Study on the Effect of Moslae Herba Oil on the Percutaneous Absorption of Active Ingredient of Evodia Rutaecarpa <i>in vitro</i>

LI Qiujuan; LIANG Yafang; SHU Juan; JIA Congling; LIU Chanchan; WU Qinan

doi:10.14148/j.issn.1672-0482.2024.0026

Volume 40 Issue 1

Jan. 2024

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Article Navigation > Journal of Nanjing University of traditional Chinese Medicine > 2024 > 40(1): 26-36

LI Qiujuan, LIANG Yafang, SHU Juan, JIA Congling, LIU Chanchan, WU Qinan. Study on the Effect of Moslae Herba Oil on the Percutaneous Absorption of Active Ingredient of Evodia Rutaecarpa in vitro[J]. Journal of Nanjing University of traditional Chinese Medicine, 2024, 40(1): 26-36. doi: 10.14148/j.issn.1672-0482.2024.0026

Citation:

LI Qiujuan, LIANG Yafang, SHU Juan, JIA Congling, LIU Chanchan, WU Qinan. Study on the Effect of Moslae Herba Oil on the Percutaneous Absorption of Active Ingredient of Evodia Rutaecarpa in vitro[J]. Journal of Nanjing University of traditional Chinese Medicine, 2024, 40(1): 26-36. doi: 10.14148/j.issn.1672-0482.2024.0026

Citation:

LI Qiujuan, LIANG Yafang, SHU Juan, JIA Congling, LIU Chanchan, WU Qinan. Study on the Effect of Moslae Herba Oil on the Percutaneous Absorption of Active Ingredient of Evodia Rutaecarpa in vitro[J]. Journal of Nanjing University of traditional Chinese Medicine, 2024, 40(1): 26-36. doi: 10.14148/j.issn.1672-0482.2024.0026

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Study on the Effect of Moslae Herba Oil on the Percutaneous Absorption of Active Ingredient of Evodia Rutaecarpa in vitro

doi: 10.14148/j.issn.1672-0482.2024.0026

LI Qiujuan^1
,,
LIANG Yafang¹,
SHU Juan¹,
JIA Congling¹,
LIU Chanchan^{1, 2
,
,},
WU Qinan^{1, 2, 3
,
,}

1.
School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
2.
Jiangsu Collaborative Innovation Center of TCM Resource Industrialization Process, Nanjing 210023, China
3.
National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing 210023, China

Received Date: 2023-07-12
Available Online: 2024-01-24

Abstract

Abstract

OBJECTIVE To investigate whether Moslae herba oil has penetration enhancing effect on the active components of Evodia rutaecarpa and its ability to promote transdermal absorption. METHODS In vitro transdermal experiments were performed using the diffusion pool and the isolated skin of rats. Using various components of Evodia rutaecarpa as indicators, HPLC was determined to calculate the umulative penetration amount of each component. Changes in the skin and cuticle layers were observed by HE staining, immunohistochemical staining, and ATR-FTIR. GC-MS was used to measure Moslae herba oil components after administration. RESULTS Moslae herba oil showed the penetration-enhancing effect on various components in Evodia rutaecarpa. Compared with the postive drug nitrogenone, the cumulative penetration amounts of hyperoside, evodiamine and rutaecarpine were greater. In addition, the sesquiterpene composition and thymol in the Moslae herba oil were more likely to be stored in the skin, which could disturb the lipid structure of the cuticle layer and promote the penetration of drugs. CONCLUSION The results provide reference for the selection of transdermal absorption agent.
- Moslae herba oil,
- Evodia rutaecarpa,
- penetration enhancers

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References(26)

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Study on the Effect of Moslae Herba Oil on the Percutaneous Absorption of Active Ingredient of Evodia Rutaecarpa in vitro

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Study on the Effect of Moslae Herba Oil on the Percutaneous Absorption of Active Ingredient of Evodia Rutaecarpa in vitro

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