2023 Vol. 39, No. 9

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Industry Status, Development and Utilization Strategies and Research Practices of Medicine and Food Homologous Traditional Chinese Medicine
GUO Sheng, WANG Yuan-yuan, ZHANG Fang, WEI Dan-dan, ZHU Yue, DUAN Jin-ao
2023, 39(9): 801-808. doi: 10.14148/j.issn.1672-0482.2023.0801
[Abstract](527) [FullText HTML] (74) [PDF 2003KB](106)
Abstract:
Medicine and food homologous traditional Chinese medicine (MFHTCM) is a type of Chinese medicinal material resource that has been gradually discovered by humans in long-term production and life practice, which combines the characteristics of both medicine and food. It is an important material foundation for the construction of a healthy China and the development of the big health industry. On the basis of summarizing and analyzing the current research status and existing problems in the industrial development process of MFHTCM in recent years, this article proposes a production layout strategy for MFHTCM based on differentiated development of medicinal and edible characteristics, a characterization strategy for MFHTCM efficacy based on modern multi-omics technology, a development strategy for new varieties and new parts of MFHTCM based on the records of Chinese herbal classics and folk application habits, and a MFHTCM development strategy of medicine and food homologous products based on probiotic fermentation technology and modern nutrition theory. All the above aim to provide technological support for promoting the high-value development and utilization of MFHTCM, and to assist in the construction of a healthy China in the new era.
The Ideological Origin, Conceptual Connotation, and Contemporary Development of "Medicine and Food homology"
WANG Xu-dong
2023, 39(9): 809-813. doi: 10.14148/j.issn.1672-0482.2023.0809
[Abstract](270) [FullText HTML] (1116) [PDF 1728KB](133)
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In the process of promoting the healthy China strategy, the guiding ideology of prevention first has led to the reform of the medical model. The concepts of "combination of prevention and treatment", "combination of treatment and maintenance", and "medicine and food homology" in traditional Chinese medicine have received unprecedented attention. However, at present, the academic community's understanding of the concept of "medicine and food homology" is not clear. The excellent traditional philosophy's understanding of the world and material is constrained by the contemporary "dual use of medicine and food" policy, with inconsistent connotations and narrow extensions, presenting a phenomenon of instrumentalization and vulgarization. The academic community and the government should adhere to the essence of traditional Chinese medicine, clarify the connotation of the concept of medicine and food homology, fully explore traditional Chinese medicine literature resources, learn from folk dietary habits, improve the current management methods for dual-use varieties of medicine and food, and make the excellent concept of medicine and food homology a source of promoting public health.
Research and Development Status, Technical Keys and Countermeasures of Medicinal and Food Homologous Products
CHENG Jian-ming, XUE Feng, ZHANG Yun-yu, JI Jing, LIU Tao-shi
2023, 39(9): 814-826. doi: 10.14148/j.issn.1672-0482.2023.0814
[Abstract](952) [FullText HTML] (83) [PDF 1886KB](137)
Abstract:
With the development of society and the improvement of people's living standards and health awareness, the modern medical model has shifted from traditional treatment to prevention and health care, and people's demand for products with the same origin of medicine and food is constantly increasing. In order to fully leverage the unique advantages of traditional Chinese medicine, explore the functions of traditional Chinese medicine with the same origin in medicine and food, as well as the "prevention and treatment of diseases", and promote the inheritance and innovation of traditional Chinese medicine, this article systematically summarizes and analyzes the origin and historical evolution of "medicine and food homology" in China, relevant regulations and policies on medicine and food homology, research status, key technologies, and existing problems of medicine and food homology products. Based on this, strategies and suggestions are proposed to solve the above problems, in order to provide references for the research and development of medicine and food homologous products.
Evaluation of the Anti-Aging Effects of Astragalus Membranaceus Based on Different Model Organisms
YANG Shu-hui, WANG Yu-meng, YIN Jia-ting, LI Cheng-xi, DUAN Jin-ao, GUO Jian-ming
2023, 39(9): 827-838. doi: 10.14148/j.issn.1672-0482.2023.0827
[Abstract](81) [FullText HTML] (16) [PDF 5719KB](17)
Abstract:
  OBJECTIVE  To observe the improving effect and preliminary mechanism of Astragalus membranaceus on natural aging model based on different model organisms.  METHODS  Non-rodent and rodent natural aging models were constructed, including three model organisms: Caenorhabditis elegans, Drosophila melanogaster and wild-type mice. Elegans and Drosophilae were divided into four groups: blank control group, low, medium and high dose groups of total extract of Astragalus membranaceus. The mice were divided into four groups: natural aging group, administration group, dirty cage aging group and dirty cage feeding plus administration group. The mice in the administration group were given the total extract of Astragalus membranaceus by gavage daily for 5 consecutive months. Elegans and drosophilae were fed until all of them died to calculate the life span and survival rate; the motor ability and pharyngeal pump frequency of elegans were evaluated. Being cultured after Day38, all drosophilae were exposed to UV irradiation for 15-30 min every 2 days until they all died to calculate their survival rate under UV stimulation. Cochineal intestinal transport and glucose absorption tests were used to evaluate the intestinal function of mice. Alcian blue periodic acid Schiff (AB-PAS) staining and Edu staining were used to observe the length of intestinal villi, the depth of crypt, the number of goblet cells, and the migration distance of intestinal stem cells in mice. The expression of related genes in the intestinal tract of mice was detected by qPCR. Paired-end sequencing analysis of small intestine contents DNA fragments was performed using the Illumina PE250 platform.  RESULTS  Astragalus membranaceus could significantly improve the natural life span of elegans (P < 0.05), restore the movement ability (P < 0.05) and pharyngeal pump rate (P < 0.01), and reduce the accumulation of lipofuscin (P < 0.01). Under UV irradiation stimulation, the lifespan of Drosophila was significantly shortened (P < 0.05), while Astragalus membranaceus could significantly prolong the lifespan and improve the motor ability of male Drosophila in the middle of life under this stress state (P < 0.05). In addition, Astragalus membranaceus significantly improved the intestinal nutrition absorption function and transport function of mice (P < 0.05), as well as the morphology of intestinal villus (P < 0.01); increased the migration distance of intestinal stem cells (P < 0.001). The sequencing results of intestinal flora showed that the species diversity and richness of intestinal flora in aging mice decreased (P < 0.01); the bacterial abundance of Firmicutes reduced significantly (P < 0.05). Astragalus could significantly increase the abundance of Bacillus, unidentified Lactobacillus in aging mice (P < 0.05, P < 0.01).  CONCLUSION  Astragalus membranaceus can prolong the life span of model organisms, improve the aging characteristics of natural aging mice, regulate the intestinal flora homeostasis and improve the activity of intestinal stem cells.
Chemical Composition Analysis and Antioxidant Activity Evaluation of Lycium barbarum Leaves with Different Strains and Maturity
ZHOU Jia-qi, GUO Sheng, LI Jie, KANG Hong-jie, GUO Lan-ping, DUAN Jin-ao
2023, 39(9): 839-848. doi: 10.14148/j.issn.1672-0482.2023.0839
[Abstract](100) [FullText HTML] (21) [PDF 2909KB](18)
Abstract:
  OBJECTIVE  To analyze the differences in multi-type resource chemical components and antioxidant activity of Lycium barbarum leaves (LBLs) with different strains and different maturity in order to provide the data support for their resource utilization.  METHODS  The content of 19 main chemical components including flavonoids, phenolic acids and alkaloids in the leaves of two L. barbarum cultivars for fruit and leaf (Ningqi No.7 and Ningqicai No.1) with different maturities were determined by UPLC-TQ-MS technology. Free radical scavenging abilities of DPPH and ABTS, and iron ion reducing ability were used to evaluate the antioxidant activity of LBLs.  RESULTS  The contents of various components in LBLs with different strains and different maturity were significantly different. The contents of each component in leaf buds and tender leaves were significantly higher than those in young leaves and mature leaves. The LBLs for fruit use have higher rutin content, while the LBLs for leaf use have higher contents of quercetin-3-O-rutose-7-O-glucoside and betaine. All samples showed good antioxidant properties, and the antioxidant activity showed a weakening trend with increasing maturity. The tender leaves of Ningqicai No. 1 had the highest DPPH scavenging ability, and the leaf buds had the highest ABTS free radical scavenging ability and iron reduction ability, while all three were higher in the leaf buds of Ningqi No. 7. The antioxidant activity of LBLs for leaf use was higher than that of LBLs for fruit use. The antioxidant activity of LBLs was significantly positively correlated with the contents of cryptochlorogenic acid, 5-O-feruloylquinic acid, quercetin-3-O-rutino-7-O-glucoside, chlorogenic acid and betaine.  CONCLUSION  The content of resourceful components and antioxidant activity of LBLs varies greatly among different strains and different maturity levels. Leaf buds and tender leaves of L. barbarum have higher content of each component and better antioxidant activity, which show higher development and application values. The development and application value of LBLs for leaf use is higher than that of LBLs for fruit use. The results can provide reference for the resource utilization of LBLs with different strains and different maturity levels.
Effect Evaluation and Mechanism of Jujing Pills in Improving Retinal Injury in Subacute Aging Mice Induced by D-galactose
LU Yun-qing, CAO Cheng, ZHENG Jia-ni, ZHU Zi-qiang, TONG Jia-xiang, QI Cheng-cheng, YUAN Lei, GUO Sheng, SU Shu-lan, KANG Hong-jie, DUAN Jin-ao, ZHU Yue
2023, 39(9): 849-859. doi: 10.14148/j.issn.1672-0482.2023.0849
[Abstract](96) [FullText HTML] (17) [PDF 3529KB](10)
Abstract:
  OBJECTIVE  To evaluate the effect of Jujing Pills on retinal injury in subacute aging mice induced by D-galactose and explore its mechanism.  METHODS  A subacute aging model was constructed by subcutaneous injection of D-galactose into mice. Western medicine positive drug AREDS2, Chinese medicine positive drug Qiju Dihuang Pills, low and high dose groups of water extract of Jujing Pill, and low and high dose groups of 50% ethanol extract of Jujing Pill were administered, respectively. Optical coherence tomography (OCT) was used to evaluate the condition of mouse retina and fundus, HE staining was adopted to assess retinal cell damage, TUNEL staining was applied to observe retinal cell apoptosis, kits were used to measure the expression of oxidative stress factors, and western blotting was used to detect the expression of retinal apoptosis and oxidative stress pathway related proteins in mice.  RESULTS  The extracts of Jujing Pills significantly increased the retinal thickness (P < 0.05), improved the retinal injury and inhibited the apoptosis of retinal cells in model mice (P < 0.05). At the same time, Jujing Pills down-regulated the expression of apoptotic proteins such as Cleaved Caspase-3 and Cleaved Caspase-9 (P < 0.05) while up-regulated the expression ratio of Bcl-2/Bax (P < 0.05). Jujing Pills also significantly increased the expression of antioxidant factors SOD and GSH (P < 0.05), decreased the production of oxidative product MDA (P < 0.05), and significantly up-regulated the expression of antioxidant proteins Nrf2 and HO-1(P < 0.05). The water extracts of Jujing Pills exerted similar retina protection effect with the 50% ethanol extracts.  CONCLUSION  Jujing Pills can improve the retinal injury of subacute aging model mice, which is related to the inhibition of retinal cell apoptosis and the improvement of oxidative stress.
Study on Quality Evaluation of Jingqishen Oral Liquid Based on HPLC-Q-TOF-MS, Fingerprint and Content Determination
ZHENG Chao, SHI De-zhi, TANG Zhi-feng, ZHANG Yun-yu, ZHONG Shao-hui, XIAO Lian-lian, LIU Hua-lan, LIAO Nan-xi, JI Jing, ZHENG Yun-feng, CHENG Jian-ming
2023, 39(9): 860-869. doi: 10.14148/j.issn.1672-0482.2023.0860
[Abstract](82) [FullText HTML] (13) [PDF 3134KB](16)
Abstract:
  OBJECTIVE  To establish HPLC-ELSD fingerprint of Jingqishen (JQS) oral liquid and the content determination method of its active ingredients.  METHODS  An Agilent TC-C18 (250 mm×4.6 mm, 5 μm) chromatographic column was used, and acetonitrile (A)-water solution (B) was adopted as the mobile phase for gradient elution to establish the HPLC-ELSD fingerprint of JQS oral liquid. The chemical composition of JQS oral liquid was analyzed by HPLC-Q-TOF-MS technology. The similarity evaluation was applied to study the data.  RESULTS  A total of 75 compounds were identified, and 14 common peaks were calibrated by the fingerprint of 10 samples. Through comparison with reference standards, a total of 8 chromatographic peaks were identified: Spinosin, Jujuboside A, Ginsenoside Rg1, Ginsenoside Re, Ginsenoside Rb1, Ginsenoside Rd, Ginsenoside Rf, Ginsenoside Rg3 were identified. In order to further control the overall quality of oral liquid, 4 active ingredients, Spinosin, Ginsenoside Rg1, Ginsenoside Re and Ginsenoside Rb1, were selected for content determination. Each active ingredient had a good linear relationship, and the established method had high sensitivity, good stability and accuracy.  CONCLUSION  The methods of content determination and fingerprint measurement established in this study are accurate and stable, and they control the quality of the JQS oral liquid comprehensively.
Study on Quality Control Indicators and Medicinal Value of Vitex Honey
RUAN Xiao-wen, ZHANG Zi-hao, LI Yan-hui, WU Qiu-mei, ZHU Hao-ran, YIN Chang-ping, WANG Xia-chang, LI Tao, LI Xuan
2023, 39(9): 870-878. doi: 10.14148/j.issn.1672-0482.2023.0870
[Abstract](105) [FullText HTML] (9) [PDF 2578KB](7)
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  OBJECTIVE  To evaluate the quality control indicators and medicinal value of Vitex Honey.  METHODS  Vitex honey samples from Du'an area of Guangxi in the past four years were collected, and their physicochemical characteristics and effects on the loperamide hydrochloride-induced transmission disorder constipation mouse models were studied.  RESULTS  The pollen grains of the Vitex Honey were mainly from Vitex flower, with a stable water content of less than 20%, conductivity below 0.8 mS·cm-1, pH between 3.67 and 3.93, free acid 27.3 to 32.3 meq·kg-1, lactones 15.6 to 21.5 meq·kg-1, total acid 35.4 to 53.7 meq·kg-1, amylase 17.6 to 21.5 U, hydroxymethylfurfural (5-HMF) 3.3 to 11.6 mg·kg-1, total phenolic content 450 to 650 mg·kg-1, and total flavonoid content 16.3 to 26.6 mg·kg-1, DPPH clearance EC50 ranges from 67.5 to 90.1 mg·mL-1. The results of thin layer identification research showed that Vitex honey exhibited different characteristic spectra compared to more than ten other types of honey, but Vitex honey exhibited relatively consistent spectral characteristics in different years; daily intaking of different concentrations of honey aqueous solution significantly improved and alleviated the constipation symptoms of loperamide hydrochloride-induced transmission disorder constipation in mice.  CONCLUSION  This study provides a beneficial exploration for the formulation of various quality standards for Vitex honey at all levels and the study of its medicinal value, in order to provide a basis for subsequent standard formulation and product development.
Exploring the Mechanism of Polygonatum cyrtonema Hua in Improving Inflammatory Fatigue Based on LC-MS Analysis and Network Pharmacology Research
LIU Tao, JI Jing, WANG Ling-chong, CHENG Jian-ming
2023, 39(9): 879-887. doi: 10.14148/j.issn.1672-0482.2023.0879
[Abstract](154) [FullText HTML] (14) [PDF 3478KB](29)
Abstract:
  OBJECTIVE  To evaluate the effective components and active mechanism of Polygonatum cyrtonema Hua in relieving inflammatory fatigue based on LC-MS analysis and network pharmacology.  METHODS  The component information of Polygonatum cyrtonema Hua was obtained through LC-MS, and the information on the targets of the components was collected. After comparing the gene targets of inflammatory fatigue, the common targets were obtained as the targets of Polygonatum cyrtonema Hua; GO functional enrichment analysis and KEGG pathway enrichment analysis of the shared gene targets were performed; finally, a pro-inflammatory cell model was used to verify the anti-inflammatory activity of Polygonatum cyrtonema Hua.  RESULTS  A total of 62 chemical components of Polygonatum cyrtonema Hua were detected by LC-MS, and 208 common targets between components and diseases were found. Network pharmacological analysis suggested that N-cis-feruloyl tyramide, β-sitosterol, 11E-octadecadienoic acid, β-D-glucuronic acid and liquiritigenin are important active components of Polygonatum cyrtonema Hua against inflammatory fatigue, and STAT3, MAPK3, AKT1, JUN, TP53, EGFR, CASP3 and IL-6 may be the key biological targets. The main biological pathways are focused on 5-HT aminergic synapses, calcium signaling pathway, JAK-STAT signaling and NF-κB pathway. The cell experiments showed that Polygonatum cyrtonema Hua had a significant inhibitory effect on LPS-induced macrophage secretion of inflammatory cytokines, indicating that Polygonatum cyrtonema Hua can exert certain anti-inflammatory actions.  CONCLUSION  The relatively large number of small molecule components in Polygonatum cyrtonema Hua can act on multiple biological targets through various biological pathways to improve inflammation-related fatigue in the body.
Effects of Restrictive Enzymatic Hydrolysis Modification on Structure and Functional Properties of Plum Seed Protein Isolates
ZHAO Xin-ru, CHENG Jian-ming, XUE Feng
2023, 39(9): 888-894. doi: 10.14148/j.issn.1672-0482.2023.0888
[Abstract](69) [FullText HTML] (24) [PDF 2387KB](6)
Abstract:
  OBJECTIVE  To explore the effects of restrictive enzymatic modification on the structural and functional characteristics of plum seed protein, using the plum seed protein isolates as the research object.  METHODS  The alcalase was used to hydrolyze plum seed protein isolates. The effects of hydrolysis time on subunits, secondary and tertiary structure, solubility, emulsifying properties, surface hydrophobicity, ζ-potential and thermal stability of protein were evaluated.  RESULTS  After enzymatic modification of plum seed protein isolates, the solubility, emulsifying activity index, emulsifying stability and surface hydrophobicity were improved by 156%, 135%, 696%, and 182%, respectively. The improvement in functional properties was attributed to the release of small molecular peptide, the increase of random coil and surface charge and unfolding of molecule induced by enzymatic modification. However, the improvement in functional properties was also dependent on the degree of hydrolysis. The excessive hydrolysis (the degree of hydrolysis > 6.3) could induce the aggregation of protein which led to a decrease in functional properties. In addition, the treatment of limited hydrolysis also reduced the thermal stability of plum seed protein isolates.  CONCLUSION  The functional properties of plum seed protein isolates can be improved by controlling the degree of hydrolysis.
Exploring the Mechanism of Compound Fresh Dendrobium Granules in Treating Alcoholic Liver Disease Based on Network Pharmacology and Experimental Verification
ZHAO Mian, QIU Yu-xuan, HU Yang, LIU Zi-han, WANG Pei-li, CHEN Wei-wei, PAN An, CHENG Jian-ming
2023, 39(9): 895-909. doi: 10.14148/j.issn.1672-0482.2023.0895
[Abstract](180) [FullText HTML] (16) [PDF 8052KB](20)
Abstract:
  OBJECTIVE  Combining network pharmacology methods and experimental verification to explore the target and potential mechanism of Compound Fresh Dendrobium Granules in treating alcoholic liver disease (ALD).  METHODS  With the help of TCMSP, ETCM, BATMAN-TCM databases and literatures, the chemical components of Compound Fresh Dendrobium Granules were searched. The optimal target compounds were screened by Swiss ADME database, and the active ingredient targets were predicted by Swiss Target Prediction database. The targets of ALD-related diseases were obtained from GeneCards, OMIM, DrugBank and DisGeNET databases. The protein-protein interaction (PPI) network analysis and "traditional Chinese medicine (TCM)-active ingredient-target-disease" network diagram were constructed using String database and Cytoscape software. The predicted potential targets were analyzed by GO/KEGG functional enrichment through DAVID database to predict the mechanism of action. A mouse model of alcoholic liver injury was constructed, and the results of network pharmacology enrichment analysis were verified by pathological staining, ELISA, qPCR and Western blot.  RESULTS  A total of 73 key active ingredients were obtained by database screening and literatures, and 720 targets were intersected with ALD. 789 BP information, 93 CC information, 204 MF information, and 194 KEGG signaling pathways were obtained by GO annotation analysis based on P < 0.05 and FDR < 0.05, which were mainly involved in metabolic pathways, PI3K/Akt signaling pathway, MAPK signaling pathway, cAMP signaling pathway, calcium signaling pathway, etc. In vivo experiments showed that, compared with the control group, mice in the model group had disorganized hepatocyte cords, indistinct hepatic lobule boundaries, obvious inflammatory cell infiltration and fat vacuoles in hepatocytes, significantly higher serum ALT and AST activity, liver tissue TG, TCHO content, and the gene expression levels of IL-1β, CXCL10 and Srebp-1c, while significantly lower CPT1 gene expression levels. The expression levels of inflammatory pathway proteins p-AKT, p-mTOR and p-p65 proteins were increased. After treatment with Compound Fresh Dendrobium Granules, the inflammatory cell infiltration and fat vacuoles in mouse hepatocytes were reduced, the cellular structure of the liver was normalized, and serum ALT and AST activity, hepatic tissue TG, TCHO content, and the gene expression levels of IL-1β, CXCL10, and Srebp-1c were significantly reduced, while the gene expression levels of CPT1 were significantly elevated. Additionally, the p-AKT, p-mTOR and p-p65 protein expression levels were also significantly reduced.  CONCLUSION  Compound Fresh Dendrobium Granules can effectively improve hepatic inflammation and lipid metabolism in mice with alcoholic liver injury, and may inhibit tissue inflammation by regulating the PI3K/Akt signaling pathway. This study preliminarily revealed the mechanisms of Compound Fresh Dendrobium Granules in preventing and treating alcoholic liver disease, which provides a reference for clinical medication and follow-up research.
Study on the Combination of Salviae Miltiorrhizae Radix et Rhizoma and Carthami Flos to Regulate Unfolded Protein Response and Improve Cardiac Function in Mice with Diabetic Cardiomyopathy
XU Mei-ling, XING Bao-tong, LI Jian-ping
2023, 39(9): 910-917. doi: 10.14148/j.issn.1672-0482.2023.0910
[Abstract](47) [FullText HTML] (3) [PDF 4553KB](6)
Abstract:
  OBJECTIVE  To explore the effects of oral administration of Salviae Miltiorrhizae Radix et Rhizoma and Carthami Flos (DH) on mice with diabetic cardiomyopathy and the underlying mechanisms.  METHODS  Forty-six C57BL/6J mice were divided into the control (CTL) group, diabetic cardiomyopathy (DCM) group, short-term DH administration (DCM-DHO) group, long-term DH administration (DCM-DHOL) group and empagliflozin positive drug (EMPA) group. A mouse model of diabetic cardiomyopathy was established using a high-fat diet (10 weeks) combined with STZ injection (120 mg·kg-1, single injection). The body weight, energy intake, and water consumption of mice were monitored and the glucose metabolism of mice was evaluated by oral glucose tolerance test (OGTT) and insulin tolerance test (ITT). Cardiac systolic function (FS) and diastolic function (MV E/A) of mice were measured by echocardiography. Molecular biological methods were used to analyze the gene and protein expression of key transcription factors such as IRE1, PERK, ATF6α, ATF4, Xbp1s, GRP94 and GRP78 in unfolded protein response signal pathway.  RESULTS  Compared with diabetic cardiomyopathy mice, the water consumption and blood glucose level of DCM-DHOL mice were decreased by 21.56% (P < 0.000 1) and 28.82% (P < 0.000 1), respectively; the insulin level was increased by 43.63% (P < 0.05) and the areas under the curves of OGTT and ITT were decreased by 16.56% (P < 0.05) and 6.82%, respectively; the FS and MV E/A were increased by 32.86% (P < 0.001) and 24.3% (P < 0.01), respectively; the gene expression levels of left ventricular IRE1, Xbp1, GRP78 and GRP94 (P < 0.05) and the protein expression level of GRP78 (P < 0.05) were also significantly increased. In DCM-DHO mice, the water consumption decreased by 10.46% (P < 0.05), cardiac diastolic function MV E/A increased by 17.87% (P < 0.01), and the mRNA levels of IRE1, Xbp1s, GRP78 and GRP94 and protein expression of GRP78 (P < 0.05) were significantly improved as compared with diabetic cardiomyopathy mice.  CONCLUSION  Oral administration of DH has a significant improvement effect on diabetic cardiomyopathy mice.
Study on Spray Drying Process and Physical Fingerprint of Tingliu Extract Based on Mixture Design
LIU Hua-lan, SHI De-zhi, GONG Xiao-wen, LIAO Nan-xi, ZHU Yu-bo, ZHENG Chao, YANG Zheng-qing, XIE Yu-xin, XIAO Lian-lian, ZHAO Mian, LIU Tao-shi, CHENG Jian-ming
2023, 39(9): 918-926. doi: 10.14148/j.issn.1672-0482.2023.0918
[Abstract](29) [FullText HTML] (6) [PDF 2873KB](3)
Abstract:
  OBJECTIVE  To improve the spray drying effect of Tingliu extract and establish its physical fingerprint.  METHODS  The added auxiliary materials were screened by the yield, moisture absorption rate and fluidity of Tingliu spray dry powder, and the ratio of the selected auxiliary materials was optimized by the method of mixing design. On this basis, the physical fingerprint of Tingliu spray dry powder composed of nine indicators, including water content, moisture absorption, angle of repose, and Karl index, was established, and the similarity evaluation of the physical fingerprint of 10 batches of Tingliu spray dry powder was evaluated by using the Pearson correlation coefficient method.  RESULTS  The final preferred excipients were light magnesium oxide, maltodextrin, hydroxypropyl-β-cyclodextrin, and by establishing the regression equation of spray dry powder yield, moisture absorption, angle of repose and screening excipient ratio, the preferred excipient ratio was dry paste: light magnesium oxide: maltodextrin: hydroxypropyl-β-cyclodextrin 0.55:0.3:0.1:0.05; under this preferred excipient ratio, the spray-dried powder yield was 64.42%, the moisture absorption rate was 13.27%, and the angle of repose was 36.81°. The similarity of the physical fingerprints of 10 batches of Tingliu spray dry powder samples was greater than 0.99.  CONCLUSION  In this study, the preferred ratio of excipients can better improve the powder yield of Tingliu spray drying, improve the properties of spray dry powder, and establish a quality control method for Tingliu spray dry powder based on physical fingerprint, which provides a reference for the quality control of Tingliu preparation process.
Research Progress on Processing Methods, Chemical Constituents, Pharmacological Action, and Prediction Analysis of Quality Markers of Black Ginger
GAO Zi-xuan, WANG Xue-qing, ZHOU Gui-sheng, WANG Tian-shu, YU Bin, YAN Hui
2023, 39(9): 927-942. doi: 10.14148/j.issn.1672-0482.2023.0927
[Abstract](93) [FullText HTML] (21) [PDF 3426KB](12)
Abstract:
Black dried ginger is a unique commodity specification of Sichuan's authentic medicinal ginger, processed through ancient methods, and is also a source of dried ginger medicinal materials used in the Japanese Pharmacopoeia. Black dried ginger has the effects of warming the middle and dispersing cold, restoring yang and unblocking the meridians, and warming the lungs and resolving yin. Commonly used in Japan for processing health food and functional beverages. Different processing methods, temperatures, and drying conditions will have an impact on the chemical composition and pharmacological effects of black dried ginger. Its chemical components are mainly volatile oil and gingerol compounds, which have anti-inflammatory, anti-tumor, and antioxidant effects. However, there is currently limited research on black dried ginger both domestically and internationally, and there is a lack of corresponding quality control evaluation standards. This article systematically reviews the research progress on the processing methods, chemical components, and pharmacological effects of black dried ginger, and predicts and analyzes the quality indicators, providing a reference for the establishment and development of quality standards for black dried ginger.
Research Status and Development Strategy Analysis of Lycii fructus Medicinal and Edible Products
TONG Li-mei, JIANG Yin-xiu, GUO Sheng, ZHANG Fang, DUAN Jin-ao
2023, 39(9): 943-953. doi: 10.14148/j.issn.1672-0482.2023.0943
[Abstract](334) [FullText HTML] (31) [PDF 3526KB](39)
Abstract:
Lycii fructus is one of the officially approved medicinal materials with homologous medicinal and food sources. With the effects of nourishing the essence and eyesight, nourishing the liver and kidneys and diverse health functions, Lycii fructus has strong market demand and broad application prospects. This article summarized and systematically analyzed the current research status of medicinal and edible homologous products of Lycii fructus from the aspect of type quantity, efficacy attribution and functional analysis, commonly used compatible medicinal materials, processing methods, and dosage form of Chinese patent drug, as well as the health functions and common dosage forms of registered health foods. Furthermore, prominent issues in the research and development were sorted and explored, and reactive development strategies for subsequent research were proposed to provide references for new product development, value realization, quality and performance improvement.
Discussion on the Protective Effect on the Myocardium of Medicinal and Edible Herb Couple of Corni Fructus-Glycyrrhizae Radix et Rhizoma Praeparata cum Melle Based on the Theory of Nourishing Yin with Sour and Sweet Tastes
JI Xun, LIANG Hui, SHI Yang-kai, ZHANG Yu, REN Meng-jiao, YU Li, WEI Kai-feng, LIU Tao
2023, 39(9): 954-960. doi: 10.14148/j.issn.1672-0482.2023.0954
[Abstract](210) [FullText HTML] (55) [PDF 2119KB](17)
Abstract:
Because of the high safety of medicinal and edible herbs, they are increasingly used in the prevention and treatment of diseases, especially chronic diseases. Myocardial related diseases caused by various myocardial injuries often have poor prognosis, which is an important problem needed to be solved urgently in clinic. Based on a large number of clinical practice experience of Professor WEI Kai-feng and modern pharmacological research, it is found that treatment of Nourishing Yin with Sour and Sweet Tastes has obvious curative effect on chronic cardiomyopathy. In order to facilitate long-term drug use, we conducted literature and experimental research on the varieties of medication-food homologous Chinese medicinal materials under the guidance of the theory of Nourishing Yin with Sour and Sweet Tastes, and finally focused on the improvement of myocardial injury by Corni Fructus-Glycyrrhizae Radix et Rhizoma Praeparata cum Melle drug pair. This article will discuss the theory of Nourishing Yin with Sour and Sweet Tastes, and the research status of Corni Fructus-Glycyrrhizae Radix et Rhizoma Praeparata cum Melle drug pair in alleviating myocardial injury under the guidance of this theory, in order to promote the application of varieties with the medicinal and edible herbs, and better serve for clinical problem solving.
Development of Big Health Products Based on Classic Famous Prescriptions and Homology of Medicine and Food
JI Jing, ZHANG Yun-yu, WANG Ling-chong, CHENG Jian-ming, WU Hao
2023, 39(9): 961-966. doi: 10.14148/j.issn.1672-0482.2023.0961
[Abstract](138) [FullText HTML] (129) [PDF 1974KB](54)
Abstract:
This article comprehensively elaborates on the development trend of medicinal and food homologous classic formulas from various aspects such as national guidance policies in recent years and the advantages and disadvantages of the development of medicinal and food homologous classic formulas. Classic power was injected into the Chinese medicine health platform while integrating modern technological research and development capabilities and developing products that are widely applicable and easily accepted by modern people. It has formed a development strategy for classic formula products based on traditional Chinese medicine theory, with medicinal and food homologous substances as raw materials, and embodying the modernization and application of traditional Chinese medicine as the goal.

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