Volume 40 Issue 3
Mar.  2024
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Article Navigation >  Journal of Nanjing University of traditional Chinese Medicine  > 2024  >  40(3): 315-328
LIU Jiahan, ZHAO Wei, WANG Yue, YANG Bingyou. Research Progress on Chemical Constituents, Pharmacological Activities and Clinical Application of Fritillaria Ussuriensis[J]. Journal of Nanjing University of traditional Chinese Medicine, 2024, 40(3): 315-328. doi: 10.14148/j.issn.1672-0482.2024.0315
Citation: LIU Jiahan, ZHAO Wei, WANG Yue, YANG Bingyou. Research Progress on Chemical Constituents, Pharmacological Activities and Clinical Application of Fritillaria Ussuriensis[J]. Journal of Nanjing University of traditional Chinese Medicine, 2024, 40(3): 315-328. doi: 10.14148/j.issn.1672-0482.2024.0315
shu

Research Progress on Chemical Constituents, Pharmacological Activities and Clinical Application of Fritillaria Ussuriensis

doi: 10.14148/j.issn.1672-0482.2024.0315

  • School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150000, China

  • Received Date: 2023-11-06
    Available Online: 2024-03-15
    Abstract
  • Fritillaria ussuriensis is a valuable traditional Chinese medicine in cold regions, which has the functions of dispersing stagnation and relieving depression, moistening lung and clearing heart. It is widely used in the treatment of diseases such as qi adverseness and cough, pharyngitis, sore and carbuncle, etc. Whether it is used alone or in combination, it has good results. It is a pure natural and efficient drug with broad development prospects. In recent years, with the deepening of research on Fritillaria ussuriensis, alkaloids, nucleosides, polysaccharides, volatile oils, organic acids and other components have been isolated.It has pharmacological activities such as relieving asthma, relieving cough, expectorant, calming, anti-inflammatory and antibacterial. By reviewing the reports of chemical constituents and pharmacological effects of Fritillaria ussuriensis in the past 40 years, this paper systematically summarizes and analyzes the research results in order to provide scientific basis for the study of pharmacodynamic substance basis and promote the development and utilization of Fritillaria ussuriensis.

     

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  • [1]
    中国医学科学院药物研究所. 中药志[M]. 北京: 人民卫生出版社, 1959.

    Institute of Materia Medica, Chinese Academy of Medical Sciences. Chinese materia medica[M]. Beijing: People's Medical Publishing House, 1959.
    [2]
    李娜. 中药川贝母与平贝母的鉴别[J]. 农业科技与装备, 2019(4): 33-35. https://www.cnki.com.cn/Article/CJFDTOTAL-NYJD201904015.htm

    LI N. Identification of Fritillaria cirrhosa and fritillary bulb[J]. Agric Sci Technol Equip, 2019(4): 33-35. https://www.cnki.com.cn/Article/CJFDTOTAL-NYJD201904015.htm
    [3]
    张雪影, 李莉娅, 蒲婧哲, 等. 川贝母及其市场常见易混品的传统鉴别[J]. 安徽中医药大学学报, 2023, 42(6): 92-96. ZHANG X Y, LI L Y, PU J Z, 等. https://www.cnki.com.cn/Article/CJFDTOTAL-AHZY202306019.htm
    [4]
    国家药典委员会. 中华人民共和国药典: 一部[M]. 北京: 中国医药科技出版社, 2020: 1088.

    National Pharmacopoeia Commission. Pharmacopoeia of the People's Republic of China: Part Ⅰ[M]. Beijing: China Medical Science and Technology Press, 2020: 1088.
    [5]
    王艳红. 平贝母质量评价的研究[D]. 长春: 吉林农业大学, 2006.

    WANG Y H. The study of quality appraisal from Bulbus fritillariae ussuriensis[D]. Changchun: Jilin Agricultural University, 2006.
    [6]
    翟映红, 于国强, 杨永茂, 等. 从川贝母中检出平贝母的理化鉴别方法[J]. 华西药学杂志, 2017, 32(6): 633-635. https://www.cnki.com.cn/Article/CJFDTOTAL-HXYO201706025.htm

    ZHAI Y H, YU G Q, YANG Y M, et al. Physical and chemical identification on distinguishing Fritillariae ussuriensis Bulbus from Fritillariae cirrhosa Bulbus[J]. West China J Pharm Sci, 2017, 32(6): 633-635. https://www.cnki.com.cn/Article/CJFDTOTAL-HXYO201706025.htm
    [7]
    于国强, 王玲玲, 王琳玲, 等. 贝母类药材的TLC鉴别[J]. 华西药学杂志, 2016, 31(4): 439-440. https://www.cnki.com.cn/Article/CJFDTOTAL-HXYO201604034.htm

    YU G Q, WANG L L, WANG L L, et al. Identification of Fritillaria by TLC[J]. West China J Pharm Sci, 2016, 31(4): 439-440. https://www.cnki.com.cn/Article/CJFDTOTAL-HXYO201604034.htm
    [8]
    孙海峰, 沈莹. 平贝母总生物碱提取工艺优化研究[J]. 化学工程师, 2018, 32(4): 9-11, 15. https://www.cnki.com.cn/Article/CJFDTOTAL-HXGC201804004.htm

    SUN H F, SHEN Y. Optimization extracting the total alkaloids from Fritillaria ussuriensis Maxim[J]. Chem Eng, 2018, 32(4): 9-11, 15. https://www.cnki.com.cn/Article/CJFDTOTAL-HXGC201804004.htm
    [9]
    占方玲, 徐玲, 陈晓颙, 等. 平贝母中4种生物碱成分的含量测定[C]//中国药学会. 北京: 2016年中国药学大会暨第十六届中国药师周, 2016: 8.

    ZHAN FL, XU L, CHEN XY, et al. Determination of 4 alkaloid components in Fritillaria fruticosa[C]//Chinese Pharmaceutical Society. Beijing: The 2016 Chinese Pharmaceutical Congress and the 16th Chinese Pharmacists Week, 2016: 8.
    [10]
    宗建法, 胡翥, 阿吉艾克拜尔·艾萨, 等. 裕民贝母生物碱类成分研究[J]. 中国中药杂志, 2019, 44(3): 495-499. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGZY201903038.htm

    ZONG J F, HU Z, HAJIAKBER A, et al. Studies on alkaloid constituents of Fritillaria yuminensis[J]. China J Chin Mater Med, 2019, 44(3): 495-499. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGZY201903038.htm
    [11]
    韩鸿萍, 徐顺连, 曹佳佳, 等. UPLC-TQD-MS/MS分析青海川贝母药材中的生物碱[J]. 化学研究与应用, 2023, 35(10): 2364-2369. https://www.cnki.com.cn/Article/CJFDTOTAL-HXYJ202310012.htm

    HAN H P, XU S L, CAO J J, et al. Analysis of alkaloids in Qinghai fritillaria D. Don based on UPLC-TQD-MS/MS[J]. Chem Res Appl, 2023, 35(10): 2364-2369. https://www.cnki.com.cn/Article/CJFDTOTAL-HXYJ202310012.htm
    [12]
    向美玲. 湖北贝母化学成分及对急性肺损伤的保护作用研究[D]. 昆明: 云南大学, 2022.

    XIANG ML. Study on Chemical composition and protective effect of Fritillaria Hubeiensis on acute lung injury[D]. Kunming: Yunnan University, 2022.
    [13]
    LIU F J, CHEN X Y, YANG J, et al. Revealing active components and action mechanism of Fritillariae Bulbus against non-small cell lung cancer through spectrum-effect relationship and proteomics[J]. Phytomedicine, 2023, 110: 154635. doi: 10.1016/j.phymed.2022.154635
    [14]
    ABLAJAN N, BO Z, XUE W J, et al. Chemical components of Aconitum barbatum var. puberulum and their cytotoxic and antibacterial activities[J]. Nat Prod Res, 2023, 37(8): 1382-1385. doi: 10.1080/14786419.2021.2005050
    [15]
    徐东铭, 贺存恒, 王淑琴, 等. 平贝碱丙的结构[J]. 药学学报, 1990, 25(2): 127-130. https://www.cnki.com.cn/Article/CJFDTOTAL-YXXB199002007.htm

    XU D M, HE C H, WANG SQ, et al. Structure of pingbeimine c[J]. Acta Pharm Sin, 1990, 25(2): 127-130. https://www.cnki.com.cn/Article/CJFDTOTAL-YXXB199002007.htm
    [16]
    SHI Y H, HUANG Q W, ZHU S M, et al. Chemical profiling of Fritillariae thunbergii Miq prepared by different processing methods reveals two new quality markers: Zhebeininoside and imperialine-3-β-D-glucoside[J]. J Ethnopharmacol, 2022, 283: 114670. doi: 10.1016/j.jep.2021.114670
    [17]
    徐东铭, 张本, 孝延文. 平贝母的化学成分研究: Ⅱ. 平贝碱甙的分离和鉴定[J]. 药学学报, 1983, 18(11): 868-870. https://www.cnki.com.cn/Article/CJFDTOTAL-YXXB198311012.htm

    XU D M, ZHANG B, XIAO Y W. Studies on chemical constituents of pingpeimu, (fritilaria ussuriensis maxim): Ⅱ. isolation and identification of pingpeimine glucoside[J]. Acta Pharm Sin, 1983, 18(11): 868-870. https://www.cnki.com.cn/Article/CJFDTOTAL-YXXB198311012.htm
    [18]
    戢爽. 基于UPLC-Q-TOF-MS/MS技术分析川贝母与浙贝母化学成分的差异及代谢组学研究[D]. 西宁: 青海师范大学, 2022.

    JI S. Analysis of chemical constituents differences between Fritillaria cirrhosa D. don and Fritillaria thunbergii and its metabolomics based on UPLC-Q-TOF-MS/MS technology[D]. Xining: Qinghai Normal University, 2022.
    [19]
    徐东铭, 王淑琴, 黄恩喜, 等. 平贝母茎叶的新甾体皂甙[J]. 植物学报, 1989, 31(4): 285-288. https://www.cnki.com.cn/Article/CJFDTOTAL-ZWXB198904006.htm

    XU D M, WANG S Q, HUANG E X, et al. New steroidal saponin of stem and leaf of fritillaria ussuriensis maxim[J]. J Integr Plant Biol, 1989, 31(4): 285-288. https://www.cnki.com.cn/Article/CJFDTOTAL-ZWXB198904006.htm
    [20]
    DU Y, ZHENG Z G, YU Y, et al. Rapid discovery of cyclopamine analogs from Fritillaria and Veratrum plants using LC-Q-TOF-MS and LC-QqQ-MS[J]. J Pharm Biomed Anal, 2017, 142: 201-209. doi: 10.1016/j.jpba.2017.04.049
    [21]
    BORA P S, AGRAWAL P, KAUSHIK N K, et al. Antiplasmodial activity of the bulbs of Fritillaria cirrhosa D. Don (Syn: Fritillaria roylei Hook.): UPLC-IM-Q-TOF-MS/MS-based biochemometric approach for the identification of marker compounds[J]. J Ethnopharmacol, 2023, 310: 116389. doi: 10.1016/j.jep.2023.116389
    [22]
    WANG R C, WANG X Y, QIAO Y F, et al. Research progress on the analysis of active ingredients and elements in Fritillaria ussuriensis Bulbus[J]. Chin J Anal Chem, 2023, 51(5): 100192. doi: 10.1016/j.cjac.2022.100192
    [23]
    WANG Y, HOU H P, REN Q, et al. Natural drug sources for respiratory diseases from Fritillaria: Chemical and biological analyses[J]. Chin Med, 2021, 16(1): 40. doi: 10.1186/s13020-021-00450-1
    [24]
    刘春红, 马宇, 何忠梅, 等. 平贝母多糖的分离纯化及抗氧化活性研究[J]. 食品科学, 2011, 32(21): 29-33. https://www.cnki.com.cn/Article/CJFDTOTAL-SPKX201121006.htm

    LIU C H, MA Y, HE Z M, et al. Partial characterization and antioxidant activity of water-soluble polysaccharide isolated from Bulbus fritillariae ussuriensis[J]. Food Sci, 2011, 32(21): 29-33. https://www.cnki.com.cn/Article/CJFDTOTAL-SPKX201121006.htm
    [25]
    ZHANG M, ZHAO H, SHEN Y, et al. Preparation, characterization and antioxidant activity evaluation in vitro of Fritillaria ussuriensis polysaccharide-zinc complex[J]. Int J Biol Macromol, 2020, 146: 462-474. doi: 10.1016/j.ijbiomac.2020.01.002
    [26]
    韩成花, 罗惠善, 李英姬. 平贝母挥发油化学成分分析[J]. 延边大学医学学报, 2006, 29(4): 264-265. https://www.cnki.com.cn/Article/CJFDTOTAL-YBYB200604018.htm

    HAN C H, LUO H S, LI Y J. Analysis of chemical constituents of volatile oil from Fritillaria ussuriensis Maxim[J]. J Med Sci Yanbian Univ, 2006, 29(4): 264-265. https://www.cnki.com.cn/Article/CJFDTOTAL-YBYB200604018.htm
    [27]
    韩成花, 罗惠善, 徐东花. 平贝母氯仿和乙酸乙酯提取物化学成分的研究[J]. 黑龙江中医药, 2008(3): 47-48. https://www.cnki.com.cn/Article/CJFDTOTAL-HLZY200803033.htm

    HAN C H, LUO H S, XU D H. Study on the chemical constituents of chloroform and ethyl acetate extracts from Fritillaria planiflorum[J]. Heilongjiang J Tradit Chin Med, 2008(3): 47-48. https://www.cnki.com.cn/Article/CJFDTOTAL-HLZY200803033.htm
    [28]
    王姝婷, 许亮, 那红宇, 等. 平贝母不同等级与氨基酸含量的相关性研究[J]. 中药材, 2021, 44(11): 2618-2623. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYCA202111023.htm

    WANG S T, XU L, NA H Y, et al. Study on the correlation between different grades and amino acids contents of fritillariae ussuriensis Bulbus[J]. J Chin Med Mater, 2021, 44(11): 2618-2623. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYCA202111023.htm
    [29]
    YANG L, ZHANG M R, YANG T C, et al. LC-MS/MS coupled with chemometric analysis as an approach for the differentiation of bulbus Fritillaria unibracteata and Fritillaria ussuriensis[J]. Phytochem Anal, 2021, 32(6): 957-969. doi: 10.1002/pca.3038
    [30]
    汪丽燕, 韩传环, 王萍. 皖贝与川贝和浙贝止咳祛痰的药理作用比较[J]. 安徽医学, 1993, 14(3): 57-58. https://www.cnki.com.cn/Article/CJFDTOTAL-AHYX199303049.htm

    WANG L Y, HAN C H, WANG P. Comparison of pharmacological effects of wanbei, Chuanbei and Zhebei on relieving cough and eliminating phlegm[J]. Anhui Med J, 1993, 14(3): 57-58. https://www.cnki.com.cn/Article/CJFDTOTAL-AHYX199303049.htm
    [31]
    李萍, 季晖, 徐国钧, 等. 贝母类中药的镇咳祛痰作用研究[J]. 中国药科大学学报, 1993, 24(6): 360-362. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGYD199306019.htm

    LI P, JI H, XU G J, et al. Studies on the antitussive and expectorant effects of Chinese drug Beimu[J]. J China Pharm Univ, 1993, 24(6): 360-362. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGYD199306019.htm
    [32]
    黄璐琦, 赵润怀. 中国中药材种业发展报告-2019[M]. 北京: 中国医药科技出版社, 2020: 187.

    HUANG L Q, ZHAO R H. Report on the development of Chinese herbal medicine seed industry in China-2019[M]. Beijing: China Medical Science and Technology Press, 2020: 187.
    [33]
    WANG D D, ZHU J Y, WANG S, et al. Antitussive, expectorant and anti-inflammatory alkaloids from Bulbus fritillariae cirrhosae[J]. Fitoterapia, 2011, 82(8): 1290-1294. doi: 10.1016/j.fitote.2011.09.006
    [34]
    WU X, OSHITA C, LI O, et al. Computational Analysis of the Viability of Ursolic Acid and Imperialine in Pei Pa Koa as Alternatives to Dextromethorphan in the Treatment of Cough[J]. ACE, 12821: 0.
    [35]
    徐东铭, 王淑琴, 黄恩喜, 等. 平贝碱乙的分离和鉴定[J]. 药学学报, 1988, 23(12): 902-905. https://www.cnki.com.cn/Article/CJFDTOTAL-YXXB198812004.htm

    XU D M, WANG S Q, HUANG E X, et al. Isolation and identification of pingpeimine b[J]. Acta Pharm Sin, 1988, 23(12): 902-905. https://www.cnki.com.cn/Article/CJFDTOTAL-YXXB198812004.htm
    [36]
    汪丽燕, 韩传环, 王萍, 等. 安徽贝母药理作用的实验研究[J]. 中国药理学通报, 1988, 4(6): 375-368. https://www.cnki.com.cn/Article/CJFDTOTAL-YAOL198806021.htm

    WANG L Y, HAN C H, WANG P, et al. Experimental study on pharmacological effects of Fritillaria Anhui[J]. Chin Pharmacol Bull, 1988, 4(6): 375-368. https://www.cnki.com.cn/Article/CJFDTOTAL-YAOL198806021.htm
    [37]
    熊玮, 郭小玲, 何嘉琅. 湖北贝母药理作用的初步研究[J]. 中草药, 1986(3): 19-22. https://www.cnki.com.cn/Article/CJFDTOTAL-ZCYO198603010.htm

    XIONG W, GUO X L, HE J L. Preliminary study on pharmacological action of Fritillaria hubeiensis[J]. Chin Tradit Herb Drugs, 1986(3): 19-22. https://www.cnki.com.cn/Article/CJFDTOTAL-ZCYO198603010.htm
    [38]
    曲淑岩, 姜秀莲, 陈颖莉, 等. 平贝母鳞茎与茎叶药理研究[J]. 特产研究, 1990, 12(1): 19-20. https://www.cnki.com.cn/Article/CJFDTOTAL-TCYA199001008.htm

    QU S Y, JIANG X L, CHEN Y L, et al. Pharmacological study on bulb and stem and leaf of Fritillaria Fritillaria[J]. Spec Wild Econ Anim Plant Res, 1990, 12(1): 19-20. https://www.cnki.com.cn/Article/CJFDTOTAL-TCYA199001008.htm
    [39]
    NILE S H, SU J J, WU D, et al. Fritillaria thunbergii Miq. (Zhe Beimu): A review on its traditional uses, phytochemical profile and pharmacological properties[J]. Food Chem Toxicol, 2021, 153: 112289. doi: 10.1016/j.fct.2021.112289
    [40]
    LIN B Q, JI H, LI P, et al. Selective antagonism activity of alkaloids from bulbs Fritillariae at muscarinic receptors: Functional studies[J]. Eur J Pharmacol, 2006, 551(1/2/3): 125-130.
    [41]
    LIU S M, YANG T C, MING T W, et al. Isosteroid alkaloids from Fritillaria cirrhosa bulbus as inhibitors of cigarette smoke-induced oxidative stress[J]. Fitoterapia, 2020, 140: 104434.
    [42]
    金鑫, 吕经纬, 边学峰, 等. 基于网络药理学和分子对接研究平贝母中生物碱的抗炎作用[J]. 中成药, 2022, 44(2): 647-652. https://www.cnki.com.cn/Article/CJFDTOTAL-ZCYA202202058.htm

    JIN X, LYU J W, BIAN X F, et al. Study on anti-inflammatory effect of alkaloids in Fritillaria Fritillaria based on network pharmacology and molecular docking[J]. Chin Tradit Pat Med, 2022, 44(2): 647-652. https://www.cnki.com.cn/Article/CJFDTOTAL-ZCYA202202058.htm
    [43]
    YI P F, WU Y C, DONG H B, et al. Peimine impairs pro-inflammatory cytokine secretion through the inhibition of the activation of NF-κB and MAPK in LPS-induced RAW264.7 macrophages[J]. Immunopharmacol Immunotoxicol, 2013, 35(5): 567-572.
    [44]
    YIN Z H, ZHANG J J, GUO Q F, et al. Pharmacological effects of verticine: Current status[J]. Evid Based Complement Alternat Med, 2019, 2019: 2394605.
    [45]
    GONG Q, LI Y W, MA H, et al. Peiminine protects against lipopolysaccharide-induced mastitis by inhibiting the AKT/NF-κB, ERK1/2 and p38 signaling pathways[J]. Int J Mol Sci, 2018, 19(9): 2637.
    [46]
    KIM E J, YOON Y P, WOO K W, et al. Verticine, ebeiedine and suchengbeisine isolated from the bulbs of Fritillaria thunbergii Miq. inhibited the gene expression and production of MUC5AC mucin from human airway epithelial cells[J]. Phytomedicine, 2016, 23(2): 95-104.
    [47]
    XU J W, ZHAO W, PAN L Y, et al. Peimine, a main active ingredient of Fritillaria, exhibits anti-inflammatory and pain suppression properties at the cellular level[J]. Fitoterapia, 2016, 111: 1-6.
    [48]
    LIU C Y, ZHEN D, DU H H, et al. Synergistic anti-inflammatory effects of peimine, peiminine, and forsythoside a combination on LPS-induced acute lung injury by inhibition of the IL-17-NF-κB/MAPK pathway activation[J]. J Ethnopharmacol, 2022, 295: 115343.
    [49]
    DU B X, CAO L, WANG K, et al. Peiminine attenuates acute lung injury induced by LPS through inhibiting lipid rafts formation[J]. Inflammation, 2020, 43(3): 1110-1119.
    [50]
    崔艳茹, 刘海云, 屈飞. 贝母辛对LPS致黏液高分泌小鼠MUC5AC和EGFR表达的影响[J]. 中药药理与临床, 2015, 1(3): 17-21. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYYL201503006.htm

    CUI Y R, LIU H Y, QU F. The effect of peimisine on LPS induced expression of MUC5AC and EGFR in mice with mucus hypersecretion[J]. Pharmacol Clin Chin Mater Med, 2015, 1(3): 17-21. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYYL201503006.htm
    [51]
    ZHANG H L, XU X Q, LIU Z H, et al. Effects of edpetiline from Fritillaria on inflammation and oxidative stress induced by LPS stimulation in RAW264.7 macrophages[J]. Acta Biochim Biophys Sin, 2021, 53(2): 229-237.
    [52]
    陈泽乃, 陆阳, 徐佩娟, 等. 中药贝母中水溶性成分的研究[J]. 中国中药杂志, 1996, 21(7): 420-422. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGZY607.017.htm

    CHEN Z N, LU Y, XU P J, et al. Study on water-soluble components in Fritillaria Fritillaria[J]. China J Chin Mater Med, 1996, 21(7): 420-422. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGZY607.017.htm
    [53]
    LEE A M, CHUNG Y C, KIM K Y, et al. Hydroethanolic extract of Fritillariae thunbergii Bulbus alleviates dextran sulfate sodium-induced ulcerative colitis by enhancing intestinal barrier integrity[J]. Nutrients, 2023, 15(12): 2810.
    [54]
    王艳红, 鲍建材, 张崇禧, 等. 中药平贝母的研究进展[J]. 人参研究, 2004, 16(3): 13-17. https://www.cnki.com.cn/Article/CJFDTOTAL-RSYJ200403004.htm

    WANG Y H, BAO J C, ZHANG C X, et al. Research progress of Fritillaria Fritillaria[J]. Ginseng Res, 2004, 16(3): 13-17. https://www.cnki.com.cn/Article/CJFDTOTAL-RSYJ200403004.htm
    [55]
    LIM J M, LEE B N, MIN J H, et al. Effect of peiminine on DNCB-induced atopic dermatitis by inhibiting inflammatory cytokine expression in vivo and in vitro[J]. Int Immunopharmacol, 2018, 56: 135-142.
    [56]
    徐东铭, 黄恩喜, 许卯力, 等. 平贝母茎叶生物碱成分的研究[J]. 中药通报, 1986, 11(11): 40-41. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGZY198611024.htm

    XU D M, HUANG E X, XU M L, et al. Studies on alkaloid constituents from stems and leaves of Fritillaria Fritillaria[J]. China J Chin Mater Med, 1986, 11(11): 40-41. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGZY198611024.htm
    [57]
    李兴斌, 高燕飞, 李吉良. 平贝母化学成分及药理活性研究进展[J]. 中医药信息, 2004, 21(4): 28-29. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYXN200404012.htm

    LI X B, GAO Y F, LI J L. The study development of chemical component and pharmacology activity of Bulbus Fritillariae Ussuriensis[J]. Inf Tradit Chin Med, 2004, 21(4): 28-29. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYXN200404012.htm
    [58]
    WU X, CHAN S W, MA J, et al. Investigation of association of chemical profiles with the tracheobronchial relaxant activity of Chinese medicinal herb Beimu derived from various Fritillaria species[J]. J Ethnopharmacol, 2018, 210: 39-46.
    [59]
    刘春红, 金钟斗, 韩宝瑞. 平贝母多糖对D-半乳糖诱导衰老模型小鼠的抗氧化作用[J]. 食品科学, 2011, 32(23): 285-288. https://www.cnki.com.cn/Article/CJFDTOTAL-SPKX201123058.htm

    LIU C H, JIN Z D, HAN B R. Antioxidant activity of polysaccharide FUP-1 from Fritillaria ussuriensis maxim in D-galactose-induced aging mouse model[J]. Food Sci, 2011, 32(23): 285-288. https://www.cnki.com.cn/Article/CJFDTOTAL-SPKX201123058.htm
    [60]
    于晓龙, 杨建玲, 朱乐, 等. 平贝母醇提物对小鼠免疫功能的影响[J]. 延边大学学报(自然科学版), 2015, 41(1): 85-88. https://www.cnki.com.cn/Article/CJFDTOTAL-YBDZ201501020.htm

    YU X L, YANG J L, ZHU Y, et al. The effect of the ethanol extract of Fritillaria ussuriensis Maxim on mice immune function[J]. J Yanbian Univ Nat Sci Ed, 2015, 41(1): 85-88. https://www.cnki.com.cn/Article/CJFDTOTAL-YBDZ201501020.htm
    [61]
    SHANG Y H, DU Q D, LIU S M, et al. Antitumor activity of isosteroidal alkaloids from the plants in the genus Veratrum and Fritillaria[J]. Curr Protein Pept Sci, 2018, 19(3): 302-310.
    [62]
    王丽杰, 张东杰. 平贝母总生物碱的抗菌活性[J]. 中国酿造, 2009(3): 90-92.

    WANG LJ, ZHANG DJ. Antibacterial activity of total alkaloids in Fritillaria planaria[J]. China Brewing, 2009(3): 90-92.
    [63]
    黄亚萍, 肖惠玲, 李艳红, 等. 贝母素乙抑制MEK/ERK的磷酸化对新生小鼠柯萨奇B病毒性心肌炎心肌细胞凋亡和炎症水平的影响[J]. 中药药理与临床, 2020, 36(1): 94-99. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYYL202001019.htm

    HUANG Y P, XIAO H L, LI Y H, et al. Effects of peiminine inhibiting MEK/ERK phosphorylation on cardiomyocyte apoptosis and inflammation level in neonatal mice with Coxsackie virus B myocarditis[J]. Pharmacol Clin Chin Mater Med, 2020, 36(1): 94-99. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYYL202001019.htm
    [64]
    郭苏兰, 李佳娜, 肖水秀. 贝母素甲对小鼠脑缺血再灌注损伤炎症反应及自噬的影响[J]. 中国老年学杂志, 2019, 5(21): 5347-5350. https://www.cnki.com.cn/Article/CJFDTOTAL-ZLXZ201921069.htm

    GUO S L, LI J N, XIAO S X. Effect of peimine A on inflammation and autophagy in cerebral ischemia-reperfusion injury in rats[J]. Chin J Gerontol, 2019, 5(21): 5347-5350. https://www.cnki.com.cn/Article/CJFDTOTAL-ZLXZ201921069.htm
    [65]
    WANG Z J, JIANG A N, XIAO H M, et al. Exploring the potential mechanism of Fritiliariae Irrhosae Bulbus on ischemic stroke based on network pharmacology and experimental validation[J]. Front Pharmacol, 2022, 13: 1049586.
    [66]
    张彬. 临床常用中成药速查[M]. 北京: 北京科学技术出版社, 2010: 86.

    ZHANG B. Quick investigation of commonly used Chinese patent medicines in clinic[M]. Beijing: Beijing Science & Technology Press, 2010: 86.
    [67]
    陆权, 鲍一笑, 王薇, 等. 金振口服液有效性和安全性的多中心、随机对照临床研究[J]. 中国实用儿科杂志, 2010(5): 383-387. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSEK201005026.htm

    LU Q, BAO Y X, WANG W, et al. A prospective multicenter randomized controlled study on the efficacy and safety of Jin-Zheng oral solution[J]. Chin J Pract Pediatr, 2010(5): 383-387. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSEK201005026.htm
    [68]
    常森, 彭秀丽. 羚竺散质量标准的研究[J]. 中国药品标准, 2011, 12(1): 67-69. https://www.cnki.com.cn/Article/CJFDTOTAL-YPBZ201101030.htm

    CHANG S, PENG X L. Quality standard for lingzhu powder[J]. Drug Stand China, 2011, 12(1): 67-69. https://www.cnki.com.cn/Article/CJFDTOTAL-YPBZ201101030.htm
    [69]
    张依, 李璇, 胡思源. 2020版《中华人民共和国药典》中儿童感冒中成药的情况分析[J/OL]. 世界中医药: 1-6. https://kns.cnki.net/kcms/detail/11.5529.R.20230327.0902.030.html.

    ZHANG Y, LI X, HU SY. Analysis of Chinese patent medicines for children's colds in Pharmacopoeia of the People's Republic of China 2020[J/OL]. World Chin Med: 1-6. https://kns.cnki.net/kcms/detail/11.5529.R.20230327.0902.030.html.
    [70]
    黄张杰, 赖平, 陈炜璇, 等. 滋肾宁神胶囊的宁心安神作用研究[J]. 中药材, 2020, 43(5): 1222-1225. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYCA202005035.htm

    HUANG Z J, LAI P, CHEN W X, et al. Study on the effect of Zishen Ningshen capsule on calming the heart and calming the nerves[J]. J Chin Med Mater, 2020, 43(5): 1222-1225. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYCA202005035.htm
    [71]
    曹桂红, 黄春青, 许波. 高效液相色谱法测定复方愈酚麻黄糖浆中盐酸麻黄碱的含量[J]. 广东化工, 2019, 46(21): 131-133. https://www.cnki.com.cn/Article/CJFDTOTAL-GDHG201921056.htm

    CAO G H, HUANG C Q, XU B. Determination of ephedrine hydrochloride in compound guaifenesin giclofenac and ephedrine syrup by HPLC[J]. Guangdong Chem Ind, 2019, 46(21): 131-133. https://www.cnki.com.cn/Article/CJFDTOTAL-GDHG201921056.htm
    [72]
    王月兰, 刘旭静. 参茸保胎丸联合烯丙雌醇治疗先兆流产临床研究[J]. 中国药业, 2022, 31(21): 85-88. https://www.cnki.com.cn/Article/CJFDTOTAL-YYGZ202221019.htm

    WANG Y L, LIU X J. Clinical study of Shenrong Baotai pills combined with allylestrenol in the treatment of threatened abortion[J]. China Pharm, 2022, 31(21): 85-88. https://www.cnki.com.cn/Article/CJFDTOTAL-YYGZ202221019.htm
    [73]
    李正刚, 曲涵婷, 李本淳, 等. HPLC法测定复方贝母片中盐酸麻黄碱和盐酸伪麻黄碱的含量[J]. 中国药品标准, 2021, 22(6): 560-563. https://www.cnki.com.cn/Article/CJFDTOTAL-YPBZ202106012.htm

    LI Z G, QU H T, LI B C, et al. Quantitative determination of ephedrine hydrochloride and pseudoephedrine hydrochloride in the Compound Beimu Tablets by HPLC[J]. Drug Stand China, 2021, 22(6): 560-563. https://www.cnki.com.cn/Article/CJFDTOTAL-YPBZ202106012.htm
    [74]
    曲阳, 赵静, 方媛, 等. 治咳川贝枇杷滴丸治疗普通感冒后咳嗽(痰热郁肺证)的随机对照多中心临床研究[J]. 中药新药与临床药理, 2022, 8(10): 1422-1427. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYXY202210017.htm

    QU Y, ZHAO J, FANG Y, et al. A randomized controlled, multi-center clinical study on Zhike Chuanbei Pipa dropping pills in the treatment of cough after common cold (phlegm-heat stagnating in lung syndrome)[J]. Tradit Chin Drug Res Clin Pharmacol, 2022, 8(10): 1422-1427. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYXY202210017.htm
    [75]
    国家药典委员会. 中华人民共和国药典临床用药须知-中药成方制剂卷: [M]. 北京: 中国医药科技出版社, 2011: 87.

    National Pharmacopoeia Committee. Pharmacopoeia of the People's Republic of China clinical drug instructions: TCM prescription preparation volume[M]. Beijing: China Medical Science and Technology Press, 2011: 87.
    [76]
    吴松强, 王伟伟. 小儿白贝止咳糖浆联合小儿豉翘清热颗粒治疗儿童上呼吸道感染的前瞻性随机对照分析[J]. 医学理论与实践, 2023, 36(13): 2255-2258. https://www.cnki.com.cn/Article/CJFDTOTAL-YXLL202313035.htm

    WU S Q, WANG W W. A prospective randomized controlled analysis of Xiaoer Baibei Zhike Syrup combined with Xiaoer Chiqiao Qingre Granule in the treatment of upper respiratory tract infection in children[J]. J Med Theory Pract, 2023, 36(13): 2255-2258. https://www.cnki.com.cn/Article/CJFDTOTAL-YXLL202313035.htm
    [77]
    崔海英. 蛇胆川贝液辅佐治疗婴儿类百日咳综合征观察[J]. 名医, 2019(4): 241. https://www.cnki.com.cn/Article/CJFDTOTAL-MGYI201904223.htm

    CUI H Y. Observation on the adjuvant treatment of infant pertussis syndrome with Shedanchuanbei liquid[J]. Famous Medicine, 2019(4): 241. https://www.cnki.com.cn/Article/CJFDTOTAL-MGYI201904223.htm
    [78]
    孙兴华, 曲齐生, 张淼, 等. 治咳川贝枇杷滴丸治疗慢性支气管炎(单纯型)急性发作(痰热郁肺证)的多中心随机双盲对照研究[J]. 药物评价研究, 2020, 43(9): 1787-1791. https://www.cnki.com.cn/Article/CJFDTOTAL-YWPJ202009018.htm

    SUN X H, QU Q S, ZHANG M, et al. A multicenter randomized and double-blind controlled study on Zhikechuanbeipipa Dropping Pills treatment of acute attack of chronic bronchitis (simple type) with phlegm heat stagnation lung syndrome[J]. Drug Eval Res, 2020, 43(9): 1787-1791. https://www.cnki.com.cn/Article/CJFDTOTAL-YWPJ202009018.htm
    [79]
    杨宁, 刘淑媛, 秦雪莹. 百咳宁颗粒辅助治疗新生儿感染性肺炎59例临床观察[J]. 中医儿科杂志, 2021, 17(6): 58-61. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYEZ202106018.htm

    YANG N, LIU S Y, QIN X Y. Clinical observation on 59 cases of neonatal infectious pneumonia treated by Baikening Keli as adjuvant therapy[J]. J Pediatr Tradit Chin Med, 2021, 17(6): 58-61. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYEZ202106018.htm
    [80]
    张露明, 董婷, 谭春梅, 等. 基于UHPLC-LTQ-Orbitrap-MS化学成分和特征图谱的小儿肺热平胶囊质量评价[J]. 中国医院药学杂志, 2022, 42(24): 2643-2649. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGYZ202224012.htm

    ZHANG L M, DONG T, TAN C M, et al. Quality evaluation of Xiao'er Feireping Capsules based on chemical constituents by UHPLC-LTQ-Orbitrap-MS and HPLC specific chromatogram[J]. Chin J Hosp Pharm, 2022, 42(24): 2643-2649. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGYZ202224012.htm
    [81]
    张传香, 何苗, 马丹凤, 等. 高效液相一测多评法定量分析小儿清热化痰栓中8种主要成分含量[J]. 儿科药学杂志, 2022, 8(10): 26-30. https://www.cnki.com.cn/Article/CJFDTOTAL-EKYX202210008.htm

    ZHANG C X, HE M, MA D F, et al. Determination of 8 main components in Xiao'er Qingre Huatan suppository by high performance liquid chromatography-quantitative analysis of multi-components by single-marker[J]. J Pediatr Pharm, 2022, 8(10): 26-30. https://www.cnki.com.cn/Article/CJFDTOTAL-EKYX202210008.htm
    [82]
    庞春燕. 基于配伍禁忌的中成药合理用药探析[J]. 中国中医药信息杂志, 2018, 25(11): 126-129. https://www.cnki.com.cn/Article/CJFDTOTAL-XXYY201811031.htm

    PANG C Y. Analysis on rational medication of TCM patent medicine based on incompatibility[J]. Chin J Inf Tradit Chin Med, 2018, 25(11): 126-129. https://www.cnki.com.cn/Article/CJFDTOTAL-XXYY201811031.htm
    [83]
    王姝婷, 杨燕云, 许亮等. 平贝母及贝母类药材本草考证[J]. 辽宁中医药大报, 2021, 23(09): 149-156. https://www.cnki.com.cn/Article/CJFDTOTAL-LZXB202109031.htm

    WANG ST, YANG YY, XU L et al. Textual research on Fritillaria planata and Fritillaria[J]. Liaoning Journal of Traditional Chinese Medicine, 2021, 23(09): 149-156. https://www.cnki.com.cn/Article/CJFDTOTAL-LZXB202109031.htm
    [84]
    DE SOUZA P, DA SILVA L M, DE ANDRADE S F, et al. Recent advances in the knowledge of naturally-derived bioactive compounds as modulating agents of the renin-angiotensin-aldosterone system: Therapeutic benefits in cardiovascular diseases[J]. Curr Pharm Des, 2019, 25(6): 670-684.
    [85]
    SHANG Y H, DU Q D, LIU S M, et al. Antitumor activity of isosteroidal alkaloids from the plants in the genus Veratrum and Fritillaria[J]. Curr Protein Pept Sci, 2018, 19(3): 302-310.
    [86]
    LIU F J, CHEN X Y, YANG J, et al. Revealing active components and action mechanism of Fritillariae Bulbus against non-small cell lung cancer through spectrum-effect relationship and proteomics[J]. Phytomedicine, 2023, 110: 154635.
    [87]
    SHANG Y H, DU Q D, LIU S M, et al. Antitumor activity of isosteroidal alkaloids from the plants in the genus Veratrum and Fritillaria[J]. Curr Protein Pept Sci, 2018, 19(3): 302-310.
    [88]
    TAN H, ZHANG G, YANG X, et al. Peimine inhibits the growth and motility of prostate cancer cells and induces apoptosis by disruption of intracellular calcium homeostasis through Ca2+/CaMKⅡ/JNK pathway[J]. J Cell Biochem, 2020, 121(1): 81-92.
    [89]
    LI J F, QIN Y Y, WANG W J, et al. Peiminine inhibits the progression of colorectal cancer through up-regulating miR-760 via declining the expression of long noncoding RNA LINC00659[J]. Anticancer Drugs, 2021, 32(2): 148-156.
    [90]
    黄亚萍, 肖惠玲, 李艳红, 等. 贝母素乙抑制MEK/ERK的磷酸化对新生小鼠柯萨奇B病毒性心肌炎心肌细胞凋亡和炎症水平的影响[J]. 中药药理与临床, 2020, 6(1): 94-99. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYYL202001019.htm

    HUANG Y P, XIAO H L, LI Y H, et al. Effects of peiminine inhibiting MEK/ERK phosphorylation on cardiomyocyte apoptosis and inflammation level in neonatal mice with Coxsackie virus B myocarditis[J]. Pharmacol Clin Chin Mater Med, 2020, 6(1): 94-99. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYYL202001019.htm
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