Volume 37 Issue 3
May  2021
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Article Navigation >  Journal of Nanjing University of traditional Chinese Medicine  > 2021  >  37(3): 366-370
LI Ye, YANG Ru-yi, LI Meng-qi, ZHANG Wen-jing, CHEN Fa-zhang. Clinical Study on Self-Made Fuzheng Jiedu Formula in Treating Cancer-Related Fatigue of Patients with Gastric Cancer after Chemotherapy[J]. Journal of Nanjing University of traditional Chinese Medicine, 2021, 37(3): 366-370. doi: 10.14148/j.issn.1672-0482.2021.0366
Citation: LI Ye, YANG Ru-yi, LI Meng-qi, ZHANG Wen-jing, CHEN Fa-zhang. Clinical Study on Self-Made Fuzheng Jiedu Formula in Treating Cancer-Related Fatigue of Patients with Gastric Cancer after Chemotherapy[J]. Journal of Nanjing University of traditional Chinese Medicine, 2021, 37(3): 366-370. doi: 10.14148/j.issn.1672-0482.2021.0366
shu

Clinical Study on Self-Made Fuzheng Jiedu Formula in Treating Cancer-Related Fatigue of Patients with Gastric Cancer after Chemotherapy

doi: 10.14148/j.issn.1672-0482.2021.0366
  • 1.

    Medical School, Qinghai University, Xining, 810000, China

  • 2.

    The Affiliated Hospital of Qinghai University, Xining, 810000, China

  • Received Date: 2021-01-12
    Available Online: 2021-12-21
  • Publish Date: 2021-05-10
    Abstract
  • OBJECTIVE  To observe the effect of self-made Fuzheng Jiedu Formula on cancer-related fatigue (CRF) of patients with gastric cancer after chemotherapy.METHODS  110 gastric cancer patients with cancer-related fatigue were randomly divided into the treatment group and the control group with 55 cases in each group. The treatment group was given self-made Fuzheng Jiedu Formula. The control group was given Zhenqi Fuzheng Capsule. The scores of Cancer Fatigue Scale(CFS)and Brief Fatigue Inventory(BFI)in both two groups before and after treatment were evaluated. The changes of T lymphocyte subsets (CD3+, CD4+, CD8+, CD4+/CD8+), tumor markers carcinoembryonic antigen (CEA), carbohydrate antigen 199 (CA-199) and carbohydrate antigen 724 (CA-724) were detected.RESULTS  After treatment, there was no difference in cognitive scores between the two groups (P>0.05). The scores of physical, emotional, total and BFI were decreased, which in the treatment group were better than those in the control group (P < 0.05, P < 0.01). The levels of CD3+, CD4+ and CD4+/CD8+ in the two groups were increased, and the levels of CD8+were decreased, which in the treatment group were betterer than those in the control group (P < 0.05). The levels of CEA, CA-199 and CA-724 in the treatment group were decreased (P < 0.05, P < 0.01), which were better than those in the control group (P < 0.05, P < 0.01).CONCLUSION  Self-made Fuzheng Jiedu Formula can significantly improve the immune function of patients, reduce the level of tumor markers, and relieve the degree of CRF in patients with gastric cancer.

     

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