Volume 39 Issue 2
Feb.  2023
Turn off MathJax
Article Contents
Article Navigation >  Journal of Nanjing University of traditional Chinese Medicine  > 2023  >  39(2): 124-130
KANG Yong, LI Chan, LIU Gui-fang, XU Shu-bin, WAN Liang-shuo, LYU Yan-lin, LIU Qing. Effect of Gubu Decoction Combined with Compound Huangbai Liquid on the Improvement of Wound in the Post-Interventional Operation for Dry Gangrene of Diabetic Foot[J]. Journal of Nanjing University of traditional Chinese Medicine, 2023, 39(2): 124-130. doi: 10.14148/j.issn.1672-0482.2023.0124
Citation: KANG Yong, LI Chan, LIU Gui-fang, XU Shu-bin, WAN Liang-shuo, LYU Yan-lin, LIU Qing. Effect of Gubu Decoction Combined with Compound Huangbai Liquid on the Improvement of Wound in the Post-Interventional Operation for Dry Gangrene of Diabetic Foot[J]. Journal of Nanjing University of traditional Chinese Medicine, 2023, 39(2): 124-130. doi: 10.14148/j.issn.1672-0482.2023.0124
shu

Effect of Gubu Decoction Combined with Compound Huangbai Liquid on the Improvement of Wound in the Post-Interventional Operation for Dry Gangrene of Diabetic Foot

doi: 10.14148/j.issn.1672-0482.2023.0124

  • Department of Interventional Vascular Surgery, Hebei Province Hospital of Chinese Medicine, Shijiazhuang 050000, China

  • Received Date: 2022-08-20
    Available Online: 2023-02-17
    Abstract
  •   OBJECTIVE  To observe the effects of Gubu decoction combined with compound Huangbai liquid on wound repair, granulation tissue growth and microvascular circulation in the foot after intervention operation for dry gangrene of diabetic foot.  METHODS  A total of 80 patients with dry gangrene of diabetic foot were selected and grouped by random number table, 40 patients in the control group and 40 patients in the treatment group. The control group was treated with compound Huangbai liquid after vascular intervention operation, while the treatment group was given with Gubu decoction combined with compound Huangbai liquid. The treatment course was four weeks. Before and after the treatment, we observed and compared the changes of vascular endothelial growth factor (VEGF), transforming growth factor β1 (TGF-β1), basic fibroblast growth factor (bFGF), nitric oxide (NO), endothelin (ET-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), interleukin-13 (IL-13), tumor necrosis factor (TNF-α), fibrinogen level, the microvascular blood perfusion in the foot, NRS score, granulation tissue growth, foot wound repairment, traditional Chinese medicine (TCM) syndrome scores, as well as the clinical efficacy of the two groups.  RESULTS  After treatment, microvascular blood perfusion in the foot increased in both groups (P < 0.01), but the result in the treatment group was better than that in the control group (P < 0.01). Besides, the area of wound, TCM syndrome scores and NRS score were reduced in both groups compared with those before treatment (P < 0.01). The patients in treatment group were fewer compared with the control group (P < 0.01), but the granulation tissue growth and wound repairment in the treatment group were better than in the control group (P < 0.01). The total efficiency of the treatment group was higher than that of the control group (P < 0.05). The levels of TNF-α, sVCAM-1 and IL-13 in both groups were lower than before treatment (P < 0. 01), but the treatment group showed better results (P < 0.01). The levels of fibrinogen and ET-1 in both groups were lower than before treatment (P < 0.01), but the treatment group showed better results (P < 0.01). The levels of NO were higher than before treatment (P < 0.01), but the result in the treatment group was higher than that in the control group (P < 0.05). The levels of VEGF, TGFβ1 and bFGFβ1 in both groups were higher than the control group (P < 0.05). The levels of VEGF, TGFβ1 and bFGF in the two groups were higher than before treatment (P < 0.01), but the levels in the treatment group were higher than those in the control group (P < 0.01).  CONCLUSION  The combination of Gubu decoction and Huangbai liquid in the post-interventional operation for dry gangrene of diabetic foot can enhance the level of growth factors, suppress inflammation, improve microvascular circulation and endothelial function of the foot, relieve pain, promote granulation tissue growth and wound repairment, and improve clinical efficacy.

     

    • FullText(HTML)
  • loading
    • References(26)
  • [1]
    韩强, 柳国斌, 秦亮, 等. 紫朱软膏对金黄色葡萄球菌感染糖尿病足溃疡炎症反应及NF-κB/JNK/PI3K信号表达的影响[J]. 天津中医药大学学报, 2021, 40(2): 226-234. https://www.cnki.com.cn/Article/CJFDTOTAL-TZYY202102021.htm

    HAN Q, LIU GB, QIN L, et al. Effect of Zizhu Ointment on inflammatory response and NF-κB/JNK/PI3K signal expression of diabetic foot ulcer infected by Staphylococcus aureus[J]. J Tianjin Univ Tradit Chin Med, 2021, 40(2): 226-234. https://www.cnki.com.cn/Article/CJFDTOTAL-TZYY202102021.htm
    [2]
    杨思思, 姜述国, 土登次成, 等. 西藏高原负压封闭引流联合含氧液冲洗治疗下肢坏疽性脓皮病一例[J]. 中华烧伤杂志, 2019, 35(1): 69-71. doi: 10.3760/cma.j.issn.1009-2587.2019.01.013

    YANG SS, JIANG SG, TU D, et al. One case of pyoderma gangrenosum in the lower limbs in Tibetan Plateau treated with vacuum sealing drainage combined with irrigation of oxygen loaded fluid[J]. Chin J Burns, 2019, 35(1): 69-71. doi: 10.3760/cma.j.issn.1009-2587.2019.01.013
    [3]
    袁洪志. 负压封闭引流术(VSD)对提高糖尿病足干性坏疽治疗保肢率的影响分析[J]. 糖尿病天地, 2020, 17(10): 125.

    YUAN HZ. Analysis of the influence of negative pressure drainage (VSD) on improving the limb salvage rate of diabetic foot gangrene[J]. Diabetes World, 2020, 17(10): 125.
    [4]
    APELQVIST J, BAKKER K, VAN HOUTUM WH, et al. International consensus and practical guidelines on the management and the prevention of the diabetic foot. International Working Group on the Diabetic Foot[J]. Diabetes Metab Res Rev, 2000, 16(S1): S84-S92. doi: 10.1002/1520-7560(200009/10)16:1+<::AID-DMRR113>3.0.CO;2-S
    [5]
    WAGNER FW. The dysvascular foot: A system for diagnosis and treatment[J]. Foot Ankle, 1981, 2(2): 64-122. doi: 10.1177/107110078100200202
    [6]
    中华医学会, 中华医学会杂志社, 中华医学会全科医学分会, 等. 2型糖尿病基层诊疗指南(实践版· 2019)[J]. 中华全科医师杂志, 2019, 18(9): 810-818. doi: 10.3760/cma.j.issn.1671-7368.2019.09.003

    Chinese Medical Association, Chinese Medical Association Journal, Chinese Medical Association Branch of General Practice, et al. Guideline for primary care of type 2 diabetes: Practice version(2019)[J]. Chin J Gen Pract, 2019, 18(9): 810-818. doi: 10.3760/cma.j.issn.1671-7368.2019.09.003
    [7]
    中国医学会第一届全国糖尿病足学术会议组. 糖尿病足(肢端坏疽)检查方法及诊断标准(草案)[J]. 中国糖尿病杂志, 1996(2): 126, 102. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGTL602.021.htm

    The First National Diabetic Foot Academic Conference Group of Chinese Medical Association. Diabetic foot (acral gangrene) examination methods and diagnostic criteria (draft)[J]. Chin J Diabetes, 1996(2): 126, 102. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGTL602.021.htm
    [8]
    中国医师协会中西医结合医师分会内分泌与代谢病学专业委员会. 糖尿病足病中医病证结合诊疗指南[J]. 中医杂志, 2021, 62(12): 1099-1104. https://www.cnki.com.cn/Article/CJFDTOTAL-ZZYZ202112017.htm

    Professional Committee of Endocrinology Metabolic Diseases Doctor Society of Integrative Medicine Chinese Medical Doctor Association. Guidelines for diagnosis and treatment of diabetic foot disease based on combination of disease and syndromes[J]. J Tradit Chin Med, 2021, 62(12): 1099-1104. https://www.cnki.com.cn/Article/CJFDTOTAL-ZZYZ202112017.htm
    [9]
    中华人民共和国中医药行业标准· 中医病证诊断疗效标准[S]. 北京: 中国标准出版社, 2012: 143, 9

    Industry Standard of Traditional Chinese Medicine of the People's Republic of China: Diagnosis and Curative effect Standard of TCM diseases[S]. Beijing: Standards press of China, 2012: 143, 9.
    [10]
    邸铁涛, 张春玲, 陈露, 等. 糖尿病足溃疡的发病机制及难愈合原因分析[J]. 贵阳中医学院学报, 2017, 39(1): 98-101. https://www.cnki.com.cn/Article/CJFDTOTAL-GYZX201701022.htm

    DI TT, ZHANG CL, CHEN L, et al. Pathogenesis of diabetic foot ulcer and analysis of the causes of impaired healing[J]. J Guiyang Univ Chin Med, 2017, 39(1): 98-101. https://www.cnki.com.cn/Article/CJFDTOTAL-GYZX201701022.htm
    [11]
    陈诚, 吴艳, 陈琴. 生肌玉红膏治疗糖尿病足溃疡的临床疗效及对创面组织内PDGFR-α表达的影响[J]. 中国美容医学, 2018, 27(9): 58-61. https://www.cnki.com.cn/Article/CJFDTOTAL-MRYX201809023.htm

    CHEN C, WU Y, CHEN Q. Clinical effect of Shengji Yuhong ointment on diabetic foot ulcers and its effect on expression of PDGFR-α in wound tissue[J]. Chin J Aesthetic Med, 2018, 27(9): 58-61. https://www.cnki.com.cn/Article/CJFDTOTAL-MRYX201809023.htm
    [12]
    施秉银, 阮瑞霞. 糖尿病足全程管理与护理[M]. 北京: 人民卫生出版社, 2017: 86-87.

    SHI BY, RUAN RX. Whole-process management and nursing care for diabetic foot[M]. Beijing: People's medical publishing house, 2017: 86-87.
    [13]
    房兴宇, 韩永峰, 付赢, 等. 化浊解毒汤联合中医外治法治疗糖尿病足的临床疗效[J]. 糖尿病天地, 2020(2): 72, 74.

    FANG XY, HAN YF, FU Y, et al. Clinical effect of Huazhuo Jiedu Decoction combined with external treatment of traditional Chinese medicine on diabetic foot[J]. Diabetes World, 2020(2): 72, 74.
    [14]
    巴元明, 胡锦庆, 谢永华, 等. 基于络病理论自拟化瘀通络汤治疗糖尿病足经验[J]. 中国医药导报, 2021, 18(2): 132-134, 142. https://www.cnki.com.cn/Article/CJFDTOTAL-YYCY202102034.htm

    BA YM, HU JQ, XIE YH, et al. Experience of self-made Huayu Tongluo Decoction in the treatment of diabetic foot based on collateral disease theory[J]. China Med Her, 2021, 18(2): 132-134, 142. https://www.cnki.com.cn/Article/CJFDTOTAL-YYCY202102034.htm
    [15]
    高妍, 周海芳, 刘朵, 等. 黄柏化学成分分析及其药理作用研究进展[J]. 亚太传统医药, 2019, 15(4): 207-209. https://www.cnki.com.cn/Article/CJFDTOTAL-YTCT201904068.htm

    GAO Y, ZHOU HF, LIU D, et al. Chemical composition analysis and pharmacological research progress of cortex phellodendri[J]. Asia Pac Tradit Med, 2019, 15(4): 207-209. https://www.cnki.com.cn/Article/CJFDTOTAL-YTCT201904068.htm
    [16]
    邱隆树. 基于临床的《外科真诠》学术思想研究[D]. 成都: 成都中医药大学, 2014.

    QIU LS. Based on clinical studies of academic thoughts of waike Zhenquan[D]. Chengdu: Chengdu University of TCM, 2014.
    [17]
    赵秉江. 黄芪多糖促进皮肤伤口愈合的作用及其相关机制的研究[D]. 兰州: 兰州大学, 2017.

    ZHAO BJ. Wound healing effect of an Astragalus membranaceus polysaccharide and its mechanism[D]. Lanzhou: Lanzhou University, 2017.
    [18]
    胡妮娜, 张晓娟. 黄芪的化学成分及药理作用研究进展[J]. 中医药信息, 2021, 38(1): 76-82. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYXN202101018.htm

    HU NN, ZHANG XJ. Research progress on chemical constituents and pharmacological effects of Astragalus membranaceus[J]. Inf Tradit Chin Med, 2021, 38(1): 76-82. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYXN202101018.htm
    [19]
    吕晓玉, 王中京. 糖尿病足创面内miR-29b表达水平与氧化应激介质、炎症细胞因子的相关性研究[J]. 海南医学院学报, 2019, 25(4): 302-304, 309. https://www.cnki.com.cn/Article/CJFDTOTAL-HNYY201904015.htm

    LV XY, WANG ZJ. The correlation of mir-29b expression level with oxidative stress mediators and inflammatory cytokines in diabetic foot wound[J]. J Hainan Med Univ, 2019, 25(4): 302-304, 309. https://www.cnki.com.cn/Article/CJFDTOTAL-HNYY201904015.htm
    [20]
    吴颖. 红外线治疗仪联合硫辛酸对糖尿病足患者血清VCAM-1和rb-FGF2及TNF-α水平的影响[J]. 医疗装备, 2021, 34(14): 58-59. https://www.cnki.com.cn/Article/CJFDTOTAL-YLZB202114030.htm

    WU Y. Effect of infrared therapeutic instrument combined with lipoic acid on serum VCAM-1, rb-FGF2 and TNF-α levels in diabetic foot patients[J]. Med Equip, 2021, 34(14): 58-59. https://www.cnki.com.cn/Article/CJFDTOTAL-YLZB202114030.htm
    [21]
    佟爱华, 张金华, 葛明芹, 等. 高压氧联合硫辛酸治疗糖尿病足的机制及对截肢的预防作用研究[J]. 中华航海医学与高气压医学杂志, 2020, 27(5): 553-556.

    TONG AH, ZHANG JH, GE MQ, et al. Mechanism of hyperbaric oxygen combined with lipoic acid in treating diabetic foot patients and its preventive effect on amputation as the adverse outcome[J]. Chin J Naut Med Hyperb Med, 2020, 27(5): 553-556.
    [22]
    盛艳丽, 王岩. 血必净注射液对糖尿病足围手术期老年患者人环氧合酶-2水平及血管功能的影响[J]. 现代中西医结合杂志, 2020, 29(35): 3952-3954, 3958. https://www.cnki.com.cn/Article/CJFDTOTAL-XDJH202035019.htm

    SHENG YL, WANG Y. Effect of Xuebijing injection on cyclooxygenase-2 level and vascular function in elderly patients with diabetic foot during perioperative period[J]. Mod J Integr Tradit Chin West Med, 2020, 29(35): 3952-3954, 3958. https://www.cnki.com.cn/Article/CJFDTOTAL-XDJH202035019.htm
    [23]
    王娟, 赵子源, 李凤翱. 糖尿病足感染患者炎症因子与D-二聚体和CD64及纤维蛋白原对病情严重程度评估及预后价值[J]. 中华医院感染学杂志, 2020, 30(3): 373-377. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHYY202003014.htm

    WANG J, ZHAO ZY, LI FA. Assessment and prognostic value of inflammatory factors, D-dimer, CD64 and fibrinogen in patients with diabetic foot infection[J]. Chin J Nosocomiology, 2020, 30(3): 373-377. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHYY202003014.htm
    [24]
    蔡亮, 金阿平. 解毒通脉方联合湿润烧伤膏治疗糖尿病足患者的疗效观察及对血清VEGF、bFGF、SDF-1α的影响[J]. 中国中医药科技, 2018, 25(3): 316-318, 321. https://www.cnki.com.cn/Article/CJFDTOTAL-TJYY201803004.htm

    CAI L, JIN AP. Clinical observation on curative effect of diabetic foot treated with Jiedu Tongmai Fang combined with Shirun Shaoshang Gao and its effects on serum VEGF, bF GF and SDF-1α[J]. Chin J Tradit Med Sci Technol, 2018, 25(3): 316-318, 321. https://www.cnki.com.cn/Article/CJFDTOTAL-TJYY201803004.htm
    [25]
    孙蕾蕾, 朱旅云, 杨少玲. 负压伤口疗法对糖尿病足轻、中度缺血创面肉芽组织转化生长因子-β1表达的影响[J]. 中华损伤与修复杂志(电子版), 2019, 14(1): 20-25. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHSX201901005.htm

    SUN LL, ZHU LY, YANG SL. Effect of negative pressure wound therapy on the expression of transforming growth factor-beta1 in granulation tissue with mild and moderate ischemia wound of diabetic foot[J]. Chin J Inj Repair Wound Heal Electron Ed, 2019, 14(1): 20-25. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHSX201901005.htm
    [26]
    宋丹丹, 李玉珍, 陶天琪, 等. 理气活血颗粒改善气滞血瘀冠心病患者足背皮肤微血管功能[J]. 微循环学杂志, 2021, 31(2): 17-21. https://www.cnki.com.cn/Article/CJFDTOTAL-WXHX202102004.htm

    SONG DD, LI YZ, TAO TQ, et al. Liqi Huoxue Granules improves microvascular dysfunction in coronary heart disease patients with qi stagnation and blood stasis[J]. Chin J Microcirc, 2021, 31(2): 17-21. https://www.cnki.com.cn/Article/CJFDTOTAL-WXHX202102004.htm
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Tables(6)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (119) PDF downloads(13) Cited by()
    Proportional views
    Related

    Copyright © Journal of Nanjing University of traditional Chinese Medicine

    Sponsored by：Nanjing University of traditional Chinese MedicineAddress：No.138 xianlin Avenue, Qixia District, Nanjing cityChina Pos：210023

    Tel：025-85811935Email：xb@njucm.edu.cn

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return