Volume 38 Issue 2
Feb.  2022
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Article Navigation >  Journal of Nanjing University of traditional Chinese Medicine  > 2022  >  38(2): 109-114
XU Xin-ming, CAI Ji-tang, LI Jing-bo, WANG Jun-jie, WU Zi-lu. Clinical Study on the Treatment of Chronic Sinusitis with Deficiency-Cold of Lung Qi by Wenyang Zhiti Decoction[J]. Journal of Nanjing University of traditional Chinese Medicine, 2022, 38(2): 109-114. doi: 10.14148/j.issn.1672-0482.2022.0109
Citation: XU Xin-ming, CAI Ji-tang, LI Jing-bo, WANG Jun-jie, WU Zi-lu. Clinical Study on the Treatment of Chronic Sinusitis with Deficiency-Cold of Lung Qi by Wenyang Zhiti Decoction[J]. Journal of Nanjing University of traditional Chinese Medicine, 2022, 38(2): 109-114. doi: 10.14148/j.issn.1672-0482.2022.0109
shu

Clinical Study on the Treatment of Chronic Sinusitis with Deficiency-Cold of Lung Qi by Wenyang Zhiti Decoction

doi: 10.14148/j.issn.1672-0482.2022.0109
  • 1.

    The Second School of Clinical Medicine, Henan University of Chinese Medicine, Zhengzhou 450002, China

  • 2.

    Department of Otolaryngology, Henan Province Hospital of Traditional Chinese Medicine, Zhengzhou 450002, China

  • Received Date: 2021-08-27
    Available Online: 2022-03-01
    Abstract
  •   OBJECTIVE  To investigate the clinical efficacy and possible mechanism of Wenyang Zhiti Decoction in the treatment of chronic sinusitis with deficiency-cold of lung qi.  METHODS  A total of 160 patients with chronic sinusitis with deficiency-cold of lung qi were randomly divided into the control group and the treatment group of 80 patients each. In the control group, enteric soft capsule and mometasone furoate nasal spray were administered. While in the treatment group, Wenyang Zhiti Decoction was given as local administration of drugs. The course of treatment was 28 days. In addition, the clinical efficacy, VAS score, traditional Chinese medicine (TCM) syndrome score, Lund-Mackay score, as well as nasal mucosal cilia clearance speed and rate of the two groups were evaluated before and after treatment. The changes of serum inflammatory factors (IL-17, IL-33, IL-37) and serum immunomodulatory factors (sTim1, sTim3, sTim4) were detected by ELISA to observe the incidence of adverse reactions.  RESULTS  After treatment, the efficiency of the treatment group was significantly increased than that of the control group (P < 0.01). The TCM syndrome score, VAS score and Lund-Mackay score of sinus CT were significantly reduced in both groups (P < 0.05, P < 0.01), but the Results in the treatment group were better than those in the control group (P < 0.01). In addition, the clearance speed and rate of nasal mucous membrane cilia were significantly increased in both groups (P < 0.05, P < 0.01), but the Results in the treatment group were better than those in the control group (P < 0.01). Besides, the serum IL-17, IL-33, sTim1, sTim3 and sTim4 were significantly reduced in both groups (P < 0.05, P < 0.01), but the Results in the treatment group were better than those in the control group (P < 0.01). The serum IL-37 level was significantly increased in both groups (P < 0.05, P < 0.01), but the result in the treatment group was better than that in the control group (P < 0.01). In addition, no significant adverse effects were observed in both groups.  CONCLUSION  Wenyang Zhiti Decoction can effectively improve the clinical symptoms of patients with chronic sinusitis with deficiency-cold of lung qi, and its mechanism may be related to the regulation of serum inflammatory factors and immunomodulatory factors.

     

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