中药经皮给药制剂的分子药剂学研究进展

薛雅琪; 王著显; 梁佩仪; 陈鸿楷; 翟丹; 刘莉; 江翠平; 申春燕; 刘强

doi:10.14148/j.issn.1672-0482.2022.0983

中药经皮给药制剂的分子药剂学研究进展

doi: 10.14148/j.issn.1672-0482.2022.0983

南方医科大学中医药学院, 广东广州 510515

基金项目:

国家自然科学基金面上项目 82074023

国家自然科学基金面上项目 81874346

详细信息

作者简介:
薛雅琪, 女, 硕士研究生, E-mail: 1359986385@qq.com

刘强, 教授, 博士, 博士生导师, 博士后合作导师, 耶鲁大学访问学者。南方医科大学中医药学院中药制剂学教研室主任, 广东省高校中药化妆品工程技术研究中心主任, 广州市白云区中药化妆品行业创新实验室主任, 广东省教育部中药速效片剂产学研结合创新平台主任。研究方向包括: 传统中药制剂的作用机理研究; 中药制剂新剂型与新技术研究; 中药健康产品开发研究与名优中成药二次开发研究; 中药与3D打印研究和中药化妆品研究与开发。承担国家自然科学基金项目5项，广东省科技计划项目4项，广东省粤港合作项目1项, 广州市民生重大科技专项2项, 开发新产品17个, 发表SCI论文40余篇, 申请专利80多项，授权30项

通讯作者:
刘强, 男, 教授, 主要从事中药新剂型与新技术研究, E-mail: liuqiang@smu.edu.cn

中图分类号: R283
计量
- 文章访问数: 183
- HTML全文浏览量: 25
- PDF下载量: 77
- 被引次数: 0
出版历程
- 收稿日期: 2022-05-11
- 网络出版日期: 2022-11-19
- 发布日期: 2022-11-10

Advances in Molecular Pharmaceutics of Transdermal Drug Delivery Preparations of Traditional Chinese Medicine

School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China

摘要

摘要: 分子药剂学是从分子水平研究制剂作用规律与机理的学科, 它可阐明经皮给药制剂的成型原理以及药物、基质、生物机体三者之间的分子间相互作用影响制剂释药、经皮渗透行为的分子机制。近年来, 分子药剂学在经皮给药制剂中得到越来越多的应用。通过对分子药剂学在中药经皮给药制剂中的应用进行文献综述, 可以探讨中药经皮给药制剂在制剂成型、释药和渗透的分子间相互作用，以及阐明中药经皮渗透促进剂促进药物渗透皮肤的分子机制, 为分子药剂学在中药经皮给药制剂中的应用提供参考, 从而推动中药经皮给药制剂的开发和应用。
- 中药 /
- 经皮给药制剂 /
- 分子药剂学 /
- 研究进展
Abstract: Molecular pharmaceutics is a discipline that studies the law and mechanism of preparations at the molecular level. It can clarify the forming principle of transdermal drug delivery and the molecular mechanism of drug release and transdermal penetration affected by the molecular interaction among drugs, matrices and organisms. In recent years, molecular pharmaceutics has been applied more and more in transdermal drug delivery. In this paper, the application of molecular pharmaceutics in transdermal drug delivery preparations of traditional Chinese medicine was reviewed, and the molecular interaction of transdermal drug delivery in preparation, drug release and skin penetration, as well as the molecular mechanism of penetration enhancer in traditional Chinese medicine promoting drug penetration into skin was investigated. It provides reference for the application of molecular pharmaceutics in the study of transdermal drug delivery preparations, so as to promote the development and wide application of transdermal drug delivery preparations of traditional Chinese medicine.
- traditional Chinese medicine /
- transdermal drug delivery preparations /
- molecular pharmaceutics /
- research progress

HTML全文

表 1 分子药剂学其他研究技术检测内容及分子间相互作用类型

Table 1. Molecular pharmacy other research technology detection index and types of intermolecular interactions

研究技术	检测内容	分子间相互作用类型
FT-IR	特征官能团位移情况、峰宽变化以及是否有新峰生成	氢键相互作用
Raman	特征官能团位移情况、峰宽变化	氢键相互作用
DSC	玻璃转化温度(T_g)的变化	氢键相互作用
XPS	药物-基质分子的质子化状态	离子间相互作用
SSNMR	药物-基质间的离子键	离子间相互作用

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