Citation: | NI Jin-yu, ZHANG Meng-meng, REN Xiang-ge, ZHANG Qiu-yue, LI Bing, YANG Meng, ZHANG Jian, ZHAI Wen-sheng. Clinical Study of Traditional Chinese Medicine Combined with Hormone Non-Tailing Therapy in the Treatment of Children with Refractory Nephrotic Syndrome[J]. Journal of Nanjing University of traditional Chinese Medicine, 2023, 39(7): 669-676. doi: 10.14148/j.issn.1672-0482.2023.0669 |
[1] |
NOONE DG, ⅡJIMA K, PAREKH R. Idiopathic nephrotic syndrome in children[J]. Lancet, 2018, 392(10141): 61-74. doi: 10.1016/S0140-6736(18)30536-1
|
[2] |
中华医学会儿科学分会肾脏学组. 儿童激素敏感、复发/依赖肾病综合征诊治循证指南(2016)[J]. 中华儿科杂志, 2017, 55(10): 729-734.
Nephrology Group of Pediatrics Branch of Chinese Medical Association. Evidence-based guidelines for the diagnosis and treatment of steroid-sensitive, relapsed/dependent nephrotic syndrome in children(2016)[J]. Chin J Pediatr, 2017, 55(10): 729-734.
|
[3] |
中华医学会儿科学分会肾脏学组. 激素耐药型肾病综合征诊治循证指南(2016)[J]. 中华儿科杂志, 2017, 55(11): 805-809. doi: 10.3760/cma.j.issn.0578-1310.2017.11.002
Nephrology Group of Pediatrics Branch of Chinese Medical Association. Evidence-based guidelines for the diagnosis and treatment of steroid-resistant nephrotic syndrome (2016)[J]. Chin J Pediatr, 2017, 55(11): 805-809. doi: 10.3760/cma.j.issn.0578-1310.2017.11.002
|
[4] |
全国儿童常见肾脏病诊治现状调研工作组. 我国儿童激素敏感、复发/依赖肾病综合征诊疗现状的多中心研究[J]. 中华儿科杂志, 2014, 52(3): 194-200.
National Working Group on Diagnosis and Treatment of Common Kidney Diseases in Children. A multicenter study on the diagnosis and treatment of steroid-sensitive, relapsed/dependent nephrotic syndrome in children in China[J]. Chin J Pediatr, 2014, 52(3): 194-200.
|
[5] |
蒋小云. 我国儿童激素敏感、复发/依赖肾病综合征诊疗现状的多中心研究[J]. 中华儿科杂志, 2014, 52(3): 194-200.
JIANG XY. A multicenter study on the diagnosis and treatment of steroid-sensitive, relapsed/dependent nephrotic syndrome in children in China[J]. Chin J Pediatr, 2014, 52(3): 194-200.
|
[6] |
BANH TH, HUSSAIN-SHAMSY N, PATEL V, et al. Ethnic differences in incidence and outcomes of childhood nephrotic syndrome[J]. Clin J Am Soc Nephrol, 2016, 11(10): 1760-1768. doi: 10.2215/CJN.00380116
|
[7] |
HJORTEN R, ANWAR Z, REIDY KJ. Long-term outcomes of childhood onset nephrotic syndrome[J]. Front Pediatr, 2016, 4: 53.
|
[8] |
中华医学会儿科学分会肾脏病学组. 小儿肾小球疾病的临床分类、诊断及治疗[J]. 中华儿科杂志, 2001, 39(12): 45-48. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHEK200112019.htm
Nephrology Group of Pediatrics Branch of Chinese Medical Association. Clinical classification, diagnosis and treatment of glomerular diseases in children[J]. Chin J Pediatr, 2001, 39(12): 45-48. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHEK200112019.htm
|
[9] |
刘华, 翟文生. 翟文生教授治疗小儿难治性肾病经验介绍[J]. 新中医, 2010, 42(4): 97-98. https://www.cnki.com.cn/Article/CJFDTOTAL-REND201004055.htm
LIU H, ZHAI WS. Professor Zhai Wensheng's experience in treating refractory nephropathy in children[J]. J N Chin Med, 2010, 42(4): 97-98. https://www.cnki.com.cn/Article/CJFDTOTAL-REND201004055.htm
|
[10] |
马融. 中医儿科学[M]. 北京: 中国中医药出版社, 2018: 199-203.
MA R. Pediatrics of Traditional Chinese Medicine[M]. Beijing: China traditional Chinese medicine press, 2018: 199-203.
|
[11] |
李乐. 基于生存量表和中医证候的小儿难治性肾病临床疗效评价方法研究[D]. 郑州: 河南中医药大学, 2018.
LI L. Research on the clinical efficacy evaluation method of pediatric refractory nephropathy based on survival scale and TCM syndrome[D]. Zhengzhou: Henan University of Traditional Chinese Medicine, 2018.
|
[12] |
KIM JS, HAN SY, IREMONGER KJ. Stress experience and hormone feedback tune distinct components of hypothalamic CRH neuron activity[J]. Nat Commun, 2019, 10(1): 5696. doi: 10.1038/s41467-019-13639-8
|
[13] |
MONTES-VILLARREAL J, PEREZ-ARREDONDO LA, RODRIGUEZ-GUTIERREZ R, et al. Serum morning cortisol as a screening test for adrenal insufficiency[J]. Endocr Pract, 2020, 26(1): 30-35. doi: 10.4158/EP-2019-0327
|
[14] |
FOCKE CMB, IREMONGER KJ. Rhythmicity matters: Circadian and ultradian patterns of HPA axis activity[J]. Mol Cell Endocrinol, 2020, 501: 110652. doi: 10.1016/j.mce.2019.110652
|
[15] |
SCHERHOLZ ML, SCHLESINGER N, ANDROULAKIS IP. Chronopharmacology of glucocorticoids[J]. Adv Drug Deliv Rev, 2019, 151/152: 245-261. doi: 10.1016/j.addr.2019.02.004
|
[16] |
KAPUGI M, CUNNINGHAM K. Corticosteroids[J]. Orthop Nurs, 2019, 38(5): 336-339. doi: 10.1097/NOR.0000000000000595
|
[17] |
夏正坤. 糖皮质激素临床应用再认识[J]. 医学研究生学报, 2018, 31(2): 113-117. https://www.cnki.com.cn/Article/CJFDTOTAL-JLYB201802002.htm
XIA ZK. The recognition of clinical application of glucocorticoids[J]. J Med Postgrad, 2018, 31(2): 113-117. https://www.cnki.com.cn/Article/CJFDTOTAL-JLYB201802002.htm
|
[18] |
PARAGLIOLA RM, PAPI G, PONTECORVI A, et al. Treatment with synthetic glucocorticoids and the hypothalamus-pituitary-adrenal axis[J]. Int J Mol Sci, 2017, 18(10): 2201.
|
[19] |
PARAGLIOLA RM, CORSELLO SM. Secondary adrenal insufficiency: From the physiopathology to the possible role of modified-release hydrocortisone treatment[J]. Minerva Endocrinol, 2018, 43(2): 183-197.
|
[20] |
高洁, 蒋志滨, 李文, 等. 基于维生素D轴探讨黄芪多糖对脓毒症肾上腺皮质功能的保护机制[J]. 中华中医药学刊, 2019, 37(8): 1910-1912. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYHS201908027.htm
GAO J, JIANG ZB, LI W, et al. Protective mechanism of Astragalus polysaccharides on adrenal cortex function in sepsis based on VitaminD axis[J]. Chin Arch Tradit Chin Med, 2019, 37(8): 1910-1912. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYHS201908027.htm
|
[21] |
杨丽潇, 张碧丽, 王文红. 大剂量糖皮质激素应用过程中早期给予ACTH大鼠下丘脑-垂体-肾上腺轴的功能及病理变化[J]. 山东医药, 2016, 56(43): 22-25. https://www.cnki.com.cn/Article/CJFDTOTAL-SDYY201643007.htm
YANG LX, ZHANG BL, WANG WH. Functional and pathological changes of HPA axis of rats in the early-stage application of ACTH during the process of using a large dose of glucocorticoid[J]. Shandong Med J, 2016, 56(43): 22-25. https://www.cnki.com.cn/Article/CJFDTOTAL-SDYY201643007.htm
|
[22] |
SPIGA F, WAITE EJ, LIU Y, et al. ACTH-dependent ultradian rhythm of corticosterone secretion[J]. Endocrinology, 2011, 152(4): 1448-1457.
|
[23] |
CAPLAN A, FETT N, ROSENBACH M, et al. Prevention and management of glucocorticoid-induced side effects: A comprehensive review: Ocular, cardiovascular, muscular, and psychiatric side effects and issues unique to pediatric patients[J]. J Am Acad Dermatol, 2017, 76(2): 201-207.
|
[24] |
HAHN D, SAMUEL SM, WILLIS NS, et al. Corticosteroid therapy for nephrotic syndrome in children[J]. Cochrane Database Syst Rev, 2020, 2020(8): CD001533.
|
[25] |
SCHERHOLZ ML, SCHLESINGER N, ANDROULAKIS IP. Chronopharmacology of glucocorticoids[J]. Adv Drug Deliv Rev, 2019, 151/152: 245-261.
|
[26] |
BROERSEN LH, PEREIRA AM, JØRGENSEN JO, et al. Adrenal insufficiency in corticosteroids use: Systematic review and meta-analysis[J]. J Clin Endocrinol Metab, 2015, 100(6): 2171-2180.
|
[27] |
王春芳, 田文国, 陈金鹏, 等. 中药抗抑郁作用及其机制研究进展[J]. 中草药, 2022, 53(9): 2890-2901. https://www.cnki.com.cn/Article/CJFDTOTAL-ZCYO202209031.htm
WANG CF, TIAN WG, CHEN JP, et al. Research progress on antidepressive effect and mechanism of traditional Chinese medicine[J]. Chin Tradit Herb Drugs, 2022, 53(9): 2890-2901. https://www.cnki.com.cn/Article/CJFDTOTAL-ZCYO202209031.htm
|
[28] |
王雪峰, 张秀英, 王美娇. 基于"少火生气, 壮火食气"理论论治儿童难治性肾病综合征[J]. 中医杂志, 2019, 60(16): 1428-1430. https://www.cnki.com.cn/Article/CJFDTOTAL-ZZYZ201916018.htm
WANG XF, ZHANG XY, WANG MJ. Treating children refractory nephrotic syndrome based on the theory of "mild fire supplements Qi, strong fire reduces Qi"[J]. J Tradit Chin Med, 2019, 60(16): 1428-1430. https://www.cnki.com.cn/Article/CJFDTOTAL-ZZYZ201916018.htm
|
[29] |
刘晓丽, 何学红. 中药在激素治疗肾病综合征过程中的临床应用[J]. 辽宁中医药大学学报, 2008, 10(12): 52-52. https://www.cnki.com.cn/Article/CJFDTOTAL-LZXB200812026.htm
LIU XL, HE XH. Clinical application of traditional Chinese medicine in the process of hormone treatment of nephrotic syndrome[J]. J Liaoning Univ Tradit Chin Med, 2008, 10(12): 52. https://www.cnki.com.cn/Article/CJFDTOTAL-LZXB200812026.htm
|
[30] |
刘洋, 刘晓鹰, 张雪荣. 麻黄附子细辛汤治疗儿童难治性肾病激素拖尾期外感病的疗效分析[J]. 世界中西医结合杂志, 2021, 16(7): 1181-1183, 1195. https://www.cnki.com.cn/Article/CJFDTOTAL-SJZX202107002.htm
LIU Y, LIU XY, ZHANG XR. Efficacy analysis of Mahuang Fuzi Xixin Decoction in treating children's refractory nephropathy in hormone tailing stage exopathic disease[J]. World J Integr Tradit West Med, 2021, 16(7): 1181-1183, 1195. https://www.cnki.com.cn/Article/CJFDTOTAL-SJZX202107002.htm
|
[31] |
赵洁, 高洁, 张孟之, 等. 黄芪多糖对脓毒血症大鼠模型肾上腺皮质醇相关合成酶及维生素D轴的影响[J]. 中华中医药学刊, 2022, 40(3): 111-114, 269. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYHS202203025.htm
ZHAO J, GAO J, ZHANG MZ, et al. Effects of Astragalus polysaccharides on adrenal cortisol related synthases and vitamin D axis in septic rats[J]. Chin Arch Tradit Chin Med, 2022, 40(3): 111-114, 269. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYHS202203025.htm
|
[32] |
钟淑娟, 郑思超, 丘秀玉, 等. 丹参素钠对慢性不可预知温和应激模型小鼠的抗抑郁作用[J]. 中国新药杂志, 2018, 27(23): 2819-2824. https://www.cnki.com.cn/Article/CJFDTOTAL-ZXYZ201823017.htm
ZHONG SJ, ZHENG SC, QIU XY, et al. Anti-depressant effects of Tanshinol Sodium in chronic unpredicted mild stress mice[J]. Chin J N Drugs, 2018, 27(23): 2819-2824. https://www.cnki.com.cn/Article/CJFDTOTAL-ZXYZ201823017.htm
|
[33] |
LEE B, SUR B, PARK J, et al. Chronic administration of baicalein decreases depression-like behavior induced by repeated restraint stress in rats[J]. Korean J Physiol Pharmacol, 2013, 17(5): 393-403.
|
[34] |
王越, 廖生俊, 鲁敏翔, 等. 黄芩苷对慢性应激抑郁模型大鼠海马内神经营养因子及下丘脑-腺垂体-肾上腺轴的影响[J]. 中南药学, 2016, 14(3): 274-277. https://www.cnki.com.cn/Article/CJFDTOTAL-ZNYX201603015.htm
WANG Y, LIAO SJ, LU MX, et al. Effect of baicalin on expression of neurotrophic factors and HPA axis in depression rat model induced by stress[J]. Cent South Pharm, 2016, 14(3): 274-277. https://www.cnki.com.cn/Article/CJFDTOTAL-ZNYX201603015.htm
|
[35] |
李海燕, 潘彦舒, 程晓娜, 等. 黄芩苷对缺血性脑损伤雄性大鼠脑保护作用的机制研究[J]. 中国中医药信息杂志, 2017, 24(6): 35-38. https://www.cnki.com.cn/Article/CJFDTOTAL-XXYY201706009.htm
LI HY, PAN YS, CHENG XN, et al. Study on mechanism of protective effects of baicalin on male rats with ischemic brain injury[J]. Chin J Inf Tradit Chin Med, 2017, 24(6): 35-38. https://www.cnki.com.cn/Article/CJFDTOTAL-XXYY201706009.htm
|
[36] |
苗雨露, 张雯霞, 王玉娥, 等. 清热解毒类中药抗炎机制研究进展[J]. 中国实验方剂学杂志, 2018, 24(9): 228-234. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSFX201809036.htm
MIAO YL, ZHANG WX, WANG Y, et al. Anti-inflammatory mechanism of antipyretic and detoxifying traditional Chinese medicine[J]. Chin J Exp Tradit Med Formulae, 2018, 24(9): 228-234. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSFX201809036.htm
|
[37] |
倪锦玉, 翟文生, 李乐, 等. 益气化瘀清热方序贯辨证治疗儿童难治性肾病综合征临床疗效观察[J]. 中国实验方剂学杂志, 2022, 28(4): 116-123. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSFX202204015.htm
NI JY, ZHAI WS, LI L, et al. Sequential treatment with syndrome differentiation on children's refractory nephrotic syndrome with Yiqi Huayu Qingre prescription[J]. Chin J Exp Tradit Med Formulae, 2022, 28(4): 116-123. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSFX202204015.htm
|
[38] |
翟文生, 杨濛, 张建, 等. 益气化瘀清热方及其拆方对嘌呤霉素氨基核苷损伤小鼠足细胞表达TRPC6的影响[J]. 中华中医药学刊, 2018, 36(1): 14-18. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYHS202005006.htm
ZHAI WS, YANG M, ZHANG J, et al. Effect of Yiqi Huayu Qingre prescription and its separations on expression of podocyte TRPC6 of mice injuried by puromycin aminonucleoside[J]. Chin Arch Tradit Chin Med, 2018, 36(1): 14-18. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYHS202005006.htm
|