Volume 39 Issue 8
Aug.  2023
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Article Navigation >  Journal of Nanjing University of traditional Chinese Medicine  > 2023  >  39(8): 794-800
TANG Jun-jie, GU Wei, QIAN Xu-dong, ZHANG Dao-guo, QIU Rong-li, WU Yin-zhi, FEI Xiao-meng, LIU Meng-xue, LANG Pei-lei, JU Rui-xin. Study on the Medicinal Value and Resource Evaluation of Jiangsu Genuine Medicinal Materials Binhai Baishouwu[J]. Journal of Nanjing University of traditional Chinese Medicine, 2023, 39(8): 794-800. doi: 10.14148/j.issn.1672-0482.2023.0794
Citation: TANG Jun-jie, GU Wei, QIAN Xu-dong, ZHANG Dao-guo, QIU Rong-li, WU Yin-zhi, FEI Xiao-meng, LIU Meng-xue, LANG Pei-lei, JU Rui-xin. Study on the Medicinal Value and Resource Evaluation of Jiangsu Genuine Medicinal Materials Binhai Baishouwu[J]. Journal of Nanjing University of traditional Chinese Medicine, 2023, 39(8): 794-800. doi: 10.14148/j.issn.1672-0482.2023.0794
shu

Study on the Medicinal Value and Resource Evaluation of Jiangsu Genuine Medicinal Materials Binhai Baishouwu

doi: 10.14148/j.issn.1672-0482.2023.0794
  • 1.

    School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China

  • 2.

    Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing 210023, China

  • 3.

    Binhai Agricultural Tourism Group Co., Ltd., Yancheng 224500, China

  • Received Date: 2023-03-28
    Available Online: 2023-08-17
    Abstract
  • This paper systematically combed and studied the herb textual research, efficacy and its material basis, and quality evaluation of Jiangsu genuine medicinal materials Binhai Baishouwu. Resource distribution, reserve, development and utilization status were also evaluated through literature review and field investigation. Binhai Baishouwu, scientifically named as Cynanchum auriculatum Royle ex Wight, is one of the species of the genus Cynanchum L. from the Asclepiadaceae family. It is one of the originals of Cynanchi Radix in herbal records with the functions of tonifying the liver and kidney, strengthening muscles and bones, nourishing blood and black hair, etc. Modern pharmacological studies show that it has the functions of anti-tumor, immune regulation and liver protection. C.auriculatum Royle ex Wight is distributed in 23 provinces, including Jiangsu and Shandong, and has been included in the standards for Chinese herbal medicine in provinces and cities such as Jiangsu, Hubei, Hunan, Guizhou, Sichuan, Chongqing, Anhui, etc. The development and utilization process of its medicinal value is slow. Binhai Baishouwu has a stable industrial foundation and a strong momentum of development, which has great room for improvement in standardized planting and deep integration of government, industry, university and research. These results laid the foundation for the further development and utilization of its industry.

     

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    • References(53)
  • [1]
    张晓榕, 陈文为. 白首乌总甾体酯甙对心脏和肝脏氧代谢的实验研究[J]. 中国医药学报, 1987, 2(5): 23-25. https://www.cnki.com.cn/Article/CJFDTOTAL-BXYY198705007.htm

    ZHANG XR, CHEN WW. Experimental study on oxygen metabolism of heart and liver by total steroidal glycosides of Radix Cynanchi Auriculati[J]. China J Tradit Chin Med Pharm, 1987, 2(5): 23-25. https://www.cnki.com.cn/Article/CJFDTOTAL-BXYY198705007.htm
    [2]
    方玉红, 李雪松, 袁素, 等. 三辨治癌合并介入治疗中晚期胃癌43例[J]. 辽宁中医杂志, 2015, 42(3): 535-536. doi: 10.13192/j.issn.1000-1719.2015.03.036

    FANG YH, LI XS, YUAN S, et al. 43 cases of advanced gastric cancer treated by cancer treatment based on SPL theory with interventional therapy[J]. Liaoning J Tradit Chin Med, 2015, 42(3): 535-536. doi: 10.13192/j.issn.1000-1719.2015.03.036
    [3]
    李翱, 欧阳詹. 李文公集[M]. 上海: 上海古籍出版社, 1993: 92.

    LI A, OUYANG Z. Li Wengong Corpus[M]. Shanghai: Shanghai Chinese classics publishing house, 1993: 92.
    [4]
    卢多逊. 开宝本草: 辑复本[M]. 尚志钧, 辑校. 合肥: 安徽科学技术出版社, 1998: 253.

    LU DX. Materia Medica of the Kaibao Era: Collected edition[M]. SHANG ZJ, annoted. Hefei: Anhui science & technology publishing house, 1998: 253.
    [5]
    苏颂. 本草图经[M]. 尚志钧, 辑校. 合肥: 安徽科学技术出版社, 1994: 314-315.

    SU S. Illustrated Classic of Materia Medica[M]. SHANG ZJ, annoted. Hefei: Anhui science & technology publishing house, 1994: 314-315.
    [6]
    唐慎微. 证类本草[M]. 郭君双, 金秀梅, 赵益梅, 校注. 北京: 中国医药科技出版社, 2011.

    TANG SW. Materia Medica Arranged According to Pattern[M]. GUO JS, JIN XM, ZHAO YM, annoted. Beijing: China medical science and technology press, 2011.
    [7]
    刘文泰. 本草品汇精要[M]. 北京: 人民卫生出版社, 1982: 394-395.

    LIU WT. Essentials of Materia Medica Distinctions[M]. Beijing: People's medical publishing house, 1982: 394-395.
    [8]
    李时珍. 本草纲目[M]. 太原: 山西科学技术出版社, 2014: 590-592.

    LI SZ. The Grand Compendium of Materia Medica[M]. Taiyuan: Shanxi scientific & technical publishers, 2014: 590-592.
    [9]
    陈嘉谟. 本草蒙筌[M]. 王淑民, 点校. 北京: 人民卫生出版社, 1988: 68-69.

    CHEN JM. Enlightening Primer of Materia Medica[M]. WANG SM, annotated. Beijing: People's medical publishing house, 1988: 68-69.
    [10]
    汪昂. 本草备要[M]. 合肥: 安徽科学技术出版社, 1990: 32.

    WANG A. Essentials of Materia Medica[M]. Hefei: Anhui science and technology publishing house, 1990: 32.
    [11]
    高木重周. 汉药何首乌的生药学研究[J]. 药学杂志, 1921(472): 487-498.

    GAOMU CZ. Pharmacognosy study of Chinese medicine polygoni multiflori radix[J]. Pharm J, 1921(472): 487-498.
    [12]
    中国医学院科学院药物研究所. 中药志: 第一册[M]. 北京: 人民卫生出版社, 1959: 243-245.

    Institute of Materia Medica, Chinese Academy of Medical Sciences. Annals of Traditional Chinese Medicine: Volume Ⅰ[M]. Beijing: People's medical publishing house, 1959: 243-245.
    [13]
    朱橚. 救荒本草校释与研究[M]. 王家葵, 张瑞贤, 李敏, 校注. 北京: 中医古籍出版社, 2007: 189-190.

    ZHU S. Proofreading and Research of Materia Medica for Famine Relief[M]. WANG JK, ZHANG RX, LI M, annoted. Beijing: Traditional Chinese medicine ancient books publishing house, 2007: 189-190.
    [14]
    吴淇浚. 植物名实图考[M]. 上海: 商务印书馆, 1957: 56.

    WU QJ. Illustrated Reference of Botanical Nomenclature[M]. Beijing: The commercial press, 1957: 56.
    [15]
    谢宗万, 邬家林. 天宝本草新编[M]. 北京: 中医古籍出版社, 2001: 55-57.

    XIE ZM, WU JL. New Edition of Tianbao Materia Medica[M]. Beijing: Traditional Chinese medicine ancient books publishing house, 2001: 55-57.
    [16]
    鲍山. 野菜博录[M]. 济南: 山东画报出版社, 2007: 303.

    BAO S. Wild Vegetables Collection[M]. Jinan: Shandong pictorial publishing house, 2007: 303.
    [17]
    朱棣. 救荒本草: 卷二[M]. 嘉靖四年刊本. 上海: 上海古籍出版社, 1959: 128.

    ZHU D. Herbal for Relief of Famines: Vol. Ⅱ[M]. Jiajing fourth year edition. Shanghai: Shanghai classics publishing house, 1959: 128.
    [18]
    中国医学科学院药物研究所. 中药志: 第二册[M]. 2版. 北京: 人民卫生出版社, 1982: 328-336.

    Institute of Materia Medica, Chinese Academy of Medical Sciences. Annals of Traditional Chinese Medicine: Volume Ⅱ[M]. 2nd ed. Beijing: People's medical publishing house, 1982: 328-336.
    [19]
    国家中医药管理局《中华本草》编委会. 中华本草: 9[M]. 上海: 上海科学技术出版社, 1999: 333-337.

    State Administration of Traditional Chinese Medicine, Chinese Materia Medica editorial board. Chinese Materia Medica: Vol. Ⅸ[M]. Shanghai: Shanghai scientific & technical publishers, 1999: 333-337.
    [20]
    南京中医药大学. 中药大辞典[M]. 2版. 上海: 上海科学技术出版社, 2014: 872-874.

    Nanjing University of Chinese Medicine. Dictionary of Traditional Chinese Medicine[M]. 2nd ed. Shanghai: Shanghai scientific & technical publishers, 2014: 872-874.
    [21]
    阜宁县地方志编纂委员会. 阜宁县志[M]. 南京: 江苏科学技术出版社, 1992.

    Funing County local Chronicles Compilation Committee. Funing County Annals[M]. Nanjing: Phoenix science press, 1992.
    [22]
    李中梓. 医宗必读[M]. 北京: 中国中医药出版社, 2020.

    LI ZZ. Required Readings from the Medical Ancestors[M]. Beijing: China press of traditional Chinese medicine, 2020.
    [23]
    张璐. 本经逢源[M]. 太原: 山西科学技术出版社, 2015: 134.

    ZHANG L. The Source of Classic of the Materia Medica[M]. Taiyuan: Shanxi scientific & technical publishers, 2015: 134.
    [24]
    黄宫绣. 本草求真[M]. 太原: 山西科学技术出版社, 2012: 50-51.

    HUANG GX. Seeking Accuracy in the Materia Medica[M]. Taiyuan: Shanxi scientific & technical publishers, 2012: 50-51.
    [25]
    李中梓. 本草通玄[M]. 北京: 中国中医药出版社, 2015: 49-50.

    LI ZZ. Penetrating the Mysteries of the Materia Medica[M]. Beijing: China press of traditional Chinese medicine, 2015: 49-50.
    [26]
    江苏省植物研究所. 新华本草纲要: 第三册[M]. 上海: 上海科学技术出版社, 1990: 259-260.

    Jiangsu Institute of Botany. Xinhua Compendium of Materia Medica: Volume 3[M]. Shanghai: Shanghai scientific & technical publishers, 1990: 259-260.
    [27]
    《全国中草药汇编》编写组. 全国中草药汇编: 上册[M]. 北京: 人民卫生出版社, 1996: 72-73.

    National Compliation of Chinese Herbal Medicine Editiorial Group. National Compilation of Chinese Herbal Medicine: Vol. 1[M]. Beijing: People's medical publishing house, 1996: 72-73.
    [28]
    黄璐琦. 中草药与民族药药材图谱[M]. 北京: 北京大学医学出版社, 2005: 32.

    HUANG LQ. Atlas of Chinese Herbal Medicine and Ethnic Medicine[M]. Beijing: Peking university medical press, 2005: 32.
    [29]
    谢凯强, 苑春茂, 蹇军友, 等. 隔山牛皮消、耳叶牛皮消和戟叶牛皮消中四个C21-甾体苷元含量比较研究[J]. 天然产物研究与开发, 2018, 30(2): 261-267. https://www.cnki.com.cn/Article/CJFDTOTAL-TRCW201802015.htm

    XIE KQ, YUAN CM, JIAN JY, et al. Comparison of contents of four C21-steroidals from Cynanchum wilfordii, Cynanchum auriculatum and Cynanchum bungei[J]. Nat Prod Res Dev, 2018, 30(2): 261-267. https://www.cnki.com.cn/Article/CJFDTOTAL-TRCW201802015.htm
    [30]
    ZHEN X, CHOI HS, KIM JH, et al. Caudatin isolated from Cynanchum auriculatum inhibits breast cancer stem cell formation via a GR/YAP signaling[J]. Biomolecules, 2020, 10(6): 925. doi: 10.3390/biom10060925
    [31]
    WANG L, CAI FJ, ZHAO W, et al. Cynanchum auriculatum royle ex wight., Cynanchum bungei decne. and Cynanchum wilfordii (maxim. ) hemsl. : Current research and prospects[J]. Molecules, 2021, 26(23): 7065. doi: 10.3390/molecules26237065
    [32]
    WANG YQ, ZHANG SJ, LU H, et al. A C21-steroidal glycoside isolated from the roots of Cynanchum auriculatum induces cell cycle arrest and apoptosis in human gastric cancer SGC-7901 cells[J]. Evid Based Complement Alternat Med, 2013, 2013: 180839.
    [33]
    赵鑫. 白首乌C21甾总苷的化学降解及降解产物抗肿瘤活性研究[D]. 南京: 南京中医药大学, 2011.

    ZHAO X. Studies on C21 steroidal glycosides degradation of Cynanchum auriculatum and antitumor activity of degradation products[D]. Nanjing: Nanjing University of Chinese Medicine, 2011.
    [34]
    伍振辉, 孟娴, 丁永芳, 等. 白首乌C-21甾体总苷对人肝癌HepG2细胞增殖、侵袭与凋亡的影响[J]. 中国中药杂志, 2018, 43(9): 1915-1921. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGZY201809027.htm

    WU ZH, MENG X, DING YF, et al. Effects of total C-21 steroidal glycosides from Cynanchum Auriculatum on proliferation invasion and apoptosis of human hepatic cancer HepG2 cells[J]. China J Chin Mater Med, 2018, 43(9): 1915-1921. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGZY201809027.htm
    [35]
    曾郁敏, 邱泽计, 潘爱群, 等. 白首乌总苷与环磷酰胺合用对荷瘤小鼠免疫功能的影响[J]. 北京中医药大学学报, 2009, 32(3): 167-169. doi: 10.3321/j.issn:1006-2157.2009.03.006

    ZENG YM, QIU ZJ, PAN AQ, et al. Influence of general steroidal glycosides from Radix Cynanchi Auriculati combined with cyclophosphamide on immunity in mice with tumor[J]. J Beijing Univ Tradit Chin Med, 2009, 32(3): 167-169. doi: 10.3321/j.issn:1006-2157.2009.03.006
    [36]
    LEE J, CHO CW, JANG M, et al. Immunostimulatory activities of a high molecular weight fraction of Cynanchum auriculatum royle ex wight root obtained by ultrafiltration[J]. Phcog Mag, 2020, 16(71): 493. doi: 10.4103/pm.pm_449_19
    [37]
    向家俊, 李齐激, 杨艳, 等. 耳叶牛皮消块根发酵产物的免疫活性及化学成分研究[J]. 中国药学杂志, 2020, 55(7): 498-503. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGYX202007002.htm

    XIANG JJ, LI QJ, YANG Y, et al. Immunological activity and chemical constituents of fermentation product in Cynanchum auriculatum royle ex wight[J]. Chin Pharm J, 2020, 55(7): 498-503. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGYX202007002.htm
    [38]
    QIN JJ, CHEN X, LIN ZM, et al. C21-steroidal glycosides and sesquiterpenes from the roots of Cynanchum bungei and their inhibitory activities against the proliferation of B and T lymphocytes[J]. Fitoterapia, 2018, 124: 193-199. doi: 10.1016/j.fitote.2017.11.014
    [39]
    WU ZH, WANG YY, MENG X, et al. Total C-21 steroidal glycosides, isolated from the root tuber of Cynanchum auriculatum Royle ex Wight, attenuate hydrogen peroxide-induced oxidative injury and inflammation in L02 cells[J]. Int J Mol Med, 2018, 42(6): 3157-3170.
    [40]
    LEE MK, YEO H, KIM J, et al. Protection of rat hepatocytes exposed to CCl4 in-vitro by cynandione A, a biacetophenone from Cynanchum wilfordii[J]. J Pharm Pharmacol, 2000, 52(3): 341-345.
    [41]
    崔伟伟, 彭蕴茹, 丁永芳. 白首乌C-21甾体总苷对肝损伤小鼠氧化应激通路的影响[J]. 中国中药杂志, 2019, 44(14): 2960-2965. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGZY201914011.htm

    CUI WW, PENG YR, DING YF. Effects of total C-21 steroidal glucosides from Cynanchum auriculatum on oxidative stress pathway in mice with liver injury[J]. China J Chin Mater Med, 2019, 44(14): 2960-2965. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGZY201914011.htm
    [42]
    DING YF, PENG ZX, DING L, et al. Baishouwu extract suppresses the development of hepatocellular carcinoma via TLR4/MyD88/NF-κB pathway[J]. Front Pharmacol, 2019, 10: 389.
    [43]
    刘泽鑫, 刘畅, 钱和. 白首乌花多糖对小鼠酒精性肝损伤的保护作用[J]. 食品研究与开发, 2020, 41(13): 72-79. https://www.cnki.com.cn/Article/CJFDTOTAL-SPYK202013015.htm

    LIU ZX, LIU C, QIAN H. Protective effect of Cynanchum auriculatum flower polysaccharide on alcoholic liver injury in mice[J]. Food Res Dev, 2020, 41(13): 72-79. https://www.cnki.com.cn/Article/CJFDTOTAL-SPYK202013015.htm
    [44]
    徐华益. 白首乌发酵乳的制备及其抗氧化功效特性的研究[D]. 扬州: 扬州大学, 2020.

    XU HY. Study on preparation of CaREW fermented milk and its antioxidant properties[D]. Yangzhou: Yangzhou University, 2020.
    [45]
    CHAI Z, HUANG WY, ZHAO X, et al. Preparation, characterization, antioxidant activity and protective effect against cellular oxidative stress of polysaccharide from Cynanchum auriculatum Royle ex Wight[J]. Int J Biol Macromol, 2018, 119: 1068-1076.
    [46]
    吴秉芹, 傅聪远, 龚树生, 等. 白首乌总磷脂促进家兔耳毛生长的研究[J]. 中国医药学报, 1987, 2(3): 29-31, 25. https://www.cnki.com.cn/Article/CJFDTOTAL-BXYY198703007.htm

    WU BQ, FU CY, GONG SS, et al. Study on the effect of total phospholipids of Cynanchum auriculatum on the growth of rabbit ear hair[J]. China J Tradit Chin Med Pharm, 1987, 2(3): 29-31, 25. https://www.cnki.com.cn/Article/CJFDTOTAL-BXYY198703007.htm
    [47]
    韩欢, 蒋日琼, 张榕文, 等. HPLC法检测白首乌及其洗发水中4-羟基苯乙酮的含量[J]. 当代化工, 2018, 47(12): 2686-2689. https://www.cnki.com.cn/Article/CJFDTOTAL-SYHH201812057.htm

    HAN H, JIANG RQ, ZHANG RW, et al. Determination of the content of 4-hydroxy acetophenone in Radix cynanchi bungei and its shampoo by HPLC[J]. Contemp Chem Ind, 2018, 47(12): 2686-2689. https://www.cnki.com.cn/Article/CJFDTOTAL-SYHH201812057.htm
    [48]
    张明, 顾小兵, 李春阳, 等. 白首乌水旱轮作种植技术研究[J]. 农业开发与装备, 2020(11): 197-198. https://www.cnki.com.cn/Article/CJFDTOTAL-NJJY202011095.htm

    ZHANG M, GU XB, LI CY, et al. Study on planting techniques of Cynanchum Auriculatum in paddy-upland rotation[J]. Agric Dev Equip, 2020(11): 197-198. https://www.cnki.com.cn/Article/CJFDTOTAL-NJJY202011095.htm
    [49]
    刘琪, 谷巍, 杨兵, 等. 基于ITS2序列的滨海白首乌及其近缘种DNA分子鉴定[J]. 中草药, 2018, 49(24): 5901-5909. https://www.cnki.com.cn/Article/CJFDTOTAL-ZCYO201824026.htm

    LIU Q, GU W, YANG B, et al. Molecular identification of Cynanchum auriculatum and its closely related species based on ITS2 sequence[J]. Chin Tradit Herb Drugs, 2018, 49(24): 5901-5909. https://www.cnki.com.cn/Article/CJFDTOTAL-ZCYO201824026.htm
    [50]
    付文焕. 中药白首乌化学对照品与药材质量标准的研究[D]. 北京: 北京中医药大学, 2003.

    FU WH. Study on chemical reference substance and quality standard of Chinese Traditional Medicine Cynanchum Auriculatum[D]. Beijing: Beijing university of Chinese medicine, 2003.
    [51]
    张晓玲, 段金廒, 钱大玮. 江苏滨海产白首乌的质量评价[J]. 现代中药研究与实践, 2006, 20(2): 22-24. https://www.cnki.com.cn/Article/CJFDTOTAL-JZZY200602008.htm

    ZHANG XL, DUAN JA, QIAN DW. Quality evaluation of Cynanchum auriculatum royle ex wight[J]. Res Pract Chin Med, 2006, 20(2): 22-24. https://www.cnki.com.cn/Article/CJFDTOTAL-JZZY200602008.htm
    [52]
    孙佳, 勾健, 秦兰, 等. 隔山消的指纹图谱建立、化学模式识别分析及多指标含量测定[J]. 中国药房, 2022, 33(6): 673-679. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGYA202206005.htm

    SUN J, GOU J, QIN L, et al. Establishment of fingerprint, analysis of chemical pattern recognition and multi-index content determination of Cynanchum auriculatum[J]. China Pharm, 2022, 33(6): 673-679. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGYA202206005.htm
    [53]
    郭兰萍, 张燕, 朱寿东, 等. 中药材规范化生产(GAP)10年: 成果、问题与建议[J]. 中国中药杂志, 2014, 39(7): 1143-1151. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGZY201407001.htm

    GUO LP, ZHANG Y, ZHU SD, et al. Good agricultural practice(GAP) of Chinese materia medica(CMM) for ten years: Achievements, problems and proposals[J]. China J Chin Mater Med, 2014, 39(7): 1143-1151. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGZY201407001.htm
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