Volume 37 Issue 5
Sep.  2021
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Article Navigation >  Journal of Nanjing University of traditional Chinese Medicine  > 2021  >  37(5): 637-641
CHENG Hai-bo, ZHOU Zhong-ying. Modern Interpretation of the Scientific Connotation of the Pathogenesis of Cancerous Toxin[J]. Journal of Nanjing University of traditional Chinese Medicine, 2021, 37(5): 637-641. doi: 10.14148/j.issn.1672-0482.2021.0637
Citation: CHENG Hai-bo, ZHOU Zhong-ying. Modern Interpretation of the Scientific Connotation of the Pathogenesis of Cancerous Toxin[J]. Journal of Nanjing University of traditional Chinese Medicine, 2021, 37(5): 637-641. doi: 10.14148/j.issn.1672-0482.2021.0637
shu

Modern Interpretation of the Scientific Connotation of the Pathogenesis of Cancerous Toxin

doi: 10.14148/j.issn.1672-0482.2021.0637
  • 1.

    The First School of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China

  • 2.

    Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor, Nanjing, 210023, China

  • Received Date: 2021-08-20
    Available Online: 2021-12-21
  • Publish Date: 2021-09-10
    Abstract
  • Pathogenesis theory of cancerous toxin is an innovative theory of traditional Chinese medicine oncology developed by the team, which has been widely used to guide the clinical differentiation and treatment for malignant tumors in recent years, and has achieved good clinical efficacy. Cancerous toxin is a specific pathogenic factor that causes malignant tumors and is the key pathogenesis for the development of malignant tumors. The team has been conducting research on the scientific connotation of pathogenesis of cancerous toxin for a long time. Through exploring the relationship between pathogenesis theory of cancerous toxin and tumor microenvironment as well as the correlation between pathogenesis of cancerous toxin and specific morbid substances in tumor microenvironment, the team comes up with that the scientific connotation of cancerous toxin is a specific morbid substance (affecting tumor genesis and development) in tumor microenvironment. In addition, the team also believes that inflammatory factors, lactic acid, angiogenic factors, immunosuppressive factors, and non-coding RNAs may be the biological basis for the pathogenesis of cancerous toxin. Applying modern oncology research progress, we interpret the scientific connotation of the pathogenesis of cancerous toxin, and provide scientific basis for further promotion of the theory of cancerous toxin and its clinical application.

     

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    • References(33)
  • [1]
    程海波. 癌毒病机理论探讨[J]. 中医杂志, 2014, 55(20): 1711-1715. https://www.cnki.com.cn/Article/CJFDTOTAL-ZZYZ201420001.htm
    [2]
    程海波, 沈卫星, 吴勉华, 等. 基于肿瘤微环境的癌毒病机理论研究[J]. 南京中医药大学学报, 2014, 30(2): 105-107. https://www.cnki.com.cn/Article/CJFDTOTAL-NJZY201402004.htm
    [3]
    程海波, 沈卫星. 癌毒病机理论与炎癌转变[J]. 中国中西医结合杂志, 2015, 35(2): 243-246. https://www.cnki.com.cn/Article/CJFDTOTAL-ZZXJ201502031.htm
    [4]
    程海波, 王俊壹. 癌毒病机的生物学基础探讨[J]. 南京中医药大学学报, 2019, 35(3): 241-244. https://www.cnki.com.cn/Article/CJFDTOTAL-NJZY201903001.htm
    [5]
    NAGARSHETH N, WICHA MS, ZOU W. Chemokines in the cancer microenvironment and their relevance in cancer immunotherapy[J]. Nat Rev Immunol, 2017, 17(9): 559-572. doi: 10.1038/nri.2017.49
    [6]
    DEY P, KIMMELMAN AC, DEPINHO RA. Metabolic codependencies in the tumor microenvironment[J]. Cancer Discov, 2021, 11(5): 1067-1081. doi: 10.1158/2159-8290.CD-20-1211
    [7]
    RUPAIMOOLE R, CALIN GA, LOPEZ-BERESTEIN G, et al. miRNA deregulation in cancer cells and the tumor microenvironment[J]. Cancer Discov, 2016, 6(3): 235-246. doi: 10.1158/2159-8290.CD-15-0893
    [8]
    赵智强, 李嘉. 略论周仲瑛教授的"癌毒"学说及其临床运用[J]. 新中医, 1998, 30(10): 6-8. https://www.cnki.com.cn/Article/CJFDTOTAL-REND810.001.htm
    [9]
    程海波, 吴勉华. 周仲瑛教授"癌毒"学术思想探析[J]. 中华中医药杂志, 2010, 25(6): 866-869. https://www.cnki.com.cn/Article/CJFDTOTAL-BXYY201006022.htm
    [10]
    QUAIL DF, JOYCE JA. Microenvironmental regulation of tumor progression and metastasis[J]. Nat Med, 2013, 19(11): 1423-1437. doi: 10.1038/nm.3394
    [11]
    程海波, 沈政洁, 孙东东, 等. 抗肿瘤中药对肿瘤微环境的干预作用评述[J]. 中医杂志, 2014, 55(15): 1343-1346, 1350. https://www.cnki.com.cn/Article/CJFDTOTAL-ZZYZ201415034.htm
    [12]
    YANG L, LIN PC. Mechanisms that drive inflammatory tumor microenvironment, tumor heterogeneity, and metastatic progression[J]. Semin Cancer Biol, 2017, 47: 185-195. doi: 10.1016/j.semcancer.2017.08.001
    [13]
    孙超, 吴铭杰, 江泽群, 等. 白花蛇舌草有效成分2-羟基-3-甲基蒽醌通过IL-6/STAT3信号通路诱导肝癌细胞凋亡作用机制[J]. 中华中医药杂志, 2018, 33(12): 5346-5350. https://www.cnki.com.cn/Article/CJFDTOTAL-BXYY201812018.htm
    [14]
    巨大维, 魏品康. 清热解毒中药在恶性肿瘤防治中的药用机理与应用[J]. 吉林中医药, 2007, 27(1): 60-62. doi: 10.3969/j.issn.1003-5699.2007.01.042
    [15]
    杨金华, 刘向前, 赵天增. 穿心莲内酯对IL-6诱导的非小细胞肺癌细胞侵袭转移的影响及机制[J]. 中国老年学杂志, 2019, 39(17): 4297-4301. doi: 10.3969/j.issn.1005-9202.2019.17.059
    [16]
    BOEDTKJER E, PEDERSEN SF. The acidic tumor microenvironment as a driver of cancer[J]. Annu Rev Physiol, 2020, 82: 103-126. doi: 10.1146/annurev-physiol-021119-034627
    [17]
    戈宏焱, 杨金刚, 房学讯, 等. 制半夏抑制基质金属蛋白酶活性及抗肿瘤机理的实验研究[J]. 时珍国医国药, 2008, 19(12): 2838-2840. doi: 10.3969/j.issn.1008-0805.2008.12.006
    [18]
    张慈安, 武峰, 毛竹君, 等. 姜半夏乙醇提取物对人胃腺癌SGC7901细胞内pH值的影响[J]. 中西医结合学报, 2011, 9(8): 894-900. https://www.cnki.com.cn/Article/CJFDTOTAL-XBZX201108013.htm
    [19]
    JIANG X, WANG J, DENG X, et al. The role of microenvironment in tumor angiogenesis[J]. J Exp Clin Cancer Res, 2020, 39(1): 204. doi: 10.1186/s13046-020-01709-5
    [20]
    黄柳向, 周晶, 喻斌, 等. 莪蚕健胃方调控HIF-1ɑ、VEGF表达对胃癌前病变的影响[J]. 中药药理与临床, 2016, 32(5): 74-78. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYYL201605021.htm
    [21]
    徐晓玉, 叶兰, 陈刚, 等. 川芎嗪对大鼠腹腔巨噬细胞表达VEGF和HIF-1α的影响[J]. 中国中药杂志, 2006, 31(19): 1608-1611. doi: 10.3321/j.issn:1001-5302.2006.19.011
    [22]
    CHEN WX, LU Y, WU JM, et al. Beta-elemene inhibits melanoma growth and metastasis via suppressing vascular endothelial growth factor-mediated angiogenesis[J]. Cancer Chemother Pharmacol, 2011, 67(4): 799-808. doi: 10.1007/s00280-010-1378-x
    [23]
    LI LH, YU R, CAI TG, et al. Effects of immune cells and cytokines on inflammation and immunosuppression in the tumor microenvironment[J]. Int Immunopharmacol, 2020, 88: 106939. doi: 10.1016/j.intimp.2020.106939
    [24]
    赵刚, 葛信国. 人参皂甙Rg3对H22荷瘤小鼠免疫微环境的影响[J]. 实用中医内科杂志, 2012, 26(17): 7-9. https://www.cnki.com.cn/Article/CJFDTOTAL-SYZY201217006.htm
    [25]
    邹品文, 赵春景, 李攀, 等. 黄芪多糖抗S180肉瘤作用及其免疫调节的影响[J]. 遵义医学院学报, 2012, 35(1): 17-20. doi: 10.3969/j.issn.1000-2715.2012.01.005
    [26]
    ATRETKHANY KSN, DRUTSKAYA MS, NEDOSPASOV SA, et al. Chemokines, cytokines and exosomes help tumors to shape inflammatory microenvironment[J]. Pharmacol Ther, 2016, 168: 98-112. doi: 10.1016/j.pharmthera.2016.09.011
    [27]
    JIANG X, WANG J, DENG X, et al. The role of microenvironment in tumor angiogenesis[J]. J Exp Clin Cancer Res, 2020, 39(1): 204. doi: 10.1007%2Fs12263-008-0076-3.pdf
    [28]
    王祥宇, 郑燕, 鲁明, 等. 肿瘤代谢与肿瘤转移[J]. 复旦学报(医学版), 2016, 43(1): 86-93. doi: 10.3969/j.issn.1672-8467.2016.01.016
    [29]
    WATSON MJ, VIGNALI PDA, MULLETT SJ, et al. Metabolic support of tumour-infiltrating regulatory T cells by lactic acid[J]. Nature, 2021, 591(7851): 645-651. doi: 10.1038/s41586-020-03045-2
    [30]
    TADOKORO H, UMEZU T, OHYASHIKI K, et al. Exosomes derived from hypoxic leukemia cells enhance tube formation in endothelial cells[J]. J Biol Chem, 2013, 288(48): 34343-34351. doi: 10.1074/jbc.M113.480822
    [31]
    YIN Y, CAI X, CHEN X, et al. Tumor-secreted miR-214 induces regulatory T cells: A major link between immune evasion and tumor growth[J]. Cell Res, 2014, 24(10): 1164-1180. doi: 10.1038/cr.2014.121
    [32]
    MENG FY, HENSON R, WEHBE-JANEK H, et al. MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer[J]. Gastroenterology, 2007, 133(2): 647-658. doi: 10.1053/j.gastro.2007.05.022
    [33]
    LOBB RJ, LIMA LG, MÖLLER A. Exosomes: Key mediators of metastasis and pre-metastatic niche formation[J]. Semin Cell Dev Biol, 2017, 67: 3-10. doi: 10.1016/j.semcdb.2017.01.004
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