Volume 35 Issue 2
Mar.  2019
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Article Navigation >  Journal of Nanjing University of traditional Chinese Medicine  > 2019  >  35(2): 130-134
YANGLi-li, BIANYao-yao, QIANHai-hua, ZHUJian-guang, XUSu, CHENHao, WANGSen, LIWen-lin, ZENGLi. A Multicenter， Randomized， Double-Blind Clinical Study of Huoxue Tongfu Formula in Postoperative Peritoneal Adhesions[J]. Journal of Nanjing University of traditional Chinese Medicine, 2019, 35(2): 130-134.
Citation: YANGLi-li, BIANYao-yao, QIANHai-hua, ZHUJian-guang, XUSu, CHENHao, WANGSen, LIWen-lin, ZENGLi. A Multicenter， Randomized， Double-Blind Clinical Study of Huoxue Tongfu Formula in Postoperative Peritoneal Adhesions[J]. Journal of Nanjing University of traditional Chinese Medicine, 2019, 35(2): 130-134.
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A Multicenter， Randomized， Double-Blind Clinical Study of Huoxue Tongfu Formula in Postoperative Peritoneal Adhesions

  • 1.

    The Clinical Medical College of Nanjing University of Chinese Medicine, Nanjing, 210023, China

  • 2.

    School of Nursing, Nanjing University of Chinese Medicine, Nanjing, 210023, China

  • 3.

    Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, China

  • 4.

    College of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou, 450008, China

  • 5.

    Anorectal Department of Yancheng Traditional Chinese Medicine Hospital, Yancheng, 224002, China

  • 6.

    The Second Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210017, China

  • 7.

    Anorectal Department of Huainan Second People's Hospital, Huainan, 232072, China

  • 8.

    Library of Nanjing University of Chinese Medicine, Nanjing, 210023, China

  • Publish Date: 2019-03-10
    Abstract
  • OBJECTIVE To observe the clinical effect of Huoxue Tongfu formula on prevention and treatment of postoperative peritoneal adhesions (PPA) and to explore its possible mechanism. METHODS 119 patients with adhesive intestinal obstruction were divided into two groups: control group (n=58) and treatment group (n=61). The control group was treated with routine therapy and the treatment group was treated with Huoxue Tongfu formula on the basis of the control group. After 4 weeks of intervention， the first time of exhaust and defecation were observed in the two groups， and the VAS score of postoperative abdominal pain was also observed. Serum transforming growth factor -β (TGF-β)， the level of fibronectin (FN) and the B-ultrasound adhesion after operation were evaluated， and the recurrence rate of the adhesive ileus and rate of its recurrent operation were observed at 1-year follow-up. RESULTS Compared with the control group， the treatment group reduced the first time of exhaust and defecation after operation (P<0.01)， lower the VAS pain score of 7 d and 14 d (P<0.01)， reduce the postoperative peritoneal adhesion formation (P<0.05)， and reduce recurrence rate of postoperative adhesive intestinal obstruction and the rate of its recurrent operation (P<0.05). Comparing with postoperative 3th day， there was statistically significant on postoperative 7th day and 14th day(P<0.05， P<0.01) in control group， and there was significant difference on postoperative 7th day and 14th day(P<0.01) in treatment group. The serum level of TGF-β and FN were significantly increased on postoperative 3th day(P<0.01) both in treatment group and control group. And there was no significant difference on postoperative 14th day(P>0.05) in treatment group. Comparing the two groups， there was a significant reduction in treatment group on postoperative 7th and 14th day(P<0.01). CONCLUSION The effect of Huoxue Tongfu formula on postoperative peritoneal adhesion is significant， and it is worthy of clinical popularization and application.

     

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    • References(23)
  • [1]
    专家组预防腹部外科手术后腹腔粘连的中国专家共识. 预防腹部外科手术后腹腔粘连的中国专家共识[J]. 中华普通外科杂志， 2017，32(11):984-988.
    [2]
    TEN BR， ISSA Y， VAN SANTBRINK EJ， et al. Burden of adhesions in abdominal and pelvic surgery: systematic review and met-analysis[J]. BMJ， 2013，347:f5588.
    [3]
    BRUGGMANN D， TCHARTCHIAN G， WALLWIENER M， et al. Intra-abdominal adhesions: definition， origin， significance in surgical practice， and treatment options[J]. Dtsch Arztebl Int， 2010，107(44):769-775.
    [4]
    VERCELLINI P， SOMIGLIANA E， VIGANO P， et al. Chronic pelvic pain in women: etiology， pathogenesis and diagnostic approach[J]. Gynecol Endocrinol， 2009，25(3):149-158.
    [5]
    RAY NF， DENTON WG， THAMER M， et al. Abdominal adhesiolysis: inpatient care and expenditures in the United States in 1994[J]. J Am Coll Surg， 1998，186(1):1-9.
    [6]
    MAVROS M N， VELMAHOS GC， LEE J， et al. Morbidity related to concomitant adhesions in abdominal surgery[J]. J Surg Res， 2014，192(2):286-292.
    [7]
    TEN BR， STOMMEL MW， STRIK C， et al. Benefits and harms of adhesion barriers for abdominal surgery: A systematic review and meta-analysis[J]. Lancet， 2014，383(9911):48-59.
    [8]
    杨丽丽， 卞尧尧， 赵敏， 等. 防治手术后腹腔粘连屏障材料:生物特性及优势与不足[J]. 中国组织工程研究， 2019，23(2):272-277.
    [9]
    王广成， 邵明亮. 丹参厚朴合剂治疗小儿肠粘连临床观察[J]. 中国实用医药， 2010，5(14):42-43.
    [10]
    刘春香. 理气活血法在妇科术后防粘连的临床应用分析[J]. 中国医药指南， 2013，11(35):199-200.
    [11]
    朱建光， 王永福， 卞尧尧. 通腑方治疗粘连性肠梗阻60例回顾性疗效评价[J]. 时珍国医国药， 2016，27(6):1409-1410.
    [12]
    曾莉， 张亚大. 大承气汤加减治疗术后粘连性肠梗阻22例[J]. 国医论坛， 2003，18(1):8.
    [13]
    曾莉， 钱海华， 赵群男， 等. 活血通腑方治疗术后粘连性肠梗阻56例临床观察[J]. 南京中医药大学学报， 2010，26(3):178-180.
    [14]
    HOLMDAHL L， RISBERG B. Adhesions: Prevention and complications in general surgery[J]. Eur J Surg， 1997，163(3):169-174.
    [15]
    中药新药临床研究指导原则（试行）[M]. 北京: 中国医药科技出版社，2002:3-6.
    [16]
    尚晓滨， 吴咸中. 术后早期炎症性肠梗阻的诊断和治疗[J]. 中国中西医结合外科杂志， 2003，9(6):56-58.
    [17]
    文谦， 赵雨， 刘劼， 等. 电针治疗功能性消化不良上腹痛综合征的临床疗效观察[J]. 四川大学学报(医学版)， 2018，49(5):817-820.
    [18]
    HAHN RG. Fluid absorption in endoscopic surgery[J]. Br J Anaesth， 2006，96(1):8-20.
    [19]
    METTLER L， HUCKE J， BOJAHR B， et al. A safety and efficacy study of a resorbable hydrogel for reduction of post-operative adhesions following myomectomy[J]. Hum Reprod， 2008，23(5):1093-1100.
    [20]
    KONINCKX PR， GOMEL V， USSIA A， et al. Role of the peritoneal cavity in the prevention of postoperative adhesions， pain， and fatigue[J]. Fertil Steril， 2016，106(5):998-1010.
    [21]
    曾莉， 徐庆， 陈卫平， 等. 活血通腑方优选方对TNF-α诱导下腹膜间皮细胞TGF-β1、FN、CTGF蛋白含量的影响[J]. 南京中医药大学学报， 2008，24(5):324-326.
    [22]
    苗立英， 薛恒， 张明群， 等. 超声诊断腹膜粘连的临床评价——20年文献分析[J]. 中国微创外科杂志， 2013，13(12):1061-1064.
    [23]
    HA US， KOH JS， CHO KJ， et al. Hyaluronic acid-carboxymethylcellulose reduced postoperative bowel adhesions following laparoscopic urologic pelvic surgery: a prospective， randomized， controlled， single-blind study[J]. BMC Urol， 2016，16(1):28.
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