induces intestinal immune injury via microbiota-mediated Th17 cell-dependent inflammation[J]. J Exp Med, 2014, 211(12): 2397-2410.
|
[35] |
WANG H, LIU JS, PENG SH, et al. Gut-lung crosstalk in pulmonary involvement with inflammatory bowel diseases[J]. World J Gastroenterol, 2013, 19(40): 6794.
|
[36] |
ZHANG H, KANG ZJ, GONG HY, et al. The digestive system is a potential route of 2019-nCov infection: A bioinformatics analysis based on single-cell transcriptomes[J/OL]. BioRxiv.https://doi.org/10.1101/2020.01.30.927806.
|
[37] |
NEISH AS, GEWIRTZ AT, ZENG H, et al. Prokaryotic regulation of epithelial responses by inhibition of IκB-α ubiquitination[J]. Science, 2000, 289(5484): 1560-1563.
|
[38] |
RATNER AJ, LYSENKO ES, PAUL MN, et al. Synergistic proinflammatory responses induced by polymicrobial colonization of epithelial surfaces[J]. P Natl Acad Sci USA, 2005, 102(9): 3429-3434.
|
[39] |
TROMPETTE A, GOLLWITZER ES, YADAVA K, et al. Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis[J]. Nat Med, 2014, 20(2): 159.
|
[40] |
DICKSON RP, SINGER BH, NEWSTEAD MW, et al. Enrichment of the lung microbiome with gut bacteria in sepsis and the acute respiratory distress syndrome[J]. Nat Microbiol, 2016, 1(10): 1-9.
|
[41] |
GAUGUET S, D'ORTONA S, AHNGER-PIER K, et al. Intestinal microbiota of mice influences resistance to Staphylococcus aureus pneumonia[J]. Infect Immun, 2015, 83(10): 4003-4014.
|
[42] |
SEGAL LN, CLEMENTE JC, TSAY JCJ, et al. Enrichment of the lung microbiome with oral taxa is associated with lung inflammation of a Th17 phenotype[J]. Nat Microbiol, 2016, 1(5): 16031.
|
[43] |
SAMUELSON DR, WELSH DA, SHELLITO JE. Regulation of lung immunity and host defense by the intestinal microbiota[J]. Front Microbiol, 2015, 6:1085.
|
[44] |
REIBMAN J, MARMOR M, FILNER J, et al. Asthma is inversely associated with Helicobacter pylori <\i>status in an urban population[J]. PLoS ONE, 2008, 3(12): e4060.
|
[45] |
HUANG Y, MAO K, CHEN X, et al. S1P-dependent interorgan trafficking of group 2 innate lymphoid cells supports host defense[J]. Science, 2018, 359(6371): 114-119.
|
[46] |
BRADLEY CP, TENG F, FELIX KM, et al. Segmented filamentous bacteria provoke lung autoimmunity by inducing gut-lung axis Th17 cells expressing dual TCRs[J]. Cell Host Microbes, 2017, 22(5): 697-704.
|
[47] |
ICHINOHE T, PANG IK, KUMAMOTO Y, et al. Microbiota regulates immune defense against respiratory tract influenza A virus infection[J]. P Natl Acad Sci USA, 2011, 108(13): 5354-5359.
|
[48] |
QIAN G, JIANG W, ZOU B, et al. LPS inactivation by a host lipase allows lung epithelial cell sensitization for allergic asthma[J]. J Exp Med, 2018, 215(9): 2397-2412.
|
[49] |
DEN BESTEN G, VAN EUNEN K, GROEN AK, et al. The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism[J]. J Lipid Res, 2013, 54(9): 2325-2340.
|
[50] |
THORBURN AN, MCKENZIE CI, SHEN S, et al. Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites[J]. Nat Commun, 2015, 6(1): 1-13.
|
[51] |
TROMPETTE A, GOLLWITZER ES, PATTARONI C, et al. Dietary fiber confers protection against flu by shaping Ly6c-patrolling monocyte hematopoiesis and CD8+ T cell metabolism[J]. Immunity, 2018, 48(5): 992-1005.
|
[52] |
HUSTED AS, TRAUELSEN M, RUDENKO O, et al. GPCR-mediated signaling of metabolites[J]. Cell Metab, 2017, 25(4): 777-796.
|
[53] |
〖JP2〗STEED AL, CHRISTOPHI GP, KAIKO GE, et al. The microbial metabolite desaminotyrosine protects from influenza through type Ⅰ interferon[J]. Science, 2017, 357(6350): 498-502.〖JP〗
|
[54] |
ZELANTE T, IANNITTI RG, CUNHA C, et al. Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22[J]. Immunity, 2013, 39(2): 372-385.
|
[55] |
SINGH N, GURAV A, SIVAPRAKASAM S, et al. Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis[J]. Immunity, 2014, 40(1): 128-139.
|
[56] |
GEIGER R, RIECKMANN JC, WOLF T, et al. L-arginine modulates T cell metabolism and enhances survival and anti-tumor activity[J]. Max Planck Soc, 2016, 167(3): 829-842.
|
[57] |
SINGH R, CHANDRASHEKHARAPPA S, BODDULURI SR, et al. Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway[J]. Nat Commun, 2019, 10(1): 1-18.
|
[58] |
MORITA N, UMEMOTO E, FUJITA S, et al. GPR31-dependent dendrite protrusion of intestinal CX3CR1+ cells by bacterial metabolites[J]. Nature, 2019, 566(7742): 110-114.
|
[59] |
孟欣,汪受传,单进军,等. 合胞病毒肺部感染对小鼠大肠黏膜组织内源性代谢物的影响[J]. 中国当代儿科杂志, 2016, 18(11): 1166-1173.
|
[60] |
钱文娟. “银翘”药对治疗H1N1肺炎的肺-肠轴相关代谢组学研究[D]. 南京:南京中医药大学,2019.
|
[61] |
PLANTINGA TS, JOHNSON MD, SCOTT WK, et al. Human genetic susceptibility to Candida infections[J]. Med Mycol, 2012, 50(8): 785-794.
|
[62] |
FYHRQUIST N, RUOKOLAINEN L, SUOMALAINEN A, et al. Acinetobacter species in the skin microbiota protect against allergic sensitization and inflammation[J]. J Allergy Clin Immunol, 2014, 134(6): 1301-1309.
|
[63] |
NEMBRINI C, SICHELSTIEL A, KISIELOW J, et al. Bacterial-induced protection against allergic inflammation through a multicomponent immunoregulatory mechanism[J]. Thorax, 2011, 66(9): 755-763.
|
[64] |
VOGEL K, BLUMER N, KORTHALS M, et al. Animal shed Bacillus licheniformis spores possess allergy-protective as well as inflammatory properties[J]. J Allergy Clin Immunol Immunopathol, 2008, 122(2): 307-312.
|
[65] |
KOCH KN, HARTUNG ML, URBAN S, et al. Helicobacter urease-induced activation of the TLR2/NLRP3/IL-18 axis protects against asthma[J]. J Clin Investig, 2015, 125(8): 3297-3302.
|
[66] |
BROWN RL, SEQUEIRA RP, CLARKE TB. The microbiota protects against respiratory infection via GM-CSF signaling[J]. Nat Commun, 2017, 8(1): 1-11.
|
[67] |
KANMANI P, CLUA P, VIZOSO-PINTO MG, et al. Respiratory commensal bacteria Corynebacterium pseudodiphtheriticum improves resistance of infant mice to respiratory syncytial virus and Streptococcus pneumoniae superinfection[J]. Front Microbiol, 2017, 8:1613.
|
[68] |
CHUA HH, CHOU HC, TUNG YL, et al. Intestinal dysbiosis featuring abundance of Ruminococcus gnavus associates with allergic diseases in infants[J]. Gastroenterology, 2018, 154(1): 154-167.
|
[69] |
NOVERR MC, FALKOWSKI NR, MCDONALD RA, et al. Development of allergic airway disease in mice following antibiotic therapy and fungal microbiota increase: role of host genetics, antigen, and interleukin-13[J]. Infect Immun, 2005, 73(1): 30-38.
|
[70] |
NOVERR MC, NOGGLE RM, TOEWS GB, et al. Role of antibiotics and fungal microbiota in driving pulmonary allergic responses[J]. Infect Immun, 2004, 72(9): 4996-5003.
|