Volume 37 Issue 3
May  2021
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Article Navigation >  Journal of Nanjing University of traditional Chinese Medicine  > 2021  >  37(3): 457-464
SONG Yi, LIU Yan, FANG Bing-qian, KANG Di, HU Li-hong. Research Progress in Antineoplastic Mechanism of Triptolide and Toxicity Attenuation by Compatibility[J]. Journal of Nanjing University of traditional Chinese Medicine, 2021, 37(3): 457-464. doi: 10.14148/j.issn.1672-0482.2021.0457
Citation: SONG Yi, LIU Yan, FANG Bing-qian, KANG Di, HU Li-hong. Research Progress in Antineoplastic Mechanism of Triptolide and Toxicity Attenuation by Compatibility[J]. Journal of Nanjing University of traditional Chinese Medicine, 2021, 37(3): 457-464. doi: 10.14148/j.issn.1672-0482.2021.0457
shu

Research Progress in Antineoplastic Mechanism of Triptolide and Toxicity Attenuation by Compatibility

doi: 10.14148/j.issn.1672-0482.2021.0457

  • Jiangsu Key Laboratory for Functional Substances of Chinese Medicine, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China

  • Received Date: 2020-01-06
    Available Online: 2021-12-21
  • Publish Date: 2021-05-10
    Abstract
  • Triptolide (TP) is a kind of natural triepoxide diterpenoid, isolated from Chinese medical herb Tripterygium wilfordii Hook F. As one of the primary biologically active ingredients, TP possesses various and potent pharmacological effects such as anti-inflammatory, immunosuppressive and anti-tumor properties. Here, we focus on the mechanisms of actions of TP in anti-tumor effects, the toxicity and the possible solutions in toxicity attenuation by compatibility. This review may provide reference for the clinical development of TP as well as its related derivatives.

     

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