Volume 38 Issue 5
May  2022
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Article Navigation >  Journal of Nanjing University of traditional Chinese Medicine  > 2022  >  38(5): 404-408
ZHANG Zheng-chun, ZHOU En-chao, JIN Chen. Effect of Yishen Shuli Formula on Microinflammatory State in Patients of 3rd-4th Stage Chronic kidney Disease with Syndromes of Spleen-Kidney Deficiency Combined with Internal Stasis and Turbidity Obstruction[J]. Journal of Nanjing University of traditional Chinese Medicine, 2022, 38(5): 404-408. doi: 10.14148/j.issn.1672-0482.2022.0404
Citation: ZHANG Zheng-chun, ZHOU En-chao, JIN Chen. Effect of Yishen Shuli Formula on Microinflammatory State in Patients of 3rd-4th Stage Chronic kidney Disease with Syndromes of Spleen-Kidney Deficiency Combined with Internal Stasis and Turbidity Obstruction[J]. Journal of Nanjing University of traditional Chinese Medicine, 2022, 38(5): 404-408. doi: 10.14148/j.issn.1672-0482.2022.0404
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Effect of Yishen Shuli Formula on Microinflammatory State in Patients of 3rd-4th Stage Chronic kidney Disease with Syndromes of Spleen-Kidney Deficiency Combined with Internal Stasis and Turbidity Obstruction

doi: 10.14148/j.issn.1672-0482.2022.0404
  • 1.

    Department of Nephropathy, Taizhou Jiangyan TCM Hospital, Taizhou 225500, China

  • 2.

    The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China

  • Received Date: 2021-09-13
    Abstract
  •   OBJECTIVE  To observe the effect of Yishen Shuli Formula on microinflammatory state in patients of 3rd-4th stage chronic kidney disease (CKD) with syndromes of spleen-kidney deficiency and internal stasis and turbidity obstruction.  METHODS  A total of 61 3rd-4th stage CKD patients with syndromes of spleen-kidney deficiency and internal stasis and turbidity obstruction were randomly divided into 31 cases in the treatment group and 30 cases in the control group (with 1 case dropped out). The control group was given basic western medicine treatment, while the treatment group was treated with Yishen Shuli Formula on top of the therapies in the control group. The intervention course lasted for 24 weeks. Before and after treatment, to both groups, we observed the traditional Chinese medicine (TCM) syndrome scores, and measured the renal function indexes [Serum creatinine (Scr), blood urea nitrogen (BUN), Estimated glomerular filtration rate (eGFR)], microinflammation indexes [Changes in the levels of hypersensitive C-reactive protein (hs-CRP), Interleukin-6 (IL-6), as well as tumor necrosis factor-α (TNF-α).  RESULTS  After treatment, the total TCM syndrome scores showed improved tendency in both groups (P < 0.01), but the results in the treatment group were better than those in the control group (P < 0.05). in addition, the TCM syndromes and clinical comprehensive efficacy of the treatment group were better than those of the control group (P < 0.05, P < 0.01). The renal function indexes of both groups showed significantly improved tendency (P < 0.01), while the results in the treatment group were better than those in the control group (P < 0.05). Besides, the serum microinflammation indexes of both groups were decreased significantly (P < 0.01), but the results in the treatment group were lower than those in the control group (P < 0.05, P < 0.01).  CONCLUSION  The combination of Yishen Shuli Formula with conventional western medicine treatment can relieve the TCM syndromes and improve overall clinical efficacy in 3rd-4th stage CKD patients with syndromes of spleen-kidney deficiency and internal stasis and turbidity obstruction, and its efficacy mechanism may be related to the amelioration of patients' microinflammatory state.

     

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