Volume 38 Issue 11
Nov.  2022
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Article Navigation >  Journal of Nanjing University of traditional Chinese Medicine  > 2022  >  38(11): 1056-1061
WANG Shu-hui, YANG Ming, ZHU Wei-feng, CHEN Li-hua, LI Zhe, WU Wen-ting, GUAN Yong-mei. Study on the Preparation and Transdermal Permeability of Soluble Microneedles Loaded with Gastrodin in vitro[J]. Journal of Nanjing University of traditional Chinese Medicine, 2022, 38(11): 1056-1061. doi: 10.14148/j.issn.1672-0482.2022.1056
Citation: WANG Shu-hui, YANG Ming, ZHU Wei-feng, CHEN Li-hua, LI Zhe, WU Wen-ting, GUAN Yong-mei. Study on the Preparation and Transdermal Permeability of Soluble Microneedles Loaded with Gastrodin in vitro[J]. Journal of Nanjing University of traditional Chinese Medicine, 2022, 38(11): 1056-1061. doi: 10.14148/j.issn.1672-0482.2022.1056
shu

Study on the Preparation and Transdermal Permeability of Soluble Microneedles Loaded with Gastrodin in vitro

doi: 10.14148/j.issn.1672-0482.2022.1056

  • Key Laboratory of Modern Chinese Medicine Preparations of Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China

  • Received Date: 2022-04-12
    Available Online: 2022-11-19
    Abstract
  •   OBJECTIVE  To prepare soluble microneedles loaded with gastrodin, and to investigate their physical and chemical properties and transdermal properties in vitro.  METHODS  The soluble microneedles loaded with gastrodin were prepared by two-step centrifugation method, and the drug loading was determined by HPLC. Morphology, mechanical properties, skin puncture performance and recovery performance were investigated. The in vitro transdermal properties were investigated by Franz diffusion cell.  RESULTS  The prepared microneedles had complete array, good flexibility and good mechanical properties. The drug loading of each tablet was up to (5.45±0.14)mg, and the skin could be successfully penetrated. The skin could be restored to its original state within 2 h after the treatment. In vitro skin infiltration results showed that the cumulative osmotic amount of gastrodin in the fully loaded microneedles reached 87% after 12 h, while the cumulative osmotic amount of gastrodin in the gastrodin solution was 12%, indicating that the soluble micro-target gastrodin had a good promoting effect on transdermal delivery of gastrodin.  CONCLUSION  The soluble microneedles prepared in this study have good mechanical strength and flexibility, and can realize transdermal delivery of water-soluble drugs.

     

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