Volume 35 Issue 6
Nov.  2019
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Article Navigation >  Journal of Nanjing University of traditional Chinese Medicine  > 2019  >  35(6): 704-707
LIHui, TIANYao-zhou, ZHANGXun-bing, GULi-mei, PANCheng-yu, ZHUFang-shi. Effect of Xifeng Huashi Recipe on Visceral Hypersensitivity in Rats with Diarrhea Predominant Irritable Bowel Syndrome[J]. Journal of Nanjing University of traditional Chinese Medicine, 2019, 35(6): 704-707.
Citation: LIHui, TIANYao-zhou, ZHANGXun-bing, GULi-mei, PANCheng-yu, ZHUFang-shi. Effect of Xifeng Huashi Recipe on Visceral Hypersensitivity in Rats with Diarrhea Predominant Irritable Bowel Syndrome[J]. Journal of Nanjing University of traditional Chinese Medicine, 2019, 35(6): 704-707.
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Effect of Xifeng Huashi Recipe on Visceral Hypersensitivity in Rats with Diarrhea Predominant Irritable Bowel Syndrome

  • 1.

    Digestive Department, Nanjing Lishui District Hospital of Traditional Chinese Medicine, Nanjing, 211299, China

  • 2.

    Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210028, China

  • Publish Date: 2019-11-10
    Abstract
  • OBJECTIVE To investigate the effect of Xifeng Huashi prescription (XFHS) on visceral hypersensitivity and SCF-Kit system in rats with diarrhea predominant irritable bowel syndrome (IBS-D). METHODS Rats were randomly divided into control group，model group， XFHS low， moderate and high dosage groups. The model was induced by separation of breast milk and coloclysis of acetic acid. High， moderate and low dosage XFHS group rats were given by gavage with different concentration of XFHS decoction，respectively. Equal saline was administrated in the normal group and model group. The abdominal withdrawal reflex was recorded， and the levels of SCF and c-Kit in the colonic tissue were detected by Western blot and qPCR. RESULTS Comparing with normal group， the grades of AWR and the levels of gastric SCF and c-Kit expression in the model group were significantly lower (P<0.05). The grades of AWR and the levels of gastric SCF and c-Kit expression in XFHS groups were significantly lower than those in the model group (P<0.05). CONCLUSION XFHS can reduce visceral hypersensitivity by inhibiting the expression of SCF-Kit system.

     

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    • References(14)
  • [1]
    ZHANG L， DUAN LP， LIU YX， et al. A meta-analysis of the prevalence and risk factors of irritable bowel syndrome in Chinese community[J]. Chin J Intern Med， 2014，53(12):969-975.
    [2]
    CHOUNG RK， LOCKE GR. Epidemiology of IBS[J]. Gastroenterol Clin N Am， 2011，40(1):1-10.
    [3]
    DROSSMAN DA. Functional gastrointestinal disorders: History， pathophysiology， clinical features and Rome Ⅳ[J]. Gastroenterology， 2016， 150:1262-1279.
    [4]
    LEKHA SAHA. Irritable bowel syndrome: Pathogenesis， diagnosis， treatment， and evidence-based medicine[J]. World J Gastroenterol， 2014， 20(22):6759-6773.
    [5]
    奚肇宏，田耀洲，陈璇，等.熄风化湿方治疗腹泻型肠易激综合征的临床观察[J].南京中医药大学学报， 2015， 31（7）:331-333.
    [6]
    魏华，彭勇，马国需，等.木香有效成分及药理作用研究进展[J]. 中草药， 2012， 43(3):613-620.
    [7]
    凌宗全.白术化学成分及药理作用研究进展[J].内蒙古中医药， 2013， 32(35):105-106.
    [8]
    孙萍萍. 白术-白芍药对治疗肠易激综合征的药效研究[D].杭州：浙江中医药大学，2015.
    [9]
    丁瑞峰， 王爱鱼， 王宏杰， 等.内脏高敏感大鼠结肠Cajal间质细胞C-KIT表达增加[J].基础医学与临床， 2012， 32(5):566-569.
    [10]
    张静瑜， 黄裕新， 秦明，等. SCF/c-Kit过度激活在肠易激综合征内脏敏化中的作用[J].山西医科大学学报， 2012， 43（3):177-181.
    [11]
    WOUTERS MM， ROEDER JL， THATAYIL VS， et al. Protein kinase Cγ mediates regulation of proliferation by the serotonin 5-hydroxytryptamine receptor 2B[J]. J Biol Chem， 2009， 284(32): 21177-21184.
    [12]
    OKAMOTO T， BARTON MJ， HENNIG GW， et al. Extensive projections of myenteric serotonergic neurons suggest they comprise the central processing unit in the colon[J]. Neurogastroenterol Motil， 2014， 26(4):556-570.
    [13]
    SHIMIZU Y， MATSUYAMA H， SHIINA T， et al. Tachykinins and their functions in the gastrointestinal tract[J]. Cell Mol Life Sci， 2008， 65(2): 295-311.
    [14]
    ZHANG H， YAN Y， SHI R， et al. Correlation of gut hormones with irritable bowel syndrome[J]. Digestion， 2008， 78(2/3): 72-76.
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