Volume 39 Issue 4
Apr.  2023
Turn off MathJax
Article Contents
Article Navigation >  Journal of Nanjing University of traditional Chinese Medicine  > 2023  >  39(4): 384-392
LIANG Xin-yu, LIN Su-qin, WANG Yi-bin, XU Jing-yi, LIU Ya-meng, XIE Cen. Research Progress on the Mechanism of Traditional Chinese Medicine in the Intervention of Nonalcoholic Steatohepatitis[J]. Journal of Nanjing University of traditional Chinese Medicine, 2023, 39(4): 384-392. doi: 10.14148/j.issn.1672-0482.2023.0384
Citation: LIANG Xin-yu, LIN Su-qin, WANG Yi-bin, XU Jing-yi, LIU Ya-meng, XIE Cen. Research Progress on the Mechanism of Traditional Chinese Medicine in the Intervention of Nonalcoholic Steatohepatitis[J]. Journal of Nanjing University of traditional Chinese Medicine, 2023, 39(4): 384-392. doi: 10.14148/j.issn.1672-0482.2023.0384
shu

Research Progress on the Mechanism of Traditional Chinese Medicine in the Intervention of Nonalcoholic Steatohepatitis

doi: 10.14148/j.issn.1672-0482.2023.0384
  • 1.

    New School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China

  • 2.

    State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai 200120, China

  • Received Date: 2022-12-11
    Available Online: 2023-04-17
    Abstract
  • Nonalcoholic fatty liver disease (NAFLD) is a metabolic syndrome that has become a public health problem of general concern. Nonalcoholic steatohepatitis (NASH) is a progressive NAFLD lesion resulting from the interaction of multiple risk factors with multiorgan involvement. Due to the complex underlying pathophysiologic mechanisms that contribute to the development and progression of NASH, there are no approved drugs to control the progression of the disease. Based on traditional Chinese medicine(TCM) theory, NAFLD belongs to the category of "Ganpi", and was divided into 4 syndrom types: liver stagnation and spleen deficiency, internal obstruction of phlegm and dampness, obstruction of dampness and heat, and interaction of phlegm and blood stasis. Chinese medicine can effectively intervene and treat different clinical types of NASH with its unique theoretical system and treatment strategy. With the continuous development of modern pharmacology and molecular biology, more and more studies have shown that TCM compound formula and active monomers can improve NASH through various mechanisms, which promotes the application of TCM. This review focuses on the mechanisms related to the improvement of NASH by TCM from the perspectives of compound formula and active monomers, in order to provide a theoretical and experimental research basis for the rational and effective treatment of NASH.

     

    • FullText(HTML)
  • loading
    • References(91)
  • [1]
    LAN T, YU Y, ZHANG J, et al. Cordycepin ameliorates nonalcoholic steatohepatitis by activation of the AMP-activated protein kinase signaling pathway[J]. Hepatology, 2021, 74(2): 686-703. doi: 10.1002/hep.31749
    [2]
    SHEKA AC, ADEYI O, THOMPSON J, et al. Nonalcoholic steatohepatitis: A review[J]. JAMA, 2020, 323(12): 1175-1183. doi: 10.1001/jama.2020.2298
    [3]
    DAY CP, JAMES OFW. Steatohepatitis: A tale of two "hits"?[J]. Gastroenterology, 1998, 114(4): 842-845. doi: 10.1016/S0016-5085(98)70599-2
    [4]
    FANG YL, CHEN H, WANG CL, et al. Pathogenesis of non-alcoholic fatty liver disease in children and adolescence: From two hit theory to multiple hit model[J]. World J Gastroenterol, 2018, 24(27): 2974-2983. doi: 10.3748/wjg.v24.i27.2974
    [5]
    崔宇胜, 纪云西. 中西医治疗非酒精性脂肪性肝炎的研究进展[J]. 中西医结合肝病杂志, 2021, 31(1): 93-96. https://www.cnki.com.cn/Article/CJFDTOTAL-ZXGB202101029.htm

    CUI YS, JI YX. Research progress on treatment of nonalcoholic steatohepatitis with traditional Chinese and western medicine[J]. Chin J Integr Tradit West Med Liver Dis, 2021, 31(1): 93-96. https://www.cnki.com.cn/Article/CJFDTOTAL-ZXGB202101029.htm
    [6]
    国家中医药管理局国家中医临床研究基地办公室. 我国16个重点病种的国家中医临床研究基地论文统计表(2008年~2013年)[J]. 世界科学技术-中医药现代化, 2013, 15(5): 1161-1261. https://www.cnki.com.cn/Article/CJFDTOTAL-SJKX201305074.htm

    Office of National TCM Clinical Research Base, State Administration of Traditional Chinese Medicine. Statistical table of papers of national clinical research base of traditional Chinese medicine for 16 key diseases in China (2008—2013)[J]. Mod Tradit Chin Med Mater Med World Sci Technol, 2013, 15(5): 1161-1261. https://www.cnki.com.cn/Article/CJFDTOTAL-SJKX201305074.htm
    [7]
    李军祥, 陈誩, 王允亮. 非酒精性脂肪性肝病中西医结合诊疗共识意见(2017年)[J]. 中国中西医结合消化杂志, 2017, 25(11): 805-811. https://www.cnki.com.cn/Article/CJFDTOTAL-ZXPW201711002.htm

    LI JX, CHEN J, WANG YL. Consensus on diagnosis and treatment of nonalcoholic fatty liver disease with integrated traditional Chinese and western medicine (2017)[J]. Chin J Integr Tradit West Med Dig, 2017, 25(11): 805-811. https://www.cnki.com.cn/Article/CJFDTOTAL-ZXPW201711002.htm
    [8]
    李文怡, 袁成民. 非酒精性脂肪性肝病的中西医治疗[J]. 临床肝胆病杂志, 2020, 36(4): 919-923. https://www.cnki.com.cn/Article/CJFDTOTAL-LCGD202004058.htm

    LI WY, YUAN CM. Research advances in integrated traditional Chinese and Western medicine therapy for nonalcoholic fatty liver disease[J]. J Clin Hepatol, 2020, 36(4): 919-923. https://www.cnki.com.cn/Article/CJFDTOTAL-LCGD202004058.htm
    [9]
    诸葛丽, 苏冬梅, 李军祥. 健脾疏肝方对小鼠非酒精性脂肪性肝炎的干预作用[J]. 中华中医药杂志, 2017, 32(7): 2942-2947. https://www.cnki.com.cn/Article/CJFDTOTAL-BXYY201707029.htm

    ZHUGE L, SU DM, LI JX. Intervention of Jianpi Shugan Decoction on non-alcoholic steatohepatitis in mice[J]. China J Tradit Chin Med Pharm, 2017, 32(7): 2942-2947. https://www.cnki.com.cn/Article/CJFDTOTAL-BXYY201707029.htm
    [10]
    姜慧, 李军祥, 韩海啸, 等. 健脾疏肝方对非酒精性脂肪性肝炎大鼠胰岛素抵抗的影响[J]. 中国中西医结合消化杂志, 2021, 29(7): 449-454. https://www.cnki.com.cn/Article/CJFDTOTAL-ZXPW202107001.htm

    JIANG H, LI JX, HAN HX, et al. Effect of Jianpi Shugan Decoction on insulin resistance in rats with nonalcoholic steatohepatitis[J]. Chin J Integr Tradit West Med Dig, 2021, 29(7): 449-454. https://www.cnki.com.cn/Article/CJFDTOTAL-ZXPW202107001.htm
    [11]
    张宁怡, 余轶群, 寇富舜, 等. 健脾疏肝方对非酒精性脂肪性肝炎大鼠肝细胞超微结构和功能的影响[J]. 环球中医药, 2021, 14(12): 2113-2120. https://www.cnki.com.cn/Article/CJFDTOTAL-HQZY202112004.htm

    ZHANG NY, YU YQ, KOU FS, et al. Effect of Jianpi Shugan Decoction on ultrastructure and function of hepatocytes in rats with non-alcoholic steatohepatitis[J]. Glob Tradit Chin Med, 2021, 14(12): 2113-2120. https://www.cnki.com.cn/Article/CJFDTOTAL-HQZY202112004.htm
    [12]
    孟雅楠, 高艳, 郝健亨, 等. 基于网络药理学探讨逍遥散治疗非酒精性脂肪性肝炎的作用机制[J]. 世界中西医结合杂志, 2021, 16(9): 1626-1632. https://www.cnki.com.cn/Article/CJFDTOTAL-SJZX202109013.htm

    MENG YN, GAO Y, HAO JH, et al. Exploring the mechanism of Xiaoyao Powder in the treatment of non-alcoholic steatohepatitis based on network pharmacology[J]. World J Integr Tradit West Med, 2021, 16(9): 1626-1632. https://www.cnki.com.cn/Article/CJFDTOTAL-SJZX202109013.htm
    [13]
    刘杨, 李明磊, 贾飞, 等. 逍遥散对非酒精性脂肪性肝炎肝郁脾虚证大鼠TLR-4/TRIF信号转导通路的影响[J]. 中国实验方剂学杂志, 2018, 24(17): 108-113. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSFX201817016.htm

    LIU Y, LI ML, JIA F, et al. Effect of xiaoyaosan on TLR-4/TRIF signal transduction pathway in rats of non-alcoholic fatty hepatitis with liver-qi stagnation and spleen deficiency syndrome[J]. Chin J Exp Tradit Med Formulae, 2018, 24(17): 108-113. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSFX201817016.htm
    [14]
    MIURA K, YANG L, VAN ROOIJEN N, et al. Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice[J]. Hepatology, 2013, 57(2): 577-589. doi: 10.1002/hep.26081
    [15]
    徐慧超, 高艳, 陈浩, 等. 逍遥散对非酒精性脂肪性肝炎大鼠Toll样受体4基因甲基化水平的调节作用[J]. 北京中医药大学学报, 2020, 43(5): 402-407. https://www.cnki.com.cn/Article/CJFDTOTAL-JZYB202005009.htm

    XU HC, GAO Y, CHEN H, et al. Treatment of nonalcoholic steatohepatitis by regulating the methylation level of TLR4 gene with Xiaoyao San[J]. J Beijing Univ Tradit Chin Med, 2020, 43(5): 402-407. https://www.cnki.com.cn/Article/CJFDTOTAL-JZYB202005009.htm
    [16]
    陈斌, 徐嘉蔚, 彭杰, 等. 基于逍遥散及其拆方研究"肝病实脾法"对肝纤维化大鼠肠道菌群的影响[J]. 临床肝胆病杂志, 2016, 32(4): 657-662. doi: 10.3969/j.issn.1001-5256.2016.04.009

    CHEN B, XU JW, PENG J, et al. Effect of "treating liver by nourishing spleen"on gut microbiota in rats with liver fibrosis based on Xiaoyao Powder and its separated recipe[J]. J Clin Hepatol, 2016, 32(4): 657-662. doi: 10.3969/j.issn.1001-5256.2016.04.009
    [17]
    封慧, 朱欣轶, 王长松. 健脾中药对肠道微生态作用机制研究进展[J]. 中国中医药信息杂志, 2018, 25(10): 137-140. https://www.cnki.com.cn/Article/CJFDTOTAL-XXYY201810033.htm

    FENG H, ZHU XY, WANG CS. Research progress in mechanism of strengthening spleen medicines for intestinal microecology[J]. Chin J Inf Tradit Chin Med, 2018, 25(10): 137-140. https://www.cnki.com.cn/Article/CJFDTOTAL-XXYY201810033.htm
    [18]
    崔翔, 盛国光, 邢宇锋, 等. 健脾化浊消脂方对非酒精性脂肪性肝炎大鼠的防治作用及机制[J]. 中华中医药杂志, 2021, 36(5): 2555-2559. https://www.cnki.com.cn/Article/CJFDTOTAL-BXYY202105027.htm

    CUI X, SHENG GG, XING YF, et al. Preventive and therapeutic effect and mechanism of Jianpi Huazhuo Xiaozhi Formula on non-alcoholic steatohepatitis in rats induced by high-fat diet[J]. China J Tradit Chin Med Pharm, 2021, 36(5): 2555-2559. https://www.cnki.com.cn/Article/CJFDTOTAL-BXYY202105027.htm
    [19]
    周晓玲, 唐农, 张悦, 等. 基于IKK/IKB/NF-κB信号通路探讨理中汤治疗非酒精性脂肪性肝炎的作用机制[J]. 中华中医药杂志, 2020, 35(6): 2771-2777. https://www.cnki.com.cn/Article/CJFDTOTAL-BXYY202006022.htm

    ZHOU XL, TANG N, ZHANG Y, et al. Study on the therapeutic effects and mechanism of Lizhong Decoction in the treatment of non-alcoholic steatohepatitis based on the signal pathway of IKK/IKB/NF-κB[J]. China J Tradit Chin Med Pharm, 2020, 35(6): 2771-2777. https://www.cnki.com.cn/Article/CJFDTOTAL-BXYY202006022.htm
    [20]
    潘益巧, 周晓玲, 李泽鹏, 等. 基于IKK/IKB/NF-κB信号通路探讨理中汤加味联合穴位埋线干预非酒精性脂肪性肝炎大鼠的作用机制[J]. 中西医结合肝病杂志, 2022, 32(1): 49-52. https://www.cnki.com.cn/Article/CJFDTOTAL-ZXGB202201014.htm

    PAN YQ, ZHOU XL, LI ZP, et al. Mechanism of Lizhong Decoction combined with acupoint catgut embedding in the treatment of non-alcoholic steatohepatitis based on IKK/IKB/NF-κB pathway[J]. Chin J Integr Tradit West Med Liver Dis, 2022, 32(1): 49-52. https://www.cnki.com.cn/Article/CJFDTOTAL-ZXGB202201014.htm
    [21]
    张悦, 周晓玲, 李泽鹏, 等. 基于Keap1/Nrf2/ARE信号通路探讨理中汤对非酒精性脂肪性肝炎大鼠抗氧化应激及其作用机制研究[J]. 辽宁中医杂志, 2021, 48(12): 10-14, 223. https://www.cnki.com.cn/Article/CJFDTOTAL-LNZY202112003.htm

    ZHANG Y, ZHOU XL, LI ZP, et al. Based on Keap1/Nrf2/ARE signaling pathway, the study of Lizhong Decoction on antioxidant stress and its mechanism in rats with nonalcoholic steatohepatitis[J]. Liaoning J Tradit Chin Med, 2021, 48(12): 10-14, 223. https://www.cnki.com.cn/Article/CJFDTOTAL-LNZY202112003.htm
    [22]
    宋琳, 陈策, 李承潇, 等. 四逆散对非酒精性脂肪性肝炎大鼠的肝保护作用研究[J]. 河北中医药学报, 2019, 34(3): 1-4. https://www.cnki.com.cn/Article/CJFDTOTAL-HZYX201903001.htm

    SONG L, CHEN C, LI CX, et al. Hepatoprotective effect of Sini San on rats with nonalcoholic steatohepatitis[J]. J Hebei Tradit Chin Med Pharmacol, 2019, 34(3): 1-4. https://www.cnki.com.cn/Article/CJFDTOTAL-HZYX201903001.htm
    [23]
    CHENG FF, MA CY, WANG XQ, et al. Effect of traditional Chinese medicine formula Sinisan on chronic restraint stress-induced nonalcoholic fatty liver disease: A rat study[J]. BMC Complement Altern Med, 2017, 17(1): 203. doi: 10.1186/s12906-017-1707-2
    [24]
    JIANG WN, LI D, JIANG T, et al. Protective effects of Chaihu Shugan San on nonalcoholic fatty liver disease in rats with insulin resistance[J]. Chin J Integr Med, 2018, 24(2): 125-132. doi: 10.1007/s11655-016-2252-4
    [25]
    白钰, 陈永灿, 赵乐, 等. 柴胡疏肝散对非酒精性脂肪性肝炎大鼠肝脏IRE-1α/NF-κB通路的影响[J]. 中华中医药杂志, 2018, 33(6): 2592-2596. https://www.cnki.com.cn/Article/CJFDTOTAL-BXYY201806102.htm

    BAI Y, CHEN YC, ZHAO L, et al. Effects of Chaihu Shugan Powder on hepatic IRE-1α/NF-κB pathway in rats with non-alcoholic steatohepatitis[J]. China J Tradit Chin Med Pharm, 2018, 33(6): 2592-2596. https://www.cnki.com.cn/Article/CJFDTOTAL-BXYY201806102.htm
    [26]
    赵文霞, 崔健娇, 张丽慧. 化痰祛湿活血方对非酒精性脂肪性肝炎大鼠相关炎性因子的影响[J]. 中华中医药杂志, 2017, 32(4): 1721-1723. https://www.cnki.com.cn/Article/CJFDTOTAL-BXYY201704093.htm

    ZHAO WX, CUI JJ, ZHANG LH. Effects of Huatan Qushi Huoxue Formula on the related inflammatory cytokines in rats with NASH[J]. China J Tradit Chin Med Pharm, 2017, 32(4): 1721-1723. https://www.cnki.com.cn/Article/CJFDTOTAL-BXYY201704093.htm
    [27]
    赵文霞, 闫乐, 段荣章. 化痰祛湿活血方对非酒精性脂肪性肝炎大鼠脂联素及其受体的干预研究[J]. 中华中医药杂志, 2014, 29(9): 2975-2977. https://www.cnki.com.cn/Article/CJFDTOTAL-BXYY201409080.htm

    ZHAO WX, YAN L, DUAN RZ. Effects of Huatan Qushi Huoxue Recipe on the expression of adiponectin and adiponectin receptors in rats with nonalcoholic steatohepatitis[J]. China J Tradit Chin Med Pharm, 2014, 29(9): 2975-2977. https://www.cnki.com.cn/Article/CJFDTOTAL-BXYY201409080.htm
    [28]
    张丽慧, 刘素彤, 张文娟, 等. 基于ADPN/PI3K/AKT信号通路探讨化痰祛湿活血方改善非酒精性脂肪性肝炎大鼠炎症损伤的机制[J]. 中华中医药杂志, 2021, 36(10): 5832-5837. https://www.cnki.com.cn/Article/CJFDTOTAL-BXYY202110028.htm

    ZHANG LH, LIU ST, ZHANG WJ, et al. Mechanism of Huatan Qushi Huoxue Formula in improving the inflammatory injury of rats with nonalcoholic steatohepatitis based on ADPN/PI3K/AKT signal pathway[J]. China J Tradit Chin Med Pharm, 2021, 36(10): 5832-5837. https://www.cnki.com.cn/Article/CJFDTOTAL-BXYY202110028.htm
    [29]
    刘杨, 李若瑜, 刘晋芳, 等. 降脂平肝汤对非酒精性脂肪性肝炎大鼠的抗炎机制研究[J]. 中国中医药现代远程教育, 2019, 17(4): 104-107. https://www.cnki.com.cn/Article/CJFDTOTAL-ZZYY201904048.htm

    LIU Y, LI RY, LIU JF, et al. Study on the anti-inflammatory mechanism of Jiangzhi Pinggan Decoction on rats with non-alcoholic steatohepatitis[J]. Chin Med Mod Distance Educ China, 2019, 17(4): 104-107. https://www.cnki.com.cn/Article/CJFDTOTAL-ZZYY201904048.htm
    [30]
    谢添弘, 李军祥, 毛堂友, 等. 茵陈二陈汤对非酒精性脂肪性肝炎模型细胞IRS-1ser307、PKBser473表达的影响[J]. 中国中西医结合消化杂志, 2018, 26(11): 919-923. https://www.cnki.com.cn/Article/CJFDTOTAL-ZXPW201811007.htm

    XIE TH, LI JX, MAO TY, et al. Yinchen and Erchen Decoction have an effect on NASH model cells via the protein expression of IRS-1ser307 and PKBser473[J]. Chin J Integr Tradit West Med Dig, 2018, 26(11): 919-923. https://www.cnki.com.cn/Article/CJFDTOTAL-ZXPW201811007.htm
    [31]
    XIE TH, LI JX, MAO TY, et al. An ErChen and YinChen Decoction ameliorates high-fat-induced nonalcoholic steatohepatitis in rats by regulating JNK1 signaling pathway[J]. Evid Based Complement Alternat Med, 2017, 2017: 4603701.
    [32]
    肖琴, 施旻, 曹征, 等. 葛根芩连汤防治非酒精性脂肪性肝炎作用相关的差异蛋白筛选[J]. 时珍国医国药, 2020, 31(6): 1309-1312. https://www.cnki.com.cn/Article/CJFDTOTAL-SZGY202006008.htm

    XIAO Q, SHI M, CAO Z, et al. Screening of differential proteins related to the prevention and treatment of nonalcoholic steatohepatitis with Gegen Qinlian Decoction[J]. Lishizhen Med Mater Med Res, 2020, 31(6): 1309-1312. https://www.cnki.com.cn/Article/CJFDTOTAL-SZGY202006008.htm
    [33]
    ZHANG CH, XIAO Q, SHENG JQ, et al. Gegen Qinlian Decoction abates nonalcoholic steatohepatitis associated liver injuries via anti-oxidative stress and anti-inflammatory response involved inhibition of toll-like receptor 4 signaling pathways[J]. Biomed Pharmacother, 2020, 126: 110076.
    [34]
    GUO Y, DING PH, LIU LJ, et al. Gegen Qinlian Decoction attenuates high-fat diet-induced steatohepatitis in rats via gut microbiota[J]. Evid Based Complement Alternat Med, 2018, 2018: 7370891.
    [35]
    侯艺鑫, 李玉鑫, 杨雪, 等. 清肝化痰活血方对大鼠非酒精性脂肪性肝炎的防治作用[J]. 中西医结合肝病杂志, 2019, 29(1): 46-49, 105. https://www.cnki.com.cn/Article/CJFDTOTAL-ZXGB201901016.htm

    HOU YX, LI YX, YANG X, et al. Preventive and therapeutic effects of Qinggan Huatan Huoxue Recipe on non-alcoholic steatohepatitis in rats[J]. Chin J Integr Tradit West Med Liver Dis, 2019, 29(1): 46-49, 105. https://www.cnki.com.cn/Article/CJFDTOTAL-ZXGB201901016.htm
    [36]
    吴柳, 张洁, 马文婷, 等. 下瘀血汤对胆碱蛋氨酸缺乏诱导的小鼠非酒精性脂肪性肝炎的抑制作用[J]. 中国肝脏病杂志(电子版), 2018, 10(3): 48-55. https://www.cnki.com.cn/Article/CJFDTOTAL-GZBZ201803013.htm

    WU L, ZHANG J, MA WT, et al. Xiayuxue Decoction inhibits methionine-choline-deficient-induced nonalcoholic steatohepatitis in mice[J]. Chin J Liver Dis Electron Version, 2018, 10(3): 48-55. https://www.cnki.com.cn/Article/CJFDTOTAL-GZBZ201803013.htm
    [37]
    吴柳, 杨广越, 张洁, 等. 下瘀血汤下调NLRP3改善高脂饮食诱导小鼠非酒精性脂肪性肝炎[J]. 中国中西医结合杂志, 2020, 40(10): 1202-1208. https://www.cnki.com.cn/Article/CJFDTOTAL-ZZXJ202010010.htm

    WU L, YANG GY, ZHANG J, et al. Xiayuxue Decoction improved HFD-induced-nonalcoholic steatohepatitis mice by down-regulating NLRP3[J]. Chin J Integr Tradit West Med, 2020, 40(10): 1202-1208. https://www.cnki.com.cn/Article/CJFDTOTAL-ZZXJ202010010.htm
    [38]
    LEFERE S, VAN DE VELDE F, HOORENS A, et al. Angiopoietin-2 promotes pathological angiogenesis and is a therapeutic target in murine nonalcoholic fatty liver disease[J]. Hepatology, 2019, 69(3): 1087-1104.
    [39]
    张定棋, 杨海琳, 徐莹, 等. 下瘀血汤及其组分对蛋氨酸-胆碱缺乏饮食诱导的小鼠非酒精性脂肪性肝炎的干预作用[J]. 上海中医药大学学报, 2021, 35(1): 41-49, 54. https://www.cnki.com.cn/Article/CJFDTOTAL-SHZD202101008.htm

    ZHANG DQ, YANG HL, XU Y, et al. Effects of Xiayuxue Decoction and its components on nonalcoholic steatohepatitis induced by methionine-choline deficient diet in mice[J]. Acad J Shanghai Univ Tradit Chin Med, 2021, 35(1): 41-49, 54. https://www.cnki.com.cn/Article/CJFDTOTAL-SHZD202101008.htm
    [40]
    朱晓宁, 汪静, 张玉蓉, 等. 祛痰活血方上调SOCS1抑制TLR4/NF-κB信号通路改善非酒精性脂肪性肝炎小鼠肝损伤[J]. 世界科学技术-中医药现代化, 2020, 22(12): 4293-4299. https://www.cnki.com.cn/Article/CJFDTOTAL-SJKX202012030.htm

    ZHU XN, WANG J, ZHANG YR, et al. Qutan Huoxue prescription up-regulates SOCS1 inhibits TLR4/NF-κB signaling pathway to improve liver injury in nonalcoholic steatohepatitis mice[J]. Mod Tradit Chin Med Mater Med World Sci Technol, 2020, 22(12): 4293-4299. https://www.cnki.com.cn/Article/CJFDTOTAL-SJKX202012030.htm
    [41]
    MORTAZAVI-JAHROMI SS, FARAZMAND A, MOTAMED N, et al. Effects of guluronic acid (G2013) on SHIP1, SOCS1 induction and related molecules in TLR4 signaling pathway[J]. Int Immunopharmacol, 2018, 55: 323-329.
    [42]
    郑佳连, 卢秉久. 行气活血祛湿方对非酒精性脂肪性肝炎小鼠模型的影响[J]. 中西医结合肝病杂志, 2020, 30(6): 527-530, 554. https://www.cnki.com.cn/Article/CJFDTOTAL-ZXGB202006014.htm

    ZHENG JL, LU BJ. Effect of the Xingqi Huoxue Qushi prescription on mice model of non-alcoholic steatohepatitis[J]. Chin J Integr Tradit West Med Liver Dis, 2020, 30(6): 527-530, 554. https://www.cnki.com.cn/Article/CJFDTOTAL-ZXGB202006014.htm
    [43]
    PETRASEK J, IRACHETA-VELLVE A, CSAK T, et al. STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease[J]. Proc Natl Acad Sci USA, 2013, 110(41): 16544-16549.
    [44]
    杨晴柔, 严茂祥, 吴黎艳, 等. 益气补肾调脂方对非酒精性脂肪性肝炎小鼠氧化应激损伤的影响[J]. 浙江中医杂志, 2019, 54(12): 881-883. https://www.cnki.com.cn/Article/CJFDTOTAL-ZJZZ201912015.htm

    YANG QR, YAN MX, WU LY, et al. Intervention research of Yiqi Bushen Tiaozhi recipe on oxidative stress injury in mice suffered from non-alcoholic steatohepatitis[J]. Zhejiang J Tradit Chin Med, 2019, 54(12): 881-883. https://www.cnki.com.cn/Article/CJFDTOTAL-ZJZZ201912015.htm
    [45]
    吴黎艳, 陆增生, 何蓓晖, 等. 益气补肾调脂方对非酒精性脂肪性肝炎小鼠肝脏内质网应激相关基因mRNA的影响[J]. 浙江中医杂志, 2021, 56(5): 315-317. https://www.cnki.com.cn/Article/CJFDTOTAL-ZJZZ202105003.htm

    WU LY, LU ZS, HE BH, et al. Effect of Yiqi Bushen Decoction on mRNA of endoplasmic reticulum stress related genes in liver of NASH mice[J]. Zhejiang J Tradit Chin Med, 2021, 56(5): 315-317. https://www.cnki.com.cn/Article/CJFDTOTAL-ZJZZ202105003.htm
    [46]
    HONG W, LI SS, CAI YQ, et al. The target microRNAs and potential underlying mechanisms of Yiqi-Bushen-Tiaozhi recipe against-non-alcoholic steatohepatitis[J]. Front Pharmacol, 2020, 11: 529553.
    [47]
    严峻彬, 聂云梦, 张婷婷, 等. 益气补肾调脂方通过调控CDKN1A改善非酒精性脂肪性肝炎的研究[J]. 中国药理学通报, 2022, 38(2): 311-318. https://www.cnki.com.cn/Article/CJFDTOTAL-YAOL202202026.htm

    YAN JB, NIE YM, ZHANG TT, et al. Study on improvement of non-alcoholic steatohepatitis by regulating CDKN1A by Yiqi-Bushen-Tiaozhi formula[J]. Chin Pharmacol Bull, 2022, 38(2): 311-318. https://www.cnki.com.cn/Article/CJFDTOTAL-YAOL202202026.htm
    [48]
    LIU Y, GAO JL, PENG M, et al. A review on central nervous system effects of gastrodin[J]. Front Pharmacol, 2018, 9: 24.
    [49]
    TANG CL, WU BC, WU JY, et al. Novel strategies using total gastrodin and gastrodigenin, or total gastrodigenin for quality control of Gastrodia elata[J]. Molecules, 2018, 23(2): 270.
    [50]
    LI N, WANG KJ, CHEN JJ, et al. Phenolic compounds from the rhizomes of Gastrodia elata[J]. J Asian Nat Prod Res, 2007, 9(3/4/5): 373-377.
    [51]
    耿雅娜, 于滨, 孔维佳. 天麻素通过激活AMPK通路减少油酸诱导的HL-7702细胞脂肪蓄积[J]. 中国药理学通报, 2015, 31(1): 39-44. https://www.cnki.com.cn/Article/CJFDTOTAL-YAOL201501010.htm

    GENG YN, YU B, KONG WJ. Gastrodin ameliorates oleic acid-induced fat accumulation through activation of AMPK pathway in HL-7702 cells[J]. Chin Pharmacol Bull, 2015, 31(1): 39-44. https://www.cnki.com.cn/Article/CJFDTOTAL-YAOL201501010.htm
    [52]
    WAN J, ZHANG YY, YANG DQ, et al. Gastrodin improves nonalcoholic fatty liver disease through activation of the adenosine monophosphate-activated protein kinase signaling pathway[J]. Hepatology, 2021, 74(6): 3074-3090.
    [53]
    YANG H, YUAN Y, LUO C, et al. Inhibitory effects of resveratrol on the human alveolar rhabdomyosarcoma cell line PLA-802 through inhibition of the TGF-β1/smad signaling pathway[J]. Pharmacology, 2016, 98(1/2): 35-41.
    [54]
    冯成军, 周艳萌, 田应娟. 基于Nrf2/ARE信号通路探讨白藜芦醇治疗非酒精性脂肪性肝炎大鼠的作用机制[J]. 中国临床解剖学杂志, 2021, 39(5): 579-585. https://www.cnki.com.cn/Article/CJFDTOTAL-ZLJZ202105017.htm

    FENG CJ, ZHOU YM, TIAN YJ. The mechanism of resveratrol in the treatment of nonalcoholic steatohepatitis in rats based on Nrf2/ARE signaling pathway[J]. Chin J Clin Anat, 2021, 39(5): 579-585. https://www.cnki.com.cn/Article/CJFDTOTAL-ZLJZ202105017.htm
    [55]
    田国燕, 顾磊, 杨劲. 白藜芦醇对小鼠非酒精性脂肪性肝炎相关肝细胞癌的治疗作用及机制研究[J]. 浙江医学, 2020, 42(3): 209-214, 303. https://www.cnki.com.cn/Article/CJFDTOTAL-ZJYE202003005.htm

    TIAN GY, GU L, YANG J. Therapeutic effect of resveratrol on nonalcoholic steatohepatitis associated hepatocellular carcinoma in mice[J]. Zhejiang Med J, 2020, 42(3): 209-214, 303. https://www.cnki.com.cn/Article/CJFDTOTAL-ZJYE202003005.htm
    [56]
    陈娟, 孔维宗, 梁凯, 等. 白藜芦醇对非酒精性脂肪性肝炎大鼠肝组织SIRT3表达的影响[J]. 实用肝脏病杂志, 2017, 20(4): 402-407. https://www.cnki.com.cn/Article/CJFDTOTAL-GBSY201704006.htm

    CHEN J, KONG WZ, LIANG K, et al. Improved expression of SIRT3 in liver tissues by resveratrol in rats with nonalcoholic steatohepatitis[J]. J Pract Hepatol, 2017, 20(4): 402-407. https://www.cnki.com.cn/Article/CJFDTOTAL-GBSY201704006.htm
    [57]
    KONG LB, AN XY, HU LX, et al. Resveratrol ameliorates nutritional steatohepatitis through the mmu-miR-599/PXR pathway[J]. Int J Mol Med, 2022, 49(4): 47.
    [58]
    CHE YY, SHI X, ZHONG XD, et al. Resveratrol prevents liver damage in MCD-induced steatohepatitis mice by promoting SIGIRR gene transcription[J]. J Nutr Biochem, 2020, 82: 108400.
    [59]
    WANG P, GAO JP, KE WX, et al. Resveratrol reduces obesity in high-fat diet-fed mice via modulating the composition and metabolic function of the gut microbiota[J]. Free Radic Biol Med, 2020, 156: 83-98.
    [60]
    YUAN CF, LIU CQ, WANG T, et al. Chikusetsu saponin IVa ameliorates high fat diet-induced inflammation in adipose tissue of mice through inhibition of NLRP3 inflammasome activation and NF-κB signaling[J]. Oncotarget, 2017, 8(19): 31023-31040.
    [61]
    TAN LL, LIU LM, JIANG ZY, et al. Inhibition of microRNA-17-5p reduces the inflammation and lipid accumulation, and up-regulates ATP-binding cassette transporterA1 inatherosclerosis[J]. J Pharmacol Sci, 2019, 139(4): 280-288.
    [62]
    罗悦, 刘朝奇, 贺海波, 等. 竹节参总皂苷通过调控自噬改善非酒精性脂肪性肝炎的实验研究[J]. 中国中药杂志, 2021, 46(9): 2260-2266. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGZY202109018.htm

    LUO Y, LIU CQ, HE HB, et al. Effect of total saponins from Panax japonicus on non-alcoholic steatohepatitis by regulating autophagy[J]. China J Chin Mater Med, 2021, 46(9): 2260-2266. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGZY202109018.htm
    [63]
    熊海容, 李聪, 何春喜, 等. 竹节参总皂苷通过调节miR-199-5p改善小鼠脂肪性肝病的实验研究[J]. 中国中药杂志, 2018, 43(17): 3525-3529. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGZY201817015.htm

    XIONG HR, LI C, HE CX, et al. Protective effects of total saponins of Panax japonicas on non-alcoholic fatty liver disease through regulating expression of miR-199-5p[J]. China J Chin Mater Med, 2018, 43(17): 3525-3529. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGZY201817015.htm
    [64]
    李聪, 刘小慧, 熊海容, 等. 竹节参皂苷Ⅳa调节miR-17-5p/MFN2信号通路改善非酒精性脂肪性肝炎[J]. 中国中药杂志, 2020, 45(19): 4725-4731. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGZY202019024.htm

    LI C, LIU XH, XIONG HR, et al. Effect of Panax japonicus saponin Ⅳa on alleviating nonalcoholic steatohepatitis by regulating miR-17-5p/MFN2 signaling pathway[J]. China J Chin Mater Med, 2020, 45(19): 4725-4731. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGZY202019024.htm
    [65]
    刘鸣昊, 张丽慧, 马庆亮, 等. 基于PI3K/AKT/NF-κB信号传导通路探讨大黄素对非酒精性脂肪性肝炎模型大鼠的影响[J]. 中华中医药杂志, 2020, 35(3): 1428-1432. https://www.cnki.com.cn/Article/CJFDTOTAL-BXYY202003103.htm

    LIU MH, ZHANG LH, MA QL, et al. Effects of emodin based on PI3K/AKT/NF-κB signaling pathway in rats with non-alcoholic steatohepatitis[J]. China J Tradit Chin Med Pharm, 2020, 35(3): 1428-1432. https://www.cnki.com.cn/Article/CJFDTOTAL-BXYY202003103.htm
    [66]
    寇小妮, 解新科, 郝明霞, 等. 大黄素介导IRS-2/PI3K/Akt通路干预大鼠非酒精性脂肪性肝炎的实验研究[J]. 疑难病杂志, 2020, 19(1): 80-84. https://www.cnki.com.cn/Article/CJFDTOTAL-YNBZ202001021.htm

    KOU XN, XIE XK, HAO MX, et al. The experimental study of emodin mediated IRS-2/PI3K/Akt pathway on nonalcoholic steatohepatitis in rats[J]. Chin J Difficult Complicat Cases, 2020, 19(1): 80-84. https://www.cnki.com.cn/Article/CJFDTOTAL-YNBZ202001021.htm
    [67]
    刘鸣昊, 张丽慧, 马庆亮, 等. 大黄素对非酒精性脂肪性肝炎模型大鼠作用及对脂联素、脂联素受体的影响[J]. 中华中医药学刊, 2020, 38(2): 187-190, 290. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYHS202002046.htm

    LIU MH, ZHANG LH, MA QL, et al. Effect of Rheum emodin on ADPN and AdipoR2 in rats with non-alcoholic steatohepatitis[J]. Chin Arch Tradit Chin Med, 2020, 38(2): 187-190, 290. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYHS202002046.htm
    [68]
    PAPIE MA, KRZY'CIAK W. The antioxidant quercetin protects HL-60 cells with high myeloperoxidase activity against pro-oxidative and apoptotic effects of etoposide[J]. Acta Biochim Pol, 2014, 61(4): 795-799.
    [69]
    刘鸣昊, 张丽慧, 马庆亮, 等. 槲皮素对非酒精性脂肪性肝炎大鼠的作用及其机制研究[J]. 中国临床药理学杂志, 2019, 35(20): 2597-2601. https://www.cnki.com.cn/Article/CJFDTOTAL-GLYZ201920018.htm

    LIU MH, ZHANG LH, MA QL, et al. Effect of the quercetin on the non-alcoholic steatohepatitis in rats and its mechanism[J]. Chin J Clin Pharmacol, 2019, 35(20): 2597-2601. https://www.cnki.com.cn/Article/CJFDTOTAL-GLYZ201920018.htm
    [70]
    刘鸣昊, 张丽慧, 马庆亮, 等. 槲皮素对非酒精性脂肪性肝炎大鼠的影响[J]. 中成药, 2019, 41(8): 1820-1825. https://www.cnki.com.cn/Article/CJFDTOTAL-ZCYA201908014.htm

    LIU MH, ZHANG LH, MA QL, et al. Effects of quercetin on rats with non-alcoholic steatohepatitis[J]. Chin Tradit Pat Med, 2019, 41(8): 1820-1825. https://www.cnki.com.cn/Article/CJFDTOTAL-ZCYA201908014.htm
    [71]
    XU Y, HAN JC, DONG JJ, et al. Metabolomics characterizes the effects and mechanisms of quercetin in nonalcoholic fatty liver disease development[J]. Int J Mol Sci, 2019, 20(5): 1220.
    [72]
    LIU JP, ZHU MH, SHI R, et al. Radix Sophorae flavescentis for chronic hepatitis B: A systematic review of randomized trials[J]. Am J Chin Med, 2003, 31(3): 337-354.
    [73]
    GAO XB, GUO S, ZHANG S, et al. Matrine attenuates endoplasmic reticulum stress and mitochondrion dysfunction in nonalcoholic fatty liver disease by regulating SERCA pathway[J]. J Transl Med, 2018, 16(1): 319.
    [74]
    TULI HS, SHARMA AK, SANDHU SS, et al. Cordycepin: A bioactive metabolite with therapeutic potential[J]. Life Sci, 2013, 93(23): 863-869.
    [75]
    QING R, HUANG ZZ, TANG YF, et al. Cordycepin negatively modulates lipopolysaccharide-induced cytokine production by up-regulation of heme oxygenase-1[J]. Int Immunopharmacol, 2017, 47: 20-27.
    [76]
    CAO T, XU RC, XU Y, et al. The protective effect of Cordycepin on diabetic nephropathy through autophagy induction in vivo and in vitro[J]. Int Urol Nephrol, 2019, 51(10): 1883-1892.
    [77]
    AN YN, LI Y, WANG XY, et al. Cordycepin reduces weight through regulating gut microbiota in high-fat diet-induced obese rats[J]. Lipids Health Dis, 2018, 17(1): 276.
    [78]
    YOON SY, PARK SJ, PARK YJ. The anticancer properties of cordycepin and their underlying mechanisms[J]. Int J Mol Sci, 2018, 19(10): 3027.
    [79]
    YANG J, LI YZ, HYLEMON PB, et al. Cordycepin inhibits LPS-induced inflammatory responses by modulating NOD-Like Receptor Protein 3 inflammasome activation[J]. Biomed Pharmacother, 2017, 95: 1777-1788.
    [80]
    SHIN S, MOON S, PARK Y, et al. Role of cordycepin and adenosine on the phenotypic switch of macrophages via induced anti-inflammatory cytokines[J]. Immune Netw, 2009, 9(6): 255-264.
    [81]
    ZHU XZ, LI XY, LIU J. Recent pharmacological studies on natural products in China[J]. Eur J Pharmacol, 2004, 500(1/2/3): 221-230.
    [82]
    ZHANG YP, DENG YJ, TANG KR, et al. Berberine ameliorates high-fat diet-induced non-alcoholic fatty liver disease in rats via activation of SIRT3/AMPK/ACC pathway[J]. Curr Med Sci, 2019, 39(1): 37-43.
    [83]
    LUO Y, TIAN GY, ZHUANG ZJ, et al. Berberine prevents non-alcoholic steatohepatitis-derived hepatocellular carcinoma by inhibiting inflammation and angiogenesis in mice[J]. Am J Transl Res, 2019, 11(5): 2668-2682.
    [84]
    HONDA M, KUBES P. Neutrophils and neutrophil extracellular traps in the liver and gastrointestinal system[J]. Nat Rev Gastroenterol Hepatol, 2018, 15(4): 206-221.
    [85]
    YANG J, MA XJ, LI L, et al. Berberine ameliorates non-alcoholic steatohepatitis in ApoE-/- mice[J]. Exp Ther Med, 2017, 14(5): 4134-4140.
    [86]
    ZHANG ZG, LI B, MENG XJ, et al. Berberine prevents progression from hepatic steatosis to steatohepatitis and fibrosis by reducing endoplasmic reticulum stress[J]. Sci Rep, 2016, 6: 20848.
    [87]
    LI H, LIU NN, LI JR, et al. Combined use of bicyclol and berberine alleviates mouse nonalcoholic fatty liver disease[J]. Front Pharmacol, 2022, 13: 843872.
    [88]
    LI J, LIU ZZ, GUO MX, et al. Metabolomics profiling to investigate the pharmacologic mechanisms of berberine for the treatment of high-fat diet-induced nonalcoholic steatohepatitis[J]. Evid Based Complement Alternat Med, 2015, 2015: 897914.
    [89]
    WANG YY, TAI YL, ZHAO D, et al. Berberine prevents disease progression of nonalcoholic steatohepatitis through modulating multiple pathways[J]. Cells, 2021, 10(2): 210.
    [90]
    YUE SJ, LIU J, WANG AT, et al. Berberine alleviates insulin resistance by reducing peripheral branched-chain amino acids[J]. Am J Physiol Endocrinol Metab, 2019, 316(1): E73-E85.
    [91]
    XU XM, YI H, WU JS, et al. Therapeutic effect of berberine on metabolic diseases: Both pharmacological data and clinical evidence[J]. Biomed Pharmacother, 2021, 133: 110984.
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Tables(2)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (833) PDF downloads(92) Cited by()
    Proportional views
    Related

    Copyright © Journal of Nanjing University of traditional Chinese Medicine

    Sponsored by：Nanjing University of traditional Chinese MedicineAddress：No.138 xianlin Avenue, Qixia District, Nanjing cityChina Pos：210023

    Tel：025-85811935Email：xb@njucm.edu.cn

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return