Volume 35 Issue 1
Jan.  2019
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Article Navigation >  Journal of Nanjing University of traditional Chinese Medicine  > 2019  >  35(1): 58-62
WUXian-xian, ZHANGJin, DINGZhi. Study of Gua Sha's Effect on the Immune Functions of the Skin and the Body in Healthy Individuals[J]. Journal of Nanjing University of traditional Chinese Medicine, 2019, 35(1): 58-62.
Citation: WUXian-xian, ZHANGJin, DINGZhi. Study of Gua Sha's Effect on the Immune Functions of the Skin and the Body in Healthy Individuals[J]. Journal of Nanjing University of traditional Chinese Medicine, 2019, 35(1): 58-62.
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Study of Gua Sha's Effect on the Immune Functions of the Skin and the Body in Healthy Individuals

  • 1.

    School of Life Sciences, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210023, China

  • 2.

    Changzhou High-Tech Research Institute of Nanjing University, Changzhou, 213164, China

  • Publish Date: 2019-01-10
    Abstract
  • OBJECTIVE In this study， we investigate Gua Sha's therapeutic mechanism from immunological approaches. METHODS Gua Sha was performed on the back of Balb/c mice and the effects on the morphology of the skin tissue were observed using histological staining. Flow cytometry and ELISA were employed to determine the proportions of local immune active cells and local and systemic cytokine levels， respectively. Antigen-specific subtype antibody titers against intradermal and intranasal vaccines were utilized to assess Gua Sha treatment on the immunological functions of the skin locally and systematically. RESULTS Blood vessel expansion， erythrocyte extravasation and increased ratios of immune active cells were observed in the skin tissue following treatment， indicating an enhanced microcirculation. Pro-inflammatory cytokines were found up-regulated， and immunosuppressive cytokines downregulated， in both treated and untreated skin areas. These showed that Gua Sha can cause local and systemic effects. Intradermal delivery of a model antigen following Gua Sha treatment induced about three-fold higher IgG titers with a more Th1-biased antibody subtype profile. CONCLUSION Gua Sha treatment can boost skin microcirculation， enhance and regulate the innate and adaptive immune functions of the skin， which contributes partially to its therapeutic effects.

     

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    • References(17)
  • [1]
    胡波，谷世喆，秦丽娜.砭石与刮痧[J].中国针灸，2007(S1): 95-96.
    [2]
    贾曼，丰芬.刮痧疗法及其应用[J].河南中医，2011， 31(12): 1368-1370.
    [3]
    王钰婷.刮痧配合外敷蜂胶治疗黄褐斑的临床研究[D].广州：中医药大学， 2013.
    [4]
    KWONG KK， KLOETZER L， WONG KK， et al. Bioluminescence imaging of heme oxygenase-1 upregulation in the Gua Sha procedure[J]. J Vis Exp， 2009(30): e1385-e1385.
    [5]
    LAUCHE R， WUBBELING K， LUDTKE R， et al. Randomized controlled pilot study: pain intensity and pressure pain thresholds in patients with neck and low back pain before and after traditional East Asian "gua sha" therapy[J]. Am J Chin Med， 2012， 40(5): 905-917.
    [6]
    NIELSEN A. Gua Sha research and the language of integrative medicine[J]. J Bodywork Movement Ther， 2009， 13(1): 63-72.
    [7]
    曾上劼.经络刮痧前后白细胞变化分析[J].黑龙江中医药，2003 (1): 41-42.
    [8]
    DING Z， VERBAAN FJ， BIVAS-BENITA M， et al. Microneedle arrays for the transcutaneous immunization of diphtheria and influenza in BALB/c mice[J]. J Control Releas， 2009， 136(1): 71-78.
    [9]
    NIELSEN A， KNOBLAUCH NT， DOBOS GJ， et al. The effect of Gua Sha treatment on the microcirculation of surface tissue: a pilot study in healthy subjects[J]. J Sci Heal， 2007， 3(5): 456-466.
    [10]
    WANG Y， OLIVER G. Current views on the function of the lymphatic vasculature in health and disease[J]. Genes Develop， 2010， 24(19): 2115-2126.
    [11]
    MCFADYEN JD， KAPLAN ZS. Platelets are not just for clots[J]. Transfusion Med Rev， 2015， 29(2): 110-119.
    [12]
    AFONSO LC， SCHARTON TM， VIEIRA LQ， et al. The adjuvant effect of interleukin-12 in a vaccine against Leishmania major[J]. Science， 1994， 263(5144): 235-237.
    [13]
    SINGH V， JAIN S， GOWTHAMAN U， et al. Co-administration of IL-1+IL-6+TNF-α with Mycobacterium tuberculosis infected macrophages vaccine induces better protective T cell memory than BCG[J]. PLoS ONE， 2011， 6(1): 438-438.
    [14]
    TOVEY MG， LALLEMAND C. Adjuvant Activity of Cytokines[M]. Clifton: Humana Press， 2010: 287-309.
    [15]
    EVANS SS， REPASKY EA， FISHER DT， et al. Fever and the thermal regulation of immunity: the immune system feels the heat[J]. Nat Rev Immunol， 2015， 15(6): 335-349.
    [16]
    苏荣华，刘颖，王光义，等.通阳刮痧疗法对佐剂性关节炎大鼠TNF-α及T淋巴细胞亚群的影响[J].贵阳医学院学报，2015， 40(9): 919-921.
    [17]
    杨进岗，袁德培.土家以酒为介质刮痧疗法对“感冒”模型大鼠 IL-2及 TNF-α含量的影响[J].中国民族民间医药，2015，24(2): 2-3.
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