Citation: | ZHUANG Yan-shuang, CAI Bao-chang, ZHANG Zi-li, MENG Qing-xiang. Research Progress of Nephrotoxicity of Traditional Chinese Medicine[J]. Journal of Nanjing University of traditional Chinese Medicine, 2022, 38(5): 390-396. doi: 10.14148/j.issn.1672-0482.2022.0390 |
[1] |
万新军. 中药肾毒性研究进展[J]. 当代医学, 2016, 22(34): 7-8. doi: 10.3969/j.issn.1009-4393.2016.34.004
WAN XJ. Research progress on nephrotoxicity of traditional Chinese Medicine[J]. Contemp Med, 2016, 22(34): 7-8. doi: 10.3969/j.issn.1009-4393.2016.34.004
|
[2] |
梁嘉豪, 路晓君, 师燕华, 等. 高效液相色谱法测定4种乌头中药中乌头碱、新乌头碱和次乌头碱[J]. 山西医科大学学报, 2021, 52(11): 1487-1491. https://www.cnki.com.cn/Article/CJFDTOTAL-SXYX202111018.htm
LIANG JH, LU XJ, SHI YH, et al. Determination of aconitine, mesaconitine and hypaconitine in four kinds of Chinese traditional medicines of Aconitum by high performance liquid chromatography[J]. J Shanxi Med Univ, 2021, 52(11): 1487-1491. https://www.cnki.com.cn/Article/CJFDTOTAL-SXYX202111018.htm
|
[3] |
张美玉, 陈明明, 张克霞, 等. 马钱子致大鼠肾毒性作用部位的化学成分[J]. 沈阳药科大学学报, 2018, 35(3): 193-198. https://www.cnki.com.cn/Article/CJFDTOTAL-SYYD201803007.htm
ZHANG MY, CHEN MM, ZHANG KX, et al. The chemical constituents of nephrotoxic action fraction of Semen strychni in rats[J]. J Shenyang Pharm Univ, 2018, 35(3): 193-198. https://www.cnki.com.cn/Article/CJFDTOTAL-SYYD201803007.htm
|
[4] |
孙晓倩. 益母草总生物碱肾毒性研究与机制探讨[D]. 济南: 山东中医药大学, 2017.
SUN XQ. Research on nephrotoxicity of total alkaloids of leonuri herba and its mechanism[D]. Jinan: Shandong University of Traditional Chinese Medicine, 2017.
|
[5] |
高书林. 半枝莲总黄酮成分及抑制肾毒性的研究[D]. 南京: 南京农业大学, 2014.
GAO SL. Studies on inhibitory effect on cisplatin induced renal injury and flavonoids constituents from Scutellaria barbata[D]. Nanjing: Nanjing Agricultural University, 2014.
|
[6] |
王青秀. 大黄及其主要成分的毒性毒理研究[D]. 北京: 中国人民解放军军事医学科学院, 2007.
WANG QX. Study on the toxicity and its mechanisms of rhubarb and its major constituents[D]. Beijing: Academy of Military Medical Sciences, 2007.
|
[7] |
冯筱懿. 中药栀子及其成分栀子苷对肾脏毒性及机制初步研究[D]. 北京: 首都医科大学, 2016.
FENG XY. The study of nephrotoxicity and primary mechanism induced by the Gardenia and its main component geniposide[D]. Beijing: Capital Medical University, 2016.
|
[8] |
程梓烨. 商陆醋制法炮制减毒存效机制研究[D]. 南京: 南京中医药大学, 2019.
CHENG ZY. Study on the effect and mechanism of Phytolaccae Radix after vinegar processing in toxicity reducing and efficacy retaining[D]. Nanjing: Nanjing University of Chinese Medicine, 2019.
|
[9] |
涂玥, 万毅刚, 孙伟, 等. 马兜铃酸肾毒性的临床特征、分子机制及治疗策略[J]. 南京中医药大学学报, 2018, 34(1): 12-18. https://www.cnki.com.cn/Article/CJFDTOTAL-NJZY201801005.htm
TU Y, WAN YG, SUN W, et al. Clinical features, molecular mechanisms and therapeutic strategies of aristolochic acid-induced nephrotoxicity[J]. J Nanjing Univ Tradit Chin Med, 2018, 34(1): 12-18. https://www.cnki.com.cn/Article/CJFDTOTAL-NJZY201801005.htm
|
[10] |
张倩倩, 王爱平, 靳洪涛. 中药肾毒性的研究进展[J]. 解放军药学学报, 2013, 29(6): 558-561. https://www.cnki.com.cn/Article/CJFDTOTAL-JFJN201306025.htm
ZHANG QQ, WANG AP, JIN HT. Research progress on nephrotoxicity of traditional Chinese medicine[J]. Pharm J Chin People's Liberation Army, 2013, 29(6): 558-561. https://www.cnki.com.cn/Article/CJFDTOTAL-JFJN201306025.htm
|
[11] |
李森辉, 庞帼敏, 戴卫波. 龙胆泻肝丸致药品不良反应21例报道[J]. 深圳中西医结合杂志, 2018, 28(18): 39-41. https://www.cnki.com.cn/Article/CJFDTOTAL-SZZX201818019.htm
LI SH, PANG GM, DAI WB. Retrospective analysis of 21 cases of adverse reactions induced by longdanxiegan pills[J]. Shenzhen J Integr Tradit Chin West Med, 2018, 28(18): 39-41. https://www.cnki.com.cn/Article/CJFDTOTAL-SZZX201818019.htm
|
[12] |
张芙蓉. 儿童苍耳子中毒致多脏器功能障碍1例报告[J]. 中国工业医学杂志, 2021, 34(3): 218-220. https://www.cnki.com.cn/Article/CJFDTOTAL-SOLE202103007.htm
ZHANG FR. A case report of multiple organ dysfunction caused by Xanthium sibiricum poisoning in children[J]. Chin J Ind Med, 2021, 34(3): 218-220. https://www.cnki.com.cn/Article/CJFDTOTAL-SOLE202103007.htm
|
[13] |
李文婷, 吴勉华. 中药马兜铃酸的肾毒性研究[J]. 世界科学技术-中医药现代化, 2015, 17(5): 1095-1099. https://www.cnki.com.cn/Article/CJFDTOTAL-SJKX201505037.htm
LI WT, WU MH. Study on nephrotoxicity of aristolochic acid in traditional Chinese medicine[J]. Mod Tradit Chin Med Mater Med World Sci Technol, 2015, 17(5): 1095-1099. https://www.cnki.com.cn/Article/CJFDTOTAL-SJKX201505037.htm
|
[14] |
孙晨, 奇锦峰, 余文浩, 等. 10种肾毒性中药对小鼠肾脏有机阴离子转运体的影响[J]. 中国药房, 2015, 26(19): 2673-2676. doi: 10.6039/j.issn.1001-0408.2015.19.25
SUN C, QI JF, YU WH, et al. Effects of 10 kinds of nephrotoxic TCM on kidney organic anion transporter in mice[J]. China Pharm, 2015, 26(19): 2673-2676. doi: 10.6039/j.issn.1001-0408.2015.19.25
|
[15] |
张贺, 王芳, 葛平, 等. 雷公藤不良反应及其配伍减毒增效研究进展[J]. 中国中医药信息杂志, 2014, 21(8): 126-129. doi: 10.3969/j.issn.1005-5304.2014.08.043
ZHANG H, WANG F, GE P, et al. Research progress on adverse reactions of Tripterygium Wilfordii and its compatibility, toxicity reduction and efficiency enhancement[J]. Chin J Inf Tradit Chin Med, 2014, 21(8): 126-129. doi: 10.3969/j.issn.1005-5304.2014.08.043
|
[16] |
陈利欣, 李晶. 雷公藤的肾毒性作用及其防治[J]. 山东医药, 2009, 49(37): 113-114. doi: 10.3969/j.issn.1002-266X.2009.37.082
CHEN LX, LI J. Nephrotoxic effect of Tripterygium Wilfordii and its prevention and treatment[J]. Shandong Med J, 2009, 49(37): 113-114. doi: 10.3969/j.issn.1002-266X.2009.37.082
|
[17] |
孙晓倩. 益母草总生物碱肾毒性研究与机制探讨[D]. 济南: 山东中医药大学, 2017.
SUN XQ. Research on nephrotoxicity of total alkaloids of leonuri herba and its mechanism[D]. Jinan: Shandong University of Traditional Chinese Medicine, 2017.
|
[18] |
孙蓉, 吴旭东, 刘建伟, 等. 雷公藤、关木通、益母草对大鼠肾毒性的比较研究[J]. 中药药理与临床, 2005, 21(2): 26-28. doi: 10.3969/j.issn.1001-859X.2005.02.012
SUN R, WU XD, LIU JW, et al. Experimental study of the rat renal toxicity of Tripterygium wilfordii, Caulis aristolochiae and Leonurus[J]. Pharmacol Clin Chin Mater Med, 2005, 21(2): 26-28. doi: 10.3969/j.issn.1001-859X.2005.02.012
|
[19] |
刘金伟, 韩林涛, 黄芳, 等. 基于1H NMR代谢组学细辛肝肾毒性的机制研究[J]. 中药药理与临床, 2020, 36(4): 131-136. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYYL202004025.htm
LIU JW, HAN LT, HUANG F, et al. Study on the hepatotoxicity and nephrotoxicity of Asarum in rats based on1H-NMR metabonomics[J]. Pharmacol Clin Chin Mater Med, 2020, 36(4): 131-136. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYYL202004025.htm
|
[20] |
宋立群, 王丽哲, 马艳春, 等. 细辛对大鼠肾功能及组织形态学的影响[J]. 中医药学刊, 2004, 22(11): 1979-1982. doi: 10.3969/j.issn.1673-7717.2004.11.004
SONG LQ, WANG LZ, MA YC, et al. The experimental study of Asarum heterotropoides Fr. Schmidt on renal injury[J]. Study J Tradit Chin Med, 2004, 22(11): 1979-1982. doi: 10.3969/j.issn.1673-7717.2004.11.004
|
[21] |
胡超, 汤响林, 李杰, 等. 补骨脂醇提物对大鼠尿内源性代谢产物的影响[J]. 中国药理学与毒理学杂志, 2015, 29(6): 931-938. doi: 10.3867/j.issn.1000-3002.2015.06.009
HU C, TANG XL, LI J, et al. Effect of ethanol extract of Fructus Psoraleae on urinary endogenous metabolites of rats[J]. Chin J Pharmacol Toxicol, 2015, 29(6): 931-938. doi: 10.3867/j.issn.1000-3002.2015.06.009
|
[22] |
邓诺. 大黄及其总蒽醌肝肾毒性研究[D]. 北京: 中国中医科学院, 2018.
DEGN N. Study on liver and kidney toxicity of rhubarb and its total anthraquinones[D]. Beijing: China Academy of Chinese Medical Sciences, 2018.
|
[23] |
彭金玲, 边育红, 王丽, 等. 马兜铃酸肾毒性的研究进展[J]. 环球中医药, 2013, 6(1): 59-64. https://www.cnki.com.cn/Article/CJFDTOTAL-HQZY201301027.htm
PENG JL, BIAN YH, WANG L, et al. Research progress of Aristolochic acid renal toxicity[J]. Glob Tradit Chin Med, 2013, 6(1): 59-64. https://www.cnki.com.cn/Article/CJFDTOTAL-HQZY201301027.htm
|
[24] |
孙文学, 盛云华, 黄坚, 等. 商陆利尿作用与肾毒性研究进展[J]. 世界中医药, 2020, 15(23): 3586-3592. doi: 10.3969/j.issn.1673-7202.2020.23.009
SUN WX, SHENG YH, HUANG J, et al. Research on diuretic activity and nephrotoxicity of Radix phytolaccae[J]. World Chin Med, 2020, 15(23): 3586-3592. doi: 10.3969/j.issn.1673-7202.2020.23.009
|
[25] |
盛昌翠. 苍耳子不同部位毒性评价及成分分析[D]. 武汉: 湖北中医药大学, 2014.
SHENG CC. Studies on different parts of the toxicity evaluation and composition analysis research of xanthii fructus[D]. Wuhan: Hubei University of Chinese Medicine, 2014.
|
[26] |
王晓烨, 林瑞超, 董世芬, 等. 含汞矿物药的毒性研究进展[J]. 中国中药杂志, 2017, 42(7): 1258-1264. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGZY201707009.htm
WANG XY, LIN RC, DONG SF, et al. Toxicity of mineral Chinese medicines containing mercury element[J]. China J Chin Mater Med, 2017, 42(7): 1258-1264. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGZY201707009.htm
|
[27] |
周霞, 尹衍玲, 赵震霄, 等. 慢性汞中毒引起肾损伤的临床表现、治疗及预后观察[J]. 职业与健康, 2001, 17(5): 7-9. doi: 10.3969/j.issn.1004-1257.2001.05.004
ZHOU X, YIN YL, ZHAO ZX, et al. Clinical manifestation, therapy and prognosis of rental injury induced by chronic mercury intoxication[J]. Occup Heal, 2001, 17(5): 7-9. doi: 10.3969/j.issn.1004-1257.2001.05.004
|
[28] |
强桂芬, 方莲花, 杜冠华. 中药蜈蚣毒的历史认识与研究现状[J]. 中药药理与临床, 2019, 35(2): 151-154. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYYL201902034.htm
QIANG GF, FANG LH, DU GH. The historical cognition and evaluation of Centipedetoxicity[J]. Pharmacol Clin Chin Mater Med, 2019, 35(2): 151-154. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYYL201902034.htm
|
[29] |
汪春飞, 马良, 侯雪峰, 等. 泽泻醇提物对大鼠肾毒性及其分子机制的探究实验[J]. 中国中药杂志, 2016, 41(18): 3432-3438. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGZY201618019.htm
WANG CF, MA L, HOU XF, et al. Study on nephrotoxicity of ethanol extract from Alismatis Rhizoma in rats and its molecular mechanism[J]. China J Chin Mater Med, 2016, 41(18): 3432-3438. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGZY201618019.htm
|
[30] |
汪春飞, 成旭东, 顾俊菲, 等. 泽泻化学物质基础及其毒性研究进展[J]. 中国中药杂志, 2015, 40(5): 840-846. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGZY201505012.htm
WANG CF, CHENG XD, GU JF, et al. Research development of the chemical material basis of Alisma orientalis and its toxicity[J]. China J Chin Mater Med, 2015, 40(5): 840-846. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGZY201505012.htm
|
[31] |
陈亮. 基于传统中药理论预测中药肾毒性的研究[D]. 广州: 暨南大学, 2018.
CHEN L. To predict nephrotoxicity of Chinese herbal medicines based on traditional Chinese herbal medicine theory[D]. Guangzhou: Jinan University, 2018.
|
[32] |
BAUER B, LIEDTKE D, JARZINA S, et al. Exploration of zebrafish larvae as an alternative whole-animal model for nephrotoxicity testing[J]. Toxicol Lett, 2021, 344: 69-81. doi: 10.1016/j.toxlet.2021.03.005
|
[33] |
谌晶晶, 唐旭霞, 徐慧芳, 等. 马兜铃酸对斑马鱼的耳毒性及肾毒性研究[J]. 听力学及言语疾病杂志, 2020, 28(1): 57-61. doi: 10.3969/j.issn.1006-7299.2020.01.015
CHEN JJ, TANG XX, XU HF, et al. The ototoxicity and nephrotoxicity of aristolochic acid in zebrafish[J]. J Audiol Speech Pathol, 2020, 28(1): 57-61. doi: 10.3969/j.issn.1006-7299.2020.01.015
|
[34] |
王雪, 韩利文, 何秋霞, 等. 马兜铃酸对斑马鱼肾损伤因子(KIM-1)表达的影响[J]. 动物学杂志, 2018, 53(4): 622-627. https://www.cnki.com.cn/Article/CJFDTOTAL-BIRD201804015.htm
WANG X, HAN LW, HE QX, et al. Effect of aristolochic acid on expression of KIM-1 in zebrafish[J]. Chin J Zool, 2018, 53(4): 622-627. https://www.cnki.com.cn/Article/CJFDTOTAL-BIRD201804015.htm
|
[35] |
郭晓, 王萌, 朱彦, 等. 中药肾毒性机制研究现状及评价方法研究进展[J]. 中草药, 2015, 46(23): 3581-3591. https://www.cnki.com.cn/Article/CJFDTOTAL-ZCYO201523025.htm
GUO X, WANG M, ZHU Y, et al. Research status of nephrotoxicity mechanism of Chinese materia medica and progress in study on evaluation methods[J]. Chin Tradit Herb Drugs, 2015, 46(23): 3581-3591. https://www.cnki.com.cn/Article/CJFDTOTAL-ZCYO201523025.htm
|
[36] |
郝然, 刘婷, 王毅, 等. 基于MDCK细胞单层的药物早期肾毒性检测初探[J]. 中国实验方剂学杂志, 2013, 19(12): 234-238. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSFX201312068.htm
HAO R, LIU T, WANG Y, et al. Preliminary research on early detection of drug nephrotoxicity based on MDCK cells monolayer[J]. Chin J Exp Tradit Med Formulae, 2013, 19(12): 234-238. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSFX201312068.htm
|
[37] |
陈松杰. 基于MDCK细胞模型的广防己体外肾毒性评价[J]. 今日药学, 2012, 22(4): 211-214. https://www.cnki.com.cn/Article/CJFDTOTAL-YAXU201204011.htm
CHEN SJ. Studies on evaluation of nephrotoxicity induced byAristolochia Fangchi based on MDCK cell model in vitro[J]. Pharm Today, 2012, 22(4): 211-214. https://www.cnki.com.cn/Article/CJFDTOTAL-YAXU201204011.htm
|
[38] |
赵筱萍, 呙敏, 张伯礼. 一种基于荧光探针和HK-2细胞的中药肾毒性物质筛查方法及其应用[J]. 中国中药杂志, 2013, 38(10): 1577-1580. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGZY201310028.htm
ZHAO XP, GUO M, ZHANG BL. An approach to screen nephrotoxic components in traditional Chinese medicine based on fluorescent probe and HK-2 cells and its application[J]. China J Chin Mater Med, 2013, 38(10): 1577-1580. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGZY201310028.htm
|
[39] |
庄延双, 蔡宝昌, 张自力. 网络药理学在中药研究中的应用进展[J]. 南京中医药大学学报, 2021, 37(1): 156-160. https://www.cnki.com.cn/Article/CJFDTOTAL-NJZY202101031.htm
ZHUANG YS, CAI BC, ZHANG ZL. Application progress of network pharmacology in traditional Chinese medicine research[J]. J Nanjing Univ Tradit Chin Med, 2021, 37(1): 156-160. https://www.cnki.com.cn/Article/CJFDTOTAL-NJZY202101031.htm
|
[40] |
郝俊霞, 高梓森, 高皓, 等. 基于网络药理学的雷公藤肾毒性机制探讨[J]. 中国实验方剂学杂志, 2019, 25(16): 142-151. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSFX201916023.htm
HAO JX, GAO ZS, GAO H, et al. Study on mechanism of nephrotoxicity of Tripterygii Radix et rhizoma based on network pharmacology[J]. Chin J Exp Tradit Med Formulae, 2019, 25(16): 142-151. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSFX201916023.htm
|
[41] |
张敏新, 汪滢, 刘志宏, 等. 基于HPLC-QTOF-MS及网络药理学探讨雷公藤多苷片肾毒性机制[J]. 中国药师, 2020, 23(12): 2322-2331. doi: 10.3969/j.issn.1008-049X.2020.12.005
ZHANG MX, WANG Y, LIU ZH, et al. Exploration of nephrotoxicity mechanism of Tripterygium polyglycoside tablets based on HPLC-QTOF-MS and network pharmacology[J]. China Pharm, 2020, 23(12): 2322-2331. doi: 10.3969/j.issn.1008-049X.2020.12.005
|
[42] |
秦昆明, 王彬, 陈林伟, 等. 代谢组学在中药现代研究的应用与展望[J]. 中国中药杂志, 2014, 39(16): 3010-3017. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGZY201416004.htm
QIN KM, WANG B, CHEN LW, et al. Perspective and application of metabonomics in modern study of traditional Chinese medicine[J]. China J Chin Mater Med, 2014, 39(16): 3010-3017. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGZY201416004.htm
|
[43] |
赵剑宇. 基于核磁共振的代谢组学方法在中药关木通肾毒性研究中的应用[D]. 北京: 中国人民解放军军事医学科学院, 2008.
ZHAO JY. Applications of NMR-based metabonomics on the studies of the nephrotoxicity of Aristolochia manshuriensis[D]. Beijing: Academy of Military Medical Sciences, 2008.
|
[44] |
刘金伟, 韩林涛, 黄芳, 等. 基于1H NMR代谢组学细辛肝肾毒性的机制研究[J]. 中药药理与临床, 2020, 36(4): 131-136. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYYL202004025.htm
LIU JW, HAN LT, HUANG F, et al. Study on the hepatotoxicity and nephrotoxicity of Asarum in rats based on1H-NMR metabonomics[J]. Pharmacol Clin Chin Mater Med, 2020, 36(4): 131-136. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYYL202004025.htm
|
[45] |
徐婷婷, 金若敏, 姚广涛. 基于基因组学技术探讨商陆肾毒性机制[J]. 中国药理学与毒理学杂志, 2013, 27(3): 472. https://www.cnki.com.cn/Article/CJFDTOTAL-YLBS201303073.htm
XU TT, JIN RM, YAO GT. Study on the mechanism of Phytolacca nephrotoxicity based on genomics technology[J]. Chin J Pharmacol Toxicol, 2013, 27(3): 472. https://www.cnki.com.cn/Article/CJFDTOTAL-YLBS201303073.htm
|