Meta-Analysis of Clinical Efficacy and Safety of Xijiao Dihuang Decoction Combined with Western Medicine in the Treatment of Anaphylactoid Purpura

JIANG Chao; XUE Ya-nan; CAO Yu-qing; DONG Ju; WANG Jun-qin; YANG Dong-qing; LI Guo-chun

doi:10.14148/j.issn.1672-0482.2023.0179

Volume 39 Issue 2

Feb. 2023

Turn off MathJax

Article Contents

Article Navigation > Journal of Nanjing University of traditional Chinese Medicine > 2023 > 39(2): 179-187

JIANG Chao, XUE Ya-nan, CAO Yu-qing, DONG Ju, WANG Jun-qin, YANG Dong-qing, LI Guo-chun. Meta-Analysis of Clinical Efficacy and Safety of Xijiao Dihuang Decoction Combined with Western Medicine in the Treatment of Anaphylactoid Purpura[J]. Journal of Nanjing University of traditional Chinese Medicine, 2023, 39(2): 179-187. doi: 10.14148/j.issn.1672-0482.2023.0179

Citation:

JIANG Chao, XUE Ya-nan, CAO Yu-qing, DONG Ju, WANG Jun-qin, YANG Dong-qing, LI Guo-chun. Meta-Analysis of Clinical Efficacy and Safety of Xijiao Dihuang Decoction Combined with Western Medicine in the Treatment of Anaphylactoid Purpura[J]. Journal of Nanjing University of traditional Chinese Medicine, 2023, 39(2): 179-187. doi: 10.14148/j.issn.1672-0482.2023.0179

Citation:

JIANG Chao, XUE Ya-nan, CAO Yu-qing, DONG Ju, WANG Jun-qin, YANG Dong-qing, LI Guo-chun. Meta-Analysis of Clinical Efficacy and Safety of Xijiao Dihuang Decoction Combined with Western Medicine in the Treatment of Anaphylactoid Purpura[J]. Journal of Nanjing University of traditional Chinese Medicine, 2023, 39(2): 179-187. doi: 10.14148/j.issn.1672-0482.2023.0179

PDF( 7235 KB)

Meta-Analysis of Clinical Efficacy and Safety of Xijiao Dihuang Decoction Combined with Western Medicine in the Treatment of Anaphylactoid Purpura

doi: 10.14148/j.issn.1672-0482.2023.0179

School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China

Received Date: 2022-02-07
Available Online: 2023-02-17

Abstract

Abstract

OBJECTIVE To systematically evaluate the efficacy and safety of Xijiao Dihuang decoction combined with western medicine in the treatment of anaphylactoid purpura. METHODS A comprehensive search of PubMed, CBM, CNKI and other databases was conducted to collect randomized controlled trials of Xijiao Dihuang decoction combined with western medicine in the treatment of anaphylactoid purpura. The literature was screened, information extracted and quality evaluated according to inclusion and exclusion criteria. The outcome indicators were evaluated according to the GRADE evidence quality grading system, and the risk of bias was assessed and Meta-analysis was performed using RevMan5. 3 software. RESULTS A total of 23 studies involving 1, 919 patients were included. Meta-analysis showed that compared with the simple western medicine treatment, the integrated Chinese and western medicine combined with Xijiao Dihuang decoction could improve the total effective rate[RD=0.18, 95%CI(0.15, 0.21), P < 0.01], reduce the recurrence rate [RD=-0.17, 95%CI(-0.334 5, -0.004 2), P < 0.05] and the adverse reaction rate [RD=-0.05, 95%CI(-0.090 5, -0.004 7), P < 0.01]. Besides, it could also reduce purpura regression time [MD=-6.73, 95%CI(-10.58, -2.89), P < 0.01], rash regression time [MD=-3.08, 95%CI(-4.25, -1.92), P < 0.01], gastrointestinal symptoms regression time [MD=-3.49, 95%CI(-5.54, -1.43), P < 0.01], abdominal pain regression time [MD=-1.97, 95%CI(-2.23, -1.71), P < 0.01], as well as joint swelling and pain regression time [MD=-6.60, 95%CI(-8.88, -4.31), P < 0.01]. The GRADE of outcome indicators included medium, low and extreme low levels. CONCLUSION Xijiao Dihuang decoction combined with conventional western medicine can improve the total effective rate of anaphylactoid purpura. In addition, it can reduce the recurrence rate, and the regression time of all clinical symptoms without increasing the adverse reaction rate.
- Xijiao Dihuang decoction,
- anaphylactoid purpura,
- integrated Chinese and western medicine,
- meta-analysis

FullText(HTML)

References(33)

References

[1]	易著文. 小儿过敏性紫癜的诊断与治疗[J]. 中国实用儿科杂志, 2009, 24(11): 827-830. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSEK200911006.htm YI ZW. Diagnosis and treatment of pediatric anaphylactoid purpura[J]. Chin J Pract Pediatr, 2009, 24(11): 827-830. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSEK200911006.htm
[2]	PRAIS D, AMIR J, NUSSINOVITCH M. Recurrent henoch-schönlein Purpura in children[J]. J Clin Rheumatol, 2007, 13(1): 25-28. doi: 10.1097/01.rhu.0000255692.46165.19
[3]	RIGANTE D. Clinical overview of vasculitic syndromes in the pediatric age[J]. Eur Rev Med Pharmacol Sci, 2006, 10(6): 337-345.
[4]	翁晓文, 孙俏丽, 李青. 犀角地黄汤治疗小儿过敏性紫癜48例[J]. 中国实用医药, 2009, 4(30): 121-122. doi: 10.3969/j.issn.1673-7555.2009.30.085 WENG XW, SUN QL, LI Q. Treatment of 48 cases of pediatric anaphylactoid purpura with Xijiao Dihuang decoction[J]. China Pract Med, 2009, 4(30): 121-122. doi: 10.3969/j.issn.1673-7555.2009.30.085
[5]	吴小红, 李雁. 犀角地黄汤主方治疗小儿过敏性紫癜的系统评价[J]. 甘肃医药, 2014, 33(1): 37-39. https://www.cnki.com.cn/Article/CJFDTOTAL-GSYY201401016.htm WU XH, LI Y. Systematic evaluation of the main formula of Xijiao Dihuang decoction in the treatment of pediatric anaphylactoid purpura[J]. Gansu Med J, 2014, 33(1): 37-39. https://www.cnki.com.cn/Article/CJFDTOTAL-GSYY201401016.htm
[6]	胡亚美, 江载芳. 诸福棠实用儿科学[M]. 北京: 人民卫生出版社, 2002: 689. HU YM, JIANG ZF. Zhu Futang Textbook of Pediatrics[M]. Beijing: People's medical publishing house, 2002: 689.
[7]	国家中医药管理局中医病证诊断疗效标准[M]. 南京: 南京大学出版社, 1994: 11. Diagnostic and Efficacy Criteria of Chinese Medicine by the National Administration of Traditional Chinese Medicine[M]. Nanjing: Nanjing university press, 1994: 11.
[8]	叶圣国. 中西医结合治疗小儿过敏性紫癜疗效观察[J]. 辽宁中医学院学报, 2005, 7(2): 151. doi: 10.3969/j.issn.1673-842X.2005.02.040 YE SG. Observation on the efficacy of combined Chinese and western medicine in the treatment of pediatric anaphylactoid purpura[J]. J Liaoning Coll Tradit Chin Med, 2005, 7(2): 151. doi: 10.3969/j.issn.1673-842X.2005.02.040
[9]	杨秀平, 李莉. 中西医结合治疗小儿过敏性紫癜疗效观察[J]. 四川中医, 2005, 23(1): 79-80. doi: 10.3969/j.issn.1000-3649.2005.01.056 YANG XP, LI L. Efficacy of combined Chinese and western medicine in the treatment of pediatric anaphylactoid purpura[J]. Sichuan J Tradit Chin Med, 2005, 23(1): 79-80. doi: 10.3969/j.issn.1000-3649.2005.01.056
[10]	郑文龙, 黄宏, 方永福. 中西医结合治疗小儿过敏性紫癜31例疗效观察[J]. 齐齐哈尔医学院学报, 2008, 29(17): 2082. doi: 10.3969/j.issn.1002-1256.2008.17.021 ZHENG WL, HUANG H, FANG YF. Efficacy of combined Chinese and western medicine in the treatment of pediatric anaphylactoid purpura in 31 cases[J]. J Qiqihar Med Coll, 2008, 29(17): 2082. doi: 10.3969/j.issn.1002-1256.2008.17.021
[11]	李浩良. 中西医结合治疗过敏性紫癜65例[J]. 河南中医, 2014, 34(8): 1587-1588. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZY201408087.htm LI HL. Combination of Chinese and western medicine in the treatment of anaphylactoid purpura in 65 cases[J]. Henan Tradit Chin Med, 2014, 34(8): 1587-1588. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZY201408087.htm
[12]	栾大丽, 马桐生. 犀角地黄汤治疗小儿过敏性紫癜临床研究[J]. 河南中医, 2016, 36(4): 653-655. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZY201604039.htm LUAN DL, MA TS. The clinical research into allergicPurpura treated with modified Rhinoceros horn and Rehmannia decoction[J]. Henan Tradit Chin Med, 2016, 36(4): 653-655. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZY201604039.htm
[13]	王文亮, 李红. 犀角地黄汤治疗小儿过敏性紫癜的临床疗效评价[J]. 临床医学工程, 2017, 24(3): 387-388. doi: 10.3969/j.issn.1674-4659.2017.03.0387 WANG WL, LI H. Evaluation on the clinical effect of Rhinoceros horn and Rehmannia decoction in the treatment of children with allergic Purpura[J]. Clin Med Eng, 2017, 24(3): 387-388. doi: 10.3969/j.issn.1674-4659.2017.03.0387
[14]	陆丽芳. 犀角地黄汤治疗小儿过敏性紫癜的疗效[J]. 现代实用医学, 2003, 15(5): 299. doi: 10.3969/j.issn.1671-0800.2003.05.034 LU LF. Efficacy of Xijiao Dihuang decoction in the treatment of pediatric anaphylactoid purpura[J]. Mod Pract Med, 2003, 15(5): 299. doi: 10.3969/j.issn.1671-0800.2003.05.034
[15]	周玉琴. 犀角地黄汤联合西药治疗小儿过敏性紫癜随机平行对照研究[J]. 实用中医内科杂志, 2013, 27(11): 95-96. https://www.cnki.com.cn/Article/CJFDTOTAL-SYZY201311051.htm ZHOU YQ. When rhino horn to combined western medicine treatment of pediatric allergicPurpura random parallel control study[J]. J Pract Tradit Chin Intern Med, 2013, 27(11): 95-96. https://www.cnki.com.cn/Article/CJFDTOTAL-SYZY201311051.htm
[16]	姚菁华. 犀角地黄汤加味治疗小儿过敏性紫癜32例疗效观察[J]. 吉林中医药, 2010, 30(9): 777-778. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYJL201009025.htm YAO JH. Efficacy of the modified Xijiao Dihuang decoction in the treatment of pediatric anaphylactoid purpura in 32 cases[J]. Jilin J Tradit Chin Med, 2010, 30(9): 777-778. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYJL201009025.htm
[17]	谷燕, 李辉文, 施晓玲. 犀角地黄汤加味治疗皮肤型过敏性紫癜20例疗效观察[J]. 湖南中医杂志, 2017, 33(10): 72-73. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZO201710036.htm GU Y, LI HW, SHI XL. Efficacy of the modified Xijiao Dihuang decoction in the treatment of 20 Cases of cutaneous anaphylactoid purpura[J]. Hunan J Tradit Chin Med, 2017, 33(10): 72-73. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZO201710036.htm
[18]	邓军. 犀角地黄汤加味治疗过敏性紫癜临床观察[J]. 中国民间疗法, 2012, 20(11): 34-35. https://www.cnki.com.cn/Article/CJFDTOTAL-ZMJL201211044.htm DENG J. Clinical observation on the treatment of anaphylactoid purpura with the modified Xijiao Dihuang decoction[J]. China's Naturopathy, 2012, 20(11): 34-35. https://www.cnki.com.cn/Article/CJFDTOTAL-ZMJL201211044.htm
[19]	烟海丽. 犀角地黄汤加味治疗过敏性紫癜40例临床观察[J]. 中医儿科杂志, 2014, 10(3): 42-44. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYEZ201403018.htm YAN HL. Clinical observation of Xijiaodihuang Decoction in treating allergicPurpura in 40 cases[J]. J Pediatr Tradit Chin Med, 2014, 10(3): 42-44. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYEZ201403018.htm
[20]	胡保华, 秦曼. 犀角地黄汤加味治疗过敏性紫癜40例临床观察[J]. 黑龙江中医药, 2013, 42(6): 21-22. https://www.cnki.com.cn/Article/CJFDTOTAL-HLZY201306015.htm HU BH, QIN M. Clinical observation of 40 cases of anaphylactoid purpura treated with the modified Xijiao Dihuang decoction[J]. Heilongjiang J Tradit Chin Med, 2013, 42(6): 21-22. https://www.cnki.com.cn/Article/CJFDTOTAL-HLZY201306015.htm
[21]	张勇. 犀角地黄汤加减治疗过敏性紫癜的临床观察[J]. 临床医药文献电子杂志, 2018, 5(69): 134. https://www.cnki.com.cn/Article/CJFDTOTAL-LCWX201869126.htm ZHANG Y. Clinical observation on the treatment of anaphylactoid purpura with the modified Xijiao Dihuang decoction[J]. Electr J Clin Med Liter, 2018, 5(69): 134. https://www.cnki.com.cn/Article/CJFDTOTAL-LCWX201869126.htm
[22]	牛晓华. 犀角地黄汤加减治疗儿童过敏性紫癫的临床研究[J]. 当代医学, 2016, 22(3): 153-154. https://www.cnki.com.cn/Article/CJFDTOTAL-DDYI201603103.htm NIU XH. Clinical study on the treatment of pediatric anaphylactoid purpura with the modified Xijiao Dihuang decoction[J]. Contemp Med, 2016, 22(3): 153-154. https://www.cnki.com.cn/Article/CJFDTOTAL-DDYI201603103.htm
[23]	赵长江, 苏小慰, 孙诗炜, 等. 犀角地黄汤加减联合西药治疗过敏性紫癜的疗效观察及对C-反应蛋白的影响[J]. 贵州医药, 2017, 41(12): 1287-1289. https://www.cnki.com.cn/Article/CJFDTOTAL-GZYI201712024.htm ZHAO CJ, SU XW, SUN SW, et al. Observation on the efficacy of the modified Xijiao Dihuang decoction combined with western medicine in the treatment of anaphylactoid purpura and the effect on C-reactive protein[J]. Guizhou Med J, 2017, 41(12): 1287-1289. https://www.cnki.com.cn/Article/CJFDTOTAL-GZYI201712024.htm
[24]	尹艳, 解德平, 解淑梅. 犀角地黄汤辅助治疗过敏性紫癜30例疗效观察[J]. 山东中医杂志, 2012, 31(12): 869, 871. YIN Y, XIE DP, XIE SM. Efficacy of Xijiao Dihuang decoction in the adjuvant treatment of anaphylactoid purpura in 30 cases[J]. Shandong J Tradit Chin Med, 2012, 31(12): 869, 871.
[25]	谌凌燕, 林卓殷, 陈鹏, 等. 犀角地黄汤对小儿过敏性紫癜免疫机制的影响[J]. 按摩与康复医学, 2015, 6(22): 24-25. https://www.cnki.com.cn/Article/CJFDTOTAL-AMYD201522012.htm CHEN LY, LIN ZY, CHEN P, et al. Effect of rhinoceros Xijiao Dihuang decoction on the immune mechanism of pediatric anaphylactoid purpura[J]. Chin Manip Rehabilitation Med, 2015, 6(22): 24-25. https://www.cnki.com.cn/Article/CJFDTOTAL-AMYD201522012.htm
[26]	李俊良, 周峰然. 犀角地黄汤加减治疗小儿过敏性紫癜(腹型)的临床观察[J]. 世界最新医学信息文摘, 2019, 19(43): 212. https://www.cnki.com.cn/Article/CJFDTOTAL-WMIA201943116.htm LI JL, ZHOU FR. Clinical observation on the treatment of pediatric anaphylactoid purpura (abdominal type) by the modified Xijiao Dihuang decoction[J]. World Latest Med Inf, 2019, 19(43): 212. https://www.cnki.com.cn/Article/CJFDTOTAL-WMIA201943116.htm
[27]	王育红. 犀角地黄汤治疗过敏性紫癜的临床观察[J]. 光明中医, 2019, 34(5): 675-677. https://www.cnki.com.cn/Article/CJFDTOTAL-GMZY201905009.htm WANG YH. Clinical observation on Xijiao Dihuang Decoction in the treatment of allergicPurpura[J]. Guangming J Chin Med, 2019, 34(5): 675-677. https://www.cnki.com.cn/Article/CJFDTOTAL-GMZY201905009.htm
[28]	任艳丽, 晁利芹. 加味犀角地黄汤辅治皮肤型过敏性紫癜临床观察[J]. 实用中医药杂志, 2019, 35(2): 176-178. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYAO201902141.htm REN YL, CHAO LQ. Clinical observation on the adjuvant treatment of cutaneous anaphylactoid purpura with the modified Xijiao Dihuang decoction[J]. J Pract Tradit Chin Med, 2019, 35(2): 176-178. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYAO201902141.htm
[29]	王祥羽. 加昧犀角地黄汤治疗小儿过敏性紫癜的临床效果观察[J]. 世界最新医学信息文摘, 2020, 20(3): 184-186. WANG XY. Clinical observation on the treatment of pediatric anaphylactoid purpura by the modified Xijiao Dihuang Decoction[J]. World Latest Med Info, 2020(3): 184-186.
[30]	张旻昱, 邹蓉, 张慧, 等. 银翘散合犀角地黄汤治疗过敏性紫癜33例临床研究[J]. 新中医, 2014, 46(1): 91-93. https://www.cnki.com.cn/Article/CJFDTOTAL-REND201401040.htm ZHANG MY, ZOU R, ZHANG H, et al. Clinical study on 33 cases of anaphylactoid purpura treated with Yinxiao powder combined with Xijiao Dihuang decoction[J]. J New Chin Med, 2014, 46(1): 91-93. https://www.cnki.com.cn/Article/CJFDTOTAL-REND201401040.htm
[31]	陈疏敏, 石琳, 吴艺, 等. 清热凉血法联合西药治疗小儿难治性过敏性紫癜[J]. 中国中医药信息杂志, 2006, 13(4): 52. https://www.cnki.com.cn/Article/CJFDTOTAL-XXYY200604027.htm CHEN SM, SHI L, WU Y, et al. Treatment of pediatric refractory anaphylactoid purpura by combining western medicine with clearing heat and cooling blood method[J]. Chin J Inf Tradit Chin Med, 2006, 13(4): 52. https://www.cnki.com.cn/Article/CJFDTOTAL-XXYY200604027.htm
[32]	高艳华. 犀角地黄汤合五味消毒饮加减治疗儿童过敏性紫癜116例[J]. 中国中医药科技, 2012, 19(2): 183-184. https://www.cnki.com.cn/Article/CJFDTOTAL-TJYY201202070.htm GAO YH. Treatment of 116 cases of pediatric anaphylactoid purpura with Xijiao Dihuang decoction combined with Wuwei Xiaodu decoction[J]. Chin J Tradit Med Sci Technol, 2012, 19(2): 183-184. https://www.cnki.com.cn/Article/CJFDTOTAL-TJYY201202070.htm
[33]	陈伟炳, 陈春妹, 范华云. 糖皮质激素联合犀角地黄汤治疗过敏性紫癜的临床观察[J]. 内科急危重症杂志, 2017, 23(6): 527-528. https://www.cnki.com.cn/Article/CJFDTOTAL-NKJW201706027.htm CHEN WB, CHEN CM, FAN HY. Clinical observation of glucocorticoids combined with Xijiao Dihuang decoction in the treatment of anaphylactoid purpura[J]. J Crit Care Intern Med, 2017, 23(6): 527-528. https://www.cnki.com.cn/Article/CJFDTOTAL-NKJW201706027.htm

Relative Articles

Supplements(0)

Cited By

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Figures(12) / Tables(2)

Get Citation

PDF

XML

Article Metrics

Article views (284) PDF downloads(24)

Meta-Analysis of Clinical Efficacy and Safety of Xijiao Dihuang Decoction Combined with Western Medicine in the Treatment of Anaphylactoid Purpura

doi: 10.14148/j.issn.1672-0482.2023.0179

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

Meta-Analysis of Clinical Efficacy and Safety of Xijiao Dihuang Decoction Combined with Western Medicine in the Treatment of Anaphylactoid Purpura

doi: 10.14148/j.issn.1672-0482.2023.0179

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

Export File

Citation

Format

Content