黄森兰, 祝茜茜, 陆姗姗, 宋芝超, 董洁, 王裔惟, 陈军. 中药挥发油透皮促渗苷类成分效果与经皮水分散失量的相关性研究[J]. 南京中医药大学学报, 2024, 40(5): 503-509. DOI: 10.14148/j.issn.1672-0482.2024.0503
引用本文: 黄森兰, 祝茜茜, 陆姗姗, 宋芝超, 董洁, 王裔惟, 陈军. 中药挥发油透皮促渗苷类成分效果与经皮水分散失量的相关性研究[J]. 南京中医药大学学报, 2024, 40(5): 503-509. DOI: 10.14148/j.issn.1672-0482.2024.0503
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HUANG Senlan, ZHU Xixi, LU Shanshan, SONG Zhichao, DONG Jie, WANG Yiwei, CHEN Jun. Research on the Correlation Between Transepidermal Glycoside Penetration Enhancement Effect and Transepidermal Water Loss Values of Essential Oils from Traditional Chinese Medicine[J]. Journal of Nanjing University of traditional Chinese Medicine, 2024, 40(5): 503-509. DOI: 10.14148/j.issn.1672-0482.2024.0503
Citation: HUANG Senlan, ZHU Xixi, LU Shanshan, SONG Zhichao, DONG Jie, WANG Yiwei, CHEN Jun. Research on the Correlation Between Transepidermal Glycoside Penetration Enhancement Effect and Transepidermal Water Loss Values of Essential Oils from Traditional Chinese Medicine[J]. Journal of Nanjing University of traditional Chinese Medicine, 2024, 40(5): 503-509. DOI: 10.14148/j.issn.1672-0482.2024.0503
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中药挥发油透皮促渗苷类成分效果与经皮水分散失量的相关性研究

Research on the Correlation Between Transepidermal Glycoside Penetration Enhancement Effect and Transepidermal Water Loss Values of Essential Oils from Traditional Chinese Medicine

    摘要
  • 摘要:
      目的  研究中药挥发油透皮促渗苷类成分效果与对经皮水分散失量(Transepidermal water loss, TEWL)的相关性。
      方法  采用HPLC法测定3种苷类成分(栀子苷、龙胆苦苷、芍药苷)的含量及油水分配系数，采用改良Franz扩散池法以离体SD大鼠腹部皮肤为透皮吸收屏障进行体外透皮实验，考察高良姜、干姜、薄荷、胡椒和吴茱萸5种中药挥发油对3种苷类成分的体外透皮促渗效果，采用经皮水分散失量评价5种中药挥发油对大鼠皮肤屏障功能的影响，通过相关性分析考察中药挥发油透皮促渗苷类成分效果与其对皮肤屏障功能影响之间的相关性。
      结果  高良姜油、干姜油、薄荷油、胡椒油能促进3种苷类成分的透皮吸收，也能显著降低大鼠的皮肤屏障功能，相关性分析结果表明中药挥发油对苷类成分的透皮促渗效果与其对皮肤经皮水分散失量的影响显著相关。
      结论  TEWL为中药挥发油透皮促渗剂的快速筛选提供了一种简便快捷的在体评价方法。

     

    Abstract:
      OBJECTIVE  To study the correlation between penetration enhancement effect and transepidermal water loss (TEWL) values of essential oils (EOs) from traditional Chinese medicine (TCM).
      METHODS  The amount of 3 kinds of glycosides(geniposide, gentiopicroside, paeoniflorin)and their oil-water partition coefficient were determined by HPLC. The penetration enhancement effect of the five EOs from Gaoliangjiang (Alpiniae Officinarum Rhizoma, AOR), Ganjiang (Zingiberis Rhizoma, ZR), Bohe (Menthae Haplocalycis Herba, MHH), Hujiao (Piperis Fructus, PF) and Wuzhuyu (Euodiae Fructus, EF) on geniposide, gentiopicroside, and paeoniflorin were performed by the modified Franz diffusion cell method with the abdominal skin of rats. The TEWL values were measured to evaluate the effect of the five EOs on the skin barrier function of rats. The correlation between penetration enhancement effect of EOs and their effect on skin barrier function was investigated by correlation analysis.
      RESULTS  AOR oil, ZR oil, MHH oil, and PF oil could improve the absorption of the three glycosides and reduce skin barrier function of rats. The results of correlation analysis showed that the penetration enhancement effect of EOs was significantly related to TEWL values following dermal administration of EOs.
      CONCLUSION  TEWL measurement technology provides a more convenient method for the selection of penetration enhancers.

     

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