Volume 40 Issue 1
Jan.  2024
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Article Navigation >  Journal of Nanjing University of traditional Chinese Medicine  > 2024  >  40(1): 47-60
CUI Ting, LI Meizhou, GAN Lifan, LIN Jiaming, LIANG Lijin, HUANG Xingpeng, ZHANG Zhipeng. Research on Water Extraction Process of Flos Lonicerae-Fructus Forsythuae Based on Network Pharmacology and Design Space[J]. Journal of Nanjing University of traditional Chinese Medicine, 2024, 40(1): 47-60. doi: 10.14148/j.issn.1672-0482.2024.0047
Citation: CUI Ting, LI Meizhou, GAN Lifan, LIN Jiaming, LIANG Lijin, HUANG Xingpeng, ZHANG Zhipeng. Research on Water Extraction Process of Flos Lonicerae-Fructus Forsythuae Based on Network Pharmacology and Design Space[J]. Journal of Nanjing University of traditional Chinese Medicine, 2024, 40(1): 47-60. doi: 10.14148/j.issn.1672-0482.2024.0047
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Research on Water Extraction Process of Flos Lonicerae-Fructus Forsythuae Based on Network Pharmacology and Design Space

doi: 10.14148/j.issn.1672-0482.2024.0047

  • Guangdong Yifang Pharmaceutical Co. Ltd., Guangdong Provincial Key Laboratory of Traditional Chinese Medicine Formula Granule, Foshan 528244, China

  • Received Date: 2023-07-20
    Available Online: 2024-01-24
    Abstract
  •   OBJECTIVE  To optimize the water extraction process of Flos Lonicerae-Fructus Forsythuae and determine the range of water extraction process parameters.  METHODS  The active components were screened by network pharmacology, and the indicator ingredients were determined in combination with the quality markers under the relevant terms of Chinese Pharmacopoeia 2020 edition and the literature. Take extraction yield and the extraction rate of the indicative component as the critical quality attributes of the water extraction process to screen critical process parameters. The mathematical model was established by Box-Behnken experimental design to investigate the interaction between CQAs and CPPs and build the design space of the water extraction process of Flos Lonicerae-Fructus Forsythuae.  RESULTS  The extraction percentages of phenolic acids, forsythoside A and forsythin were screened as the index components; specifications of medicinal slices, extraction time and water addition were the key process parameters. Based on the establishment and optimization of the design space, the optimum water extraction process was obtained as follows: the medicinal slice of Lian-Qiao was broken into 0.8-1.2 cm, adding 12 times the amount of water in the first and extract for 30-50 min, 10 times the amount of water in the second and extract for 25-30 min.  CONCLUSION  The verification results show that the measured value obtained by using the design space method to optimize the water extraction process is close to the predicted value, indicating that the method is stable and reliable, which can provide ideas for its further process development and quality control for the couple medicines of Flos Lonicerae-Fructus Forsythuae.

     

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