Volume 37 Issue 3
May  2021
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Article Navigation >  Journal of Nanjing University of traditional Chinese Medicine  > 2021  >  37(3): 371-375
LU Dong-xue, YAN Jing, SUN Zhi-guang, LI Xuan, LIU Feng, WANG Ya-jun, GE Fei. Clinical Efficacy and Mechanism of Wumei Pill in the Treatment of Chemotherapy-induced Intestinal Mucositis[J]. Journal of Nanjing University of traditional Chinese Medicine, 2021, 37(3): 371-375. doi: 10.14148/j.issn.1672-0482.2021.0371
Citation: LU Dong-xue, YAN Jing, SUN Zhi-guang, LI Xuan, LIU Feng, WANG Ya-jun, GE Fei. Clinical Efficacy and Mechanism of Wumei Pill in the Treatment of Chemotherapy-induced Intestinal Mucositis[J]. Journal of Nanjing University of traditional Chinese Medicine, 2021, 37(3): 371-375. doi: 10.14148/j.issn.1672-0482.2021.0371
shu

Clinical Efficacy and Mechanism of Wumei Pill in the Treatment of Chemotherapy-induced Intestinal Mucositis

doi: 10.14148/j.issn.1672-0482.2021.0371
  • 1.

    The Second Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210023, China

  • 2.

    The First School of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China

  • 3.

    The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210009, China

  • 4.

    Department of Orthopedics and Traumatology, Pukou Hospital of Traditional Chinese Medicine, Nanjing, 211800, China

  • 5.

    Hai'an TCM Hospital Affiliated to Hanlin College, Nanjing University of Chinese Medicine, Nantong, 226600, China

  • Received Date: 2020-11-22
    Available Online: 2021-12-21
  • Publish Date: 2021-05-10
    Abstract
  • OBJECTIVE   To observe the effect of Wumei pill on diarrhea in chemotherapy-induced intestinal mucositis (CIM) and its possible mechanism of action.METHODS   We selected 50 CIM outpatients with diarrhea in Hai'an TCM Hospital, and divided them into the treatment group with 25 cases and the control group with 25 cases in accordance with the random number table. In the control group, oral loperamide was administered, while as for the treatment group, Chinese herbal decoction Wumei pill was given. The total course of treatment was four weeks. The incidence rate of diarrhea and the total effective rate of the patients were observed, and the scores of traditional Chinese medicine (TCM) syndrome were evaluated. In addition, we measured serum inflammatory factors and After treatment, the incidence rate of diarrhea and the scores of TCM syndrome were decreased in both groups (P < 0.05, P < 0.01), and results in the treatment group were better than those in the control group (P < 0.01). The clinical efficacy rate of the treatment group was higher than that of the control group (P < 0.05). The levels of serum interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), diamine oxidase (DAO), endothelin (ET) and D-lactate were decreased (P < 0.05, P < 0.01), while the levels of interleukin 10 (IL10) were increased (P < 0.01). The abundances of enteropathogenic bacteria were reduced while the abundances of probiotics were increased (P < 0.05, P < 0.01), and the treatment group were better than the control group (P < 0.01).CONCLUSION   Wumei pill can significantly improve the symptoms associated with diarrhea of CIM, and the mechanism may be related to the anti-inflammatory response, improvement of intestinal mucosal barrier function and regulation of intestinal flora under the multi-target effect of the Chinese herbal compound.

     

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