留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

基于图论探讨经方人工智能研究路径

刘畅 瞿溢谦 李煜 曹灵勇 林树元

刘畅, 瞿溢谦, 李煜, 曹灵勇, 林树元. 基于图论探讨经方人工智能研究路径[J]. 南京中医药大学学报, 2023, 39(10): 979-985. doi: 10.14148/j.issn.1672-0482.2023.0979
引用本文: 刘畅, 瞿溢谦, 李煜, 曹灵勇, 林树元. 基于图论探讨经方人工智能研究路径[J]. 南京中医药大学学报, 2023, 39(10): 979-985. doi: 10.14148/j.issn.1672-0482.2023.0979
LIU Chang, QU Yi-qian, LI Yu, CAO Ling-yong, LIN Shu-yuan. Discussion on Classical Formula Artificial Intelligence Research Path Based on Graph Theory[J]. Journal of Nanjing University of traditional Chinese Medicine, 2023, 39(10): 979-985. doi: 10.14148/j.issn.1672-0482.2023.0979
Citation: LIU Chang, QU Yi-qian, LI Yu, CAO Ling-yong, LIN Shu-yuan. Discussion on Classical Formula Artificial Intelligence Research Path Based on Graph Theory[J]. Journal of Nanjing University of traditional Chinese Medicine, 2023, 39(10): 979-985. doi: 10.14148/j.issn.1672-0482.2023.0979

基于图论探讨经方人工智能研究路径

doi: 10.14148/j.issn.1672-0482.2023.0979
基金项目: 

浙江省中医药管理局中医药现代化专项 2022ZZ010

浙江中医药大学横向(涉企)项目 2020-HT-837

详细信息
    作者简介:

    刘畅, 女, 住院医师, E-mail:acuwomen@126.com

    通讯作者:

    曹灵勇,男,教授,主要从事中医临床基础理论的研究,E-mail:caolingyong@163.com

    林树元,男,副教授,主要从事中医药人工智能的研究,E-mail:lin_shuyuan@foxmail.com

  • 中图分类号: R2-03

Discussion on Classical Formula Artificial Intelligence Research Path Based on Graph Theory

  • 摘要: 分析了经方理论与图论的相关性, 提出基于图论的经方人工智能(AI)研究路径,从逻辑推理和命题逻辑角度分析图论与经方理论、思维的相关性, 提出可行的研究路径。图论的应用能解决经方智能化研究中的知识表示问题, 图的属性和度量方法有助于从中医思维出发进行知识发现, 图的矩阵表示和图连通性能为经方智能辅助诊疗模型融入领域知识, 提升模型效率。图论可为经方AI研究提供理论指导, 基于图论的知识图谱等研究技术可为经方AI研究中的难题提供解决方案。

     

  • 图  1  矩阵示意图

    Figure  1.  Representation of matrix diagrams

    图  2  患者“症-证图”(举例)

    Figure  2.  Symptom-syndrome diagram of patients (example)

    图  3  “症-证图”与“药-证图”相应(举例)

    Figure  3.  Correspondence between symptom-syndrome diagram and medicine-syndrome diagram (example)

    图  4  通过“症-证图”分类判断六经病证

    Figure  4.  Determining the syndromes of the six meridians through the classification of symptom-syndrome diagram

    图  5  通过“药-证图”与“症-证图”匹配筛选“方证相应”路径

    Figure  5.  Filtering the formula-syndrome correspondence path by matching the medicine-syndrome diagram with the symptom-syndrome diagram

    图  6  六经分类模型与GCN提取图的空间特征示意图

    注: Gi为医案映射到知识图谱中获得的子图, Gj为其中一个六经病证标准子图, lL的列向量, U是以为单位特征向量的矩阵, λ为特征值, f为图中任意N维向量。

    Figure  6.  Schematic diagram of spatial features between the six-meridian classification model and GCN extraction diagram

    图  7  基于知识推理的方证相应示意图

    Figure  7.  Schematic diagram of formula-syndrome correspondence based on knowledge reasoning

  • [1] 白景瑄, 胡晓娟, 许家佗. 基于复杂网络技术的中医诊疗规律研究进展[J]. 时珍国医国药, 2020, 31(9): 2207-2209. https://www.cnki.com.cn/Article/CJFDTOTAL-SZGY202009051.htm

    BAI JX, HU XJ, XU JT. Research progress of TCM diagnosis and treatment law based on complex network technology[J]. Lishizhen Med Mater Med Res, 2020, 31(9): 2207-2209. https://www.cnki.com.cn/Article/CJFDTOTAL-SZGY202009051.htm
    [2] 王曦廷, 卢涛. 中医药认知计算: 概念、框架与路径[J]. 中华中医药杂志, 2022, 37(1): 35-40. https://www.cnki.com.cn/Article/CJFDTOTAL-BXYY202201006.htm

    WANG XT, LU T. Cognitive computation of Chinese medicine: Concept, framework and pathway[J]. China J Tradit Chin Med Pharm, 2022, 37(1): 35-40. https://www.cnki.com.cn/Article/CJFDTOTAL-BXYY202201006.htm
    [3] 卜月华, 王维凡, 吕新忠. 图论及其应用[M]. 2版. 南京: 东南大学出版社, 2015: 2.

    BU YH, WANG WF, LYU XZ. Graph Theory and Its Application[M]. 2nd ed. Nanjing: Southeast university press, 2015: 2.
    [4] FORTUNATO S. Community detection in graphs[J]. Phys Rep, 2010, 486(3/4/5): 75-174.
    [5] 许进, 张雷. DNA计算机原理、进展及难点(Ⅰ): 生物计算系统及其在图论中的应用[J]. 计算机学报, 2003, 26(1): 1-11. https://www.cnki.com.cn/Article/CJFDTOTAL-JSJX200301000.htm

    XU J, ZHANG L. DNA computer principle, advances and difficulties (Ⅰ): Biological computing system and its applications to graph theory[J]. Chin J Comput, 2003, 26(1): 1-11. https://www.cnki.com.cn/Article/CJFDTOTAL-JSJX200301000.htm
    [6] STAVRAKAS V, MELAS IN, SAKELLAROPOULOS T, et al. Network reconstruction based on proteomic data and prior knowledge of protein connectivity using graph theory[J]. PLoS ONE, 2015, 10(5): e0128411. doi: 10.1371/journal.pone.0128411
    [7] KEMPE D, KLEINBERG J, TARDOSE. Maximizing the spread of influence through a social network[C]//Proceedings of the ninth ACM SIGKDD international conference on Knowledge discovery and data mining. August 24-27, 2003, Washington, D.C. . New York: ACM, 2003: 137-146.
    [8] 樊新荣. 《伤寒论》三阳三阴病证的证素辨证研究[J]. 湖南中医药大学学报, 2015, 35(1): 41-43. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZX201501013.htm

    FAN XR. Syndrome-element study of the three-Yang and three-Yin differentiation in "treatise on febrile diseases"[J]. J Tradit Chin Med Univ Hunan, 2015, 35(1): 41-43. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZX201501013.htm
    [9] 贾春华. 基于命题逻辑的《伤寒论》方证理论体系研究[D]. 北京: 北京中医药大学, 2006.

    JIA CH. Research on the theoretical system of prescription and syndrome in treatise on febrile diseases based on propositional logic[D]. Beijing: Beijing University of Chinese Medicine, 2006.
    [10] 王鑫, 邹磊, 王朝坤, 等. 知识图谱数据管理研究综述[J]. 软件学报, 2019, 30(7): 2139-2174. https://www.cnki.com.cn/Article/CJFDTOTAL-RJXB201907016.htm

    WANG X, ZOU L, WANG CK, et al. Research review on knowledge graph data management[J]. J Softw, 2019, 30(7): 2139-2174. https://www.cnki.com.cn/Article/CJFDTOTAL-RJXB201907016.htm
    [11] 王松, 李正钧, 杨涛, 等. 中医药知识图谱研究现状及发展趋势[J]. 南京中医药大学学报, 2022, 38(3): 272-278. doi: 10.14148/j.issn.1672-0482.2022.0272

    WANG S, LI ZJ, YANG T, et al. Current status and development trend of knowledge graph research in traditional Chinese medicine[J]. J Nanjing Univ Tradit Chin Med, 2022, 38(3): 272-278. doi: 10.14148/j.issn.1672-0482.2022.0272
    [12] 虞红蕾, 曹灵勇, 瞿溢谦, 等. 消渴病经方知识图谱构建与知识发现[J]. 浙江中医药大学学报, 2022, 46(2): 113-119, 125. https://www.cnki.com.cn/Article/CJFDTOTAL-BHON202202001.htm

    YU HL, CAO LY, QU YQ, et al. Knowledge graph construction and knowledge discovery of classic prescriptions of diabetes disease[J]. J Zhejiang Chin Med Univ, 2022, 46(2): 113-119, 125. https://www.cnki.com.cn/Article/CJFDTOTAL-BHON202202001.htm
    [13] SAXENA A, CHAKRABARTI S, TALUKDAR P. Question answering over temporal knowledge graphs[EB/OL]. [2023-03-01]. https://arxiv.org/abs/2106.01515.
    [14] 魏泽林, 张帅, 王建超. 基于知识图谱问答系统的技术实现[J]. 软件工程, 2021, 24(2): 38-44. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGGC202102009.htm

    WEI ZL, ZHANG S, WANG JC. Implementation of question answering based on knowledge graph[J]. Softw Eng, 2021, 24(2): 38-44. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGGC202102009.htm
    [15] 郭超峰, 施学丽. 基于复杂网络理论的经方"方证相应"研究: 以桂枝汤为例[J]. 辽宁中医杂志, 2013, 40(3): 438-440. https://www.cnki.com.cn/Article/CJFDTOTAL-LNZY201303024.htm

    GUO CF, SHI XL. A study on the correspondence of prescriptions and syndromes in classical Chinese medicine based on complex network theory: Taking Guizhi Decoction as an example[J]. Liaoning J Tradit Chin Med, 2013, 40(3): 438-440. https://www.cnki.com.cn/Article/CJFDTOTAL-LNZY201303024.htm
    [16] 刘礼荣. 基于复杂网络的《金匮要略》病传规律研究[D]. 杭州: 浙江中医药大学, 2019.

    LIU LR. Study on the law of disease transmission of synopsis of golden chamber based on complex network[D]. Hangzhou: Zhejiang Chinese Medical University, 2019.
    [17] BLONDEL VD, GUILLAUME JL, LAMBIOTTE R, et al. Fast unfolding of communities in large networks[J]. J Stat Mech, 2008, 2008(10): P10008.
    [18] BAI YS, DING H, BIAN S, et al. SimGNN: A neural network approach to fast graph similarity computation[EB/OL]. [2023-03-01]. https://arxiv.org/abs/1808.05689.
    [19] SHUMAN DI, NARANG SK, FROSSARD P, et al. The emerging field of signal processing on graphs: Extending high-dimensional data analysis to networks and other irregular domains[J]. IEEE Signal Process Mag, 2013, 30(3): 83-98.
    [20] 杨涛, 朱学芳. 中医辨证智能化研究现状及发展趋势[J]. 南京中医药大学学报, 2021, 37(4): 597-601. doi: 10.14148/j.issn.1672-0482.2021.0597

    YANG T, ZHU XF. Discussion on the status and development trend of research on intellectualization of Chinese medicine syndrome differentiation[J]. J Nanjing Univ Tradit Chin Med, 2021, 37(4): 597-601. doi: 10.14148/j.issn.1672-0482.2021.0597
    [21] 刘震, 赵壮, 林祺, 等. 基于图论的智能针灸机器人取穴原理研究[J]. 世界中医药, 2018, 13(8): 1992-1996. https://www.cnki.com.cn/Article/CJFDTOTAL-SJZA201808043.htm

    LIU Z, ZHAO Z, LIN Q, et al. Research on the principle of intelligent acupuncture and moxibustion robot acupoint selection based on graph theory[J]. World Tradit Chin Med, 2018, 13(8): 1992-1996. https://www.cnki.com.cn/Article/CJFDTOTAL-SJZA201808043.htm
    [22] XU Q, GUO Q, WANG CX, et al. Network differentiation: A computational method of pathogenesis diagnosis in traditional Chinese medicine based on systems science[J]. Artif Intell Med, 2021, 118: 102134.
    [23] 尹丹, 周璐, 周雨玫, 等. 中医经方知识图谱"图搜索模式"设计研究[J]. 中国中医药信息杂志, 2019, 26(8): 94-98. https://www.cnki.com.cn/Article/CJFDTOTAL-XXYY201908019.htm

    YIN D, ZHOU L, ZHOU YM, et al. Study on design of graph search pattern of knowledge graph of TCM classic prescriptions[J]. Chin J Inf Tradit Chin Med, 2019, 26(8): 94-98. https://www.cnki.com.cn/Article/CJFDTOTAL-XXYY201908019.htm
  • 加载中
图(7)
计量
  • 文章访问数:  190
  • HTML全文浏览量:  23
  • PDF下载量:  23
  • 被引次数: 0
出版历程
  • 收稿日期:  2023-03-02
  • 网络出版日期:  2023-11-10
  • 发布日期:  2023-10-10

目录

    /

    返回文章
    返回