Volume 38 Issue 2
Feb.  2022
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Article Navigation >  Journal of Nanjing University of traditional Chinese Medicine  > 2022  >  38(2): 103-108
HE Jin-bo, MAO Zheng-rong, SONG Peng-yang. Clinical Study on the Treatment of Severe Pneumonia Combined with Acute Gastrointestinal Injury by Supplemented Xuanbai Chengqi Decoction[J]. Journal of Nanjing University of traditional Chinese Medicine, 2022, 38(2): 103-108. doi: 10.14148/j.issn.1672-0482.2022.0103
Citation: HE Jin-bo, MAO Zheng-rong, SONG Peng-yang. Clinical Study on the Treatment of Severe Pneumonia Combined with Acute Gastrointestinal Injury by Supplemented Xuanbai Chengqi Decoction[J]. Journal of Nanjing University of traditional Chinese Medicine, 2022, 38(2): 103-108. doi: 10.14148/j.issn.1672-0482.2022.0103
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Clinical Study on the Treatment of Severe Pneumonia Combined with Acute Gastrointestinal Injury by Supplemented Xuanbai Chengqi Decoction

doi: 10.14148/j.issn.1672-0482.2022.0103

  • The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China

  • Received Date: 2021-09-28
    Available Online: 2022-03-01
    Abstract
  •   OBJECTIVE  To evaluate the clinical efficacy of Supplemented Xuanbai Chengqi Decoction in the treatment of severe pneumonia combined with acute gastrointestinal injury (AGI).  METHODS  In a randomized controlled study, 76 patients with severe pneumonia combined with AGI were randomly divided into the control group and the treatment group, 38 patients in each group. The control group was given conventional western medical treatment, including active treatment of protopathy and complicating disease. In addition, early administration of enteral nutrition and gastrointestinal excitomotor were given in the group. The patients in the treatment group were treated with supplemented Xuanbai Chengqi Decoction intranasally on top of the treatments in the control group. The course of treatment was 7 days and the clinical efficacy of the two groups was evaluated before treatment and 7 days after treatment. The changes of gastrointestinal function indexes [Gastrointestinal failure (GIF) score, enteral nutrition daily feeding amount and intraabdominal pressure (IAP)] were measured before treatment, 3 and 7 days after the treatment separately. Motilin (MTL) levels and diamine oxidase (DAO) activity were measured by ELISA. Besides, the duration of mechanical ventilation, ICU stay length and 28-d mortality rate were recorded.  RESULTS  After treatment, the total effective rate of the treatment group was better than that of the control group (P < 0.05). The GIF, enteral nutrition daily feeding amount and IAP of the treatment group significantly improved (P < 0.01). However, the GIF, enteral nutrition daily feeding amount and IAP of the treatment group showed better Results than those of the control group after 7 days of treatment (P < 0.05). In addition, the serum MTL level and DAO activity were significantly increased in both groups after 3 and 7 days of treatment (P < 0.01). However, the MTL levels in the treatment group were significantly higher than those in the control group after 3 and 7 days of treatment (P < 0.05, P < 0.01). The duration of mechanical ventilation and ICU stay length in the treatment group were significantly less than those in the control group (P < 0.01). Besides, there was no significant difference in the 28-d mortality rate between the two groups (P > 0.05).  CONCLUSION  Supplemented Xuanbai Chengqi Decoction can effectively improve the gastrointestinal function of patients with severe pneumonia combined with AGI, shorten the ICU stay length, and promote the recovery of patients.

     

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    • References(18)
  • [1]
    HIRANI NA, MACFARLANE JT. Impact of management guidelines on the outcome of severe community acquired pneumonia[J]. Thorax, 1997, 52(1): 17-21. doi: 10.1136/thx.52.1.17
    [2]
    REINTAM BLASER A, MALBRAIN MLNG, STARKOPF J, et al. Gastrointestinal function in intensive care patients: Terminology, definitions and management. Recommendations of the ESICM Working Group on Abdominal Problems[J]. Intensive Care Med, 2012, 38(3): 384-394. doi: 10.1007/s00134-011-2459-y
    [3]
    任珊, 宫蕊, 龙玲, 等. 厚朴排气合剂对肺炎合并急性胃肠功能损伤患者预后的影响研究[J]. 现代中西医结合杂志, 2020, 29(18): 1973-1976. doi: 10.3969/j.issn.1008-8849.2020.18.008

    REN S, GONG R, LONG L, et al. Study on the effect of Houpo Paiqi mixture on the prognosis of patients with pneumonia complicated with acute gastrointestinal injury[J]. Mod J Integr Tradit Chin West Med, 2020, 29(18): 1973-1976. doi: 10.3969/j.issn.1008-8849.2020.18.008
    [4]
    高志凌, 金魁, 赵越, 等. 益气通腑方干预老年严重脓毒症患者急性胃肠损伤的临床研究[J]. 时珍国医国药, 2018, 29(4): 902-904. https://www.cnki.com.cn/Article/CJFDTOTAL-SZGY201804045.htm

    GAO ZL, JIN K, ZHAO Y, et al. Clinical study of Yiqi Tongfu Prescription on acute gastrointestinal injury in elderly patients with severe sepsis[J]. Lishizhen Med Mater Med Res, 2018, 29(4): 902-904. https://www.cnki.com.cn/Article/CJFDTOTAL-SZGY201804045.htm
    [5]
    孙芳园, 许开亮, 袁林, 等. 电针结合穴位敷贴治疗脓毒症急性胃肠损伤的临床研究[J]. 中国中医急症, 2020, 29(7): 1165-1167, 1195. doi: 10.3969/j.issn.1004-745X.2020.07.011

    SUN FY, XU KL, YUAN L, et al. Study on electroacupuncture combined with acupoint application on acute gastrointestinal injury due to Sepsis[J]. J Emerg Tradit Chin Med, 2020, 29(7): 1165-1167, 1195. doi: 10.3969/j.issn.1004-745X.2020.07.011
    [6]
    于凯江, 管向东, 严静. 中国重症医学专科资质培训教材[M]. 2版. 北京: 人民卫生出版社, 2016: 4-6.

    YU KJ, GUAN XD, YAN J. Training Materials for Specialty Qualification of Critical Care Medicine in China[M]. 2nd edition. Beijing: People's medical publishing house, 2016: 4-6.
    [7]
    陈灏珠, 林果为, 王吉耀. 实用内科学[M]. 14版. 北京: 人民卫生出版社, 2013: 1722.

    CHEN HZ, LIN GW, WANG JY. Practice of Internal Medicine[M]. 14th edition. Beijing: People's medical publishing house, 2013: 1722.
    [8]
    BROWN SM, JONES BE, JEPHSON AR, et al. Validation of the Infectious Disease Society of America/American Thoracic Society 2007 guidelines for severe community-acquired pneumonia[J]. Crit Care Med, 2009, 37(12): 3010-3016. doi: 10.1097/CCM.0b013e3181b030d9
    [9]
    REINTAM A, PARM P, KITUS R, et al. Gastrointestinal failure score in critically ill patients: A prospective observational study[J]. Crit Care, 2008, 12(4): R90. doi: 10.1186/cc6958
    [10]
    KRON IL, HARMAN PK, NOLAN SP. The measurement of intra-abdominal pressure as a criterion for abdominal re-exploration[J]. Ann Surg, 1984, 199(1): 28-30. doi: 10.1097/00000658-198401000-00005
    [11]
    BLASER AR, POEZE M, MALBRAIN MLNG, et al. Gastrointestinal symptoms during the first week of intensive care are associated with poor outcome: A prospective multicentre study[J]. Intens Care Med, 2013, 39(5): 899-909. doi: 10.1007/s00134-013-2831-1
    [12]
    秦景明. 症因脉治[M]. 北京: 人民卫生出版社, 2006: 287.

    QIN JM. Symptom, Cause, Pulse, and Treatment[M]. Beijing: People's medical publishing house, 2006: 287.
    [13]
    吴瑭. 温病条辨[M]. 北京: 人民卫生出版社, 2005: 53.

    WU T. Warm Disease Stripe Discrimination[M]. Beijing: People's medical publishing house, 2005: 53.
    [14]
    王欢. 胃肠激素与胃肠道功能及疾病的关系[J]. 医学综述, 2013, 19(15): 2735-2738. doi: 10.3969/j.issn.1006-2084.2013.15.016

    WANG H. The relationship between gastrointestinal hormones and gastrointestinal function and diseases[J]. Med Rev, 2013, 19(15): 2735-2738. doi: 10.3969/j.issn.1006-2084.2013.15.016
    [15]
    SANGER GJ. Motilin receptor neuropharmacology: Revised understanding[J]. Curr Opin Pharmacol, 2012, 12(6): 641-646. doi: 10.1016/j.coph.2012.07.012
    [16]
    MENG Y, ZHANG Y, LIU M, et al. Evaluating intestinal permeability by measuring plasma endotoxin and diamine oxidase in children with acute lymphoblastic leukemia treated with high-dose methotrexate[J]. Anticancer Agents Med Chem, 2016, 16(3): 387-392. doi: 10.2174/1871520615666150812125955
    [17]
    焦东海, 沈学敏, 景炳文. 单味大黄治疗急性胰腺炎17年研究[J]. 中医杂志, 1994, 35(3): 172-173. https://www.cnki.com.cn/Article/CJFDTOTAL-ZZYZ199403030.htm

    JIAO DH, SHEN XM, JING BW. Single rhubarb in the treatment of acute pancreatitis for 17 years[J]. J Tradit Chin Med, 1994, 35(3): 172-173. https://www.cnki.com.cn/Article/CJFDTOTAL-ZZYZ199403030.htm
    [18]
    陈德昌, 景炳文, 杨兴易, 等. 大黄对肠黏膜屏障保护作用的机制探讨[J]. 中国危重病急救医学, 1996(8): 449-450. https://www.cnki.com.cn/Article/CJFDTOTAL-ZWZB608.000.htm

    CHEN DC, JING BW, YANG XY, et al. The discussion on Mechanism of protective effect of rhubarb on intestinal mucosal barrier[J]. Chin Crit Care Med, 1996(8): 449-450. https://www.cnki.com.cn/Article/CJFDTOTAL-ZWZB608.000.htm
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