经典名方中金银花的本草考证

蔡芷辰; 刘训红; 曹宜; 陈仁寿; 程建明

doi:10.14148/j.issn.1672-0482.2023.1242

经典名方中金银花的本草考证

doi: 10.14148/j.issn.1672-0482.2023.1242

蔡芷辰^1,,
刘训红^{2, 3},
曹宜¹,
陈仁寿^{1, 3, ,},
程建明^{2, 3}

1.
南京中医药大学中医药文献研究院，江苏南京 210023
2.
南京中医药大学药学院，江苏南京 210023
3.
江苏省经典名方工程研究中心，江苏南京 210023

基金项目:

江苏省基础研究计划自然科学基金 BK20220479

江苏省普通高校自然科学研究项目 012071003734

详细信息

作者简介:
蔡芷辰, 女, 讲师, E-mail: caizhichen2008@126.com

通讯作者:
陈仁寿, 男, 教授, 博士生导师, 主要从事本草典籍与中医流派的研究，E-mail: njcrs@126.com

中图分类号: R282.71
计量
- 文章访问数: 197
- HTML全文浏览量: 22
- PDF下载量: 22
- 被引次数: 0
出版历程
- 收稿日期: 2023-06-15
- 网络出版日期: 2023-12-20
- 发布日期: 2023-12-10

Herbal Textual Research of Lonicerae Japonicae Flos in Famous Classical Prescriptions

CAI Zhi-chen^1
,,
LIU Xun-hong^{2, 3},
CAO Yi¹,
CHEN Ren-shou^{1, 3
, ,},
CHENG Jian-ming^{2, 3}

1.
Institute of Literature in Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China
2.
School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
3.
Jiangsu Engineering Research Center of Classical Prescriptions, Nanjing 210023, China

摘要

摘要: 金银花一名始载于南宋本草著作《履巉岩本草》, 宋以后, 金银花一名逐渐被后世延用, 成为药材正名。古代金银花的品种来源复杂, 自2005版《中国药典》记载忍冬Lonicera. japonica Thunb.为金银花的唯一来源。药用部位为花蕾或带初开的花, 多用生品, 炮制辅料以酒为主, 山东、河南为道地产区, 在头茬采收的花蕾品质更佳。基于当前考证结果，结合近现代的研究结果及资源栽培情况, 《古代经典名方目录(第一批)》所载3首含金银花的经典名方(即四妙勇安汤、五味消毒饮和托里消毒散)的应用和开发建议使用忍冬L. japonica Thunb.为基原, 山东、河南等道地产区的生品, 且优选头茬采收的二白至大白期的花蕾入药。并基于以上3首经典名方的临床应用文献和文献计量学方法分析得到方剂中金银花的常用剂量和平均剂量, 可作为经典名方开发时金银花的参考用量。
- 经典名方 /
- 金银花 /
- 本草考证 /
- 基原 /
- 药用部位 /
- 采收 /
- 剂量
Abstract: The name "Lonicerae Japonicae Flos" was first published in Materia Medica from Steep Mountainsides of the Southern Song Dynasty. After the Song Dynasty, the name was gradually used by later generations and became the proper name of medicinal materials. The origin of the varieties of LJF is complicated in ancient times. Since the 2005 edition of the Chinese Pharmacopoeia has stipulated that L. japonica Thunb. is the only source of LJF, and medicinal parts are buds or flowers with initial bloom. It is mostly used for raw products, and the processing accessories are mainly wine. Shandong and Henan are the genuine producing area, and the quality of flower buds harvested at the first crop is better. Based on current research results combined with modern research results and resource cultivation situation, the application and development of the classic prescriptions containing LJF (Simiao Yong'an Soup, Wuwei Disinfectant Drink and Tuoli Disinfection San) in the Catalogue of Ancient Classic Recipes (The First Batch) is suggested to use raw materials from Shandong, Henan, and other genuine producing areas with L. japonica Thunb. being the origin, and the buds harvested from the first crop during the second white to big white period were preferred for medicinal use. Based on the clinical application literature of famous classical prescriptions and bibliometric methods, the common dosage and average dosage of LJF in the three prescriptions were obtained, which could be used as the reference dosage of LJF in the development and utilization of famous classical prescriptions.
- famous classical prescriptions /
- Lonicerae Japonicae Flos /
- herbal textual research /
- origin /
- medicinal parts /
- harvesting time /
- dosage

HTML全文

图 1 《中华本草》《本草纲目》及《本草纲目彩色图谱》中金银花的基原和药材图

Figure 1. The origin and medicinal materials of LJF in Chinese Materia Medica, The Grand Compendium of Materia Medica and Colorful Atlas of "The Grand Compendium of Materia Medica"

下载: 全尺寸图片幻灯片

图 2 当今忍冬和灰毡毛忍冬的植物和药材

Figure 2. Plants and medicinal materials of L. japonica Thunb. and L. macranthoides Hand.-Mazz.

下载: 全尺寸图片幻灯片

表 1 现代金银花的基原及记载来源

Table 1. The origin and recorded sources of Lonicerae Japonicae Flos

名称	基原	记载来源
金银花	忍冬 L. japonica Thunb.、华南忍冬 L. confusa (Sweet)DC.、菰腺忍冬 L. hypoglauca Miq.、黄褐毛忍冬 L. fulvotomentosa Hsu et S.C. Cheng	《中药大辞典》(1977)
金银花	忍冬 L. japonica Thunb.、华南忍冬 L. confusa (Sweet)DC.、菰腺忍冬 L. hypoglauca Miq.、黄褐毛忍冬 L. fulvotomentosa Hsu et S.C. Cheng	《中华本草》(1999)
金银花	忍冬 L. japonica Thunb.	《中国药典》(1963)
金银花	忍冬 L. japonica Thunb.、红腺忍冬 L. hypoglauca Miq.、山银花 L. confusa DC. 或毛花柱忍冬 L. dasystyla Rehd.	《中国药典》(1977)
金银花	忍冬 L. japonica Thunb.、红腺忍冬 L. hypoglauca Miq.、山银花 L. confusa DC. 或毛花柱忍冬 L. dasystyla Rehd.	《中国药典》(1985)
金银花	忍冬 L. japonica Thunb.、红腺忍冬 L. hypoglauca Miq.、山银花 L. confusa DC. 或毛花柱忍冬L.dasystyla Rehd	《中国药典》(1990)
金银花	忍冬 L. japonica Thunb.、红腺忍冬 L. hypoglauca Miq.、山银花 L. confusa DC. 或毛花柱忍冬 L. dasystyla Rehd.	《中国药典》(1995)
金银花	忍冬 L. japonica Thunb.、红腺忍冬 L. hypoglauca Miq.、山银花 L. confusa DC. 或毛花柱忍冬 L. dasystyla Rehd.	《中国药典》(2000)
金银花山银花	忍冬 L. japonica Thunb. 灰毡毛忍冬 L. macranthoides Hand.-Mazz.、红腺忍冬 L. hypoglauca Miq.、华南忍冬 L. confusa DC. 或黄褐毛忍冬 L. fulvotomentosa Hsu et S. C. Cheng	《中国药典》(2005)
金银花山银花	忍冬 L. japonica Thunb. 灰毡毛忍冬 L. macranthoides Hand.-Mazz.、红腺忍冬 L. hypoglauca Miq.、华南忍冬 L. confusa DC. 或黄褐毛忍冬 L. fulvotomentosa Hsu et S. C. Cheng	《中国药典》(2010)
金银花山银花	忍冬 L. japonica Thunb. 灰毡毛忍冬 L. macranthoides Hand.-Mazz.、红腺忍冬 L. hypoglauca Miq.、华南忍冬 L. confusa DC. 或黄褐毛忍冬 L. fulvotomentosa Hsu et S. C. Cheng	《中国药典》(2015)
金银花山银花	忍冬 L. japonica Thunb. 灰毡毛忍冬 L. macranthoides Hand.-Mazz.、红腺忍冬 L. hypoglauca Miq.、华南忍冬 L. confusa DC. 或黄褐毛忍冬 L. fulvotomentosa Hsu et S. C. Cheng	《中国药典》(2020)

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表 2 3首经典名方中金银花剂量考证

Table 2. Name of prescriptions and research on the dosage of LJF in ancient literatures

方剂	方源	金银花剂量
四妙勇安汤	《验方新编》卷二	三两
托里消毒散	《陈氏小儿痘疹方论》	七分
	《伤寒全生集》卷四	-
	《古今医鉴》卷十五	三钱
	《外科正宗》卷一	一钱
	《张氏医通》卷十六	-
	《同寿录》卷三	-
五味消毒饮	《医宗金鉴》卷七十二	三钱
注：“-”表示该书中无金银花剂量记载。

下载: 导出CSV

表 3 现代临床文献中金银花的使用剂量(g)

Table 3. Dosage of Lonicerae Japonicae Flos in clinical literature studies of prescriptions (g)

方剂	常用量	最小量	最大量	平均用量
四妙勇安汤	30	10	120	39.5
五味消毒饮	15	6	50	20.2
托里消毒散	15	6	15	12.6

下载: 导出CSV

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