中医药靶向线粒体质量控制防治女性生殖障碍性疾病的研究进展

费玉叶; 马桦; 司雨; 任青玲

doi:10.14148/j.issn.1672-0482.2023.0788

中医药靶向线粒体质量控制防治女性生殖障碍性疾病的研究进展

doi: 10.14148/j.issn.1672-0482.2023.0788

费玉叶^1,,
马桦¹,
司雨¹,
任青玲^2, ,

1.
南京中医药大学第一临床医学院, 江苏南京 210023
2.
南京中医药大学附属医院, 江苏南京 210029

基金项目:

江苏省中医药管理局创新中心项目 ZX202102

江苏省教育厅研究生创新项目 SJCX22_0770

详细信息

作者简介:
费玉叶，女，硕士研究生, E-mail: 1278157649@qq.com

通讯作者:
任青玲，女，教授，主任医师，主要从事下生殖道感染性疾病研究, E-mail: yfy0047@njucm.edu.cn

中图分类号: R285.5
计量
- 文章访问数: 241
- HTML全文浏览量: 13
- PDF下载量: 20
- 被引次数: 0
出版历程
- 收稿日期: 2023-03-01
- 网络出版日期: 2023-08-17
- 发布日期: 2023-08-10

Research Progress of TCM Prevention and Treatment of Female Reproductive Disorders Based on Mitochondrial Quality Control

FEI Yu-ye^1
,,
MA Hua¹,
SI Yu¹,
REN Qing-ling^{2
, ,}

1.
The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, China
2.
The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China

摘要

摘要: 女性生殖障碍性疾病是以生育力障碍为特征的临床综合征, 可引起不孕、复发性流产、体外胚胎发育异常等, 严重降低患者生活质量, 给社会带来较大的经济负担。线粒体作为第二信使, 参与许多关键的生物过程, 其功能异常可诱导细胞功能障碍, 引起一系列生殖障碍性疾病的发生。近年来的研究发现, 以线粒体生物发生、融合与裂变、自噬及钙调节等异常为特征的线粒体质量控制(MQC)失衡在女性生殖障碍中发挥重要作用。该研究综述了MQC在女性生殖障碍性疾病中的作用进展, 总结了靶向MQC治疗生殖障碍性疾病的中医药治疗, 以期为生殖障碍性疾病的治疗策略研究提供借鉴及思路。
- 线粒体质量控制 /
- 女性生殖障碍 /
- 中医药 /
- 研究进展
Abstract: Female reproductive disorder is a clinical syndrome characterized by fertility disorder, which can cause infertility, recurrent abortion, abnormal in vitro embryonic development, etc, seriously reduce the quality of life of patients, and bring greater economic burden to the society. As a second messenger, mitochondria are involved in many key biological processes. Abnormal function of mitochondria can induce cell dysfunction and cause a series of reproductive disorders. Recent studies have found that mitochondrial quality control (MQC) imbalance, characterized by abnormalities in mitochondrial biogenesis, fusion and fission, autophagy and calcium regulation, plays an important role in female reproductive disorders. This study reviewed the progress of the role of MQC in female reproductive disorders, and summarized the traditional Chinese medicine treatment targeting MQC in the treatment of reproductive disorders, in order to provide reference and ideas for the study of treatment strategies for reproductive disorders.
- mitochondrial quality control /
- female reproductive disorder /
- traditional Chinese medicine /
- research progress

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