南京中医药大学学报

A Six-Dimension Syndrome Differentiation Approach Based on Membrane System Theory

MA Xue-yan, TIAN Yuan-Shuo, WANG Yang, QIN Xue-ying, LIU Tie-gang, GU Xiao-hong

2023, 39(8): 701-706. doi: 10.14148/j.issn.1672-0482.2023.0701

[Abstract](270) [FullText HTML] (39) [PDF 1902KB](71)

Abstract:
This article explores the dialectical approach based on membrane theory by identifying the cause, nature, location, stage, trend, and pathology of the disease. It emphasizes that when identifying the cause of the disease, comprehensive consideration should be given to the pathogenic factors and the syndromes within the membrane system, and attention should be paid to the dynamic nature of the cause; when identifying the nature of the disease, pay attention to the cold and hot attributes, especially the cold and hot inclusions caused by membrane blockage; when identifying the location of the disease, determine whether there is multi-system membrane damage; when identifying the stage of the disease, it is necessary to distinguish Wei, Qi, Ying, blood stages; when identifying the tendency of the disease, compare and analyze the change of healthy and evil Qi; When identifying the pathology of the disease, it is necessary to determine whether there are changes such as membrane Qi block, abnormal water and liquid metabolism, and coexistence of contradictory pathological states. The article emphasizes the understanding of the physiological and pathological characteristics of the systemic membrane system from the perspective of the holistic view and system theory, which provides references for clinical diagnosis and treatment of diseases, especially infectious diseases, multi-system diseases and syndromes, recurrent diseases and syndromes, and difficult diseases and syndromes with unknown etiology.

Discussion on Treatment of Glucose and Lipid Metabolism Diseases from the Perspective of Mutual Interference of Clear and Turbid Qi

ZHANG Yong, ZHANG Xiao-bo, SHEN Tao

2023, 39(8): 707-714. doi: 10.14148/j.issn.1672-0482.2023.0707

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Abstract:
The mutual interference of clear and turbid qi refers to the imbalance between the rise and fall of clear qi and turbid qi: the failure of clear qi to rise and turbid qi to fall, and the obstruction of the transfer of fine substances, which become a summary of the pathogenesis of endogenous turbid pathogens. Bile acids can regulate the body's glucose and lipid metabolism and energy metabolism by activating bile acid receptors, which is an important way for the intestinal tract to regulate the homeostasis of glucose and lipid metabolism. It is proposed that the receptor of intestinal bile acid is the biological basis of the mutual interference of clear and turbid qi theory; the mutual interference of clear and turbid qi, as well as the endogenous turbid pathogens, are the key pathogenesis of glucose and lipid metabolism diseases in traditional Chinese medicine; and ascending clear qi and lowering turbid qi is an important treatment method in traditional Chinese medicine for the prevention and treatment of glucose and lipid metabolism diseases. Under the guidance of the mutual interference of clear and turbid qi theory, regulating the intestinal bile acid receptors to treat glucose and lipid metabolism diseases is of great value in clarifying the modern biological basis of the "mutual interference of clear and turbid qi" theory, and provides new ideas for TCM to treat glycolipid metabolic diseases.

Syndrome Differentiation and Treatment of Monkeypox Based on Traditional Chinese Medicine's Understanding of Variola

WAN Jin-sheng, LIU Tao

2023, 39(8): 715-719. doi: 10.14148/j.issn.1672-0482.2023.0715

[Abstract](252) [FullText HTML] (59) [PDF 1047KB](43)

Abstract:
Studying the understanding and treatment experience of ancient physicians on the etiology and pathogenesis of variola has important guiding significance for the use of traditional Chinese medicine theories and methods to prevent and treat monkeypox. By reviewing the understanding of physicians from the Western Jin Dynasty to the Qing Dynasty on the etiology, pathogenesis, diagnosis, differentiation, treatment and prevention of variola, this study aims to explore the origin and development of variola diagnosis and treatment, in order to provide ideas and methods for clinical research on the prevention and treatment of monkeypox disease.

TCM Countermeasures for Common Clinical Problems of Refractory Mycoplasma Pneumoniae Pneumonia

DAI Lin-xin, XIE Jing

2023, 39(8): 720-727. doi: 10.14148/j.issn.1672-0482.2023.0720

[Abstract](263) [FullText HTML] (27) [PDF 1134KB](32)

Abstract:
Refractory mycoplasma pneumoniae pneumonia (RMPP) is developed from mycoplasma pneumoniae pneumonia (MPP). The incidence rate among children shows a rising trend year by year, and it is likely to be complicated by multiple organ injuries if the course is prolonged. Aiming at the current common clinical problems of RMPP, this paper summarizes the TCM treatment experience and countermeasures to provide a reference for the clinical treatment and research of RMPP.

Liuwei Dihuang Formula Ameliorates Aberrant Cholesterol Metabolism in Postmenopausal APOE^-/- Mice by Regulating Intestinal Microbiota and Bile Acid Metabolism

ZHANG Shu-rui, FENG Han, DING Xue, ZHU Rui-gong, ZHANG Qi-chun, LI Yu, MENG Qing-hai, BIAN Hui-min

2023, 39(8): 728-737. doi: 10.14148/j.issn.1672-0482.2023.0728

[Abstract](307) [FullText HTML] (39) [PDF 3949KB](42)

Abstract:
OBJECTIVE To investigate the regulation of intestinal microbiota and bile acid metabolism by Liuwei Dihuang formula (LW) to ameliorate postmenopausal cholesterol metabolism abnormalities and its possible mechanism of action. METHODS APOE^-/- mice with bilateral ovariectomy were given a high-fat diet to replicate the postmenopausal cholesterol abnormality model, 0.13 mg·kg^-1 estrogen and 9.0 g·kg^-1 LW were used for treatment. The levels of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-c) and high-density lipoprotein cholesterol (HDL-c) in serum, TC in liver and feces were measured by biochemical methods. The levels of tumor necrosis factor α (TNF-α), interleukin-6 (IL-6) and interleukin-1β (IL-1β) in serum were measured by enzyme-linked immunoassay. The levels of total bile acids (TBA) in the liver, serum, gallbladder and feces were measured by biochemical methods. Hepatic lipid damage was observed by HE and oil red staining. Fecal bile acids were quantified by ultra-performance liquid chromatography-mass spectrometry (UPLC-MS). 16S rRNA sequencing was used to analyze the colonic microbiota of mice. The correlation between postmenopausal fecal bile acid fractions and intestinal microbiota was analyzed. RESULTS LW reduced serum TC, TG, LDL-c as well as TNF-α, IL-1β, IL-6 levels (P < 0.01) and increased HDL-c level in models (P < 0.01). LW ameliorated liver injury and reduced liver lipid accumulation. LW also reduced serum, gallbladder and hepatic TBA levels (P < 0.01) and increased fecal TBA excretion (P < 0.01); it also reduced fecal levels of conjugated bile acids such as TαMCA, TβMCA, TCA, TCDCA, TDCA and CA(P < 0.05, P < 0.01) and increased the level of secondary bile acid LCA (P < 0.01). LW restored the balance of colonic microbiota in model mice, upregulated the relative abundance of Allobaculum (P < 0.01), and downregulated the relative abundance of Oscillospira and Prevotella (P < 0.05). CONCLUSION LW ameliorates the cholesterol abnormalities in model mice by reshaping the composition of the colonic microbiota to restore the balance of the microbiota and increasing the excretion of fecal secondary bile acids to reduce cholesterol deposition in the serum and liver.

Mechanism of Yi Ceng Application in Alleviating Synovial Fibrosis Induced by Transforming Growth Factor-β1 in Rats with Knee Osteoarthritis Based on PI3K/AKT/HIF-1α Signal Pathway

LIU De-ren, LIAO Tai-yang, WEI Yi-bao, FANG Yuan, WANG Pei-min, MAO Jun, WU Peng

2023, 39(8): 738-745. doi: 10.14148/j.issn.1672-0482.2023.0738

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Abstract:
OBJECTIVE To investigate the effect of Yi Ceng application on the expression of TGF-β1, α-SMA and COL1A1 in synovial fibrosis of rats with knee osteoarthritis (KOA) and the regulation of PI3K/AKT/HIF-1α signal pathway. METHODS 30 SPF SD rats were randomly divided into blank group, model group and Yi Ceng group. The animal model of synovial fibrosis of knee joint was established with 200 ng transforming growth factor-β1 (TGF-β1) recombinant protein, once every 2 days, lasting for 3 times. After 14 days of modeling, the synovial tissue was obtained after the external application of Yi Ceng for 28 days. HE and Masson staining were used to observe the pathological changes of synovium. The expression of p-PI3K, p-AKT, HIF-1α, TGF-β1, α-SMA and COL1A1 in synovium was detected by immunohistochemistry. Fibroblast-like synoviocytes (FLSs) were isolated from the knee joint of male SD rats and induced with 10 ng·mL^-1 TGF-β1 for 24 h to establish KOA synovial fibrosis cell model, then intervened with Yi Ceng freeze-dried powder for 24 h. PI3K, p-PI3K, AKT, p-AKT, HIF-1α, TGF-β1, α-SMA and COL1A1 protein expressions in synoviocytes were detected by Western blot. HIF-1α, TGF-β1, α-SMA and COL1A1 mRNA expressions in synoviocytes were detected by qPCR. RESULTS Compared with the control group, the synovitis and synovial fibrosis of the model group were significantly aggravated (P < 0.01) in HE and Masson staining, and the expressions of p-PI3K, p-AKT, HIF-1α, TGF-β1, α-SMA and COL1A1 were increased (P < 0.01). The protein expressions of p-PI3K/PI3K, p-AKT/AKT, HIF-1α, TGF-β1, α-SMA and COL1α1 in synoviocytes were increased (P < 0.05, P < 0.01), and the mRNA expressions of HIF-1α, TGF-β1, α-SMA and COL1A1 in synoviocytes were increased (P < 0.01). Compared with the model group, synovitis and synovial fibrosis were improved, and the expression levels of p-PI3K, p-AKT, HIF-1α, TGF-β1, α-SMA and COL1A1 were decreased in the Yi Ceng group (P < 0.05, P < 0.01).The protein expressions of p-PI3K/PI3K, p-AKT/AKT, HIF-1α, TGF-β1, α-SMA and COL1A1 were decreased (P < 0.05), and mRNA levels of HIF-1α, TGF-β1, α-SMA and COL1A1 were downregulated (P < 0.05, P < 0.01). CONCLUSION Yi Ceng application can effectively improve the synovial fibrosis induced by recombinant TGF-β1 in KOA rats by decreasing the expression of TGF-β1, α-SMA and COL1A1 via the PI3K/AKT/HIF-1α signal pathway.

Effects of Chaihu Plus Longgu Muli Decoction on Microglial Polarization and Synaptic Plasticity in Post-Stroke Depressed Rats

LIU Yuan-yue, HU Dan, DING Cai-xia, LI Chuan-you, XIAO Jing, LI Ting-ting, GUO Xue-yan, SHENG Lei

2023, 39(8): 746-752. doi: 10.14148/j.issn.1672-0482.2023.0746

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OBJECTIVE To investigate the effects of Chaihu Plus Longgu Muli Decoction on behavior, microglial polarization and synaptic plasticity in post-stroke depression model (PSD) rats. METHODS 50 SD rats were divided into sham operation group, model group, and low, medium and high dose groups of Chaihu Plus Longgu Muli Decoction. After middle cerebral artery occlusion (MCAO) operation, chronic unpredictable mild stimulation (CUMS) was performed for 4 weeks, PSD model was established, and Chaihu Plus Longgu Muli Decoction was treated. After treatment, Longa nerve function score was measured, and depression-like manifestations were detected by sucrose preference test and forced swimming test. The expression levels of inflammatory factors interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-10 (IL-10) and tumor necrosis factor-α (TNF-α) in hippocampus were determined by enzyme-linked immunosorbent assay (ELISA). The expression levels of CD16/CD32, CD206 and postsynaptic dense protein-95 (PSD95) in the hippocampus of rats were labeled and quantified by immunofluorescence and Western blot. The synaptic ultrastructure was detected by radio microscopy and the synaptic structure was visualized. RESULTS Compared with the sham operation group, the sucrose preference rate of rats in the model group decreased (P < 0.01), the static time of forced swimming experiment was prolonged (P < 0.01), the expression levels of inflammatory cytokines IL-1β, IL-6 and TNF-α in the hippocampus region and the fluorescence intensity of CD16/CD32 protein in M1 phenotype were increased(P < 0.01), PSD-95, CD206 protein levels were significantly decreased(P < 0.05, P < 0.01), CD16 protein level was increased (P < 0.01). Compared with the model group, the above indexes in the medium and high dose groups of Chaihu Plus Longgu Muli Decoction were significantly improved (P < 0.01). CONCLUSION Chaihu Plus Longgu Muli Decoction can improve the behavioral changes related to post-stroke depression in PSD model rats, and the mechanism may be related to the regulation of microglial polarization and anti-inflammatory, thereby improving synaptic plasticity.

Medication Rule and Molecular Mechanism of Chinese Medicine in the Treatment of Diminished Ovarian Reserve Based on Data Mining and Network Pharmacology

CUI Shu-na, LIN fei, ZHU Yue, JIN Xue-ning, HUANG Dan, CHEN Ting-ting, YANG Han, LI Shi-hua

2023, 39(8): 753-763. doi: 10.14148/j.issn.1672-0482.2023.0753

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OBJECTIVE To explore the medication patterns of traditional Chinese medicine in treating diminished ovarian reserve (DOR), summarize the characteristics of the disease and medication ideas, and reveal the material basis and mechanism of action of commonly used medicines in clinical practice by data mining technology and network pharmacology approach. METHODS Collect clinical literature related to the treatment of DOR from China National Knowledge Infrastructure (CNKI). Extract prescription information, establish a medication database, and analyze the distribution of syndrome types and medication patterns. Use network pharmacology methods to elucidate the key targets and molecular mechanisms of high-frequency medicine combinations with the effects of tonifying the kidney and nourishing Yin and blood in the treatment of DOR with liver and kidney Yin deficiency syndrome. RESULTS 64 prescriptions and 120 traditional Chinese medicines were screened from the database. The commonly used and strongly correlated medicines for DOR treatment were Cuscuta chinensis, Rehmanniae Radix Praeparata, Angelica, Radix Paeoniae Alba, Epimedium brevicornu Maxim, Fructus Lycii. The combination of six high-frequency medicines contains 40 active components and 163 targets for treating DOR with liver and kidney Yin deficiency syndrome, involving PGR, ESR1, VEGFA, etc. The key signaling pathways mainly include cancer pathways, interactions between cytokines and their receptors, progestogen-mediated oocyte maturation, etc. CONCLUSION This paper preliminarily analyzed the compatibility law of traditional Chinese medicine in treating DOR, adhering to the essence of "kidney deficiency", with nourishing liver and kidney essence and blood as the main treatment principle, and supplemented by regulating qi, resolving blood stasis, strengthening the spleen, and soothing the liver. At the molecular level, the mechanism of high-frequency medicine combination treatment for DOR with liver and kidney Yin deficiency syndrome was revealed, which provided a theoretical basis for the development and clinical application of subsequent DOR medicine.

Study on the Characteristic Specturm and Color Change of Steamed Rehmanniae Radix Praeparata and Optimization of Processing Technology

LIU Liao-yuan, JI Yu-hua, WANG Wen-li, GAN Li-fan, HUANG Yao, ZENG Zhao-jun, ZHANG Zhi-peng

2023, 39(8): 764-774. doi: 10.14148/j.issn.1672-0482.2023.0764

[Abstract](130) [FullText HTML] (14) [PDF 3072KB](13)

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OBJECTIVE To optimize the processing technique of Shudihuang (Rehmanniae Radix Praeparata, RRP) by Box-Behnken response surface model based on the change rule of characteristic spectrum and color. METHODS Multivariate statistical methods including Pearson correlation analysis, cluster analysis, principal component analysis (PCA) and orthogonal partial least squares-discriminate analysis (OPLS-DA) were used to analyze the color changes and the peak area changes of the characteristic spectrum in the processing of RRP, and to screen key quality markers (Q-markers) for RRP. Q-markers were used to evaluate the effects of steaming time, drying temperature, and drying time on the quality of RRP, and the Box-Behnken response surface method was used to determine the optimal processing technique. RESULTS The established characteristic spectrum of Shengdihuang (Rehmanniae Radix, RR) and RRP marked 18 and 20 common peaks, respectively. Among them, peak 19(5-HMF)was a new chemical component produced after the processing of RR. There was a significant difference in color (ΔE^* > 12) after 2 h of evaporation, and the peak area of each characteristic was significantly different from RR. The ΔE^* of RRP at different steaming time points was 0.28~4.76, indicating that the color difference could not be recognized by the naked eye. RRP from different processing points could be clustered into 3 groups with chromaticity values L^*, a^*, b^*, E^* as variables, and RRP from different processing points could be clustered into 4 groups with chromaticity values L^*, a^*, b^*, E^*, and iridoid glycosides, phenylethanolglycosides and 5-HMF as variables. The optimum processing technique of steamed RRP was as follows: moistening water was 0.3 times the amount of medicinal material, moistening time was 24 h, steaming time was 2.17 h, drying temperature was 61.15 ℃, and drying time was 13.73 h. CONCLUSION The established response surface model is accurate and predictable, the established characteristic spectrum and the optimized processing method of RRP are stable and feasible. Combining with the color change rule of the processing process, it can provide a reference for comprehensive utilization and the quality control of RRP.

Effect of Modified Tianwang Buxin Dan on Functional Constipation with Mood Disorder Based on Resting State Functional Magnetic Resonance Imaging

ZHANG Dan, LIU Jia-li, ZHOU Mei-yu, LIU Han-song, QIAN Hai-hua

2023, 39(8): 775-782. doi: 10.14148/j.issn.1672-0482.2023.0775

[Abstract](137) [FullText HTML] (29) [PDF 2314KB](19)

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OBJECTIVE To investigate the effects of modified Tianwang Buxin Dan on constipation symptoms, mood disorders, serum 5-HT, substance P (SP) and vasoactive intestinal peptide (VIP) levels in patients with functional constipation, and to observe the changes in brain function of patients before and after treatment with resting state functional magnetic resonance imaging (fMRI). METHODS A total of 70 functional constipation patients with Yin deficiency and intestinal dryness and treated at the proctology department of Jiangsu Provincial Hospital of Traditional Chinese Medicine from August 2021 to March 2022 were randomly divided into a treatment group and a control group, with 35 cases each (5 cases dropped out of the control group and 6 cases dropped out of the treatment group). The control group was orally treated with polyethylene glycol powder, and the treatment group was orally treated with modified Tianwang Buxin Dan. The course of treatment for both groups was 8 weeks. Before and after treatment, the changes in TCM clinical symptoms and signs (including defecation interval, defecation difficulty level, and faces characteristics) of the two groups of patients were observed, and the Hamilton depression scale (HAMD), Hamilton anxiety scale (HAMA), and symptom checklist-90 (SCL-90) were adopted to evaluate the emotional and psychological state changes of the patients. Forty patients (21 patients in the treatment group and 19 patients in the control group) were randomly selected for brain resting state fMRI to analyze the characteristics of the amplitude of low-frequency fluctuations (ALFF). RESULTS After treatment, the TCM clinical symptoms and signs in both groups of patients were significantly improved (P < 0.05, P < 0.01), the HAMD score, HAMA score, and depression and anxiety factors in SCL-90 were significantly improved (P < 0.05), the therapeutic efficacy of the treatment group was superior to the control group (P < 0.05, P < 0.01). The levels of serum 5-HT and SP in both groups were significantly higher than those before treatment (P < 0.05), and the content of serum VIP was significantly reduced (P < 0.05), with the treatment group demonstrating better improvement (P < 0.05). fMRI scanning showed that after treatment, the brain activity of the anterior cingulate gyrus, orbitofrontal gyrus and hippocampus responsible for emotional regulation in the two groups decreased, and the brain activity of the auxiliary motor area responsible for somatic sensation and motor control and the precentral gyrus increased (P < 0.01). In addition, in the treatment group, decreased activity in the medial prefrontal cortex, amygdala, hypothalamus and other brain regions related to the emotional arousal network and hypothalamus pituitary adrenal (HPA) axis was noticed (P < 0.01). CONCLUSION The modified Tianwang Buxin Dan can not only alleviate the constipation symptoms of functional constipation patients, but also improve depression and anxiety scores. The mechanism may be related to regulating the activities of brain regions responsible for emotion, somatic sensation and HPA axis.

Clinical Efficacy of Jieyu Fuwei Powder Combined with Acupoint Catgut Embedding in the Treatment of Syndrome Functional Dyspepsia with Liver and Stomach Disharmony and Its Impact on Brain-Gut Peptides

JI Wei-peng, YANG Yan, LI Kun, JI Yu, TIAN Zu-cheng, DAI Hai-feng, CHEN An, GE Fei

2023, 39(8): 783-787. doi: 10.14148/j.issn.1672-0482.2023.0783

[Abstract](166) [FullText HTML] (32) [PDF 1045KB](26)

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OBJECTIVE To study the clinical efficacy of Jieyu Fuwei Powder combined with acupoint catgut embedding in the treatment of functional dyspepsia (FD) with liver and stomach disharmony and its impact on brain gut peptides. METHODS 62 cases of FD patients with chronic liver and stomach disharmony were enrolled in the digestive department and acupuncture and moxibustion department of Hai'an Hospital of Chinese Medicine, and were randomly divided into a control group and a treatment group, with 31 cases in each group (1 case dropped out of the control group). The control group was orally treated with mosapride citrate, and the treatment group was treated with Jieyu Fuwei Powder combined with acupoint catgut embedding. The clinical efficiency of the two groups was compared. Before and after treatment, the TCM syndrome score, modified severity of dyspepsia assessment (mSODA) score of the two groups of patients were observed, and serum levels of brain-gut peptides [Calcitonin gene related peptide (CGRP), Substance P (SP), Motilin (MTL), and Gastrin (GAS)] were detected. During the treatment, the adverse reactions of the two groups of patients were observed. RESULTS After treatment, the total effective rate of the treatment group was significantly higher than that of the control group (P < 0.05). The TCM syndrome scores of bilateral fullness, epigastric fullness, pain, and belching, as well as mSODA scores of the two groups of patients were improved compared to those before treatment (P < 0.05, P < 0.01), and the treatment group showed better efficacy than the control group (P < 0.05, P < 0.01). The levels of serum CGRP and SP in the two groups of patients were significantly decreased (P < 0.01), with average significant increases in MTL and GAS(P < 0.01), and the treatment group displayed better improvement than the control group (P < 0.05, P < 0.01). The incidence of adverse reactions in the treatment group was lower than that in the control group (P < 0.05). CONCLUSION Jieyu Fuwei Powder combined with acupoint catgut embedding is more effective than mosapride citrate group in the treatment of FD with liver and stomach disharmony, and its mechanism may be related to the regulation of brain-gut peptides.

Research Progress of TCM Prevention and Treatment of Female Reproductive Disorders Based on Mitochondrial Quality Control

FEI Yu-ye, MA Hua, SI Yu, REN Qing-ling

2023, 39(8): 788-793. doi: 10.14148/j.issn.1672-0482.2023.0788

[Abstract](241) [FullText HTML] (13) [PDF 1098KB](20)

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Female reproductive disorder is a clinical syndrome characterized by fertility disorder, which can cause infertility, recurrent abortion, abnormal in vitro embryonic development, etc, seriously reduce the quality of life of patients, and bring greater economic burden to the society. As a second messenger, mitochondria are involved in many key biological processes. Abnormal function of mitochondria can induce cell dysfunction and cause a series of reproductive disorders. Recent studies have found that mitochondrial quality control (MQC) imbalance, characterized by abnormalities in mitochondrial biogenesis, fusion and fission, autophagy and calcium regulation, plays an important role in female reproductive disorders. This study reviewed the progress of the role of MQC in female reproductive disorders, and summarized the traditional Chinese medicine treatment targeting MQC in the treatment of reproductive disorders, in order to provide reference and ideas for the study of treatment strategies for reproductive disorders.

Study on the Medicinal Value and Resource Evaluation of Jiangsu Genuine Medicinal Materials Binhai Baishouwu

TANG Jun-jie, GU Wei, QIAN Xu-dong, ZHANG Dao-guo, QIU Rong-li, WU Yin-zhi, FEI Xiao-meng, LIU Meng-xue, LANG Pei-lei, JU Rui-xin

2023, 39(8): 794-800. doi: 10.14148/j.issn.1672-0482.2023.0794

[Abstract](210) [FullText HTML] (20) [PDF 1908KB](17)

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This paper systematically combed and studied the herb textual research, efficacy and its material basis, and quality evaluation of Jiangsu genuine medicinal materials Binhai Baishouwu. Resource distribution, reserve, development and utilization status were also evaluated through literature review and field investigation. Binhai Baishouwu, scientifically named as Cynanchum auriculatum Royle ex Wight, is one of the species of the genus Cynanchum L. from the Asclepiadaceae family. It is one of the originals of Cynanchi Radix in herbal records with the functions of tonifying the liver and kidney, strengthening muscles and bones, nourishing blood and black hair, etc. Modern pharmacological studies show that it has the functions of anti-tumor, immune regulation and liver protection. C.auriculatum Royle ex Wight is distributed in 23 provinces, including Jiangsu and Shandong, and has been included in the standards for Chinese herbal medicine in provinces and cities such as Jiangsu, Hubei, Hunan, Guizhou, Sichuan, Chongqing, Anhui, etc. The development and utilization process of its medicinal value is slow. Binhai Baishouwu has a stable industrial foundation and a strong momentum of development, which has great room for improvement in standardized planting and deep integration of government, industry, university and research. These results laid the foundation for the further development and utilization of its industry.

2023 Vol. 39, No. 8

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