Volume 38 Issue 4
Apr.  2022
Turn off MathJax
Article Contents
Article Navigation >  Journal of Nanjing University of traditional Chinese Medicine  > 2022  >  38(4): 291-297
YAN Xi-wu, MENG Ting, LIU Jin-feng, HONG Yu-xing, KANG Jiao-yang, LIU Huai-jun, CHANG Cheng. Clinical Study on Early Intervention of Qianyang Yuyin Granules to Slow Progression of Leukoencephalopathy in Hypertensive Patients with Cognitive Impairment[J]. Journal of Nanjing University of traditional Chinese Medicine, 2022, 38(4): 291-297. doi: 10.14148/j.issn.1672-0482.2022.0291
Citation: YAN Xi-wu, MENG Ting, LIU Jin-feng, HONG Yu-xing, KANG Jiao-yang, LIU Huai-jun, CHANG Cheng. Clinical Study on Early Intervention of Qianyang Yuyin Granules to Slow Progression of Leukoencephalopathy in Hypertensive Patients with Cognitive Impairment[J]. Journal of Nanjing University of traditional Chinese Medicine, 2022, 38(4): 291-297. doi: 10.14148/j.issn.1672-0482.2022.0291
shu

Clinical Study on Early Intervention of Qianyang Yuyin Granules to Slow Progression of Leukoencephalopathy in Hypertensive Patients with Cognitive Impairment

doi: 10.14148/j.issn.1672-0482.2022.0291
  • 1.

    The First School of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China

  • 2.

    The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China

  • Received Date: 2021-11-15
    Available Online: 2022-04-13
    Abstract
  •   OBJECTIVE  To observe the clinical efficacy of Qianyang Yuyin Granules in the treatment of hypertensive patients with cognitive impairment and the effect on their leukoencephalopathy volume.  METHODS  The patients were randomly divided into 64 cases in the treatment group, 33 cases in the control group, and 34 cases in the donepezil group by randomized controlled, multicenter enrollment. In the control group, the patients were treated with conventional western medicine, while in the treatment group and donepezil group, the patients were separately treated with Qianyang Yuyin Granules and donepezil based on the therapies in the control group. The course of the treatment was 6 months.The changes of blood pressure, leukoencephalopathy volume, Mini-Mental State Examination (MMSE), Vascular Dementia Assessment Scale (VaDAS-cog), as well as traditional Chinese medicine (TCM) syndrome score were compared before and after treatment in the three groups. Besides, the changes of safety indexes such as blood routine examination, liver and kidney function were also observed.  RESULTS  After treatment, blood pressure was lowered significantly in all three groups (P < 0.01), with no significant differences between each groups(P>0.05). The TCM syndrome score were reduced in all three groups (P < 0.01), while the treatment group showed better results than the control group and the donepezil group did (P < 0.01). The leukoencephalopathy volumes were increased significantly in all three groups (P < 0.01), but the increase of leukoencephalopathy volume in the treatment group was less than that in the control group and the donepezil group (P < 0.05). MMSE scores were increased significantly in the treatment group (P < 0.01), whose results were better than those in the control group and the donepezil group (P < 0.01). VaDAS-cog scores were decreased significantly in the treatment group (P < 0.01), whose results were also better than those in the control group (P < 0.01). In addition, no significant adverse reactions were observed in any of the three groups during the treatment period.  CONCLUSION  The Qianyang Yuyin Granules can notably improve the cognitive function of hypertensive patients, and can evidently slow their progression of leukoencephalopathy with safety.

     

    • FullText(HTML)
  • loading
    • References(28)
  • [1]
    WANG ZW, CHEN Z, ZHANG LF, et al. Status of hypertension in China[J]. Circulation, 2018, 137(22): 2344-2356. doi: 10.1161/CIRCULATIONAHA.117.032380
    [2]
    TADIC M, CUSPIDI C, HERING D. Hypertension and cognitive dysfunction in elderly: Blood pressure management for this global burden[J]. BMC Cardiovasc Disord, 2016, 16: 208. doi: 10.1186/s12872-016-0386-0
    [3]
    DONG SY, MANIAR S, MANOLE MD, et al. Cerebral hypoperfusion and other shared brain pathologies in ischemic stroke and Alzheimer's disease[J]. Transl Stroke Res, 2018, 9(3): 238-250. doi: 10.1007/s12975-017-0570-2
    [4]
    丁康, 赵菁, 马诺莎, 等. 潜阳育阴颗粒治疗高血压病(阴虚阳亢证)的临床研究[J]. 时珍国医国药, 2015, 26(5): 1149-1150. https://www.cnki.com.cn/Article/CJFDTOTAL-SZGY201505045.htm

    DING K, ZHAO J, MA NS, et al. Clinical study on Qianyang Yuyin granules in the treatment of hypertension (yin deficiency and yang hyperactivity syndrome)[J]. Lishizhen Med Mater Med Res, 2015, 26(5): 1149-1150. https://www.cnki.com.cn/Article/CJFDTOTAL-SZGY201505045.htm
    [5]
    周玲燕. 潜阳育阴剂早期介入高血压治疗改善认知损害临床研究[D]. 南京: 南京中医药大学, 2019.

    ZHOU LY. Clinical research on early interventional treatment of hypertension with Qianyang Yuyin granules to improve cognitive impairment[D]. Nanjing: Nanjing University of Chinese Medicine, 2019.
    [6]
    YUSHKEVICH PA, PIVEN J, HAZLETT HC, et al. User-guided 3D active contour segmentation of anatomical structures: Significantly improved efficiency and reliability[J]. NeuroImage, 2006, 31(3): 1116-1128. doi: 10.1016/j.neuroimage.2006.01.015
    [7]
    中华医学会, 中华医学会杂志社, 中华医学会全科医学分会, 等. 高血压基层诊疗指南(实践版·2019)[J]. 中华全科医师杂志, 2019, 18(8): 723-731. doi: 10.3760/cma.j.issn.1671-7368.2019.08.004

    Chinese Medical Association, Chinese Medical Journals Publishing House, Chinese Society of General Practice, et al. Guideline for primary care of hypertension: Practice version(2019)[J]. Chin J Gen Pract, 2019, 18(8): 723-731. doi: 10.3760/cma.j.issn.1671-7368.2019.08.004
    [8]
    田金洲, 时晶, 张新卿, 等. 轻度认知损害临床研究指导原则(草案)[J]. 中西医结合学报, 2008, 6(1): 9-14. https://www.cnki.com.cn/Article/CJFDTOTAL-XBZX200801003.htm

    TIAN JZ, SHI J, ZHANG XQ, et al. Guiding principles of clinical research on mild cognitive impairment(protocol)[J]. J Chin Integr Med, 2008, 6(1): 9-14. https://www.cnki.com.cn/Article/CJFDTOTAL-XBZX200801003.htm
    [9]
    中华医学会老年医学分会老年神经病学组, 脑小血管病认知功能障碍诊疗指南中国撰写专家组. 脑小血管病相关认知功能障碍中国诊疗指南(2019)[J]. 中华老年医学杂志, 2019, 38(4): 345-354. https://www.cnki.com.cn/Article/CJFDTOTAL-AAEC201903002.htm

    Geriatric Neurology Group, Chinese Society of Geriatrics, Clinical Practice Guideline for Cognitive Impairment of Cerebral Small Vessel Disease Writing Group. Clinical practice guideline for cognitive impairment of cerebral small vessel disease of China (2019)[J]. Chin J Geriatr, 2019, 38(4): 345-354. https://www.cnki.com.cn/Article/CJFDTOTAL-AAEC201903002.htm
    [10]
    中华医学会神经病学分会, 中华医学会神经病学分会脑血管病学组. 中国脑小血管病诊治共识[J]. 中华神经科杂志, 2015, 48(10): 838-844. doi: 10.3760/cma.j.issn.1006-7876.2015.10.004

    Chinese Society of Neurology, Chinese Society of Neurology, Cerebrovascular Disease Group. Consensus on the diagnosis and treatment of cerebral small vessel disease in China[J]. Chin J Neurol, 2015, 48(10): 838-844. doi: 10.3760/cma.j.issn.1006-7876.2015.10.004
    [11]
    中药新药临床研究指导原则: 试行[M]. 北京: 中国医药科技出版社, 2002: 73-76.

    Guiding Principles for Clinical Research of New Chinese Medicine: Trial Implementation[M]. Beijing: China medical science press, 2002.
    [12]
    胡盛寿, 高润霖, 刘力生, 等. 《中国心血管病报告2018》概要[J]. 中国循环杂志, 2019, 34(3): 209-220. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGXH201903002.htm

    HU SS, GAO RL, LIU LS, et al. Summary of the 2018 report on cardiovascular diseases in China[J]. Chin Circ J, 2019, 34(3): 209-220. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGXH201903002.htm
    [13]
    WANG JF, LIANG Y, CHEN HY, et al. Structural changes in white matter lesion patients and their correlation with cognitive impairment[J]. Neuropsychiatr Dis Treat, 2019, 15: 1355-1363. doi: 10.2147/NDT.S194803
    [14]
    IADECOLA C, YAFFE K, BILLER J, et al. Impact of hypertension on cognitive function: A scientific statement from the American heart association[J]. Hypertension, 2016, 68(6): e67-e94.
    [15]
    JAVANSHIRI K, WALDÖ ML, FRIBERG N, et al. Atherosclerosis, hypertension, and diabetes in Alzheimer's disease, vascular dementia, and mixed dementia: Prevalence and presentation[J]. J Alzheimer's Dis, 2018, 65(4): 1247-1258. doi: 10.3233/JAD-180644
    [16]
    洪于兴, 宁美, 颜习武, 等. 中医药干预肠道菌群防治高血压合并认知障碍的探讨[J]. 南京中医药大学学报, 2021, 37(1): 140-144. doi: 10.14148/j.issn.1672-0482.2021.0140

    HONG YX, NING M, YAN XW. Discussion on prevention and treatment of hypertension with cognitive impairment by intervention of intestinal flora with Chinese medicine[J]. J Nanjing Univ Tradit Chin Med, 2021, 37(1): 140-144. doi: 10.14148/j.issn.1672-0482.2021.0140
    [17]
    项成刚, 张艳, 礼海. 中医对原发性高血压病因病机的认识[J]. 世界中西医结合杂志, 2010, 5(4): 356-357. https://www.cnki.com.cn/Article/CJFDTOTAL-SJZX201004040.htm

    XIANG CG, ZHANG Y, LI H. Understanding of etiology and pathogenesis of essential hypertension in Chinese medicine[J]. World J Integr Tradit West Med, 2010, 5(4): 356-357. https://www.cnki.com.cn/Article/CJFDTOTAL-SJZX201004040.htm
    [18]
    程国彭. 医学心悟[M]. 北京: 中国中医出版社, 2018: 231-233.

    CHENG GP. Medical Insight[M]. Beijing: China press of traditional Chinese medicine, 2018: 231-233.
    [19]
    严士海, 方祝元, 王欣彤, 等. 潜阳育阴颗粒对SHR大鼠肾脏CTGF的影响[J]. 中华中医药学刊, 2017, 35(2): 386-389, 520. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYHS201702036.htm

    YAN SH, FANG ZY, WANG XT, et al. Effect of Qianyang Yuyin granules on kidney CTGF of SHR rats[J]. Chin Arch Tradit Chin Med, 2017, 35(2): 386-389, 520. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYHS201702036.htm
    [20]
    邹冲, 蒋卫民, 张思奇, 等. 潜阳育阴颗粒改善高血压早期肾损害指标的临床研究[J]. 中西医结合心脑血管病杂志, 2021, 19(6): 897-902. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYYY202106004.htm

    ZOU C, JIANG WM, ZHANG SQ, et al. Effect of Qianyang Yuyin Granule on early renal damage index of hypertension[J]. Chin J Integr Med Cardio Cerebrovasc Dis, 2021, 19(6): 897-902. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYYY202106004.htm
    [21]
    武立华. 基于Sestrin2信号通路调控氧化应激探讨潜阳育阴颗粒对高血压肾损害的干预作用[D]. 南京: 南京中医药大学, 2020.

    WU LH. Regulation of oxidative stress of hypertension-induced renal damage via Sestrin2 signaling pathway and intervention effect of Qian Yang yu Yin granules[D]. Nanjing: Nanjing University of Chinese Medicine, 2020.
    [22]
    方媛. 基于TGF-β1信号通路调控心、肾纤维化及潜阳育阴颗粒的干预作用[D]. 南京: 南京中医药大学, 2019.

    FANG Y. Regulation of myocardial and renal fibrosis via TGF-β1 signaling pathway and intervention effect of Qianyang Yuyin granules[D]. Nanjing: Nanjing University of Chinese Medicine, 2019.
    [23]
    刘健, 李碧霞, 杜金玲, 等. 潜阳育阴颗粒治疗阴虚阳亢型高血压早期肾损害患者的临床研究[J]. 南京中医药大学学报, 2019, 35(3): 262-265. http://xb.njucm.edu.cn/article/id/ZR20190307

    LIU J, LI BX, DU JL, et al. Clinical study of Qianyang Yuyin granules treating early renal damage patients with Yin deficiency and Yang hyperactivity type hypertension[J]. J Nanjing Univ Tradit Chin Med, 2019, 35(3): 262-265. http://xb.njucm.edu.cn/article/id/ZR20190307
    [24]
    王明艳, 江励华, 杜伟峰, 等. 山茱萸炮制增效活性部位对老年小鼠大脑衰老影响的研究[J]. 中医药信息, 2009, 26(5): 30-32. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYXN200905013.htm

    WANG MY, JIANG LH, DU WF, et al. Effects of processing synergistic active parts of Cornus officinalis on brain aging in aged mice[J]. Inf Tradit Chin Med, 2009, 26(5): 30-32. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYXN200905013.htm
    [25]
    王爱梅, 陈亚奇, 李旻, 等. 山茱萸多糖对衰老模型大鼠学习记忆能力及海马突触可塑性的影响[J]. 中国实验方剂学杂志, 2016, 22(13): 131-136.

    WANG AM, CHEN YQ, LI M, et al. Effects of polysaccharide from corni fructus on learning and memory ability and hippocampal synaptic plasticity of aging model rats[J]. Chin J Exp Tradit Med Formulae, 2016, 22(13): 131-136.
    [26]
    GUPTA M, KING KS, SRINIVASA R, et al. Association of 3.0-T brain magnetic resonance imaging biomarkers with cognitive function in the Dallas heart study[J]. JAMA Neurol, 2015, 72(2): 170.
    [27]
    WANG R, FRATIGLIONI L, LAVESKOG A, et al. Do cardiovascular risk factors explain the link between white matter hyperintensities and brain volumes in old age? A population-based study[J]. Eur J Neurol, 2014, 21(8): 1076-1082.
    [28]
    DE GROOT M, VERHAAREN BFJ, DE BOER R, et al. Changes in normal-appearing white matter precede development of white matter lesions[J]. Stroke, 2013, 44(4): 1037-1042.
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(1)  / Tables(8)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (274) PDF downloads(22) Cited by()
    Proportional views
    Related

    Copyright © Journal of Nanjing University of traditional Chinese Medicine

    Sponsored by：Nanjing University of traditional Chinese MedicineAddress：No.138 xianlin Avenue, Qixia District, Nanjing cityChina Pos：210023

    Tel：025-85811935Email：xb@njucm.edu.cn

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return