经皮给药系统促渗新技术新方法的研究进展

何金英; 张永萍

doi:10.14148/j.issn.1672-0482.2022.1043

经皮给药系统促渗新技术新方法的研究进展

doi: 10.14148/j.issn.1672-0482.2022.1043

何金英^1,,
张永萍^{1, 2, 3, ,}

1.
贵州中医药大学药学院, 贵州贵阳 550025
2.
贵州省民族药经皮给药工程技术研究中心, 贵州贵阳 550025
3.
国家苗药工程技术研究中心, 贵州贵阳 550025

基金项目:

国家自然科学基金面上项目 81873020

详细信息

作者简介:
何金英，女，硕士研究生，E-mail: 1971394557@qq.com

张永萍，二级教授，博士生导师。享受国务院特殊津贴专家，贵州省核心专家、省管专家，贵州省教学名师，国家中医药管理局中药药剂学重点学科带头人。现任国家苗药工程技术研究中心副主任，国家中医药管理局中药制剂实验室主任，贵州省中药民族药炮制与制剂工程技术研究中心主任，贵州省民族药经皮给药制剂工程技术研究中心副主任，贵州省药物新剂型新工艺科技创新人才团队”领衔人。兼任中华中医药学会中药制剂分会常委兼副秘书长，中国民族医药学会苗医药分会副会长等。作为第一第二完成人荣获教育部科技进步奖二等奖1项、省级科技进步一等奖1项、二等奖3项、三等奖6项

通讯作者:
张永萍，女, 教授, 博士生导师，主要从事中药及民族药新制剂、新剂型与新技术开发研究，E-mail: zgygpg@126.com

中图分类号: R283
计量
- 文章访问数: 278
- HTML全文浏览量: 140
- PDF下载量: 53
- 被引次数: 0
出版历程
- 收稿日期: 2022-07-19
- 网络出版日期: 2022-11-19
- 发布日期: 2022-11-10

Research Progress of New Technologies and Methods for Promoting Penetration of Transdermal Drug Delivery Systems

HE Jin-ying^1
,,
ZHANG Yong-ping^{1, 2, 3
, ,}

1.
School of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China
2.
Guizhou Province Traditional Chinese Medicine and Ethnic Medicine Processing and Preparation Engineering Technology Research Center, Guiyang 550025, China
3.
National Miao Medicine Engineering Technology Research Center, Guiyang 550025, China

摘要

摘要: 经皮给药可以避免口服给药后的胃肠道消化反应和肝脏首过效应、注射给药引起的疼痛，具有简、便、效、廉的特点, 受到越来越多人的关注。但经皮给药吸收效率低的问题阻碍了经皮药物的广泛应用。通过查阅相关文献发现, 近年来纳米载体促渗、中药挥发油促渗、物理促渗新方法新技术, 为提高经皮给药制剂的开发提供了新策略。重点从这3个方面进行归纳总结并分析存在的问题, 以期为经皮给药的制剂开发提供借鉴和参考。
- 经皮给药 /
- 纳米载体促渗 /
- 中药挥发油促渗 /
- 物理促渗 /
- 新技术
Abstract: In recent years, transdermal administration has been more and more popular because of its simplicity, convenience, efficacy and low cost because it can overcome the shortcomings of gastrointestinal digestive reaction after oral administration, liver first-pass effect, and pain caused by injection administration. more and more people's attention. However, solving the low absorption efficiency of transdermal administration has become a key problem in the research of modern pharmaceutical preparations. By consulting relevant literature, it is found that nanocarriers, new methods of promoting penetration of volatile oils of traditional Chinese medicine, and new technologies of physical penetration provide new ideas for improving the absorption efficiency of transdermal drug delivery; therefore, this paper focuses on summarizing and analyzing the existing In order to provide reference and reference for the new technology and new method of percutaneous permeation promotion for external use.
- transdermal drug delivery /
- nanocarriers to promote penetration /
- promoting penetration of volatile oils of TCM /
- physical penetration /
- new technology

HTML全文

图 1 立方液晶促渗作用

Figure 1. The permeation-promoting effect of cubosomes

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图 2 微乳促渗作用

Figure 2. The penetration-enhancing effect of microemulsion

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图 3 挥发油促渗作用

Figure 3. The permeation-promoting effect of volatile oil

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图 4 中药及其主要挥发油成分

Figure 4. Traditional Chinese medicine and its main volatile oil components

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图 5 纳米晶片促渗作用

Figure 5. The penetration-promoting effect of nanochips

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图 6 微针促渗作用

Figure 6. The effect of microneedles on promoting penetration

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图 7 负压促渗作用

Figure 7. The negative pressure to promote permeability

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