Volume 39 Issue 2
Feb.  2023
Turn off MathJax
Article Contents
Article Navigation >  Journal of Nanjing University of traditional Chinese Medicine  > 2023  >  39(2): 157-169
ZHONG Wen-feng, HONG Wan-min, LIU Xiao-xia, JI Yu-hua, WANG Wen-li, WANG Kai-dong, SUN Dong-mei. Study on Processe of Aristolochia Contorta Bge. Based on Characteristic Spectrum Combined with Effective Toxicity Value and Appearance Characters[J]. Journal of Nanjing University of traditional Chinese Medicine, 2023, 39(2): 157-169. doi: 10.14148/j.issn.1672-0482.2023.0157
Citation: ZHONG Wen-feng, HONG Wan-min, LIU Xiao-xia, JI Yu-hua, WANG Wen-li, WANG Kai-dong, SUN Dong-mei. Study on Processe of Aristolochia Contorta Bge. Based on Characteristic Spectrum Combined with Effective Toxicity Value and Appearance Characters[J]. Journal of Nanjing University of traditional Chinese Medicine, 2023, 39(2): 157-169. doi: 10.14148/j.issn.1672-0482.2023.0157
shu

Study on Processe of Aristolochia Contorta Bge. Based on Characteristic Spectrum Combined with Effective Toxicity Value and Appearance Characters

doi: 10.14148/j.issn.1672-0482.2023.0157

  • Guangdong Yifang Pharmaceutical Co. Ltd./Key Lab of TCM Formulation Granules Enterprises in Guangdong Province, Foshan 528244, China

  • Received Date: 2022-05-18
    Available Online: 2023-02-17
    Abstract
  •   OBJECTIVE  Based on the characteristic spectrum combined with the determination of effective Toxiciy appearance character, to study the changes of toxic components in the processing of Aristolochia contorta Bge.  METHODS  The characteristic chromatogram of 17 batches of Aristolochia contorta Bge. was established by HPLC, and the parameters of honey, dilution times, humid time and frying time were investigated. Samples were taken at intervals in the process, the chromaticity value and characteristic map were measured, and the comprehensive evaluation of appearance characters and intrinsic toxicity values was carried out.  RESULTS  10 common peaks were calibrated and 6 characteristic peaks were identified in the characteristic spectrum of Aristolochia contorta Bge., among which peak 2 was magnoflorine, peak 5 was 7-hydroxy aristolochic acid A, peak 6 was aristolochic acid D, peak 8 was aristolochic acid B, peak 9 was aristolochic acidⅠ, and peak 10 was aristolochic acidⅠ. According to the pre-treatment investigation, the dosage of honey was 25 kg of refined honey per 100 kg of products to be roasted, the honey was diluted by 3 times amount of water, and the humid time was 60 min. The processing process showed that the peak area of the toxic components of Aristolochia contorta Bge. decreased obviously with the processing time, and the toxic value of magnoflorine and five toxic components gradually increased. According to the comprehensive evaluation of appearance traits and intrinsic toxicity value, the samples processed for 19-27 min ranked in the top five, processing time was determined to be 23-27 min.  CONCLUSION  After Aristolochia contorta Bge. is processed, the relative contents of toxic components decreases, while the toxic value increases. The quality evaluation method of effective toxicity value combined with appearance characteristics can provide reference for the processing of toxic Chinese herbal pieces

     

    • FullText(HTML)
  • loading
    • References(9)
  • [1]
    国家药典委员会. 中华人民共和国药典: 一部[S]. 北京: 中国医药科技出版社, 2015.

    Chinese Pharmacopoeia Commission. Pharmacopoeia of People's Republic of China: Ⅰ[S]. Beijing: China medical science press, 2015.
    [2]
    朱文静, 张立丹, 周玥, 等. 马兜铃酸及马兜铃科中药临床使用风险差异研究[J]. 中国药物警戒, 2022, 19(11): 1213-1217. https://www.cnki.com.cn/Article/CJFDTOTAL-YWJJ202211011.htm

    ZHU WJ, ZHANG LD, ZHOU Y, et al. Risk difference between aristolochic acid and clinical use of traditional Chinese medicines in Aristolochiaceae[J]. Chin J Pharmacovigil, 2022, 19(11): 1213-1217. https://www.cnki.com.cn/Article/CJFDTOTAL-YWJJ202211011.htm
    [3]
    王帆, 王静, 黄恺, 等. 马兜铃酸Ⅰ致急性肾损伤的分子机制研究[J]. 天然产物研究与开发, 2022, 34(5): 848-855. https://www.cnki.com.cn/Article/CJFDTOTAL-TRCW202205014.htm

    WANG F, WANG J, HUANG K, et al. Study on mechanism of aristolochic acid Ⅰ induced acute kidney injury[J]. Nat Prod Res Dev, 2022, 34(5): 848-855. https://www.cnki.com.cn/Article/CJFDTOTAL-TRCW202205014.htm
    [4]
    姜峰, 岳丽君, 朱丹. 马兜铃酸毒副作用研究概述[J]. 中国药物评价, 2021, 38(5): 405-408. https://www.cnki.com.cn/Article/CJFDTOTAL-YAPJ202105009.htm

    JIANG F, YUE LJ, ZHU D. The review and analysis of aristolochic acid side-effects[J]. Chin J Drug Eval, 2021, 38(5): 405-408. https://www.cnki.com.cn/Article/CJFDTOTAL-YAPJ202105009.htm
    [5]
    刘东方. 甘遂醋制减毒存效机制研究[D]. 南京: 南京中医药大学, 2021.

    LIU DF. Study the mechanism of reducing toxicity and preserving effect of Kansui stir-fryed with vinegar[D]. Nanjing: Nanjing University of Chinese Medicine, 2021.
    [6]
    杨标, 李正红, 杨武亮, 等. 不同炮制方法对马兜铃中马兜铃酸类物质含量的影响[J]. 时珍国医国药, 2012, 23(10): 2553-2555. https://www.cnki.com.cn/Article/CJFDTOTAL-SZGY201210075.htm

    YANG B, LI ZH, YANG WL, et al. The effect of various drug processing technologies on the contents of aristolochic acid analogues in axistolchiae fructus[J]. Lishizhen Med Mater Med Res, 2012, 23(10): 2553-2555. https://www.cnki.com.cn/Article/CJFDTOTAL-SZGY201210075.htm
    [7]
    郑晓倩, 徐超, 金传山, 等. 基于颜色变化的"九蒸九晒"黄精炮制火候及内外在质量的相关性研究[J]. 中草药, 2022, 53(6): 1719-1729. https://www.cnki.com.cn/Article/CJFDTOTAL-ZCYO202206013.htm

    ZHENG XQ, XU C, JIN CS, et al. Research on relationship between processing degree and internal and external quality of Polygonatum cyrtonema processed by "nine-steaming and nine-suncuring" based on color change[J]. Chin Tradit Herb Drugs, 2022, 53(6): 1719-1729. https://www.cnki.com.cn/Article/CJFDTOTAL-ZCYO202206013.htm
    [8]
    洪婉敏, 方朝缵, 纪玉华, 等. 当归不同药用部位炒焦过程中颜色与化学成分的变化规律研究[J]. 中药材, 2022, 45(3): 586-593. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYCA202203013.htm

    HONG WM, FANG ZZ, JI YH, et al. Study on color and composition changes of different parts of the processing of Angelica sinensis(Oliv. ) Diels[J]. J Chin Med Mater, 2022, 45(3): 586-593. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYCA202203013.htm
    [9]
    张定堃, 王伽伯, 杨明, 等. 中药品质整合评控实践: 附子品质综合指数[J]. 中国中药杂志, 2015, 40(13): 2582-2588. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGZY201513018.htm

    ZHANG DK, WANG JB, YANG M, et al. Exploring in integrated quality evaluation of Chinese herbal medicines: The integrated quality index(IQI) for aconite[J]. China J Chin Mater Med, 2015, 40(13): 2582-2588. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGZY201513018.htm
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(11)  / Tables(7)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (114) PDF downloads(5) Cited by()
    Proportional views
    Related

    Copyright © Journal of Nanjing University of traditional Chinese Medicine

    Sponsored by：Nanjing University of traditional Chinese MedicineAddress：No.138 xianlin Avenue, Qixia District, Nanjing cityChina Pos：210023

    Tel：025-85811935Email：xb@njucm.edu.cn

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return