Comparative Study on Colloidal Silica Dioxide and β-Cyclodextrin Solidifying Clove Volatil Oil

OBJECTIVE To compare the characteristics of two different methods that solidified clove volatile oil (CVO) using β-cyclodextrin and colloidal silicon dioxide SYLOID 244FP. METHODS The CVO-solidified powder was prepared by saturated aqueous solution method and grinding method using β-cyclodextrin and colloidal silicon dioxide as carrier. The content of eugenol was determined by HPLC and the yield was compared. The structures of the solidified powder was characterized by differential scanning calorimetry (DSC). The stability of the two kinds of solidified powder was investigated by accelerated test. RESULTS The average yield of eugenol in the β-cyclodextrin solidified powder and in colloidal silicon dioxide solidified powder was 78.59% and 98.69%， respectively. The endothermic peak of the two kinds of solidified powder was disappeared in the phase of DSC. The loss ratios of eugenol in clove volatile oil， β-cyclodextrin solidified powder and colloidal silicon dioxide solidified powder were 17.35%， 1.76% and 3.74%， respectively at 60 ℃ for 8 h， while eugenol loss ratios were 24.29%， 4.64% and 5.97% in an open state. CONCLUSION Both colloidal silicon dioxide and β-cyclodextrin can solidify clove volatile oil， but the former needs less excipient， and preparation process with higher clove volatil oil yield， which shows high research value and potential application prospect.