Meta-Analysis of Clinical Efficacy and Safety of Xijiao Dihuang Decoction Combined with Western Medicine in the Treatment of Anaphylactoid Purpura
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摘要:
结果 系统评价犀角地黄汤联合西药治疗过敏性紫癜的疗效与安全性。 方法 全面检索PubMed、CBM、CNKI等数据库, 收集犀角地黄汤联合西药治疗过敏性紫癜的随机对照试验。按纳入和排除标准对文献进行筛选、信息提取和质量评价。根据GRADE证据质量分级系统对结局指标进行评价, 采用RevMan5.3软件进行偏倚风险评估与Meta分析。 结果 共纳入23项研究, 1 919例患者。Meta分析显示, 相较于单纯的西药治疗方式, 联合了犀角地黄汤的中西结合疗法可以提高总有效率[RD=0.18，95%CI(0.15，0.21)，P < 0.01], 降低复发率[RD=-0.17, 95%CI(-0.334 5，-0.004 2)，P < 0.05]和不良反应率[RD=-0.05，95%CI(-0.090 5，-0.004 7)，P < 0.01], 减少紫癜消退时间[MD=-6.73, 95%CI(-10.58, -2.89), P < 0.01], 皮疹消退时间[MD=-3.08，95%CI(-4.25，-1.92)，P < 0.01], 消化道症状消退时间[MD=-3.49, 95%CI(-5.54, -1.43), P < 0.01], 腹痛消退时间[MD=-1.97，95%CI(-2.23，-1.71)，P < 0.01], 关节肿痛消退时间[MD=-6.60，95%CI(-8.88，-4.31)，P < 0.01]。各项结局指标的GRADE分级包括中、低和极低级。 结论 犀角地黄汤联合西药常规治疗可以提高过敏性紫癜的总有效率, 降低复发率, 改善各项临床症状的消退时间且不增加不良反应率。 Abstract:OBJECTIVE To systematically evaluate the efficacy and safety of Xijiao Dihuang decoction combined with western medicine in the treatment of anaphylactoid purpura. METHODS A comprehensive search of PubMed, CBM, CNKI and other databases was conducted to collect randomized controlled trials of Xijiao Dihuang decoction combined with western medicine in the treatment of anaphylactoid purpura. The literature was screened, information extracted and quality evaluated according to inclusion and exclusion criteria. The outcome indicators were evaluated according to the GRADE evidence quality grading system, and the risk of bias was assessed and Meta-analysis was performed using RevMan5. 3 software. RESULTS A total of 23 studies involving 1, 919 patients were included. Meta-analysis showed that compared with the simple western medicine treatment, the integrated Chinese and western medicine combined with Xijiao Dihuang decoction could improve the total effective rate[RD=0.18, 95%CI(0.15, 0.21), P < 0.01], reduce the recurrence rate [RD=-0.17, 95%CI(-0.334 5, -0.004 2), P < 0.05] and the adverse reaction rate [RD=-0.05, 95%CI(-0.090 5, -0.004 7), P < 0.01]. Besides, it could also reduce purpura regression time [MD=-6.73, 95%CI(-10.58, -2.89), P < 0.01], rash regression time [MD=-3.08, 95%CI(-4.25, -1.92), P < 0.01], gastrointestinal symptoms regression time [MD=-3.49, 95%CI(-5.54, -1.43), P < 0.01], abdominal pain regression time [MD=-1.97, 95%CI(-2.23, -1.71), P < 0.01], as well as joint swelling and pain regression time [MD=-6.60, 95%CI(-8.88, -4.31), P < 0.01]. The GRADE of outcome indicators included medium, low and extreme low levels. CONCLUSION Xijiao Dihuang decoction combined with conventional western medicine can improve the total effective rate of anaphylactoid purpura. In addition, it can reduce the recurrence rate, and the regression time of all clinical symptoms without increasing the adverse reaction rate. -
表 1 纳入研究文献的基本特征(x±s)
Table 1. Basic characteristics of the included study literature (x±s)
纳入研究 受试人数(男/女) 年龄/岁 干预措施 疗程 结局指标 试验组 对照组 叶圣国2005[8] T: 30(17/13)C: 30(18/12) — 常规治疗+犀角地黄汤 常规治疗 7 d ①③ 杨秀平2005[9] T: 90(53/37)C: 90(59/31) T: 9.56±1.17C: 9.69±2.26 常规治疗+犀角地黄汤 常规治疗 10~15 d ①② 郑文龙2008[10] 66(26/40)* — 常规治疗+犀角地黄汤 常规治疗 — ② 李浩良2014[11] T: 65(30/35)C: 63(29/34) — 常规治疗+犀角地黄汤 常规治疗 — ① 栾大丽2016[12] T: 45(21/24)C: 45(22/23) T: 7.7±2.8C: 7.5±3.1 常规治疗+犀角地黄汤 常规治疗 — ①③④⑥⑦⑧ 王文亮2017[13] T: 57(30/27)C: 57(29/28) T: 7.13±2.19C: 6.94±2.41 常规治疗+犀角地黄汤 常规治疗 — ①③④⑥⑦⑧ 陆丽芳2003[14] T: 38(23/15)C: 30(18/12) — 常规治疗+犀角地黄汤 常规治疗 14 d ① 翁晓文2009[4] 92(60/32)* — 常规治疗+犀角地黄汤 常规治疗 7 d ①② 周玉琴2013[15] T: 20(11/09)C: 20(12/08) T: 11.6±4.8C: 11.5±4.5 常规治疗+犀角地黄汤 常规治疗 21 d ①③ 姚菁华2010[16] T: 32(20/12)C: 32(19/13) — 常规治疗+犀角地黄汤 常规治疗 15 d ① 谷燕2017[17] T: 20(09/11)C: 20(12/08) T: 12.5±5.3C: 11.6±6.7 常规治疗+犀角地黄汤 常规治疗 21 d ① 邓军2012[18] T: 45(26/19)C: 45(23/22) T: 11.53±4.55C: 11.62±4.83 常规治疗+犀角地黄汤 常规治疗 21 d ①② 烟海丽2014[19] T: 40(27/13)C: 40(29/11) T: 7.81±2.87C: 7.60±3.14 常规治疗+犀角地黄汤 常规治疗 14 d ①⑤⑥⑧ 胡保华2013[20] T: 20(10/10)C: 20(11/09) — 常规治疗+犀角地黄汤 常规治疗 21 d ①② 张勇2018[21] T: 50(35/15)C: 50(30/20) T: 10.6±1.0C: 10.2±1.2 常规治疗+犀角地黄汤 常规治疗 14-28 d ① 牛晓华2016[22] T: 44(28/16)C: 44(26/18) T: 9.76±2.03C: 9.81±2.12 常规治疗+犀角地黄汤 常规治疗 14 d ①④⑥⑧ 赵长江2017[23] T: 81(49/32)C: 27(16/11) T: 6.71±2.52C: 7.01±2.73 常规治疗+犀角地黄汤 常规治疗 10 d ①③⑤⑥⑦ 尹艳2012[24] T: 30(20/10)C: 30(21/09) — 常规治疗+犀角地黄汤 常规治疗 7~14 d ①②⑤⑥⑦ 谌凌燕2015[25] T: 22(11/11)C: 23(12/11) T: 8.31±1.45C: 8.13±1.32 常规治疗+犀角地黄汤 常规治疗 6周 ① 李俊良2019[26] T: 35(20/15)C: 35(19/16) T: 7.11±2.52C: 7.34±2.62 常规治疗+犀角地黄汤 常规治疗 14 d ①④⑦ 王育红2019[27] T: 55(41/14)C: 55(40/15) T: 6. 79±2. 55C: 6. 75±2. 53 常规治疗+犀角地黄汤 常规治疗 10 d ①⑤⑥⑦ 任艳丽2019[28] T: 53(33/20)C: 53(34/19) T: 10.64±2.12C: 10.37±2.41 常规治疗+犀角地黄汤 常规治疗 14 d ①③ 王祥羽2020[29] T: 40(18/22)C: 40(21/19) T: 10.98±2.41C: 11.01±2.36 常规治疗+犀角地黄汤 常规治疗 — ①③④⑥⑦⑧ 注: 结局指标: ①总有效率; ②复发率; ③不良反应; ④紫癜消退时间; ⑤皮疹消退时间; ⑥关节肿痛消退时间; ⑦腹痛消退时间; ⑧消化道反应消退时间。T: 试验组; C: 对照组。*2组受试者总人数。“—”为未报告。 
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表 2 犀角地黄汤联合西药治疗过敏性紫癜GRADE证据评价
Table 2. GRADE evidence evaluation of Xijiao Dihuang decoction combined with western medicine for the treatment of anaphylactoid purpura
结局指标 文献数 研究局限性 结果不一致性 证据间接性 结果不准确性 发表偏倚 升级条件 证据质量等级 结局指标 总有效率 22 0 0 0 0 0 无 中 关键结局 复发率 4 0 -1a 0 -1b -1c 无 极低 重要结局 紫癜消退时间 5 0 -1a 0 -1b -1c 无 极低 重要结局 皮疹消退时间 4 0 -1a 0 0 0 无 中 重要结局 消化道症状消退时间 5 0 -1a 0 -1b -1c 无 极低 重要结局 腹痛消退时间 7 0 0 0 0 0 无 中 重要结局 关节肿痛消退时间 8 0 -1a 0 0 -1c 无 低 重要结局 不良反应率 8 0 0 0 0 0 无 中 关键结局 注: a.结果存在较大异质性; b.样本量偏少, 可信区间较宽; c.可能存在发表偏倚
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[1] 易著文. 小儿过敏性紫癜的诊断与治疗[J]. 中国实用儿科杂志, 2009, 24(11): 827-830. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSEK200911006.htmYI ZW. Diagnosis and treatment of pediatric anaphylactoid purpura[J]. Chin J Pract Pediatr, 2009, 24(11): 827-830. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSEK200911006.htm [2] PRAIS D, AMIR J, NUSSINOVITCH M. Recurrent henoch-schönlein Purpura in children[J]. J Clin Rheumatol, 2007, 13(1): 25-28. doi: 10.1097/01.rhu.0000255692.46165.19 [3] RIGANTE D. Clinical overview of vasculitic syndromes in the pediatric age[J]. Eur Rev Med Pharmacol Sci, 2006, 10(6): 337-345. [4] 翁晓文, 孙俏丽, 李青. 犀角地黄汤治疗小儿过敏性紫癜48例[J]. 中国实用医药, 2009, 4(30): 121-122. doi: 10.3969/j.issn.1673-7555.2009.30.085WENG XW, SUN QL, LI Q. Treatment of 48 cases of pediatric anaphylactoid purpura with Xijiao Dihuang decoction[J]. China Pract Med, 2009, 4(30): 121-122. doi: 10.3969/j.issn.1673-7555.2009.30.085 [5] 吴小红, 李雁. 犀角地黄汤主方治疗小儿过敏性紫癜的系统评价[J]. 甘肃医药, 2014, 33(1): 37-39. https://www.cnki.com.cn/Article/CJFDTOTAL-GSYY201401016.htmWU XH, LI Y. Systematic evaluation of the main formula of Xijiao Dihuang decoction in the treatment of pediatric anaphylactoid purpura[J]. Gansu Med J, 2014, 33(1): 37-39. https://www.cnki.com.cn/Article/CJFDTOTAL-GSYY201401016.htm [6] 胡亚美, 江载芳. 诸福棠实用儿科学[M]. 北京: 人民卫生出版社, 2002: 689.HU YM, JIANG ZF. Zhu Futang Textbook of Pediatrics[M]. Beijing: People's medical publishing house, 2002: 689. [7] 国家中医药管理局中医病证诊断疗效标准[M]. 南京: 南京大学出版社, 1994: 11.Diagnostic and Efficacy Criteria of Chinese Medicine by the National Administration of Traditional Chinese Medicine[M]. Nanjing: Nanjing university press, 1994: 11. [8] 叶圣国. 中西医结合治疗小儿过敏性紫癜疗效观察[J]. 辽宁中医学院学报, 2005, 7(2): 151. doi: 10.3969/j.issn.1673-842X.2005.02.040YE SG. Observation on the efficacy of combined Chinese and western medicine in the treatment of pediatric anaphylactoid purpura[J]. J Liaoning Coll Tradit Chin Med, 2005, 7(2): 151. doi: 10.3969/j.issn.1673-842X.2005.02.040 [9] 杨秀平, 李莉. 中西医结合治疗小儿过敏性紫癜疗效观察[J]. 四川中医, 2005, 23(1): 79-80. doi: 10.3969/j.issn.1000-3649.2005.01.056YANG XP, LI L. Efficacy of combined Chinese and western medicine in the treatment of pediatric anaphylactoid purpura[J]. Sichuan J Tradit Chin Med, 2005, 23(1): 79-80. doi: 10.3969/j.issn.1000-3649.2005.01.056 [10] 郑文龙, 黄宏, 方永福. 中西医结合治疗小儿过敏性紫癜31例疗效观察[J]. 齐齐哈尔医学院学报, 2008, 29(17): 2082. doi: 10.3969/j.issn.1002-1256.2008.17.021ZHENG WL, HUANG H, FANG YF. Efficacy of combined Chinese and western medicine in the treatment of pediatric anaphylactoid purpura in 31 cases[J]. J Qiqihar Med Coll, 2008, 29(17): 2082. doi: 10.3969/j.issn.1002-1256.2008.17.021 [11] 李浩良. 中西医结合治疗过敏性紫癜65例[J]. 河南中医, 2014, 34(8): 1587-1588. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZY201408087.htmLI HL. Combination of Chinese and western medicine in the treatment of anaphylactoid purpura in 65 cases[J]. Henan Tradit Chin Med, 2014, 34(8): 1587-1588. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZY201408087.htm [12] 栾大丽, 马桐生. 犀角地黄汤治疗小儿过敏性紫癜临床研究[J]. 河南中医, 2016, 36(4): 653-655. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZY201604039.htmLUAN DL, MA TS. The clinical research into allergicPurpura treated with modified Rhinoceros horn and Rehmannia decoction[J]. Henan Tradit Chin Med, 2016, 36(4): 653-655. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZY201604039.htm [13] 王文亮, 李红. 犀角地黄汤治疗小儿过敏性紫癜的临床疗效评价[J]. 临床医学工程, 2017, 24(3): 387-388. doi: 10.3969/j.issn.1674-4659.2017.03.0387WANG WL, LI H. Evaluation on the clinical effect of Rhinoceros horn and Rehmannia decoction in the treatment of children with allergic Purpura[J]. Clin Med Eng, 2017, 24(3): 387-388. doi: 10.3969/j.issn.1674-4659.2017.03.0387 [14] 陆丽芳. 犀角地黄汤治疗小儿过敏性紫癜的疗效[J]. 现代实用医学, 2003, 15(5): 299. doi: 10.3969/j.issn.1671-0800.2003.05.034LU LF. Efficacy of Xijiao Dihuang decoction in the treatment of pediatric anaphylactoid purpura[J]. Mod Pract Med, 2003, 15(5): 299. doi: 10.3969/j.issn.1671-0800.2003.05.034 [15] 周玉琴. 犀角地黄汤联合西药治疗小儿过敏性紫癜随机平行对照研究[J]. 实用中医内科杂志, 2013, 27(11): 95-96. https://www.cnki.com.cn/Article/CJFDTOTAL-SYZY201311051.htmZHOU YQ. When rhino horn to combined western medicine treatment of pediatric allergicPurpura random parallel control study[J]. J Pract Tradit Chin Intern Med, 2013, 27(11): 95-96. https://www.cnki.com.cn/Article/CJFDTOTAL-SYZY201311051.htm [16] 姚菁华. 犀角地黄汤加味治疗小儿过敏性紫癜32例疗效观察[J]. 吉林中医药, 2010, 30(9): 777-778. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYJL201009025.htmYAO JH. Efficacy of the modified Xijiao Dihuang decoction in the treatment of pediatric anaphylactoid purpura in 32 cases[J]. Jilin J Tradit Chin Med, 2010, 30(9): 777-778. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYJL201009025.htm [17] 谷燕, 李辉文, 施晓玲. 犀角地黄汤加味治疗皮肤型过敏性紫癜20例疗效观察[J]. 湖南中医杂志, 2017, 33(10): 72-73. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZO201710036.htmGU Y, LI HW, SHI XL. Efficacy of the modified Xijiao Dihuang decoction in the treatment of 20 Cases of cutaneous anaphylactoid purpura[J]. Hunan J Tradit Chin Med, 2017, 33(10): 72-73. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZO201710036.htm [18] 邓军. 犀角地黄汤加味治疗过敏性紫癜临床观察[J]. 中国民间疗法, 2012, 20(11): 34-35. https://www.cnki.com.cn/Article/CJFDTOTAL-ZMJL201211044.htmDENG J. Clinical observation on the treatment of anaphylactoid purpura with the modified Xijiao Dihuang decoction[J]. China's Naturopathy, 2012, 20(11): 34-35. https://www.cnki.com.cn/Article/CJFDTOTAL-ZMJL201211044.htm [19] 烟海丽. 犀角地黄汤加味治疗过敏性紫癜40例临床观察[J]. 中医儿科杂志, 2014, 10(3): 42-44. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYEZ201403018.htmYAN HL. Clinical observation of Xijiaodihuang Decoction in treating allergicPurpura in 40 cases[J]. J Pediatr Tradit Chin Med, 2014, 10(3): 42-44. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYEZ201403018.htm [20] 胡保华, 秦曼. 犀角地黄汤加味治疗过敏性紫癜40例临床观察[J]. 黑龙江中医药, 2013, 42(6): 21-22. https://www.cnki.com.cn/Article/CJFDTOTAL-HLZY201306015.htmHU BH, QIN M. Clinical observation of 40 cases of anaphylactoid purpura treated with the modified Xijiao Dihuang decoction[J]. Heilongjiang J Tradit Chin Med, 2013, 42(6): 21-22. https://www.cnki.com.cn/Article/CJFDTOTAL-HLZY201306015.htm [21] 张勇. 犀角地黄汤加减治疗过敏性紫癜的临床观察[J]. 临床医药文献电子杂志, 2018, 5(69): 134. https://www.cnki.com.cn/Article/CJFDTOTAL-LCWX201869126.htmZHANG Y. Clinical observation on the treatment of anaphylactoid purpura with the modified Xijiao Dihuang decoction[J]. Electr J Clin Med Liter, 2018, 5(69): 134. https://www.cnki.com.cn/Article/CJFDTOTAL-LCWX201869126.htm [22] 牛晓华. 犀角地黄汤加减治疗儿童过敏性紫癫的临床研究[J]. 当代医学, 2016, 22(3): 153-154. https://www.cnki.com.cn/Article/CJFDTOTAL-DDYI201603103.htmNIU XH. Clinical study on the treatment of pediatric anaphylactoid purpura with the modified Xijiao Dihuang decoction[J]. Contemp Med, 2016, 22(3): 153-154. https://www.cnki.com.cn/Article/CJFDTOTAL-DDYI201603103.htm [23] 赵长江, 苏小慰, 孙诗炜, 等. 犀角地黄汤加减联合西药治疗过敏性紫癜的疗效观察及对C-反应蛋白的影响[J]. 贵州医药, 2017, 41(12): 1287-1289. https://www.cnki.com.cn/Article/CJFDTOTAL-GZYI201712024.htmZHAO CJ, SU XW, SUN SW, et al. Observation on the efficacy of the modified Xijiao Dihuang decoction combined with western medicine in the treatment of anaphylactoid purpura and the effect on C-reactive protein[J]. Guizhou Med J, 2017, 41(12): 1287-1289. https://www.cnki.com.cn/Article/CJFDTOTAL-GZYI201712024.htm [24] 尹艳, 解德平, 解淑梅. 犀角地黄汤辅助治疗过敏性紫癜30例疗效观察[J]. 山东中医杂志, 2012, 31(12): 869, 871.YIN Y, XIE DP, XIE SM. Efficacy of Xijiao Dihuang decoction in the adjuvant treatment of anaphylactoid purpura in 30 cases[J]. Shandong J Tradit Chin Med, 2012, 31(12): 869, 871. [25] 谌凌燕, 林卓殷, 陈鹏, 等. 犀角地黄汤对小儿过敏性紫癜免疫机制的影响[J]. 按摩与康复医学, 2015, 6(22): 24-25. https://www.cnki.com.cn/Article/CJFDTOTAL-AMYD201522012.htmCHEN LY, LIN ZY, CHEN P, et al. Effect of rhinoceros Xijiao Dihuang decoction on the immune mechanism of pediatric anaphylactoid purpura[J]. Chin Manip Rehabilitation Med, 2015, 6(22): 24-25. https://www.cnki.com.cn/Article/CJFDTOTAL-AMYD201522012.htm [26] 李俊良, 周峰然. 犀角地黄汤加减治疗小儿过敏性紫癜(腹型)的临床观察[J]. 世界最新医学信息文摘, 2019, 19(43): 212. https://www.cnki.com.cn/Article/CJFDTOTAL-WMIA201943116.htmLI JL, ZHOU FR. Clinical observation on the treatment of pediatric anaphylactoid purpura (abdominal type) by the modified Xijiao Dihuang decoction[J]. World Latest Med Inf, 2019, 19(43): 212. https://www.cnki.com.cn/Article/CJFDTOTAL-WMIA201943116.htm [27] 王育红. 犀角地黄汤治疗过敏性紫癜的临床观察[J]. 光明中医, 2019, 34(5): 675-677. https://www.cnki.com.cn/Article/CJFDTOTAL-GMZY201905009.htmWANG YH. Clinical observation on Xijiao Dihuang Decoction in the treatment of allergicPurpura[J]. Guangming J Chin Med, 2019, 34(5): 675-677. https://www.cnki.com.cn/Article/CJFDTOTAL-GMZY201905009.htm [28] 任艳丽, 晁利芹. 加味犀角地黄汤辅治皮肤型过敏性紫癜临床观察[J]. 实用中医药杂志, 2019, 35(2): 176-178. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYAO201902141.htmREN YL, CHAO LQ. Clinical observation on the adjuvant treatment of cutaneous anaphylactoid purpura with the modified Xijiao Dihuang decoction[J]. J Pract Tradit Chin Med, 2019, 35(2): 176-178. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYAO201902141.htm [29] 王祥羽. 加昧犀角地黄汤治疗小儿过敏性紫癜的临床效果观察[J]. 世界最新医学信息文摘, 2020, 20(3): 184-186.WANG XY. Clinical observation on the treatment of pediatric anaphylactoid purpura by the modified Xijiao Dihuang Decoction[J]. World Latest Med Info, 2020(3): 184-186. [30] 张旻昱, 邹蓉, 张慧, 等. 银翘散合犀角地黄汤治疗过敏性紫癜33例临床研究[J]. 新中医, 2014, 46(1): 91-93. https://www.cnki.com.cn/Article/CJFDTOTAL-REND201401040.htmZHANG MY, ZOU R, ZHANG H, et al. Clinical study on 33 cases of anaphylactoid purpura treated with Yinxiao powder combined with Xijiao Dihuang decoction[J]. J New Chin Med, 2014, 46(1): 91-93. https://www.cnki.com.cn/Article/CJFDTOTAL-REND201401040.htm [31] 陈疏敏, 石琳, 吴艺, 等. 清热凉血法联合西药治疗小儿难治性过敏性紫癜[J]. 中国中医药信息杂志, 2006, 13(4): 52. https://www.cnki.com.cn/Article/CJFDTOTAL-XXYY200604027.htmCHEN SM, SHI L, WU Y, et al. Treatment of pediatric refractory anaphylactoid purpura by combining western medicine with clearing heat and cooling blood method[J]. Chin J Inf Tradit Chin Med, 2006, 13(4): 52. https://www.cnki.com.cn/Article/CJFDTOTAL-XXYY200604027.htm [32] 高艳华. 犀角地黄汤合五味消毒饮加减治疗儿童过敏性紫癜116例[J]. 中国中医药科技, 2012, 19(2): 183-184. https://www.cnki.com.cn/Article/CJFDTOTAL-TJYY201202070.htmGAO YH. Treatment of 116 cases of pediatric anaphylactoid purpura with Xijiao Dihuang decoction combined with Wuwei Xiaodu decoction[J]. Chin J Tradit Med Sci Technol, 2012, 19(2): 183-184. https://www.cnki.com.cn/Article/CJFDTOTAL-TJYY201202070.htm [33] 陈伟炳, 陈春妹, 范华云. 糖皮质激素联合犀角地黄汤治疗过敏性紫癜的临床观察[J]. 内科急危重症杂志, 2017, 23(6): 527-528. https://www.cnki.com.cn/Article/CJFDTOTAL-NKJW201706027.htmCHEN WB, CHEN CM, FAN HY. Clinical observation of glucocorticoids combined with Xijiao Dihuang decoction in the treatment of anaphylactoid purpura[J]. J Crit Care Intern Med, 2017, 23(6): 527-528. https://www.cnki.com.cn/Article/CJFDTOTAL-NKJW201706027.htm -
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