Volume 39 Issue 2
Feb.  2023
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Article Navigation >  Journal of Nanjing University of traditional Chinese Medicine  > 2023  >  39(2): 118-123
GONG Fan-ying, DU Yu-ying, LI Jia, FAN Yu, ZHANG He-lu, MA Jia-wei, WANG Shun, LIU Fu-ming. Effect of Kangxinshuai Formula on Cardiac Function and Oxidative Stress in Patients with Chronic Heart Failure[J]. Journal of Nanjing University of traditional Chinese Medicine, 2023, 39(2): 118-123. doi: 10.14148/j.issn.1672-0482.2023.0118
Citation: GONG Fan-ying, DU Yu-ying, LI Jia, FAN Yu, ZHANG He-lu, MA Jia-wei, WANG Shun, LIU Fu-ming. Effect of Kangxinshuai Formula on Cardiac Function and Oxidative Stress in Patients with Chronic Heart Failure[J]. Journal of Nanjing University of traditional Chinese Medicine, 2023, 39(2): 118-123. doi: 10.14148/j.issn.1672-0482.2023.0118
shu

Effect of Kangxinshuai Formula on Cardiac Function and Oxidative Stress in Patients with Chronic Heart Failure

doi: 10.14148/j.issn.1672-0482.2023.0118
  • 1.

    The Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing 210029, China

  • 2.

    School of Medical Technology, Nantong Health Collage of Jiangsu Province, Nantong 226010, China

  • 3.

    Department of Chinese Medicine, Aoyang Hospital, Zhangjiagang 215600, China

  • Received Date: 2022-10-20
    Available Online: 2023-02-17
    Abstract
  •   OBJECTIVE  To observe the effect of Kangxinshuai formula on cardiac function and oxidative stress in patients suffering from chronic heart failure with qi-yin deficiency and phlegm-stasis combined with water-stagnation (chronic heart failure for short).  METHODS  A total of 100 patients with chronic heart failure who met the inclusion criteria were selected and divided into 50 cases each in the observation group and the control group according to the random number table. The control group was given standardized treatment for chronic heart failure, while the observation group was treated with the Kangxinshuai formula on top of the treatment of the control group. The course of treatment was 12 weeks. Before and after the treatment, we observed the changes in the traditional Chinese medicine (TCM) syndrome score, clinical efficacy, New York Heart Association (NYHA) cardiac function classification, 6 min walking test (6MWT), Minnesota heart failure quality of life questionnaire (MLHFQ), echocardiographic parameters [left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD), left ventricular ejection fraction (LVEF)], serum N-terminal pro brain natriuretic peptide (NT-proBNP), soluble growth stimulator gene 2 protein (sST2), as well as endogenous antioxidant stress factors [heme oxygenase-1 (HO-1), peroxidase (SOD), glutathione peroxidase (GPx), quinone oxidoreductase-1 (NQO-1)], and evaluated the related safety indexes.  RESULTS  After treatment, the TCM syndrome score, clinical efficacy, NYHA cardiac function classification, 6MWT, MLHFQ score, echocardiographic parameters, NT-proBNP, and sST2 showed better results in the observation group (P < 0.05), so the clinical effects of the observation group were better than those of the control group (P < 0.05, P < 0.01). Besides, endogenous anti-oxidative stress factor levels were improved in both groups (P < 0.01), while the observation group performed better than the control group (P < 0.01).  CONCLUSION  Kangxinshuai formula combined with standardized treatment for chronic heart failure can improve the clinical efficacy, cardiac function classification and prognosis of chronic heart failure. The possible mechanism is related to increasing the level of endogenous anti-oxidative stress factors, reducing cardiac oxidative stress damage, improving antioxidant capacity, and delaying cardiac remodeling.

     

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