Volume 39 Issue 7
Jul.  2023
Turn off MathJax
Article Contents
Article Navigation >  Journal of Nanjing University of traditional Chinese Medicine  > 2023  >  39(7): 693-700
LIU Pan-ru, GUO Xi, TANG Yi-zhao, WANG Hai-dan, GUO Yun-ke, YIN Ai-ling, LI Yong-ming, ZHOU Wei. Research on the Interaction Between Autoimmune Diseases and Gut Microbiota and Regulation of Chinese Herbal Medicines[J]. Journal of Nanjing University of traditional Chinese Medicine, 2023, 39(7): 693-700. doi: 10.14148/j.issn.1672-0482.2023.0693
Citation: LIU Pan-ru, GUO Xi, TANG Yi-zhao, WANG Hai-dan, GUO Yun-ke, YIN Ai-ling, LI Yong-ming, ZHOU Wei. Research on the Interaction Between Autoimmune Diseases and Gut Microbiota and Regulation of Chinese Herbal Medicines[J]. Journal of Nanjing University of traditional Chinese Medicine, 2023, 39(7): 693-700. doi: 10.14148/j.issn.1672-0482.2023.0693
shu

Research on the Interaction Between Autoimmune Diseases and Gut Microbiota and Regulation of Chinese Herbal Medicines

doi: 10.14148/j.issn.1672-0482.2023.0693
  • 1.

    State Key Laboratory of Active Components and Efficacy of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China

  • 2.

    Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China

  • 3.

    Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing 210001, China

  • 4.

    School of Medicine and Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China

  • Received Date: 2023-03-11
    Available Online: 2023-07-15
    Abstract
  • Autoimmune diseases are characterized as the destruction of self-tolerance, abnormal activation of immune cells, production of autoantibodies and the release of large amounts of inflammatory factors, which in turn result in multisystem damage. The gut microbiota balance is closely related to the host health.Dysbiosis of gut microbiota has been identified in relation to many autoimmune diseases, including rheumatoid arthritis ulcerative colitis and autoimmune thyroiditis, etc. There has strong relationship between Chinese herbal medicine and its ability to alter the composition of the gut microbiota, and many studies has been proved that Chinese herbal medicine has therapeutic effect by reshaping the intestinal micro-ecological structure. In this review, we aim to investigate how gut microbiota affects the occurrence and development of autoimmune diseases, and to correlate the effects of Chinese herbal medicine on the regulation of gut microbiota with its effectiveness in disease prevention and treatment, with a view to providing a certain reference basis for the clinical application and pharmacological research of Chinese herbal medicine.

     

    • FullText(HTML)
  • loading
    • References(67)
  • [1]
    HOOPER LV, MACPHERSON AJ. Immune adaptations that maintain homeostasis with the intestinal microbiota[J]. Nat Rev Immunol, 2010, 10(3): 159-169. doi: 10.1038/nri2710
    [2]
    ADAK A, KHAN MR. An insight into gut microbiota and its functionalities[J]. Cell Mol Life Sci, 2019, 76(3): 473-493. doi: 10.1007/s00018-018-2943-4
    [3]
    SÁNCHEZ-TAPIA M, TOVAR AR, TORRES N. Diet as regulator of gut microbiota and its role in health and disease[J]. Arch Med Res, 2019, 50(5): 259-268. doi: 10.1016/j.arcmed.2019.09.004
    [4]
    KAU AL, AHERN PP, GRIFFIN NW, et al. Human nutrition, the gut microbiome and the immune system[J]. Nature, 2011, 474(7351): 327-336. doi: 10.1038/nature10213
    [5]
    SHEN HK, ZHAO ZT, ZHAO ZJ, et al. Native and engineered probiotics: Promising agents against related systemic and intestinal diseases[J]. Int J Mol Sci, 2022, 23(2): 594. doi: 10.3390/ijms23020594
    [6]
    ZHANG X, CHEN BD, ZHAO LD, et al. The gut microbiota: Emerging evidence in autoimmune diseases[J]. Trends Mol Med, 2020, 26(9): 862-873. doi: 10.1016/j.molmed.2020.04.001
    [7]
    方心宇, 冷瑞雪, 范引光, 等. 自身免疫性疾病流行病学研究进展[J]. 中华疾病控制杂志, 2021, 25(8): 869-873. doi: 10.16462/j.cnki.zhjbkz.2021.08.001

    FANG XY, LENG RX, FAN YG, et al. Research advances in the epidemiology of autoimmune diseases[J]. Chin J Dis Contr Prev, 2021, 25(8): 869-873. doi: 10.16462/j.cnki.zhjbkz.2021.08.001
    [8]
    DANIELI MG, ANTONELLI E, PIGA MA, et al. Alarmins in autoimmune diseases[J]. Autoimmun Rev, 2022, 21(9): 103142. doi: 10.1016/j.autrev.2022.103142
    [9]
    FUGGER L, JENSEN LT, ROSSJOHN J. Challenges, progress, and prospects of developing therapies to treat autoimmune diseases[J]. Cell, 2020, 181(1): 63-80. doi: 10.1016/j.cell.2020.03.007
    [10]
    SAURIN S, MEINECK M, ERKEL G, et al. Drug candidates for autoimmune diseases[J]. Pharmaceuticals, 2022, 15(5): 503. doi: 10.3390/ph15050503
    [11]
    赵丽丹, 孟夏, 徐浩杰, 等. 肠道菌群在自身免疫性疾病治疗中的前景[J]. 协和医学杂志, 2022, 13(5): 740-746. https://www.cnki.com.cn/Article/CJFDTOTAL-XHYX202205005.htm

    ZHAO LD, MENG X, XU HJ, et al. Prospect of gut microbiota-based intervention in autoimmune disease control[J]. Med J Peking Union Med Coll Hosp, 2022, 13(5): 740-746. https://www.cnki.com.cn/Article/CJFDTOTAL-XHYX202205005.htm
    [12]
    LU C, XU K, GUO H. The relationship of PADI4_94 polymorphisms with the morbidity of rheumatoid arthritis in Caucasian and Asian populations: A meta-analysis and system review[J]. Clin Rheumatol, 2018, 37(2): 289-296. doi: 10.1007/s10067-017-3964-3
    [13]
    中华医学会风湿病学分会. 2018中国类风湿关节炎诊疗指南[J]. 中华内科杂志, 2018, 57(4): 242-251. doi: 10.3760/cma.j.issn.0578-1426.2018.04.004

    Chinese Rheumatology Association. 2018 Chinese guideline for the diagnosis and treatment of rheumatoid arthritis[J]. Chin J Intern Med, 2018, 57(4): 242-251. doi: 10.3760/cma.j.issn.0578-1426.2018.04.004
    [14]
    NOACK M, MIOSSEC P. Th17 and regulatory T cell balance in autoimmune and inflammatory diseases[J]. Autoimmun Rev, 2014, 13(6): 668-677. doi: 10.1016/j.autrev.2013.12.004
    [15]
    VAGHEF-MEHRABANY E, ALIPOUR B, HOMAYOUNI-RAD A, et al. Probiotic supplementation improves inflammatory status in patients with rheumatoid arthritis[J]. Nutrition, 2014, 30(4): 430-435. doi: 10.1016/j.nut.2013.09.007
    [16]
    FAN ZX, ROSS RP, STANTON C, et al. Lactobacillus casei CCFM1074 alleviates collagen-induced arthritis in rats via balancing Treg/Th17 and modulating the metabolites and gut microbiota[J]. Front Immunol, 2021, 12: 680073. doi: 10.3389/fimmu.2021.680073
    [17]
    SUN HJ, GUO YK, WANG HD, et al. Gut commensal Parabacteroides distasonis alleviates inflammatory arthritis[J]. Gut, 2023, 2023: 327756.
    [18]
    ZHANG X, ZHANG DY, JIA HJ, et al. The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment[J]. Nat Med, 2015, 21(8): 895-905. doi: 10.1038/nm.3914
    [19]
    SCHER JU, SCZESNAK A, LONGMAN RS, et al. Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis[J]. eLife, 2013, 2: e01202. doi: 10.7554/eLife.01202
    [20]
    HASAN H, ISMAIL H, EL-ORFALI Y, et al. Therapeutic benefits of Indole-3-Carbinol in adjuvant-induced arthritis and its protective effect against methotrexate induced-hepatic toxicity[J]. BMC Complement Altern Med, 2018, 18(1): 337. doi: 10.1186/s12906-018-2408-1
    [21]
    SHIRANI K, IRANSHAHI M, ASKARI VR, et al. Comparative evaluation of the protective effects of oral administration of auraptene and umbelliprenin against CFA-induced chronic inflammation with polyarthritis in rats[J]. Biomed Pharmacother, 2021, 139: 111635. doi: 10.1016/j.biopha.2021.111635
    [22]
    PANG J, MA SP, XU XY, et al. Effects of rhizome of Atractylodes koreana (Nakai) Kitam on intestinal flora and metabolites in rats with rheumatoid arthritis[J]. J Ethnopharmacol, 2021, 281: 114026. doi: 10.1016/j.jep.2021.114026
    [23]
    LI YZ, DAI MX, WANG LL, et al. Polysaccharides and glycosides from Aralia echinocaulis protect rats from arthritis by modulating the gut microbiota composition[J]. J Ethnopharmacol, 2021, 269: 113749. doi: 10.1016/j.jep.2020.113749
    [24]
    RUI Z, ZHANG L, LI XF, et al. Pterostilbene exert an anti-arthritic effect by attenuating inflammation, oxidative stress, and alteration of gut microbiota[J]. J Food Biochem, 2022, 46(5): e14011.
    [25]
    XIAO M, FU XP, NI YL, et al. Protective effects of Paederia scandens extract on rheumatoid arthritis mouse model by modulating gut microbiota[J]. J Ethnopharmacol, 2018, 226: 97-104. doi: 10.1016/j.jep.2018.08.012
    [26]
    GUO LX, WANG HY, LIU XD, et al. Saponins from Clematis mandshurica Rupr. regulates gut microbiota and its metabolites during alleviation of collagen-induced arthritis in rats[J]. Pharmacol Res, 2019, 149: 104459. doi: 10.1016/j.phrs.2019.104459
    [27]
    HE Y, CHENG B, GUO BJ, et al. Metabonomics and 16S rRNA gene sequencing to study the therapeutic mechanism of Danggui Sini Decoction on collagen-induced rheumatoid arthritis rats with Cold Bi syndrome[J]. J Pharm Biomed Anal, 2023, 222: 115109. doi: 10.1016/j.jpba.2022.115109
    [28]
    ALTOMARE A, PUTIGNANI L, DEL CHIERICO F, et al. Gut mucosal-associated microbiota better discloses inflammatory bowel disease differential patterns than faecal microbiota[J]. Dig Liver Dis, 2019, 51(5): 648-656. doi: 10.1016/j.dld.2018.11.021
    [29]
    BARYSHNIKOVA N, USPENSKIY Y, SUVOROVA M, et al. P690 Changes of intestinal microbiota in patients with inflammatory bowel diseases[J]. J Crohns Colitis, 2021, 15(Supplement_1): S607.
    [30]
    TAKAHASHI K, NISHIDA A, FUJIMOTO T, et al. Reduced abundance of butyrate-producing bacteria species in the fecal microbial community in Crohn ' s disease[J]. Digestion, 2016, 93(1): 59-65. doi: 10.1159/000441768
    [31]
    YAO Y, CAI XY, FEI WD, et al. The role of short-chain fatty acids in immunity, inflammation and metabolism[J]. Crit Rev Food Sci Nutr, 2022, 62(1): 1-12. doi: 10.1080/10408398.2020.1854675
    [32]
    ATARASHI K, TANOUE T, OSHIMA K, et al. Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota[J]. Nature, 2013, 500(7461): 232-236. doi: 10.1038/nature12331
    [33]
    SINGH SB, COFFMAN CN, CARROLL-PORTILLO A, et al. Notch signaling pathway is activated by sulfate reducing bacteria[J]. Front Cell Infect Microbiol, 2021, 11: 695299. doi: 10.3389/fcimb.2021.695299
    [34]
    ROWAN F, DOCHERTY NG, MURPHY M, et al. Desulfovibrio bacterial species are increased in ulcerative colitis[J]. Dis Colon Rectum, 2010, 53(11): 1530-1536. doi: 10.1007/DCR.0b013e3181f1e620
    [35]
    INFLAMMATORY BOWEL DISEASE GROUP CSOG. Chinese consensus on diagnosis and treatment in inflammatory bowel disease (2018, Beijing)[J]. J Dig Dis, 2021, 22(6): 298-317. doi: 10.1111/1751-2980.12994
    [36]
    NAKASE H, UCHINO M, SHINZAKI S, et al. Evidence-based clinical practice guidelines for inflammatory bowel disease 2020[J]. J Gastroenterol, 2021, 56(6): 489-526. doi: 10.1007/s00535-021-01784-1
    [37]
    LIU YL, ZHOU MY, YANG M, et al. Pulsatilla chinensis saponins ameliorate inflammation and DSS-induced ulcerative colitis in rats by regulating the composition and diversity of intestinal flora[J]. Front Cell Infect Microbiol, 2021, 11: 728929. doi: 10.3389/fcimb.2021.728929
    [38]
    LI PZ, WU MN, XIONG WC, et al. Saikosaponin-d ameliorates dextran sulfate sodium-induced colitis by suppressing NF-κB activation and modulating the gut microbiota in mice[J]. Int Immunopharmacol, 2020, 81: 106288. doi: 10.1016/j.intimp.2020.106288
    [39]
    LV H, JIA HP, CAI WJ, et al. Rehmannia glutinosa polysaccharides attenuates colitis via reshaping gut microbiota and short-chain fatty acid production[J]. J Sci Food Agric, 2023, 103(8): 3926-3938. doi: 10.1002/jsfa.12326
    [40]
    WU H, RAO Q, MA GC, et al. Effect of triptolide on dextran sodium sulfate-induced ulcerative colitis and gut microbiota in mice[J]. Front Pharmacol, 2020, 10: 1652. doi: 10.3389/fphar.2019.01652
    [41]
    LONG J, LIU XK, KANG ZP, et al. Ginsenoside Rg1 ameliorated experimental colitis by regulating the balance of M1/M2 macrophage polarization and the homeostasis of intestinal flora[J]. Eur J Pharmacol, 2022, 917: 174742. doi: 10.1016/j.ejphar.2022.174742
    [42]
    ZHANG HR, ZHUO SX, SONG DN, et al. Icariin inhibits intestinal inflammation of DSS-induced colitis mice through modulating intestinal flora abundance and modulating p-p65/p65 molecule[J]. Turk J Gastroenterol, 2021, 32(4): 382-392. doi: 10.5152/tjg.2021.20282
    [43]
    PENG L, GAO XY, NIE L, et al. Astragalin attenuates dextran sulfate sodium (DSS)-induced acute experimental colitis by alleviating gut microbiota dysbiosis and inhibiting NF-κB activation in mice[J]. Front Immunol, 2020, 11: 2058. doi: 10.3389/fimmu.2020.02058
    [44]
    WANG K, YANG QQ, MA QX, et al. Protective effects of salvianolic acid A against dextran sodium sulfate-induced acute colitis in rats[J]. Nutrients, 2018, 10(6): 791. doi: 10.3390/nu10060791
    [45]
    LI HB, CHEN XH, LIU JY, et al. Ethanol extract of Centella asiatica alleviated dextran sulfate sodium-induced colitis: Restoration on mucosa barrier and gut microbiota homeostasis[J]. J Ethnopharmacol, 2021, 267: 113445. doi: 10.1016/j.jep.2020.113445
    [46]
    JIA YQ, YUAN ZW, ZHANG XS, et al. Total alkaloids of Sophora alopecuroides L. ameliorated murine colitis by regulating bile acid metabolism and gut microbiota[J]. J Ethnopharmacol, 2020, 255: 112775. doi: 10.1016/j.jep.2020.112775
    [47]
    LEE DSW, ROJAS OL, GOMMERMAN JL. B cell depletion therapies in autoimmune disease: Advances and mechanistic insights[J]. Nat Rev Drug Discov, 2021, 20(3): 179-199. doi: 10.1038/s41573-020-00092-2
    [48]
    DWIVEDI SN, KALARIA T, BUCH H. Thyroid autoantibodies[J]. J Clin Pathol, 2023, 76(1): 19-28. doi: 10.1136/jcp-2022-208290
    [49]
    BRČIĆ L, BARIĆ AN, GRAČAN S, et al. Association of established thyroid peroxidase autoantibody (TPOAb) genetic variants with Hashimoto ' s thyroiditis[J]. Autoimmunity, 2016, 49(7): 480-485. doi: 10.1080/08916934.2016.1191475
    [50]
    GONG BS, WANG CY, MENG FR, et al. Association between gut microbiota and autoimmune thyroid disease: A systematic review and meta-analysis[J]. Front Endocrinol, 2021, 12: 774362. doi: 10.3389/fendo.2021.774362
    [51]
    KNEZEVIC J, STARCHL C, TMAVA BERISHA A, et al. Thyroid-gut-axis: How does the microbiota influence thyroid function?[J]. Nutrients, 2020, 12(6): 1769. doi: 10.3390/nu12061769
    [52]
    牧亚峰, 左新河, 向楠, 等. 基于"肠道菌群-黏膜屏障"探讨芪箭消瘿方对自身免疫性甲状腺炎大鼠的作用机制研究[J]. 中国中医基础医学杂志, 2022, 28(3): 362-369. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYJC202203014.htm

    MU YF, ZUO XH, XIANG N, et al. Study on mechanism of Qijian Xiaoying recipe on autoimmune thyroiditis rats based on intestinal flora mucosal barrier[J]. J Basic Chin Med, 2022, 28(3): 362-369. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYJC202203014.htm
    [53]
    董天娇. 基于代谢组学及肠道菌群探讨软坚消瘿颗粒对EAT大鼠的作用机制[D]. 沈阳: 辽宁中医药大学, 2022.

    DONG TJ. Based on metabonomics and intestinal flora, the mechanism of Ruanjian Xiaoying Granule on EAT rats was discussed[D]. Shenyang: Liaoning University of Traditional Chinese Medicine, 2022.
    [54]
    牧亚峰, 向楠, 左新河, 等. 白芍总苷对自身免疫性甲状腺炎大鼠肠黏膜屏障及肠道菌群的影响[J]. 中草药, 2021, 52(11): 3269-3277. https://www.cnki.com.cn/Article/CJFDTOTAL-ZCYO202111014.htm

    MU YF, XIANG N, ZUO XH, et al. Effects of total glucosides of Paeonia lactiflora on intestinal mucosal barrier and intestinal flora in rats with autoimmune thyroiditis[J]. Chin Tradit Herb Drugs, 2021, 52(11): 3269-3277. https://www.cnki.com.cn/Article/CJFDTOTAL-ZCYO202111014.htm
    [55]
    郭风宜, 刘子玉, 王智民, 等. 益气化痰活血方对自身免疫性甲状腺炎小鼠肠道菌群的影响[J]. 时珍国医国药, 2023, 34(2): 292-295. https://www.cnki.com.cn/Article/CJFDTOTAL-SZGY202302010.htm

    GUO FY, LIU ZY, WANG ZM, et al. Effect of Yiqi Huatan Huoxue recipe on intestinal flora in mice with autoimmune thyroiditis[J]. Lishizhen Med Mater Med Res, 2023, 34(2): 292-295. https://www.cnki.com.cn/Article/CJFDTOTAL-SZGY202302010.htm
    [56]
    ZHANG SW, GANG XK, YANG S, et al. The alterations in and the role of the Th17/treg balance in metabolic diseases[J]. Front Immunol, 2021, 12: 678355. doi: 10.3389/fimmu.2021.678355
    [57]
    LI D, GUO B, WU HJ, et al. Interleukin-17 in systemic lupus erythematosus: A comprehensive review[J]. Autoimmunity, 2015, 48(6): 353-361. doi: 10.3109/08916934.2015.1037441
    [58]
    ZHANG MX, YIN XF. AB0137 diversity analysis of intestinal flora in patients with systemic lupus erythematosus[J]. Ann Rheum Dis, 2020, 79: 1369.
    [59]
    ZHANG LL, WEI W. Anti-inflammatory and immunoregulatory effects of paeoniflorin and total glucosides of paeony[J]. Pharmacol Ther, 2020, 207: 107452. doi: 10.1016/j.pharmthera.2019.107452
    [60]
    ZHAO X, TANG XJ, YAN Q, et al. Triptolide ameliorates lupus via the induction of miR-125a-5p mediating Treg upregulation[J]. Int Immunopharmacol, 2019, 71: 14-21. doi: 10.1016/j.intimp.2019.02.047
    [61]
    MOMTAZI-BOROJENI AA, HAFTCHESHMEH SM, ESMAEILI SA, et al. Curcumin: A natural modulator of immune cells in systemic lupus erythematosus[J]. Autoimmun Rev, 2018, 17(2): 125-135. doi: 10.1016/j.autrev.2017.11.016
    [62]
    LIAO JY, LIU Y, WU HJ, et al. The role of icaritin in regulating Foxp3/IL17a balance in systemic lupus erythematosus and its effects on the treatment of MRL/lpr mice[J]. Clin Immunol, 2016, 162: 74-83. doi: 10.1016/j.clim.2015.11.006
    [63]
    王维钊, 向晓星. Treg/Th17、Th1/Th2平衡在自身免疫性肝炎中的免疫学机制及诊疗新靶点[J]. 临床肝胆病杂志, 2019, 35(8): 1874-1877. doi: 10.3969/j.issn.1001-5256.2019.08.051

    WANG WZ, XIANG XX. Immunological mechanism of Treg/Th17 and Th1/Th2 balance in autoimmune hepatitis and new targets for diagnosis and treatment[J]. J Clin Hepatol, 2019, 35(8): 1874-1877. doi: 10.3969/j.issn.1001-5256.2019.08.051
    [64]
    LIU YL, YAN WM, YUAN W, et al. Treg/Th17 imbalance is associated with poor autoimmune hepatitis prognosis[J]. Clin Immunol, 2019, 198: 79-88. doi: 10.1016/j.clim.2018.11.003
    [65]
    MANFREDO VIEIRA S, HILTENSPERGER M, KUMAR V, et al. Translocation of a gut pathobiont drives autoimmunity in mice and humans[J]. Science, 2018, 359(6380): 1156-1161. doi: 10.1126/science.aar7201
    [66]
    LIU QY, HE W, TANG RQ, et al. Intestinal homeostasis in autoimmune liver diseases[J]. Chin Med J, 2022, 135(14): 1642-1652. doi: 10.1097/CM9.0000000000002291
    [67]
    ZHU LR, LI SS, ZHENG WQ, et al. Targeted modulation of gut microbiota by traditional Chinese medicine and natural products for liver disease therapy[J]. Front Immunol, 2023, 14: 1086078. doi: 10.3389/fimmu.2023.1086078
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(1)  / Tables(3)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (891) PDF downloads(56) Cited by()
    Proportional views
    Related

    Copyright © Journal of Nanjing University of traditional Chinese Medicine

    Sponsored by：Nanjing University of traditional Chinese MedicineAddress：No.138 xianlin Avenue, Qixia District, Nanjing cityChina Pos：210023

    Tel：025-85811935Email：xb@njucm.edu.cn

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return