Research Status and Prospect on the Houpu Mahuang Decoction
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摘要: 厚朴麻黄汤出自《金匮要略》, 是国家中医药管理局首批公布的百首经典名方之一, 是呼吸系统疾病常用方剂。对厚朴麻黄汤的化学成分、药效与作用机制及临床应用等方面的研究进行分析和梳理, 发现厚朴麻黄汤中主要含有生物碱类、黄酮类、糖苷类、木脂素类、挥发油类、酚类等成分, 具有抑制气道炎症、平喘、调节免疫、保护气道屏障等作用, 临床应用于慢性阻塞性肺疾病、慢性支气管炎、哮喘等疾病均取得较好疗效。未来可加强物质基础研究、质量标准及物质基准建立、深入机制探索、揭示药效科学内涵、提高临床研究证据质量、建立临床预测模型等多方面的研究, 为成方制剂的研发申报和新药的研发提供依据, 以期更好地回归临床, 服务于临床, 促进中医药现代化和国际化。Abstract: Houpu Mahuang Decoction, from the Essentials from the golden cabinet, is a commonly used prescription for respiratory diseases. In recent years, research on the pharmacology and mechanism of action of Houpu Mahuang Decoction has received some attention. It has been found that Houpu Mahuang Decoction plays a protective role in chronic airway diseases by inhibiting airway inflammation, relieving asthma, regulating immunity, and protecting airway barriers. Based on this, it is proposed to strengthen research on material basis, establish quality standards and material benchmarks, explore in-depth mechanisms, reveal the scientific connotation of drug efficacy, improve the quality of clinical research evidence, establish clinical prediction models, and other aspects in the future. This will provide a basis for the research and development of prescription formulations and new drugs, in order to better return to clinical practice, serve clinical practice, and promote the modernization and internationalization of TCM.
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Key words:
- Houpu Mahuang Decoction /
- classical formula /
- research status /
- prospect
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图 1 厚朴麻黄汤中厚朴的代表化合物结构
Figure 1. Representative compound structure of Mangnolia officinalis in Houpu Mahuang Decoction
图 2 厚朴麻黄汤中麻黄的代表化合物结构
Figure 2. Representative compound structure of ephedra in Houpu Mahuang Decoction
图 3 厚朴麻黄汤中苦杏仁的代表化合物结构
Figure 3. Representative compound structure of bitter almonds in Houpu Mahuang Decoction
图 4 厚朴麻黄汤中细辛的代表化合物结构
Figure 4. Representative compound structure of Asarum in Houpu Mahuang Decoction
图 5 厚朴麻黄汤中干姜的代表化合物结构
Figure 5. Representative compound structure of dried ginger in Houpu Mahuang Decoction
图 6 厚朴麻黄汤中半夏的代表化合物结构
Figure 6. Representative compound structure of Pinellia ternata in Houpu Mahuang Decoction
图 7 厚朴麻黄汤中五味子的代表化合物结构
Figure 7. Representative compound structures of Schisandra chinensis in Houpu Mahuang Decoction
图 8 厚朴麻黄汤作用机制相关的慢性气道疾病发病机制
Figure 8. The pathogenesis of chronic airway disease related to the action mechanism of Houpu Mahuang Decoction
表 1 厚朴麻黄汤临床应用所涉疾病的文献分布
Table 1. Literature distribution of diseases involved in the clinical application of Houpu Mahuang Decoction
疾病种类 文献篇数 文献支持度/% 慢性阻塞性肺疾病 76 57.25 慢性支气管炎 40 30.53 支气管哮喘 9 6.87 咳嗽 4 3.05 肺心病 1 0.76 慢性心力衰竭 1 0.76 支原体肺炎 1 0.76 
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