Clinical Observation on the Treatment of Chronic Atrophic Gastritis with Syndrome of Spleen Deficiency and Stasis
Obstruction by Shenqi Taohong Decoction and Its Mechanism

TAO Ming-hao; DAI Yan-miao; LU Xi-rong; YANG Wei; XUE Bo-yu

doi:10.14148/j.issn.1672-0482.2021.0503

Volume 37 Issue 4

Jul. 2021

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Article Navigation > Journal of Nanjing University of traditional Chinese Medicine > 2021 > 37(4): 503-507

TAO Ming-hao, DAI Yan-miao, LU Xi-rong, YANG Wei, XUE Bo-yu. Clinical Observation on the Treatment of Chronic Atrophic Gastritis with Syndrome of Spleen Deficiency and StasisObstruction by Shenqi Taohong Decoction and Its Mechanism[J]. Journal of Nanjing University of traditional Chinese Medicine, 2021, 37(4): 503-507. doi: 10.14148/j.issn.1672-0482.2021.0503

Citation:

TAO Ming-hao, DAI Yan-miao, LU Xi-rong, YANG Wei, XUE Bo-yu. Clinical Observation on the Treatment of Chronic Atrophic Gastritis with Syndrome of Spleen Deficiency and Stasis Obstruction by Shenqi Taohong Decoction and Its Mechanism[J]. Journal of Nanjing University of traditional Chinese Medicine, 2021, 37(4): 503-507. doi: 10.14148/j.issn.1672-0482.2021.0503

Citation:

TAO Ming-hao, DAI Yan-miao, LU Xi-rong, YANG Wei, XUE Bo-yu. Clinical Observation on the Treatment of Chronic Atrophic Gastritis with Syndrome of Spleen Deficiency and Stasis Obstruction by Shenqi Taohong Decoction and Its Mechanism[J]. Journal of Nanjing University of traditional Chinese Medicine, 2021, 37(4): 503-507. doi: 10.14148/j.issn.1672-0482.2021.0503

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Clinical Observation on the Treatment of Chronic Atrophic Gastritis with Syndrome of Spleen Deficiency and Stasis Obstruction by Shenqi Taohong Decoction and Its Mechanism

doi: 10.14148/j.issn.1672-0482.2021.0503

TAO Ming-hao^{1, 2
,},
DAI Yan-miao¹,
LU Xi-rong¹,
YANG Wei¹,
XUE Bo-yu^{2, 3
,
,}

1.
Digestive System Department, Traditional Chinese Medicine Hospital of Kunshan, Kunshan, 215300, China
2.
Kunshan Workstation of TCM Master Zhou Zhongying Inheritance Studio, Kunshan, 215300, China
3.
The First School of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China

Received Date: 2021-04-20
Available Online: 2021-12-21
Publish Date: 2021-07-10

Abstract

Abstract

OBJECTIVE To study the clinical efficacy of Shenqi Taohong decoction in treating chronic atrophic gastritis with syndrome of spleen deficiency and stasis obstruction.METHODS From January 2018 to June 2019, a total of 80 patients with chronic atrophic gastritis identified as spleen deficiency and stasis obstruction syndrome were selected from the Department of Spleen, Stomach, Liver and Gallbladder, Traditional Chinese Medicine Hospital of Kunshan, and randomly divided into treatment group and control group according to random number table (40 cases in each group). The treatment group received Shenqi Taohong decoction orally, while the control group received Wei Fuchun Tablets orally. Both groups were treated continuously for 12 weeks. The Traditional Chinese medicine (TCM)syndrome score, the degree of gastric mucosal atrophy, and the expression levels of Trefoil factor2 (TFF2) and Nuclear factor-κB (NF-κB) in gastric mucosa were observed before and after treatment.RESULTS After treatment, the TCM syndrome score, the degree of gastric mucosal atrophy spreading staging and pathological integral in the 2 groups were significantly improved (P < 0.01), but the treatment group was better than the control group (P < 0.05, P < 0.01). In addition, the expression levels of TFF2 in the gastric mucosa were increased and the expression levels of NF-κB were decreased in the 2 groups (P < 0.01), but the treatment group was better than the control group (P < 0.05).CONCLUSION Shenqi Taohong decoction can effectively improve the main TCM syndromes, gastroscopic results, and pathological manifestations of chronic atrophic gastritis in the syndrome of spleen deficiency and stasis obstruction, and its mechanism may be related to increasing TFF2 expression levels and decreasing NF-κB expression levels in gastric mucosa to promote repair of damaged gastric mucosa and reduce atrophy and intestinal metaplasia of gastric mucosa.
- Shenqi Taohong decoction,
- chronic atrophic gastritis,
- syndrome of spleen deficiency and stasis obstruction,
- TFF2,
- NF-κB

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References

[1]	林果为, 王吉耀, 葛均波. 实用内科学[M]. 15版. 北京: 人民卫生出版社, 2017: 1508-1510.
[2]	DU Y, BAI Y, XIE P, et al. Chronic gastritis in China: A national multi-center survey[J]. BMC Gastroenterol, 2014, 14: 21. doi: 10.1186/1471-230X-14-21
[3]	ADAMU MA, WECK MN, GAO L, et al. Incidence of chronic atrophic gastritis: Systematic review and meta-analysis of follow-up studies[J]. Eur J Epidemiol, 2010, 25(7): 439-448. doi: 10.1007/s10654-010-9482-0
[4]	MARQUES-SILVA L, AREIA M, ELVAS L, et al. Prevalence of gastric precancerous conditions: A systematic review and meta-analysis[J]. Eur J Gastroenterol Hepatol, 2014, 26(4): 378-387. doi: 10.1097/MEG.0000000000000065
[5]	HUNT RH, CAMILLERI M, CROWE SE, et al. The stomach in health and disease[J]. Gut, 2015, 64(10): 1650-1668. doi: 10.1136/gutjnl-2014-307595
[6]	房静远, 杜奕奇, 刘文忠. 中国慢性胃炎共识意见(2017, 上海)[J]. 中华消化杂志, 2017, 37(11): 721-738. doi: 10.3760/cma.j.issn.0254-1432.2017.11.001
[7]	中药新药临床研究指导原则[M]. 北京: 中国医药科技出版社, 2002: 124-129.
[8]	中国中西医结合学会消化系统疾病专业委员会. 胃肠疾病中医症状评分表[J]. 中国中西医结合消化杂志, 2011, 19(1): 66-68. https://www.cnki.com.cn/Article/CJFDTOTAL-ZXPW201101030.htm
[9]	中华医学会消化内镜学分会. 慢性胃炎的内镜分型分级标准及治疗的试行意见[J]. 中华消化内镜杂志, 2004, 21(2): 77-78. doi: 10.3760/cma.j.issn.1007-5232.2004.02.001
[10]	李军祥, 陈誩, 吕宾, 等. 慢性萎缩性胃炎中西医结合诊疗共识意见(2017年)[J]. 中国中西医结合消化杂志, 2018, 26(2): 121-131. https://www.cnki.com.cn/Article/CJFDTOTAL-ZXPW201802003.htm
[11]	灵枢经[M]. 北京: 人民卫生出版社, 2005: 33.
[12]	叶柏. 单兆伟治疗慢性萎缩性胃炎经验[J]. 辽宁中医杂志, 2012, 39(2): 229-231. https://www.cnki.com.cn/Article/CJFDTOTAL-LNZY201202016.htm
[13]	叶天士. 临证指南医案[M]. 北京: 北京科学技术出版社, 2014: 326.
[14]	许泽君, 李晴晴. 孟河医派脾胃病诊治特色探析[J]. 江苏中医药, 2014, 46(6): 73-74. https://www.cnki.com.cn/Article/CJFDTOTAL-JSZY201406040.htm
[15]	张挹芳, 李宗庭, 张子明. 孟河传人张泽生张继泽中医承启集[M]. 南京: 东南大学出版社, 2010: 7-8.
[16]	徐景藩. 徐景藩脾胃病临证经验集粹[M]. 北京: 科学出版社, 2010: 58-59.
[17]	廖纬琳, 陈国忠, 胡辉, 等. 胃复春治疗慢性萎缩性胃炎的Meta分析[J]. 辽宁中医杂志, 2015, 42(1): 11-15. https://www.cnki.com.cn/Article/CJFDTOTAL-LNZY201501004.htm
[18]	朱亮亮, 田金徽, 拜争刚, 等. 胃复春治疗慢性萎缩性胃炎的系统评价[J]. 中国循证医学杂志, 2009, 9(1): 81-87. https://www.cnki.com.cn/Article/CJFDTOTAL-ZZXZ200901019.htm
[19]	石淑青, 蔡建庭. 三叶因子Ⅰ和Ⅱ在胃癌和癌前状态中的表达[J]. 中华内科杂志, 2004, 43(3): 195-197. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHNK200403013.htm
[20]	侯亮, 荣芳. 三叶因子Ⅱ在不同胃黏膜病变中的表达及意义[J]. 长治医学院学报, 2010, 24(1): 13-15. https://www.cnki.com.cn/Article/CJFDTOTAL-CZYX201001007.htm
[21]	王韶华, 崔东来, 谢永强, 等. 环氧合酶-2, 核因子-κB异常表达与胃癌关系的探讨[J]. 北京医学, 2006, 28(2): 84-86. https://www.cnki.com.cn/Article/CJFDTOTAL-BJYX200602008.htm

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Clinical Observation on the Treatment of Chronic Atrophic Gastritis with Syndrome of Spleen Deficiency and Stasis Obstruction by Shenqi Taohong Decoction and Its Mechanism

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