Volume 37 Issue 3
May  2021
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Article Navigation >  Journal of Nanjing University of traditional Chinese Medicine  > 2021  >  37(3): 360-365
QI Xiu-chun, SUN Nan, GUO Xi-qin, HAN Chong-tao, CHEN Xin, CHENG Shuai-bang. The Effect of Zhihuang Zhitong Powder on Acute Ankle Sprain and Morphology of Injured Ligament[J]. Journal of Nanjing University of traditional Chinese Medicine, 2021, 37(3): 360-365. doi: 10.14148/j.issn.1672-0482.2021.0360
Citation: QI Xiu-chun, SUN Nan, GUO Xi-qin, HAN Chong-tao, CHEN Xin, CHENG Shuai-bang. The Effect of Zhihuang Zhitong Powder on Acute Ankle Sprain and Morphology of Injured Ligament[J]. Journal of Nanjing University of traditional Chinese Medicine, 2021, 37(3): 360-365. doi: 10.14148/j.issn.1672-0482.2021.0360
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The Effect of Zhihuang Zhitong Powder on Acute Ankle Sprain and Morphology of Injured Ligament

doi: 10.14148/j.issn.1672-0482.2021.0360
  • 1.

    Henan Province Hospital of TCM, The Second Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, 450000, China

  • 2.

    Luoyang Orthopedic-Traumatological Hospital of Henan Province, Henan Provincial Orthopedic Hospital, Zhengzhou, 450000, China

  • 3.

    The Third Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, 450000, China

  • Received Date: 2020-12-21
    Available Online: 2021-12-21
  • Publish Date: 2021-05-10
    Abstract
  • OBJECTIVE  To discuss the effect of Zhihuang Zhitong Powder on acute ankle sprain and morphology of injured ligament.METHODS  The 92 patients with acute ankle sprain were randomly divided into the control group and the observation group, 46 cases each. The control group was given the basic therapy combined with Diclofenac Diethylamine Emulgel while the observation group was given the basic therapy combined with Zhihuang Zhitong Powder. The course lasted 14 days. The efficacy of the two groups were compared after treatment in terms of those indexes, including the pain score of visual analogue scale (VAS), the level of serum oxidative stress factors, the ankle circumcision, the ankle flexion, the activity of back extension, the thickness of damaged ligament and the changes in ankle function. The period of pain relief and swollen joint recovery along with adverse skin reactions in the two groups were recorded.RESULTS  After treatment, the pain score of VAS, the thickness of the anterior cruciate ligament and the anterior cruciate ligament, the ankle circumcision, scores of the ankle flexion, the activity of back extension, as well as the ankle and hind foot function evaluation table were significantly improved(P < 0.05). The activity of superoxide dismutase (SOD) was higher than before treatment (P < 0.05). The level of alondialdehyde (MDA), fibroblast growth factor (FGF)-2, conversion growth factor (TGF)-β1, matrix metalloproteinases (MMP)-9 and interleukin-1β (IL-1β) were lower than those of the same group before treatment. the observation group was higher than that in the control group (P < 0.05). The total efficiency of the observation group was better than that of the control group (P < 0.05). The period of pain relief and swollen joint recovery in the observation group were shorter than those of the control group (P < 0.05). There was no statistical difference in the incidence of adverse skin reactions in the two groups (P>0.05).CONCLUSION  The effect of Zhihuang Zhitong Powder in the treatment of acute ankle sprain was better than that of Diclofenac Diethylamine Emulgel, which can enhance antioxidant activity, inhibit oxidative stress response, improve lateral ligament morphology, and promote the recovery of ankle function.

     

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    • References(22)
  • [1]
    ZIAI P, BENCA E, WENZEL F, et al. Peroneal tendinosis as a predisposing factor for the acute lateral ankle sprain in runners[J]. Knee Surg Sports Traumatol Arthrosc, 2016, 24(4): 1175-1179. doi: 10.1007/s00167-015-3562-3
    [2]
    BOSSARD DS, REMUS A, DOHERTY C, et al. Developing consensus on clinical assessment of acute lateral ankle sprain injuries: Protocol for an international and multidisciplinary modified Delphi process[J]. Br J Sports Med, 2018, 52(23): 1539. doi: 10.1136/bjsports-2017-099007
    [3]
    DOHERTY C, BLEAKLEY C, HERTEL J, et al. Gait biomechanics in participants, six months after first-time lateral ankle sprain[J]. Int J Sports Med, 2016, 37(7): 577-583. doi: 10.1055/s-0035-1564172
    [4]
    苏甦, 李晓玲. 长期口服非甾体抗炎药患者的胃肠道和心血管不良反应防治策略[J]. 临床药物治疗杂志, 2017, 15(2): 7-11. doi: 10.3969/j.issn.1672-3384.2017.02.002
    [5]
    余翔, 金志超, 梁德, 等. 急性踝关节扭伤的中医药治疗进展[J]. 中国中医急症, 2017, 26(12): 2169-2172, 2177. doi: 10.3969/j.issn.1004-745X.2017.12.030
    [6]
    李黎, 孙燕, 廖怀章, 等. 活血化瘀利水方对大鼠急性软组织损伤模型血清IL-6、组胺影响的实验研究[J]. 湖南中医药大学学报, 2016, 36(3): 21-23. doi: 10.3969/j.issn.1674-070X.2016.03.006
    [7]
    马运峰. 栀黄止痛散治疗急性软组织损伤的临床疗效评价[D]. 贵阳: 贵阳中医学院, 2010.
    [8]
    吴桂春. 急性踝关节外侧韧带损伤的MRI评价[J]. 中国现代药物应用, 2013, 7(7): 25-26. doi: 10.3969/j.issn.1673-9523.2013.07.019
    [9]
    孙树椿, 孙之镐. 临床骨伤科学[M]. 北京: 人民卫生出版社, 2006: 754.
    [10]
    国家中医药管理局. 中医病证诊断疗效标准[S]. 南京: 南京大学出版社, 1994.
    [11]
    中国中西医结合学会骨伤科分会. 外踝韧带损伤的中西医结合治疗专家共识[J]. 中华骨科杂志, 2019, 39(11): 653-659. doi: 10.3760/cma.j.issn.0253-2352.2019.11.001
    [12]
    ARONS AMM, KRABBE P, JAN VDWG, et al. Visual analogue scales[J]. Qual Life Res, 2015, 22(5): 979-986.
    [13]
    WALTER WR, HIRSCHMANN A, ALAIA EF, et al. JOURNAL CLUB: MRI evaluation of midtarsal (chopart) sprain in the setting of acute ankle injury[J]. Am J Roentgenol, 2018, 210(2): 386-395. doi: 10.2214/AJR.17.18503
    [14]
    SCHNEIDER W, JURENITSCH S. Normative data for the American Orthopedic Foot and Ankle Society ankle-hindfoot, midfoot, hallux and lesser toes clinical rating system[J]. Int Orthop, 2016, 40(2): 301-306. doi: 10.1007/s00264-015-3066-2
    [15]
    中药新药临床研究指导原则(试行)[M]. 北京: 中国医药科技出版社, 2002: 126-128.
    [16]
    黄帝内经素问[M]. 田代华, 校注. 北京: 人民军医出版社, 2011.
    [17]
    吴谦. 御纂医宗金鉴[M]. 山西科学技术出版社, 2011.
    [18]
    姜仁建, 蒲萍. 中医理筋手法加中药外敷治疗急性踝关节扭伤的临床研究[J]. 中国中医急症, 2019, 28(7): 1215-1217. doi: 10.3969/j.issn.1004-745X.2019.07.023
    [19]
    吴乐彬, 吴雪华, 卢立炳. 自制活血止痛膏联合推拿治疗急性踝关节扭伤的疗效观察[J]. 中国中医药科技, 2016, 23(6): 737-738. https://www.cnki.com.cn/Article/CJFDTOTAL-TJYY201606050.htm
    [20]
    刘方舟, 李园白, 李萌, 等. 基于网络药理学的浙产栀子藏红花素类成分药理作用机制研究[J]. 中草药, 2019, 50(8): 1873-1879. https://www.cnki.com.cn/Article/CJFDTOTAL-ZCYO201908015.htm
    [21]
    尚坤, 李敬文, 常美月, 等. 中药冰片药理作用研究进展[J]. 吉林中医药, 2018, 38(4): 439-441. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYJL201804018.htm
    [22]
    任星宇, 罗敏, 邓才富, 等. 白芷挥发油提取方法及药理作用的研究进展[J]. 中国药房, 2017, 28(29): 4167-4170. doi: 10.6039/j.issn.1001-0408.2017.29.38
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