中医药表型组学相关术语释义与应用

王小强; 杜鑫; 曹谦; 田园; 姜小燕; 高晨皓; 刘子渝; 陶星星; 许婷; 雷明; 叶玲玉; 郭东更; 程海波; 段大跃

doi:10.14148/j.issn.1672-0482.2023.0210

中医药表型组学相关术语释义与应用

doi: 10.14148/j.issn.1672-0482.2023.0210

王小强^1,,
杜鑫¹,
曹谦¹,
田园¹,
姜小燕¹,
高晨皓¹,
刘子渝¹,
陶星星¹,
许婷¹,
雷明¹,
叶玲玉^{1, 2, 3},
郭东更³,
程海波⁴,
段大跃^{1, 2, 3, ,}

1.
西南医科大学附属中医医院中医药表型组学研究中心, 四川泸州 646000
2.
西南医科大学中西医结合研究所, 四川泸州 646000
3.
宁夏回族自治区人民医院自身免疫性疾病与精准医学重点实验室, 宁夏银川 750001
4.
南京中医药大学第一临床医学院, 江苏南京 210029

基金项目:

泸州市人民政府-西南医科大学高层次人才引进专项资助(段大跃团队)

国家中医药管理局中医药创新团队及人才支持计划项目 ZYYCXTD-C-202207

宁夏回族自治区自身免疫性疾病精准医学重点实验室项目基金宁科规划字(2020)16号

详细信息

作者简介:
王小强, 男, 住院医师, Email: 1032016926@qq.com

段大跃美国内华达州立大学医学院终身荣誉教授，西南医科大学中医药表型组学研究中心主任、特聘教授, 从事中西临床医学实践、药理学教学以及心血管药理学、离子通道、功能性基因组学和蛋白质组学、表型组学的研究40余年，国际著名心血管药理学家、离子通道及表型组学专家。2008年起开创了氯离子通道表型组学、心血管表型组学、中医药表型组学及表型组学等研究领域; 2017年建立西南医科大学中医药表型组学研究中心，创立了中医药表型组学学科，为传统中医药辨证论治和引领现代新精准医学科学发展提供创新性理论依据和科学标准

通讯作者:
段大跃, 男, 教授, 主要从事中医药表型组学研究, Email: dduan@swmu.edu.cn

中图分类号: R28
计量
- 文章访问数: 233
- HTML全文浏览量: 118
- PDF下载量: 41
- 被引次数: 0
出版历程
- 收稿日期: 2023-01-05
- 网络出版日期: 2023-03-21
- 发布日期: 2023-03-10

Interpretation and Application of Terms Related to Phenomics of Traditional Chinese Medicine

1.
Center for Phenomics, Hospital of Traditional Chinese Medicine Affiliated to Southwest Medical University, Luzhou 646000, China
2.
Institute of Integrated Chinese and Western Medicine, Southwest Medical University, Luzhou 646000, China
3.
Key Laboratory of Autoimmune Diseases and Precision Medicie, People's Hospital of Ningxia Hui Autonomous Region, Yinchuan 750001, China
4.
The First School of Clinical Medicine, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China

摘要

摘要: 中医药表型组学是研究传统中医药学的新兴学科。“表型”“表型组”和“表型组学”等作为舶来术语名词, 与传统中医药学原创术语的结合衍生出中医表型、证候表型、证候表型组、证候表型组学、复方药物表型组学、方剂组学等新术语。近年来, 学者们在中医药表型组学研究中对相关术语进行了概念诠释, 同时也产生了一些概念错位、术语误用、观点各异等问题, 故为了构建中医药表型组学研究体系, 有必要对中医药表型组学相关术语释义与应用进行正本清源与深度剖析, 以期在学科发展之初即建立统一的概念及术语, 为中医药表型组学的学科发展奠定坚实基础。
- 中医 /
- 证候 /
- 表型 /
- 表型组 /
- 表型组学
Abstract: Phenomics has been emerging as a new discipline for the study of traditional Chinese medicine (TCM), including zhenghou patterns and fang-ji. As imported terms, "phenotype", "phenome", and "phenomics" combined with the original TCM terms have derived new terminologies such as TCM phenotype, zhenghou phenotype, zhenghou phenome, zhenghou phenomics, fu-fang pharmacophenomics, fangjiomics etc. In recent years, investigators have made conceptual interpretations of relevant terms of TCM phenomics to develop a research system of TCM phenomics. However, this also resulted in problems and confusions with the misalignment of concepts, misuse of terms, and view discrepancies. It is therefore necessary to clarify the original sources of terminologies and analyze the terminologies in-depth to establish unified concepts and terminologies at the beginning of the development of the discipline and lay a solid foundation for the development of the discipline of TCM phenomics.
- traditional Chinese medicine /
- zhenghou /
- phenotype /
- phenome /
- phenomics

HTML全文

图 1 表型-基因型关系向表型组-基因组关系研究范式的变迁进程示意图

Figure 1. Schematic diagram of the transformation process from phenotype-genotype to phenome-genome research paradigm

下载: 全尺寸图片幻灯片

图 2 中医药表型组学概念及研究方法示意图

Figure 2. Scematic diagram of the concept and research method of TCM phenomics

下载: 全尺寸图片幻灯片

表 1 现代西医学与传统中医学对疾病的认识、定义和分类的区别

Table 1. Differences between modern western medicine and TCM in understanding, definition and classification of diseases

名称	现代西医学	传统中医学
疾病(Illness or sickness)	人体形态与功能偏离正常值范围的状态	人体偏离正常的阴阳动态平衡的状态
病(Disease)	基于解剖系统、器官、组织、细胞的临床表型特征及其特异的病理生理分子机制及病变发生发展规律定义病种并建立国际疾病分类法(ICD)	以整体观和阴阳五行学说, 基于脏腑、经络、气血精津、卫气营血、三焦、病因等理论对疾病发生发展全过程以及病情发展的独特规律定义病种
症(Symptom)	各个背离正常生理范围的异常现象, 包括症状与体征等, 即临床表型	阴阳失调的所有表现, 包括精气神、舌象、脉象等异常现象, 即临床表型
证(Zhenghou pattern)		根据中医特有的望闻问切四诊所获资料, 对病因、病位、病性、病机、病势、病人体质以及季节气候与周围环境等本质所作的综合概括, 即临床表型组

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