Volume 38 Issue 9
Sep.  2022
Turn off MathJax
Article Contents
Article Navigation >  Journal of Nanjing University of traditional Chinese Medicine  > 2022  >  38(9): 803-809
GONG Fanying, ZOU Fei, ZHU Yan, ZHOU Mei-hui, DU Yu-ying, WANG Shun, ZHANG Chun-qin, YU Qiu-yu, LIU Fu-ming. Clinical Study on the Effect of Jingling Granules on Vascular Elasticity in Patients with Atherosclerosis[J]. Journal of Nanjing University of traditional Chinese Medicine, 2022, 38(9): 803-809. doi: 10.14148/j.issn.1672-0482.2022.0803
Citation: GONG Fanying, ZOU Fei, ZHU Yan, ZHOU Mei-hui, DU Yu-ying, WANG Shun, ZHANG Chun-qin, YU Qiu-yu, LIU Fu-ming. Clinical Study on the Effect of Jingling Granules on Vascular Elasticity in Patients with Atherosclerosis[J]. Journal of Nanjing University of traditional Chinese Medicine, 2022, 38(9): 803-809. doi: 10.14148/j.issn.1672-0482.2022.0803
shu

Clinical Study on the Effect of Jingling Granules on Vascular Elasticity in Patients with Atherosclerosis

doi: 10.14148/j.issn.1672-0482.2022.0803
  • 1.

    The Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing 210029, China

  • 2.

    Department of Geriatrics, Jiangning TCM Hospital, Nanjing 211100, China

  • 3.

    Department of Cardiology, Wuhu TCM Hospital, Wuhu 241000, China

  • 4.

    Department of TCM, Hospital of the Air Force, Eastern Theater of the Chinese People's Liberation Army, Nanjing 210002, China

  • Received Date: 2022-06-11
    Available Online: 2022-09-19
    Abstract
  •   OBJECTIVE  To observe the effects of Jingling granules on the traditional Chinese medicine (TCM) syndrome score, arterial elasticity and morphological function, blood lipids, blood rheology, as well as serum inflammatory factors in patients with atherosclerosis of qi-yin deficiency and phlegm-blood stasis.  METHODS  A total of 100 patients with atherosclerosis who met the inclusion criteria were randomly divided into control group and experimental group, 50 patients in each group. The control group was treated with atorvastatin, while the experimental group was administered with Jingling granules based on the treatment of the control group. The changes in the two groups were compared in terms of the TCM syndrome score, carotid intima-media thickness (IMT), ultrafast pulse wave velocity (UFPWV) indexes [pulse wave velocity-beginning of systole (PWV-BS), pulse wave velocity-end of systole (PWV-BS), pulse wave velocity-end of systole (PWV-ES)], blood lipids, blood rheological indexes (whole blood high shear viscosity, whole blood medium shear viscosity, whole blood low shear viscosity, plasma viscosity), serum inflammatory factors C-reactive protein (CRP), interleukin-6 (IL-6), interleukin-8 (IL-8), as well as the liver and kidney function.  RESULTS  After treatment, the TCM syndrome scores of the two groups were significantly reduced (P < 0. 01), but the result of the experiment group was better than that of the control group (P < 0.01). The bilateral carotid PWV-BS and PWV-ES of the experiment group were reduced (P < 0.01), and the bilateral carotid PWV-ES and left carotid PWV-BS of the control group were reduced (P < 0.05), but the change of the right carotid PWV-ES of the experiment group was better than that of the control group (P < 0.05). The levels of TC, TG and LDL-C showed better results in both groups (P < 0.01), while the change of TC level was better in the experiment group than in the control group (P < 0.01). Besides, the levels of whole blood medium shear viscosity and whole blood low shear viscosity, as well as plasma viscosity were reduced in both groups (P < 0.05), but the change of whole blood low shear viscosity showed better result in the experiment group than in the control group (P < 0.05). In addition, the levels of serum CRP, IL-6 and IL-8 were reduced in the experiment group (P < 0.05), and the levels of IL-6 and IL-8 were reduced in the control group (P < 0.05). However, the changes of CRP levels in the experiment group were better than those in the control group (P < 0.05). No significant adverse reactions were observed in both groups during the treatment.  CONCLUSIONS  Jingling granules, combined with atorvastatin, can achieve the better clinical efficacy in treating patients with atherosclerosis of qi-yin deficiency and phlegm-blood stasis, in terms of the TCM syndrome scores, vascular elasticity, TC, TG, LDL-C levels, inflammatory factors CRP, IL-6, IL-8 levels, the levels of whole blood medium shear viscosity, whole blood low shear viscosity, and plasma viscosity.

     

    • FullText(HTML)
  • loading
    • References(32)
  • [1]
    王燕逍翔, 白建军, 宇传华. 基于全球视角的中国心血管病疾病负担现状及趋势[J]. 公共卫生与预防医学, 2021, 32(6): 6-11. doi: 10.3969/j.issn.1006-2483.2021.06.002

    WANG Y, BAI JJ, YU CH. Status and trend of cardiovascular disease burden in China from a global perspective[J]. J Public Heal Prev Med, 2021, 32(6): 6-11. doi: 10.3969/j.issn.1006-2483.2021.06.002
    [2]
    中国心血管健康与疾病报告编写组. 中国心血管健康与疾病报告2020概要[J]. 中国循环杂志, 2021, 36(6): 521-545. doi: 10.3969/j.issn.1000-3614.2021.06.001

    The Writing Committee of the Report on Cardiovascular Health and Diseases in China. Report on cardiovascular health and diseases burden in China: An updated summary of 2020[J]. Chin Circ J, 2021, 36(6): 521-545. doi: 10.3969/j.issn.1000-3614.2021.06.001
    [3]
    AGUILAR-BALLESTER M, HERRERO-CERVERA A, VINUE A, et al. Impact of cholesterol metabolism in immune cell function and atherosclerosis[J]. Nutrients, 2020, 12(7): 20-21.
    [4]
    PADRO T, VILAHUR G, BADIMON L. Dyslipidemias and microcirculation[J]. Curr Pharm Des, 2018, 24(25): 2921-2926. doi: 10.2174/1381612824666180702154129
    [5]
    李桂源. 病理生理学[M]. 2版. 北京: 人民卫生出版社, 2010: 343-344.

    LI GY. Pathophysiology[M]. 2nd ed. Beijing: People's medical publishing house, 2010: 343-344.
    [6]
    RUPARELIA N, CHOUDHURY R. Inflammation and atherosclerosis: What is on the horizon?[J]. Heart Br Cardiac Soc, 2020, 106(1): 80-85.
    [7]
    CAVALCANTE JL, LIMA JAC, REDHEUIL A, et al. Aortic stiffness: Current understanding and future directions[J]. J Am Coll Cardiol, 2011, 57(14): 1511-1522. doi: 10.1016/j.jacc.2010.12.017
    [8]
    周永昌, 郭万学. 超声医学[M]. 北京: 人民军医出版社, 2012: 689.

    ZHOU YC, GUO WX. Ultrasound Medicine[M]. Beijing: People's military medical press, 2012: 689.
    [9]
    中药新药临床研究指导原则[M]. 北京: 中国医药科技出版社, 2002.

    Guiding Principles of Clinical Research on Noval Chinese Medicine[M]. Beijing: China medical science press, 2002.
    [10]
    李灿东, 吴承玉. 中医诊断学[M]. 北京: 中国中医药出版社, 2012.

    LI CD, WU CY. Diagnostics of TCM[M]. Beijing: China press of traditional Chinese medicine, 2012.
    [11]
    PAPAGEORGIOU N, BRIASOULIS A, ANDROULAKIS E, et al. Imaging subclinical atherosclerosis: Where do we stand?[J]. Curr Cardiol Rev, 2016, 13(1): 47-55. doi: 10.2174/1573403X12666160803095855
    [12]
    YIN LX, MA CY, WANG S, et al. Reference values of carotid ultrafast pulse-wave velocity: A prospective, multicenter, population-based study[J]. J Am Soc Echocardiogr, 2021, 34(6): 629-641. doi: 10.1016/j.echo.2021.01.003
    [13]
    黄辉, 朱正球, 栾云, 等. 超极速超声成像脉搏波技术在早期颈动脉粥样硬化风险动态评估中的应用价值[J]. 东南大学学报(医学版), 2017, 36(1): 9-13. doi: 10.3969/j.issn.1671-6264.2017.01.003

    HUANG H, ZHU ZQ, LUAN Y, et al. Application of ultrafast ultrasound imaging pulse wave velocity in dynamical indication of early carotid atherosclerosis risk[J]. J Southeast Univ Med Sci Ed, 2017, 36(1): 9-13. doi: 10.3969/j.issn.1671-6264.2017.01.003
    [14]
    NEZU T, HOSOMI N, AOKI S, et al. Carotid intima-media thickness for atherosclerosis[J]. J Atheroscler Thromb, 2016, 23(1): 18-31. doi: 10.5551/jat.31989
    [15]
    OJIMA S, KUBOZONO T, KAWASOE S, et al. Association of risk factors for atherosclerosis, including high-sensitivity C-reactive protein, with carotid intima-media thickness, plaque score, and pulse wave velocity in a male population[J]. Hypertens Res, 2020, 43(5): 422-430. doi: 10.1038/s41440-019-0388-2
    [16]
    MANCIA G, FAGARD R, NARKIEWICZ K, et al. 2013 ESH/ESC Guidelines for the management of arterial hypertension[J]. Blood Press, 2013, 22(4): 193-278. doi: 10.3109/08037051.2013.812549
    [17]
    ZHU ZQ, CHEN LS, WANG H, et al. Carotid stiffness and atherosclerotic risk: Non-invasive quantification with ultrafast ultrasound pulse wave velocity[J]. Eur Radiol, 2019, 29(3): 1507-1517. doi: 10.1007/s00330-018-5705-7
    [18]
    ZHU ZQ, CHEN LS, JIANG XZ, et al. Absent atherosclerotic risk factors are associated with carotid stiffening quantified with ultrafast ultrasound imaging[J]. Eur Radiol, 2021, 31(5): 3195-3206. doi: 10.1007/s00330-020-07405-4
    [19]
    HALASZ G, PIEPOLI MF. Focus on atherosclerosis and lipids[J]. Eur J Prev Cardiol, 2020, 27(15): 1571-1574. doi: 10.1177/2047487320960642
    [20]
    ZHANG XG, LIU J, WANG M, et al. Twenty-year epidemiologic study on LDL-C levels in relation to the risks of atherosclerotic event, hemorrhagic stroke, and cancer death among young and middle-aged population in China[J]. J Clin Lipidol, 2018, 12(5): 1179-1189. doi: 10.1016/j.jacl.2018.06.011
    [21]
    GENEROSO G, JANOVSKY CCPS, BITTENCOURT MS. Triglycerides and triglyceride-rich lipoproteins in the development and progression of atherosclerosis[J]. Curr Opin Endocrinol Diabetes Obes, 2019, 26(2): 109-116. doi: 10.1097/MED.0000000000000468
    [22]
    赵丽娜. 血脂与血流变学检测指标在心血管疾病临床应用中的价值探讨[J]. 中国现代药物应用, 2020, 14(2): 38-40. https://www.cnki.com.cn/Article/CJFDTOTAL-ZWYY202002019.htm

    ZHAO LN. Discussion on the role of blood lipid and rheological indexes in the clinical application of cardiovascular diseases[J]. Chin J Mod Drug Appl, 2020, 14(2): 38-40. https://www.cnki.com.cn/Article/CJFDTOTAL-ZWYY202002019.htm
    [23]
    杨秀英. 动脉硬化症、高血压病、冠心病、糖尿病与健康人血液流变学指标对比观察[J]. 潍坊医学院学报, 1988, 10(4): 14-16. https://www.cnki.com.cn/Article/CJFDTOTAL-MAKE198804004.htm

    YANG XY. Observation with contrast of blood index between nomal man and the patients with hypertension, arteriosclerosisi coronary heart disease and diabeted mellitus[J]. J Weifang Med Coll, 1988, 10(4): 14-16. https://www.cnki.com.cn/Article/CJFDTOTAL-MAKE198804004.htm
    [24]
    ZHU Y, XIAN X, WANG Z, et al. Research progress on the relationship between atherosclerosis and inflammation[J]. Biomolecules, 2018, 23(3): 80.
    [25]
    BEVERLY JK, BUDOFF MJ. Atherosclerosis: Pathophysiology of insulin resistance, hyperglycemia, hyperlipidemia, and inflammation[J]. J Diabetes, 2020, 12(2): 102-104. doi: 10.1111/1753-0407.12970
    [26]
    张鸥. 阿托伐他汀对动脉粥样硬化患者外周血中PPAR γ的作用研究及相关炎症因子与动脉粥样硬化关系的建模分析[D]. 郑州: 郑州大学, 2016.

    ZHANG O. The investigation on the effect of atorvastatin on peripheral blood PPARγ of patients suffered with atherosclerosis and modeling analysis for the correlation of atherosclerosis and inflammatory factors[D]. Zhengzhou: Zhengzhou University, 2016.
    [27]
    陈宇, 周芸湄, 李丹, 等. 黄精的现代药理作用研究进展[J]. 中药材, 2021, 44(1): 240-244. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYCA202101046.htm

    CHEN Y, ZHOU YM, LI D, et al. Advances in modern pharmacological effects of rhizoma polygonati[J]. J Chin Med Mater, 2021, 44(1): 240-244. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYCA202101046.htm
    [28]
    杨燕燕, 谢金东, 俞春英, 等. 灵芝多糖对动脉粥样硬化ApoE-/-小鼠血脂及LOX-1、TNF-α、ICAM1的影响[J]. 山东医药, 2018, 58(1): 33-36. doi: 10.3969/j.issn.1002-266X.2018.01.010

    YANG YY, XIE JD, YU CY, et al. Effects of ganoderan on blood lipids and LOX-1, TNF-α and ICAM1 in atherosclerotic ApoE-/- mice[J]. Shandong Med J, 2018, 58(1): 33-36. doi: 10.3969/j.issn.1002-266X.2018.01.010
    [29]
    宋囡, 陈宁, 曹慧敏, 等. 绞股蓝总苷调控生物节律相关蛋白对ApoE-/-小鼠动脉粥样硬化的影响[J]. 中华中医药学刊, 2021, 39(8): 248-251, 284-285. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYHS202108061.htm

    SONG N, CHEN N, CAO HM, et al. Effects of Gynostemma pentaphyllum saponins on atherosclerosis in ApoE-/- mice by regulating biological rhythm related proteins[J]. Chin Arch Tradit Chin Med, 2021, 39(8): 248-251, 284-285. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYHS202108061.htm
    [30]
    蒋素素, 曾娅玲, 宁洁, 等. 姜黄素下调IDOL水平促进肝细胞摄取血浆LDLC[J]. 中国动脉硬化杂志, 2021, 29(9): 751-760. doi: 10.3969/j.issn.1007-3949.2021.09.004

    JIANG SS, ZENG YL, NING J, et al. Curcumin promotes the hepatocytes-uptake of plasma LDLC by down-regulating IDOL level[J]. Chin J Arterioscler, 2021, 29(9): 751-760. doi: 10.3969/j.issn.1007-3949.2021.09.004
    [31]
    SOLEIMANI V, SAHEBKAR A, HOSSEINZADEH H. Turmeric (Curcuma longa) and its major constituent (curcumin) as nontoxic and safe substances: Review[J]. Phytother Res, 2018, 32(6): 985-995. doi: 10.1002/ptr.6054
    [32]
    WU M, LI XY, WANG SZ, et al. Polydatin for treating atherosclerotic diseases: A functional and mechanistic overview[J]. Biomed Pharmacother, 2020, 128: 110308. doi: 10.1016/j.biopha.2020.110308
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Tables(10)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (71) PDF downloads(20) Cited by()
    Proportional views
    Related

    Copyright © Journal of Nanjing University of traditional Chinese Medicine

    Sponsored by：Nanjing University of traditional Chinese MedicineAddress：No.138 xianlin Avenue, Qixia District, Nanjing cityChina Pos：210023

    Tel：025-85811935Email：xb@njucm.edu.cn

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return