南京中医药大学学报

Exploration of Integrated Traditional Chinese and Western Medicine Treatment Mode for Malignant Tumors

WANG Junyi, LI Liu, SHEN Weixin, WU Mianhua, ZHOU Zhongying, CHENG Haibo

2024, 40(3): 217-222. doi: 10.14148/j.issn.1672-0482.2024.0217

[Abstract](327) [FullText HTML] (38) [PDF 1171KB](58)

Abstract:
Malignant tumors are major diseases that seriously threaten human health. Although the integration of traditional Chinese and Western medicine has become an expert consensus on treatment of malignant tumors in China, a mature treatment mode of integrated traditional Chinese and Western medicine has not yet been formed. This paper explores the construction of integrated traditional Chinese and Western medicine treatment mode for malignant tumors, namely synergistic therapy, palliative therapy, and preventive therapy, covering different stages of malignant tumors, in order to give full play to the advantages and characteristics of integrated traditional Chinese and Western medicine treatment in the treatment of malignant tumors.

Strategies for Preventing and Treating Allergic Rhinitis in Children with Chinese Medicine

DAI Qigang, LI Tao, QIAN Xiang, DOU Yuzhu, HUANG Lingyin, GAO Jiawen, WANG Shouchuan

2024, 40(3): 223-228. doi: 10.14148/j.issn.1672-0482.2024.0223

[Abstract](166) [FullText HTML] (29) [PDF 1111KB](25)

Abstract:
Allergic rhinitis is a common allergic disease in children. Its pathogenesis is complex and it is difficult to achieve a radical cure or effective and stable long-term treatment goals. Chinese medicine has obvious advantages in preventing and treating allergic rhinitis in children due to its wide range of targets, long-lasting effects and few adverse reactions. This paper proposes that the onset of allergic rhinitis is mostly caused by the dysfunction of the lungs, spleen and kidneys, the external wind triggering the underlying wind, and the combination of the two winds. A staged prevention and treatment strategy of Chinese medicine should be adopted, which includes dispersing external wind, suppressing underlying wind, and promoting lungs and orifices during the attack period to treat its symptoms, and preventing external wind, calming down underlying wind, and regulating and tonifying the lungs, spleen, and kidneys during the remission period to treat its root cause; meanwhile, attention should be paid to avoiding the adverse effects of congenital endowment factors and the induction of acquired environmental factors, strengthening the body's health to protect against the evil wind, preventing the transformation of existing diseases and the recurrence of allergic rhinitis in children at all stages.

Discussion on the Common Pathogenesis and Transmission Mechanism of Exogenous Febrile Diseases

WEI Kaifeng, YANG Jin

2024, 40(3): 229-233. doi: 10.14148/j.issn.1672-0482.2024.0229

[Abstract](214) [FullText HTML] (18) [PDF 1034KB](29)

Abstract:
The article explores the common pathogenesis and transmission mechanism of exogenous febrile diseases. It points out that the invasion of external evils leads to the wei qi resisting evils, the struggle between good and evil, and the stagnation of yang qi, thus showing a series of febrile disease syndromes, and the pathogenesis is characterized by "stagnation-deficiency". The theory of "qi-blood and body-function" is used to summarize the transmission and change patterns of febrile disease syndromes, and the course of febrile diseases is summarized into two stages: qi and blood. The qi phase includes the wei phase, mainly characterized by functional disorders; the blood phase includes the nutrient phase, mainly characterized by substantial damage and accompanied by more severe functional disorders. The pathogenesis of severe exogenous febrile diseases transformation includes excessive heat stimulating blood circulation, heat inducing pericardium closure, excessive heat activating wind, the source of generation and transformation being cut off, cold-conversion of Shaoyin, and collapse of healthy qi, etc.

Exploration of Aging-Induced Cognitive Impairment Based on Qiluo Theory of Essence, Qi and Spirit

LI Yawen, LI Hongrong, LU Xuan, SHEN Xiaogang, ZHANG Jiehan, ZHANG Runtao, NIU Kunxu, ZHANG Shixiong

2024, 40(3): 234-239. doi: 10.14148/j.issn.1672-0482.2024.0234

[Abstract](142) [FullText HTML] (12) [PDF 1078KB](26)

Abstract:
Cognitive dysfunction is the main manifestation of aging, which has become a hot topic of global concern as aging intensifies. This article proposes that essence is the origin of life, qi is the driving force of life, and spirit is the embodiment of life. Guided by the qiluo theory of essence, qi, and spirit, the key pathogenesis and corresponding treatment methods of cognitive impairment caused by aging are proposed: kidney essence deficiency and brain marrow insufficiency are the fundamental, primordial qi deficiency and brain meridian obstruction are the key, brain spirit dystrophy and spirit activity dysfunction are the manifestations; the treatment is to tonify the kidney and essence to fill brain marrow, warm and nourish primordial qi to unblock brain meridians, enhance brain sprit to improve spirit activity, expecting to be beneficial for delaying and preventing aging-caused cognitive impairment.

Astragalus Mongholicus Bunge-Curcuma Aromatica-Paridis Rhizoma Inhibits Metastasis of Colon Cancer via the PERK/eIF2α/ATF4 Signaling Pathway

ZHANG Huilan, GUO Wenhui, SU Tingting, CHEN Si, YU Qianhui, YIN Qihang, WAN Linlu, WANG Xu, TANG Decai

2024, 40(3): 240-248. doi: 10.14148/j.issn.1672-0482.2024.0240

[Abstract](148) [FullText HTML] (22) [PDF 4617KB](32)

Abstract:
OBJECTIVE To investigate the mechanism of anti-colorectal cancer growth and metastasis-related effects of Astragalus mongholicus Bunge-Curcuma aromatica-Paridis Rhizoma (Qi-Zhu-Zao) pairing through PERK/eIF2α/ATF4 signaling pathway mediating endoplasmic reticulum stress. METHODS Twenty-four BALB/c male mice were randomly divided into sham-operated group, model group, 5-FU (5-fluorouracil) group (25 mg·kg^-1), and Qi-Zhu-Zao high dose group (5.85 g·kg^-1), Qi-Zhu-Zao low dose group(2.925 g·kg^-1) (n=6) to construct a mouse model of colorectal cancer in situ transplantation tumor, and the intervention effect of Qi-Zhu-Zao combination on tumor growth was assessed by the change of tumor volume size after 15 days of administration; the intervention effect of Qi-Zhu-Zao combination on tumor growth was assessed by H&E. Pathological staining was used to evaluate the effect of Qi-Zhu-Zao combination on the liver and tumor tissues of mice. The changes of MDA, SOD and GSH-Px levels were detected by enzyme-linked immunosorbent assay (ELISA); the expression of PERK/eIF2α/ATF4 signaling pathway and EMT-related proteins were detected by protein immunoblotting (Western blot). RESULTS Compared with the model group, the tumor volume was significantly reduced (P < 0.000 1), liver and spleen metastases were less pronounced in the Qi-Zhu-Zao high-dose group, and histopathological staining results of liver tissue and tumor produced changes in oxidative stress indicators SOD, MDA, and GSH-Px, upregulation of ER stress-related proteins p-PERK, p-IF2α, and ATF4, etc., upregulated the protein expression levels of E-Cadherin, downregulated N-Cadherin, Vimentin, and Snail, and inhibited the EMT process (P < 0.01 or P < 0.05). CONCLUSION In this paper, we investigated the regulatory mechanism related to the inhibition of colorectal cancer growth and metastasis by the combination of Qi-Zhu-Zao trigonal medicine, and demonstrated that it may inhibit the growth and metastasis of colorectal cancer by activating the PERK/eIF2α/ATF4 pathway to induce sustained ER stress and affect the EMT process of colorectal cancer.

Wenshen Tongluo Zhitong Recipe Improves the Osteogenic Differentiation of BMSC and Bone Loss in Senile Osteoporosis Model Mice by Inhibiting Macrophage Senescence

ZHANG Tianchi, LI Muzhe, NIU Yuanyuan, GUO Yang, WANG Lining, TIAN Linkun, WANG Yuheng, WANG Quanquan, MA Yong

2024, 40(3): 249-260. doi: 10.14148/j.issn.1672-0482.2024.0249

[Abstract](87) [FullText HTML] (22) [PDF 6706KB](16)

Abstract:
OBJECTIVE To study the intervention effects of Wenshen Tongluo Zhitong Recipe(WTZR) on macrophage senescence and senile osteoporosis. METHODS The senescent macrophage model was established using hydrogen peroxide (H₂O₂) and subsequently divided into four groups: control, model, low-dose drug-treated serum, and high-dose drug-treated serum.β-galactosidase staining, Western blot and qPCR were employed to evaluate the mRNA expression of senescence markers p21 and p53. ROS staining and JC-1 staining were applied to assess mitochondrial function in macrophages. The mRNA levels of Interleukin(IL)-6, IL-10, CD206, and inducible nitric oxide synthase (iNOS) were determined by qPCR analysis. Immunofluorescence was used to evaluate arginase(ARG1) and iNOS protein expressions for assessing the impact of drug-containing serum on macrophage polarization. qPCR analysis was conducted to measure osteocalcin(OCN), collagen type Ⅰ alpha 1(Col1a1), runt-related transcription factor 2(Runx2) mRNA levels as osteoblast-related markers; ALP staining along with alizarin red staining were performed to evaluate the effect of macrophage conditioned medium treated with drug-containing serum on bone marrow mesenchymal stromal cell(BMSC)osteogenic differentiation. C57BL/6J mice were randomly allocated into four groups: control group, model group, WTZR low-dose group, and WTZR high-dose group. The senile osteoporosis (SOP) mouse model was established by D-galactose. Micro-CT scanning analyzed femur microstructure while HE staining detected pathological changes in femur bone tissue samples collected from each experimental condition. Furthermore, Western blot was used to detect the senescence-related molecules p21 and p53 and the osteogenesis-related markers OCN and Runx2, qPCR analysis measured tibial expression levels of senescence-related molecules (p21, p53) as well as macrophage polarisation-related molecules (IL-6, iNOS, CD206, and IL-10) to assess the effect of this compound on a mouse model simulating SOP. RESULTS Following intervention with serum containing WTZR, there was a significant decrease in the number of senescent positive cells compared to the model group. Additionally, there was a notable decrease in p21 and p53 mRNA and proteins expression (P < 0.05, P < 0.01, P < 0.001). Furthermore, drug-containing WTZR effectively inhibited ROS production induced by H₂O₂ and mitigated mitochondrial membrane potential reduction in macrophages (P < 0.05, P < 0.001). Treatment with drug-containing WTZR resulted in down-regulated mRNA expression of M1-related gene iNOS (P < 0.05) while up-regulating mRNA expression of M2-related genes CD163 and CD206 (P < 0.05). The drug-containing WTZR significantly reduced fluorescence intensity for iNOS (P < 0.01) while increasing ARG1 (P < 0.05) fluorescence intensity. Moreover, conditioned medium from macrophages treated with drug-containing serum increased ALP positive cell count (P < 0.01, P < 0.001), alizarin red positive area (P < 0.05), as well as Col1a1, Runx2 and OCN mRNA expression levels (P < 0.05, P < 0.01). The Tb.N, BMD, and BV/TV were significantly higher in the WTZR group compared to the model group (P < 0.05, P < 0.01, P < 0.001); meanwhile, Tb.Sp was notably lower than that observed in the model group (P < 0.05, P < 0.01); bone trabeculae were significantly improved, increased in number and widened. Additionally, the compound could significantly inhibit the D-galactose induced up-regulation of tibial senescence-related genes and proteins p21 and p53(P < 0.05, P < 0.001, P < 0.0001), promote the expression of osteogenesis-related markers OCN and Runx2 protein(P < 0.01, P < 0.0001), promote the down-regulation of M1 related genes IL-6 and iNOS (P < 0.05), and promote the expression of M2 related genes IL-10 and CD206 (P < 0.05, P < 0.01). CONCLUSION Wenshen Tongluo Zhitong Recipe may play an anti-osteoporosis effect by inhibiting macrophage senescence and promoting the osteogenic differentiation of BMSC.

Effects of Yueju Pill on Depressive Behavior, Functional Dyspepsia and PACAP/PAC1-R Expression in CUMS Mice

WANG Yan, GAO Tiantian, WANG Ziying, CHEN Gang, TAO Weiwei

2024, 40(3): 261-267. doi: 10.14148/j.issn.1672-0482.2024.0261

[Abstract](82) [FullText HTML] (31) [PDF 3812KB](10)

Abstract:
OBJECTIVE To explore the effects of Yueju Pill on depression and gastrointestinal function in depressed co-morbid functional dyspepsia mice. METHODS C57BL/6J mice were randomly divided into control group, model group, Yueju Pill low-dose group, Yueju Pill high-dose group and positive drug group. A co-morbidity model was constructed using chronic unpredictable mild stress (CUMS), and the mice were assessed for depression-like behaviour and neuronal damage by behavioural tests and Nissl staining; gastrointestinal function was assessed by HE staining of gastric and intestinal tissues, gastric emptying rate, and small intestinal propulsive rate; PACAP, VIP, IL-6, TNF-α, and BDNF expression were detected by ELISA; PAC1-R, Vipr1, and Vipr2 protein expression were detected by protein immunoblotting. RESULTS Mice in the model group showed depression-like behaviour, reduced number of hippocampal nidus, slowed gastrointestinal motility, elevated serum inflammatory factors IL-6 and TNF-α (P < 0.05, P < 0.01), and reduced expression of PACAP, VIP, and BDNF (P < 0.05, P < 0.01), The PAC1-R, VPAC1-R, VPAC2-R expression decreased in the hippocampus and gastric sinus, duodenal tissue (P < 0.05, P < 0.01). Compared with the model group, the low and high dose groups of Yueju Pill improved the above indexes except for Vipr1 and Vipr2 (P < 0.05, P < 0.01). CONCLUSION Yueju Pill can reduce inflammatory factors through PACAP/PAC1-R, increase the level of BDNF, and improve the depression-like behaviour and gastrointestinal dysfunction in CUMS mice.

Antipyretic Activity of Sulfhydryl Active Fractions Extracted From Bubali Cornu

HUANG Siying, FENG Qiyuan, BAO Wanglin, HUANG Xiaozheng, WU Wenxing, ZHAO Ming, DUAN Jinao, LIU Rui

2024, 40(3): 268-277. doi: 10.14148/j.issn.1672-0482.2024.0268

[Abstract](63) [FullText HTML] (11) [PDF 2267KB](7)

Abstract:
OBJECTIVE To extract the -SH active fractions (SHF) from Bubali Cornu (water buffalo horn) and evaluate its antipyretic activity. METHODS SHF was extracted from Bubali Cornu by SDS-DTT, and the content of native thiols (-SH) was determined by Ellman reagent method. SHF was identified based on nano LC-MS/MS technology. Evaluation of antipyretic activity of SHF was based on LPS-induced fever rat model. The levels of PGE₂, IL-1β, and TNF-α in plasma as well as the levels of cAMP, PGE₂, and TNF-α in the hypothalamus were measured by ELISA kits. An untargeted metabolomics approach was used to further investigate the intervention of SHF on plasma metabolites in febrile rats. RESULTS SDS-DTT could effectively extract SHF from Bubali Cornu, in which the main components were type Ⅰ, type Ⅱ keratins and keratin-associated proteins, which were rich in Cys, and the ratio of -SH to protein in SHF was increased about 20 times more than that of traditional decoction. SHF could significantly decrease (P < 0.01) the body temperature which lasted for 4.5 hours. SHF could also significantly decrease the levels of PGE₂, IL-1β, TNF-α and cAMP in plasma and hypothalamic. A total of 137 potentially differential metabolites were identified from plasma samples of the control and model groups, of which 31 metabolites could be dialed back after SHF administration, including lysophosphatidic acid, phosphatidylinositol, phosphatidic acid, triglycerides, phosphatidylcholine and so on, which were mainly involved in the glycerophospholipid metabolic pathway. CONCLUSION SHF has precise antipyretic effect, and the dosage of 1/10 of the aqueous extract can show its comparable antipyretic effect, which provides the direction and basis for the basic research on the antipyretic efficacy of Bubali Cornu.

Changes in Intestinal Toxicity and Component Analysis of Mongolian Medicine Euphorbia Pekinensis Rupr before and after Processing with Milk

LIU Lu, YU Hongli, WU Hao, WANG Xinzhi, CUI Xiaobing, CAO Yu, LIN Weihao, SHEN Changli, CAO Jie

2024, 40(3): 278-288. doi: 10.14148/j.issn.1672-0482.2024.0278

[Abstract](64) [FullText HTML] (11) [PDF 2177KB](5)

Abstract:
OBJECTIVE To explore the correlation between changes in intestinal toxicity and changes in component composition of the Mongolian medicine Euphorbia pekinensis Rupr (EPR) before and after processing with milk. METHODS Mice were given 95% ethanol extract of raw EPR, milk-processed EPR and water-processed EPR by gavage. The purgative effect and intestinal inflammatory toxicity changes of EPR before and after milk processing were investigated using the fecal water content and the levels of inflammatory factors TNF-α and IL-1β in each intestinal segment of mice as indicators; LC-MS/MS was used to analyze the composition changes of the 95% alcohol extract of EPR before and after milk processing. RESULTS Compared with the blank group, the raw and water processed products of EPR could significantly increase the water content of mouse feces and the levels of TNF-α and IL-1β in each intestinal segment (P < 0.05); compared with the raw product group, all indicators in the milk processing group were significantly reduced (P < 0.05), while there was no significant difference in the water processing group, indicating that water processing cannot attenuate toxicity, and the auxiliary material milk is the key auxiliary material to reduce the toxicity of EPR. Mass spectrometry analysis results showed that a total of 50 components were identified in EPR, including 38 terpenoid components, 6 phenolic acid components, and 6 other components. The content of each component decreased to varying degrees after milk processing. Principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA) were performed on the mass spectrum data of raw materials and products, and it was found that the components of raw materials and products can be obviously clustered into 2 categories. 13 differential components of raw materials and products were screened through t test, and 11 of which were terpene components, indicating that the composition of terpene components changed significantly after milk processing. 17 components derived from EPR were detected in the residual liquid of milk excipients after processing, of which 16 were terpenoids, indicating that the terpenoid components of EPR were transferred to the excipient milk during the soaking and processing processes. CONCLUSION The toxicity of EPR is reduced and the purgative effect is alleviated after milk processing. The attenuation mechanism may be that during the milk soaking and processing processes, terpenoid components are transferred to the milk, and the content of toxic components in the decoction pieces is reduced, thereby reducing the toxicity.

Chemometrics Analysis for Multi-Component Contents and Antioxidant Activity for Estimation on Quality Markers of Schisandrae Chinensis Fructus Standard Decoction

LIN Weixiong, WANG Shoufu, CHEN Shiyan, CHEN Qingyi, MO Qiuyi, WU Xiaoying, ZHANG Zheng, DENG Lihong

2024, 40(3): 289-301. doi: 10.14148/j.issn.1672-0482.2024.0289

[Abstract](75) [FullText HTML] (19) [PDF 3396KB](10)

Abstract:
OBJECTIVE To estimate the quality markers of antioxidant activity for standard decoction of Schisandrae Chinensis Fructus. METHODS 15 batches of Schisandrae Chinensis Fructus standard decoctions were subjected to quality evaluation by ultra high-performance liquid chromatography (UPLC) based on single-marker (QAMS) method, before being summarized by chemometrics analysis. The antioxidant abilities of 15 batches of samples were determined by DPPH and ABTS methods, while gray correlation analysis (GRA) and the partial least squares regression (PLSR) methods were subsequently applied to investigating the relationship between the contents of 8 components and the antioxidant activity. Ultimately, molecule docking was utilized to explore the binding properties between candidate quality markers and the core targets of anti-oxidation, with the experimental verification being executed on the individual compound by in vitro anti-oxidation. RESULTS There was no remarkable difference between the results of QAMS and external standard method (ESM), with P valued greater than 0.05. And it was speculated that protocatechuic acid, gomisin A, schizantherin B and schisandrin B were the constituents of quality difference. Moreover, the 4 quality variation components were reckoned to be the alternative markers on antioxidant according to the results of GRA and PLSR. The molecule docking result also showed that 4 candidate quality markers presented good binding affinity with the antioxidant core targets. The antioxidant capacity was presumably originated from the collaborated effects by multi-components in the standard decoction of Schisandrae Chinensis Fructus. In the interim, protocatechuic acid exhibited noteworthy antioxidant efficacy with dosage-depended manner in the results of single-compound verification, which was best conformed to the characteristics of quality markers and supposed to be the antioxidant quality marker for Schisandrae Chinensis Fructus standard decoction. CONCLUSION This research predicts the potential antioxidant substances on the basis of content determination by UPLC and in vitro antioxidant assay, but also provides rational foundation for quality assessment on other preparations of Schisandrae Chinensis Fructus.

Clinical Efficacy of Erdong Xiaoke Formula in Treating Type 2 Diabetes Dry Eyes with Yin Deficiency and Heat Excess Syndrome and Its Influence on Serum IL-17 and IL-1β

SUN Xinyi, JI Huijie, SHI Li, SHEN Huxing, YU Jiangyi, DONG Yingying

2024, 40(3): 302-308. doi: 10.14148/j.issn.1672-0482.2024.0302

[Abstract](130) [FullText HTML] (13) [PDF 1093KB](23)

Abstract:
OBJECTIVE To observe the clinical efficacy of Erdong Xiaoke Formula in the treatment of type 2 diabetes dry eyes with yin deficiency and heat excess syndrome and its effect on serum interleukin 17 (IL-17) and interleukin 1β (IL-1β), and to explore the therapeutic mechanism of Erdong Xiaoke Formula. METHODS 110 cases of type 2 diabetes patients with dry eyes of yin deficiency and heat excess syndrome from Jiangsu Province Hospital of Chinese Medicine were enrolled and randomly divided into a treatment group and a control group, 55 cases each. 5 cases dropped out of the treatment group and 4 cases dropped out of the control group. The control group was given a basic hypoglycemic regimen combined with topical sodium hyaluronate eye drops. The treatment group was given Erdong Xiaoke Formula in addition to the treatment in the control group. The treatment course for both groups was 4 weeks. Changes in TCM syndrome scores of the two groups of patients were observed before and after treatment, and the clinical efficacy of TCM was evaluated. Blood glucose and pancreatic islet function-related indicators [fasting blood glucose (FBG), fasting insulin (FINS), fasting C-peptide (FCP), postprandial 2 h blood glucose (PBG), insulin secretion function index (HOMA-β), insulin resistance index (HOMA)-IR)], ocular surface indicators [tear break up time (BUT), corneal sodium fluorescein staining (FL), Schirmer Ⅰ test (SⅠT)], and inflammation-related indicators (IL-17, IL-1β) were detected. The occurrence of adverse reactions in the two groups of patients was observed during the treatment period. RESULTS After treatment, the total scores of TCM syndromes in both groups were significantly reduced (P < 0.01), the treatment group was better than the control group (P < 0.01), and the total effective rate of TCM syndromes in the treatment group was higher than that of the control group (P < 0.01); SⅠT and BUT of patients in both groups increased significantly (P < 0.01), and the treatment group was better than the control group (P < 0.05, P < 0.01); the FL of patients in both groups significantly reduced (P < 0.01), and there was no significant difference between the groups; the serum IL-17 and IL-1β of the patients in the treatment group decreased significantly (P < 0.01), which was significantly better than that of the control group (P < 0.05). There were no significant changes in blood glucose and pancreatic islet function-related indicators in the two groups before and after treatment (P>0.05). During the treatment, no obvious adverse reactions were observed in the two groups. CONCLUSION Erdong Xiaoke Formula can improve SⅠT, BUT, FL and eye symptoms in patients with diabetic dry eye, effectively treat diabetic dry eye, and reduce ocular surface inflammation. Its mechanism may be related to reducing serum inflammatory factors IL-17 and IL-1β.

Treating Emotional Disorders from the Classification of Gallbladder

WU Yijun, SUN Yongkang, XU Fangbiao, SONG Yanbo, LIU Wenbo, JIANG Shuang, LIAO Haohao, WANG Xinzhi

2024, 40(3): 309-314. doi: 10.14148/j.issn.1672-0482.2024.0309

[Abstract](118) [FullText HTML] (16) [PDF 1095KB](27)

Abstract:
This article summarizes the unique viewpoints and experience application of the famous and veteran Chinese medicine practitioner, Professor Wang Xinzhi, in treating emotional diseases from the perspective of gallbladder theory. Based on the physiological functions and characteristics of the gallbladder in Chinese medicine, it is proposed that the "heart mind-gallbladder-viscera" axis dominates the generation and changes of emotions, and it is believed that gallbladder failure is the key pathogenesis of emotional disorders. The treatment of clinical syndromes should be based on the type of gallbladder, and emotional diseases can be divided into types of insufficient gallbladder qi, unfavorable Shaoyang, gallbladder and heat excess, timidity-deficiency, and heart-gallbladder indecision, according to clinical manifestations; based on the basic principle of adjusting the functions of the heart, spleen, liver, gallbladder, kidney and other organs, treatment methods such as tonifying the spleen and kidneys, increasing gallbladder qi, resolving Shaoyang, clearing gallbladder heat, warming yang and replenishing qi, calming the mind, resolving phlegm and removing blood stasis should be used, highlighting the joint treatment of the heart and the gallbladder, and the simultaneous regulation of the liver and gallbladder, so that the mind can be at ease, the gallbladder can be decisive, and the emotions can be harmonious.

Research Progress on Chemical Constituents, Pharmacological Activities and Clinical Application of Fritillaria Ussuriensis

LIU Jiahan, ZHAO Wei, WANG Yue, YANG Bingyou

2024, 40(3): 315-328. doi: 10.14148/j.issn.1672-0482.2024.0315

[Abstract](146) [FullText HTML] (18) [PDF 3027KB](18)

Abstract:
Fritillaria ussuriensis is a valuable traditional Chinese medicine in cold regions, which has the functions of dispersing stagnation and relieving depression, moistening lung and clearing heart. It is widely used in the treatment of diseases such as qi adverseness and cough, pharyngitis, sore and carbuncle, etc. Whether it is used alone or in combination, it has good results. It is a pure natural and efficient drug with broad development prospects. In recent years, with the deepening of research on Fritillaria ussuriensis, alkaloids, nucleosides, polysaccharides, volatile oils, organic acids and other components have been isolated.It has pharmacological activities such as relieving asthma, relieving cough, expectorant, calming, anti-inflammatory and antibacterial. By reviewing the reports of chemical constituents and pharmacological effects of Fritillaria ussuriensis in the past 40 years, this paper systematically summarizes and analyzes the research results in order to provide scientific basis for the study of pharmacodynamic substance basis and promote the development and utilization of Fritillaria ussuriensis.

2024 Vol. 40, No. 3

ArchiveMore+

Author field More+

Edit fieldMore+