Volume 38 Issue 5
May  2022
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Article Navigation >  Journal of Nanjing University of traditional Chinese Medicine  > 2022  >  38(5): 461-466
TAN Chun-xia, YANG Na-na, QI Ling-yu, LIN Lu-lu, LI Yue-jie, YANG Jing-wen, LIU Cun-zhi, SHI Guang-xia. Effects of Intestinal Microorganisms on Knee Osteoarthritis Based on 'Gut-Joint' Axis[J]. Journal of Nanjing University of traditional Chinese Medicine, 2022, 38(5): 461-466. doi: 10.14148/j.issn.1672-0482.2022.0461
Citation: TAN Chun-xia, YANG Na-na, QI Ling-yu, LIN Lu-lu, LI Yue-jie, YANG Jing-wen, LIU Cun-zhi, SHI Guang-xia. Effects of Intestinal Microorganisms on Knee Osteoarthritis Based on "Gut-Joint" Axis[J]. Journal of Nanjing University of traditional Chinese Medicine, 2022, 38(5): 461-466. doi: 10.14148/j.issn.1672-0482.2022.0461
shu

Effects of Intestinal Microorganisms on Knee Osteoarthritis Based on "Gut-Joint" Axis

doi: 10.14148/j.issn.1672-0482.2022.0461
  • 1.

    School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing 100029, China

  • 2.

    International Acupuncture and Moxibustion Innovation Institute, Beijing University of Chinese Medicine, Beijing 100029, China

  • Received Date: 2021-10-19
    Abstract
  • In recent years, with the rapid development of microbiology, the concept of "gut-joint" axis has been put forward in modern medicine. The "gut-joint" axis plays an important role in intestinal microorganisms and joint diseases. Disturbance of intestinal microorganisms leads to chronic systemic low-grade inflammation, which further aggravates the pathological course of osteoarthritis. Regulating the balance of intestinal microorganisms may improve the symptoms of knee osteoarthritis by suppressing local immune inflammatory responses in the gastrointestinal tract or the knee. Based on the "gut-joint" axis, this paper discusses the potential effects of intestinal microorganisms on knee osteoarthritis, and the potential ways of treatment of knee osteoarthritis.

     

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  • [1]
    LEIFER VP, KATZ JN, LOSINA E. The burden of OA-health services and economics[J]. Osteoarthr Cartil, 2021, 30(1): 10-16.
    [2]
    HUNTER DJ, BIERMA-ZEINSTRA S. Osteoarthritis[J]. Lancet, 2019, 393(10182): 1745-1759. doi: 10.1016/S0140-6736(19)30417-9
    [3]
    ZHANG Y, JORDAN JM. Epidemiology of osteoarthritis[J]. Clin Geriatr Med, 2010, 26(3): 355-369. doi: 10.1016/j.cger.2010.03.001
    [4]
    FERREIRA RM, DUARTE JA, GONÇALVES RS. Non-pharmacological and non-surgical interventions to manage patients with knee osteoarthritis: An umbrella review[J]. Acta Reumatol Port, 2018, 43(3): 182-200.
    [5]
    张晓哲, 张栋, 马玉峰, 等. 通络止痛凝胶制剂对膝骨关节炎大鼠的影响[J]. 中华中医药杂志, 2019(5): 2184-2188. https://www.cnki.com.cn/Article/CJFDTOTAL-BXYY201905071.htm

    ZHANG XZ, ZHANG D, MA YF, et al. Effects of Tongluo Zhitong gel preparation on knee osteoarthritis in rats[J]. China J Tradit Chin Med Pharm, 2019(5): 2184-2188. https://www.cnki.com.cn/Article/CJFDTOTAL-BXYY201905071.htm
    [6]
    ULICI V, KELLEY KL, AZCARATE-PERIL MA, et al. Osteoarthritis induced by destabilization of the medial Meniscus is reduced in germ-free mice[J]. Osteoarthr Cartil, 2018, 26(8): 1098-1109. doi: 10.1016/j.joca.2018.05.016
    [7]
    SJÖGREN K, ENGDAHL C, HENNING P, et al. The gut microbiota regulates bone mass in mice[J]. J Bone Miner Res, 2012, 27(6): 1357-1367. doi: 10.1002/jbmr.1588
    [8]
    CYPERS H, VAN PRAET L, VARKAS G, et al. Relevance of the gut/joint axis for the management of spondyloarthritis in daily clinical practice[J]. Curr Opin Rheumatol, 2014, 26(4): 371-376. doi: 10.1097/BOR.0000000000000070
    [9]
    KAMADA N, SEO SU, CHEN GY, et al. Role of the gut microbiota in immunity and inflammatory disease[J]. Nat Rev Immunol, 2013, 13(5): 321-335. doi: 10.1038/nri3430
    [10]
    KAMADA N, CHEN GY, INOHARA N, et al. Control of pathogens and pathobionts by the gut microbiota[J]. Nat Immunol, 2013, 14(7): 685-690. doi: 10.1038/ni.2608
    [11]
    BRANDTZAEG P. Homing of mucosal immune cells: A possible connection between intestinal and articular inflammation[J]. Aliment Pharmacol Ther, 1997, 11(S3): 24-37.
    [12]
    BIVER E, BERENBAUM F, VALDES AM, et al. Gut microbiota and osteoarthritis management: An expert consensus of the European society for clinical and economic aspects of osteoporosis, osteoarthritis and musculoskeletal diseases (ESCEO)[J]. Ageing Res Rev, 2019, 55: 100946. doi: 10.1016/j.arr.2019.100946
    [13]
    GRAZIANI C, TALOCCO C, DE SIRE R, et al. Intestinal permeability in physiological and pathological conditions: Major determinants and assessment modalities[J]. Eur Rev Med Pharmacol Sci, 2019, 23(2): 795-810.
    [14]
    KABEERDOSS J, SANDHYA P, DANDA D. Gut inflammation and microbiome in spondyloarthritis[J]. Rheumatol Int, 2016, 36(4): 457-468. doi: 10.1007/s00296-015-3414-y
    [15]
    BOER CG, RADJABZADEH D, MEDINA-GOMEZ C, et al. Intestinal microbiome composition and its relation to joint pain and inflammation[J]. Nat Commun, 2019, 10(1): 4881. doi: 10.1038/s41467-019-12873-4
    [16]
    LIU Y, DING W, WANG HL, et al. Gut microbiota and obesity-associated osteoarthritis[J]. Osteoarthritis Cartilage, 2019, 27(9): 1257-1265. doi: 10.1016/j.joca.2019.05.009
    [17]
    PICCO P, GATTORNO M, MARCHESE N, et al. Increased gut permeability in juvenile chronic arthritides. A multivariate analysis of the diagnostic parameters[J]. Clin Exp Rheumatol, 2000, 18(6): 773-778.
    [18]
    HINDRYCKX P, LAUKENS D, SERRY G, et al. Subclinical gut inflammation in spondyloarthritis is associated with a pro-angiogenic intestinal mucosal phenotype[J]. Ann Rheum Dis, 2011, 70(11): 2044-2048. doi: 10.1136/ard.2010.149229
    [19]
    KRZYSIEK R, LEFEVRE EA, BERNARD J, et al. Regulation of CCR6 chemokine receptor expression and responsiveness to macrophage inflammatory protein-3alpha/CCL20 in human B cells[J]. Blood, 2000, 96(7): 2338-2345. doi: 10.1182/blood.V96.7.2338
    [20]
    JACQUES P, ELEWAUT D, MIELANTS H. Interactions between gut inflammation and arthritis/spondylitis[J]. Curr Opin Rheumatol, 2010, 22(4): 368-374. doi: 10.1097/BOR.0b013e3283393807
    [21]
    SIAKAVELLAS SI, BAMIAS G. Tumor necrosis factor-like cytokine TL1A and its receptors DR3 and DcR3: Important new factors in mucosal homeostasis and inflammation[J]. Inflamm Bowel Dis, 2015, 21(10): 2441-2452.
    [22]
    FANTINI MC, PALLONE F, MONTELEONE G. Common immunologic mechanisms in inflammatory bowel disease and spondylarthropathies[J]. World J Gastroenterol, 2009, 15(20): 2472-2478. doi: 10.3748/wjg.15.2472
    [23]
    KOLASINSKI SL, NEOGI T, HOCHBERG MC, et al. 2019 American college of rheumatology/arthritis foundation guideline for the management of osteoarthritis of the hand, hip, and knee[J]. Arthritis Care Res (Hoboken), 2020, 72(2): 149-162. doi: 10.1002/acr.24131
    [24]
    BERTHELOT JM, SELLAM J, MAUGARS Y, et al. Cartilage-gut-microbiome axis: A new paradigm for novel therapeutic opportunities in osteoarthritis[J]. RMD Open, 2019, 5(2): e001037. doi: 10.1136/rmdopen-2019-001037
    [25]
    PANAIOTOV S, FILEVSKI G, EQUESTRE M, et al. Cultural isolation and characteristics of the blood microbiome of healthy individuals[J]. AiM, 2018, 8(5): 406-421. doi: 10.4236/aim.2018.85027
    [26]
    PESESSE L, SANCHEZ C, HENROTIN Y. Osteochondral plate angiogenesis: A new treatment target in osteoarthritis[J]. Joint Bone Spine, 2011, 78(2): 144-149. doi: 10.1016/j.jbspin.2010.07.001
    [27]
    TAUROG JD, RICHARDSON JA, CROFT JT, et al. The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats[J]. J Exp Med, 1994, 180(6): 2359-2364. doi: 10.1084/jem.180.6.2359
    [28]
    MU QH, KIRBY J, REILLY CM, et al. Leaky gut as a danger signal for autoimmune diseases[J]. Front Immunol, 2017, 8: 598. doi: 10.3389/fimmu.2017.00598
    [29]
    JETHWA H, ABRAHAM S. The evidence for microbiome manipulation in inflammatory arthritis[J]. Rheumatology (Oxford), 2017, 56(9): 1452-1460.
    [30]
    HUANG ZY, CHEN J, LI BL, et al. Faecal microbiota transplantation from metabolically compromised human donors accelerates osteoarthritis in mice[J]. Ann Rheum Dis, 2020, 79(5): 646-656. doi: 10.1136/annrheumdis-2019-216471
    [31]
    ZHAO Y, CHENG M, ZOU L, et al. Hidden link in gut-joint axis: Gut microbes promote rheumatoid arthritis at early stage by enhancing ascorbate degradation[J]. Gut, 2021, 71(5): 1041-1043.
    [32]
    SHI N, LI N, DUAN XW, et al. Interaction between the gut microbiome and mucosal immune system[J]. Mil Med Res, 2017, 4: 14.
    [33]
    POTGIETER M, BESTER J, KELL DB, et al. The dormant blood microbiome in chronic, inflammatory diseases[J]. FEMS Microbiol Rev, 2015, 39(4): 567-591. doi: 10.1093/femsre/fuv013
    [34]
    HUANG ZY, KRAUS VB. Does lipopolysaccharide-mediated inflammation have a role in OA?[J]. Nat Rev Rheumatol, 2016, 12(2): 123-129. doi: 10.1038/nrrheum.2015.158
    [35]
    HUANG ZY, STABLER T, PEI FX, et al. Both systemic and local lipopolysaccharide (LPS) burden are associated with knee OA severity and inflammation[J]. Osteoarthr Cartil, 2016, 24(10): 1769-1775. doi: 10.1016/j.joca.2016.05.008
    [36]
    WOLF AJ, UNDERHILL DM. Peptidoglycan recognition by the innate immune system[J]. Nat Rev Immunol, 2018, 18(4): 243-254. doi: 10.1038/nri.2017.136
    [37]
    SCHRIJVER IA, MELIEF MJ, TAK PP, et al. Antigen-presenting cells containing bacterial peptidoglycan in synovial tissues of rheumatoid arthritis patients coexpress costimulatory molecules and cytokines[J]. Arthritis Rheum, 2000, 43(10): 2160-2168. doi: 10.1002/1529-0131(200010)43:10<2160::AID-ANR3>3.0.CO;2-T
    [38]
    SOMMER F, BÄCKHED F. The gut microbiota: Masters of host development and physiology[J]. Nat Rev Microbiol, 2013, 11(4): 227-238. doi: 10.1038/nrmicro2974
    [39]
    QAIYUM Z, LIM M, INMAN RD. The gut-joint axis in spondyloarthritis: Immunological, microbial, and clinical insights[J]. Semin Immunopathol, 2021, 43(2): 173-192. doi: 10.1007/s00281-021-00845-0
    [40]
    FORTUNA R, HART DA, SHARKEY KA, et al. Effect of a prebiotic supplement on knee joint function, gut microbiota, and inflammation in adults with co-morbid obesity and knee osteoarthritis: Study protocol for a randomized controlled trial[J]. Trials, 2021, 22(1): 255. doi: 10.1186/s13063-021-05212-w
    [41]
    RIOS JL, BOMHOF MR, REIMER RA, et al. Protective effect of prebiotic and exercise intervention on knee health in a rat model of diet-induced obesity[J]. Sci Rep, 2019, 9(1): 3893. doi: 10.1038/s41598-019-40601-x
    [42]
    KOROTKYI OH, VOVK AA, DRANITSINA AS, et al. The influence of probiotic diet and chondroitin sulfate administration on Ptgs2, Tgfb1 and Col2a1 expression in rat knee cartilage during monoiodoacetate-induced osteoarthritis[J]. Minerva Med, 2019, 110(5): 419-424.
    [43]
    XIANG L, PENG LL, DU WX, et al. Protective effects of Bifidobacterium on intestinal barrier function in LPS-induced enterocyte barrier injury of caco-2 monolayers and in a rat NEC model[J]. PLoS ONE, 2016, 11(8): e0161635. doi: 10.1371/journal.pone.0161635
    [44]
    HENROTIN Y, PATRIER S, PRALUS A, et al. Protective actions of oral administration of Bifidobacterium longum CBi0703 in spontaneous osteoarthritis in dunkin hartley Guinea pig model[J]. Cartilage, 2021, 13(S2): 1204-1213.
    [45]
    SCHOTT EM, FARNSWORTH CW, GRIER A, et al. Targeting the gut microbiome to treat the osteoarthritis of obesity[J]. JCI Insight, 2018, 3(8): e95997. doi: 10.1172/jci.insight.95997
    [46]
    王天琪, 石广霞, 杨娜娜, 等. 基于"脑肠轴"学说探讨针刺改善膝骨关节炎的理论基础[J]. 河北中医药学报, 2019, 34(5): 61-64. https://www.cnki.com.cn/Article/CJFDTOTAL-HZYX201905017.htm

    WANG TQ, SHI GX, YANG NN, et al. On the theoretical basis of acupuncture in improving knee osteoarthritis based on "brain-gut axis" theory[J]. J Hebei Tradit Chin Med Pharmacol, 2019, 34(5): 61-64. https://www.cnki.com.cn/Article/CJFDTOTAL-HZYX201905017.htm
    [47]
    王文炎, 梁凤霞, 宋爱群, 等. 针灸调节肠道微生物群的现状与思考[J]. 针刺研究, 2019, 44(1): 71-74. https://www.cnki.com.cn/Article/CJFDTOTAL-XCYJ201901014.htm

    WANG WY, LIANG FX, SONG AQ, et al. Current situation and thinking on the intestinal microflora regulation with acupuncture and moxibustion[J]. Acupunct Res, 2019, 44(1): 71-74. https://www.cnki.com.cn/Article/CJFDTOTAL-XCYJ201901014.htm
    [48]
    SI YC, MIAO WN, HE JY, et al. Regulating gut flora dysbiosis in obese mice by electroacupuncture[J]. Am J Chin Med, 2018: 1-17.
    [49]
    LU MJ, HE Y, GONG MR, et al. Role of neuro-immune cross-talk in the anti-obesity effect of electro-acupuncture[J]. Front Neurosci, 2020, 14: 151. doi: 10.3389/fnins.2020.00151
    [50]
    肖延成, 徐波, 张力, 等. 碘乙酸钠诱导的大鼠膝骨关节炎模型肠道菌群变化及其潜在影响[J]. 中国中医骨伤科杂志, 2020, 28(4): 1-5. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGZG202004026.htm

    XIAO YC, XU B, ZHANG L, et al. Intestinal flora changes and its potential effects in rats with knee osteoarthritis induced by iodoacetate sodium[J]. Chin J Tradit Med Traumatol Orthop, 2020, 28(4): 1-5. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGZG202004026.htm
    [51]
    李湘力, 蔡敬宙, 林泳, 等. 针刺疗法调节IBS-D大鼠肠道菌群结构和促进肠紧密连接的作用研究[J]. 广州中医药大学学报, 2019, 36(7): 1022-1028. https://www.cnki.com.cn/Article/CJFDTOTAL-REST201907021.htm

    LI XL, CAI JZ, LIN Y, et al. Study on acupuncture therapy in regulating gut microbiota and promoting intestinal tight junction in IBS-D rats[J]. J Guangzhou Univ Tradit Chin Med, 2019, 36(7): 1022-1028. https://www.cnki.com.cn/Article/CJFDTOTAL-REST201907021.htm
    [52]
    WANG TQ, LI LR, TAN CX, et al. Effect of electroacupuncture on gut microbiota in participants with knee osteoarthritis[J]. Front Cell Infect Microbiol, 2021, 11: 597431. doi: 10.3389/fcimb.2021.597431
    [53]
    XIE LL, ZHAO YL, YANG J, et al. Electroacupuncture prevents osteoarthritis of high-fat diet-induced obese rats[J]. Biomed Res Int, 2020, 2020: 9380965.
    [54]
    WU YR, KUANG GY, LU FG, et al. Pathological relationship between intestinal flora and osteoarthritis and intervention mechanism of Chinese medicine[J]. Chin J Integr Med, 2019, 25(9): 716-720. doi: 10.1007/s11655-019-3224-2
    [55]
    TONG XL, XU J, LIAN FM, et al. Structural alteration of gut microbiota during the amelioration of human type 2 diabetes with hyperlipidemia by metformin and a traditional Chinese herbal formula: A multicenter, randomized, open label clinical trial[J]. mBio, 2018, 9(3): e02392-e02317.
    [56]
    ZHANG HY, TIAN JX, LIAN FM, et al. Therapeutic mechanisms of traditional Chinese medicine to improve metabolic diseases via the gut microbiota[J]. Biomed Pharmacother, 2021, 133: 110857. doi: 10.1016/j.biopha.2020.110857
    [57]
    CUI HX, ZHANG LS, LUO Y, et al. A purified anthraquinone-glycoside preparation from rhubarb ameliorates type 2 diabetes mellitus by modulating the gut microbiota and reducing inflammation[J]. Front Microbiol, 2019, 10: 1423. doi: 10.3389/fmicb.2019.01423
    [58]
    CHEN MY, LIAO ZQ, LU BY, et al. Huang-Lian-Jie-du-decoction ameliorates hyperglycemia and insulin resistant in association with gut microbiota modulation[J]. Front Microbiol, 2018, 9: 2380. doi: 10.3389/fmicb.2018.02380
    [59]
    CHANG CJ, LIN CS, LU CC, et al. Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota[J]. Nat Commun, 2015, 6: 7489. doi: 10.1038/ncomms8489
    [60]
    SI YH, MA Y, GUO Y, et al. Efficacy and safety of Shaoyang Xibi Decoction in patients with knee osteoarthritis: A multi-center, single-blind, randomized controlled trial[J]. J Tradit Chin Med, 2018, 38(5): 733-739. doi: 10.1016/S0254-6272(18)30912-9
    [61]
    DE SIRE A, DE SIRE R, PETITO V, et al. Gut-joint axis: The role of physical exercise on gut microbiota modulation in older people with osteoarthritis[J]. Nutrients, 2020, 12(2): 574. doi: 10.3390/nu12020574
    [62]
    LI KF, LIU AL, ZONG WH, et al. Moderate exercise ameliorates osteoarthritis by reducing lipopolysaccharides from gut microbiota in mice[J]. Saudi J Biol Sci, 2021, 28(1): 40-49. doi: 10.1016/j.sjbs.2020.08.027
    [63]
    COULSON S, BUTT H, VECCHIO P, et al. Green-lipped mussel extract (Perna canaliculus) and glucosamine sulphate in patients with knee osteoarthritis: Therapeutic efficacy and effects on gastrointestinal microbiota profiles[J]. Inflammopharmacology, 2013, 21(1): 79-90. doi: 10.1007/s10787-012-0146-4
    [64]
    GUAN Z, JIA J, ZHANG C, et al. Gut microbiome dysbiosis alleviates the progression of osteoarthritis in mice[J]. Clin Sci, 2020, 134(23): 3159-3174. doi: 10.1042/CS20201224
    [65]
    FAVAZZO LJ, HENDESI H, VILLANI DA, et al. The gut microbiome-joint connection: Implications in osteoarthritis[J]. Curr Opin Rheumatol, 2020, 32(1): 92-101. doi: 10.1097/BOR.0000000000000681
    [66]
    GUSS JD, ZIEMIAN SN, LUNA M, et al. The effects of metabolic syndrome, obesity, and the gut microbiome on load-induced osteoarthritis[J]. Osteoarthritis Cartilage, 2019, 27(1): 129-139. doi: 10.1016/j.joca.2018.07.020
    [67]
    METCALFE D, HARTE AL, ALETRARI MO, et al. Does endotoxaemia contribute to osteoarthritis in obese patients?[J]. Clin Sci, 2012, 123(11): 627-634. doi: 10.1042/CS20120073
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