基于结构中药学思维的中药研究方法探讨——以外用中药为例

乔宏志; 陈熹; 陈军; 狄留庆

doi:10.14148/j.issn.1672-0482.2022.0970

基于结构中药学思维的中药研究方法探讨——以外用中药为例

doi: 10.14148/j.issn.1672-0482.2022.0970

乔宏志^1,,
陈熹²,
陈军^3, ,,
狄留庆¹

1.
南京中医药大学药学院, 江苏省中药高效给药系统工程技术研究中心, 江苏南京 210023
2.
南京大学生命科学学院, 江苏南京 210023
3.
江苏省中医外用药开发与应用工程研究中心, 江苏南京 210023

基金项目:

国家自然科学基金面上项目 82274220

中央本级重大增减支项目 2060302-1907-04

江苏省高等学校自然科学研究重大项目 20KJA360004

江苏省六大人才高峰项目 SWYY-057

详细信息

作者简介:
乔宏志, 男, 副教授, 主要从事结构中药学研究, E-mail: qiaohz@njucm.edu.cn

陈军, 教授, 博士生导师, 美国堪萨斯大学访问学者, 江苏省青蓝工程中青年学术带头人, 国家中医药管理局重点学科南京中医药大学中药药剂学科后备带头人, 世界中医药联合会经皮给药委员会副秘书长，民进江苏省委医卫体育委员会副主任，主要从事中药经皮给药制剂和中药脂质体的研究

通讯作者:
陈军，男，教授，博士生导师，主要从事中药外用研究，E-mail: chenjun75@njucm.edu.cn

中图分类号: R285
计量
- 文章访问数: 320
- HTML全文浏览量: 23
- PDF下载量: 51
- 被引次数: 0
出版历程
- 收稿日期: 2022-09-11
- 网络出版日期: 2022-11-19
- 发布日期: 2022-11-10

The Perspective of the Research on Traditional Chinese Medicine Based on Structural Chinese Medicine: Taking the External Use of TCM as An Example

1.
School of Pharmacy, Jiangsu Engineering Research Center for Efficient Delivery System of TCM, Nanjing University of Chinese Medicine, Nanjing 210023, China
2.
School of Life Sciences, Nanjing University, Nanjing 210023, China
3.
Jiangsu Provincial Engineering Research Center of TCM External Medication Development and Application, Nanjing 210023, China

摘要

摘要: 物质在不同尺度的聚集状态是决定其性质的关键因素。结构中药学是以中药中天然存在的或经加工形成的聚集态为对象, 研究其组成结构特征、形成机制、体内命运及其功能关联性的中药学新兴交叉领域。相较于中药传统的分子层次研究, 结构中药学的研究对象具有跨尺度、异质性、多效应的特点, 是从介观视角和空间维度对中药药效物质和起效机制的再认识和再研究。中药外用是中医传承千年的用药特色, 但其科学内涵缺乏深入的阐释。笔者以外用中药为例分析了目前中药研究中存在的共性和个性问题, 并提出基于结构中药学思维的研究路径, 以期为相关领域提供参考。
- 结构中药学 /
- 中药外用 /
- 药效物质 /
- 团簇 /
- 聚集体 /
- 相分离 /
- 囊泡 /
- 炭药 /
- 作用机制
Abstract: The aggregation state of matter at different scales is the key factor to determine its properties. Structural Chinese medicine is a new cross field of Chinese medicine to study the composition and structure characteristics, formation mechanism, fate in vivo and functional correlation of clusters and aggregates naturally existing or formed by processing in traditional Chinese medicine (TCM). Compared with the traditional molecular level research of TCM, the research objects of structural Chinese medicine have the characteristics of cross-scale, heterogeneity and multi-effect. It is a re-understanding and re-study of the pharmacodynamic substances and the effective mechanism of TCM from the mesoscopic perspective and spatial dimension. External use has been the characteristic of TCM for thousands of years, but lack of in-depth explanation. Taking the external use of TCM as an example, this paper analyzes the common and individual problems existing in the research of TCM, and puts forward the research path based on the thinking of structural Chinese medicine, in order to provide reference for the related fields.
- structural Chinese medicine /
- external use of traditional Chinese medicine /
- pharmacodynamic substance /
- clusters /
- aggregate /
- phase separation /
- vesicles /
- carbonized traditional Chinese medicine /
- mechanism of action

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