Volume 39 Issue 10
Oct.  2023
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Article Navigation >  Journal of Nanjing University of traditional Chinese Medicine  > 2023  >  39(10): 999-1005
SUN Shu-xian, GU Xiao-qun, QIAN Pei-yao, YU Xue-rui, ZHENG Jie, ZHAO Qian, LI Jia-yu, HONG Min. Exploring the Target and Mechanism of Sanfeng Tongqiao Dropping Pills in the Treatment of Allergic Rhinitis Based on Systematic Pharmacological Methods[J]. Journal of Nanjing University of traditional Chinese Medicine, 2023, 39(10): 999-1005. doi: 10.14148/j.issn.1672-0482.2023.0999
Citation: SUN Shu-xian, GU Xiao-qun, QIAN Pei-yao, YU Xue-rui, ZHENG Jie, ZHAO Qian, LI Jia-yu, HONG Min. Exploring the Target and Mechanism of Sanfeng Tongqiao Dropping Pills in the Treatment of Allergic Rhinitis Based on Systematic Pharmacological Methods[J]. Journal of Nanjing University of traditional Chinese Medicine, 2023, 39(10): 999-1005. doi: 10.14148/j.issn.1672-0482.2023.0999
shu

Exploring the Target and Mechanism of Sanfeng Tongqiao Dropping Pills in the Treatment of Allergic Rhinitis Based on Systematic Pharmacological Methods

doi: 10.14148/j.issn.1672-0482.2023.0999
  • 1.

    Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China

  • 2.

    Yangtze River Pharmaceutical Group, Taizhou 225321, China

  • 3.

    School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China

  • Received Date: 2023-01-19
    Available Online: 2023-11-10
    Abstract
  •   OBJECTIVE  To screen the active components of Sanfeng Tongqiao (SFTQ) by using network pharmacological method and to investigate the target and mechanism of SFTQ in the treatment of allergic rhinitis (AR).  METHODS  The active components and targets of SFTQ were screened by TCMSP. TCMSP and TTD database were used to screen AR-related therapeutic targets. SFTQ active components-AR target network was constructed by Cytoscape to predict potential targets. KEGG pathway enrichment analysis was performed on Davidv 6.8 database. An AR mouse model was established, and different doses of SFTQ were used for intervention during the stimulation period. The results were evaluated through behavioral indicators, pathological sections, HE staining, peripheral blood EOS and IgE levels, and the number of ILC2 in cervical lymph nodes.  RESULTS  42 active components and 16 potential targets were identified. KEGG enrichment analysis revealed 18 potential signaling pathways involving T cell receptor signaling pathway, HIF-1 signaling pathway, etc. In vivo, SFTQ significantly reduced the frequency of sneezing and rubbing, the degree of mucosal thickening, peripheral blood EOS, IgE level and the amount of ILC2 in cervical lymph nodes.  CONCLUSION  Using systems pharmacology methods, the study revealed the multi-component, multi-target, and multi-pathway characteristics of SFTQ in treating AR, providing possible targets and active components for the mechanism study of SFTQ, and laying the foundation for a more comprehensive understanding and application of this prescription.

     

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