中药壁虎抗肿瘤的研究现状及展望

陈林伟; 戴培培; 江勇; 魏妮娜; 徐柳; 王琴; 陈志鹏

doi:10.14148/j.issn.1672-0482.2022.0892

中药壁虎抗肿瘤的研究现状及展望

doi: 10.14148/j.issn.1672-0482.2022.0892

陈林伟^{1, 2,},
戴培培¹,
江勇¹,
魏妮娜¹,
徐柳¹,
王琴²,
陈志鹏^1, ,

1.
南京中医药大学药学院, 江苏南京 210023
2.
南京中医药大学泰州附属医院, 江苏泰州 225300

基金项目:

国家自然科学基金面上项目 81903802

详细信息

作者简介:
陈林伟, 男，博士研究生, 主管中药师, E-mail: chenlinwei89@126.com

陈志鹏，南京中医药大学A类特聘教授, 博士生导师，第六批全国老中医药专家经验继承人, 药物制剂专业负责人, 南京中医药大学科学技术处副处长。长期从事中药炮制和制剂研究, 主持国家自然科学基金4项，国家重点研发计划子课题1项。以第一或通讯作者发表高质量学术论文60余篇。获得教育部高等学校科学研究优秀成果奖(自然科学奖)二等奖，江苏省高校科学研究成果奖(自然科学奖)二等奖等科技奖励3项入选江苏省“333高层次人才培养工程”第二层次、江苏省“青蓝工程”中青年学术带头人、江苏省“六大人才高峰”高层次人才

通讯作者:
陈志鹏, 教授, 博士生导师, 主要从事中药新型递释系统研究, E-mail: czpcpu2000@hotmail.com

中图分类号: R285.5
计量
- 文章访问数: 362
- HTML全文浏览量: 92
- PDF下载量: 37
- 被引次数: 0
出版历程
- 收稿日期: 2022-04-11
- 网络出版日期: 2022-10-25
- 发布日期: 2022-10-10

Research Status and Prospect of Gecko Therapy for Tumor

1.
School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
2.
Taizhou Hospital Affiliated to Nanjing University of Chinese Medicine, Taizhou 225300, China

摘要

摘要: 中药壁虎在我国药用历史悠久, 目前仍被广泛用于各种肿瘤疾病的治疗, 尤其对消化系统肿瘤的治疗效果最佳, 具有毒副作用小等优点。近年来国内外学者对壁虎抗肿瘤的物质基础和药理作用进行了大量研究, 取得了一定的研究成果, 但其成分种类复杂, 作用机制仍不清楚。从壁虎抗肿瘤的本草考证、有效成分、临床应用及药理作用四个方面进行系统地归纳总结, 为壁虎抗肿瘤的深入研究及新药开发提供参考。
- 壁虎 /
- 抗肿瘤 /
- 本草考证 /
- 有效成分 /
- 临床应用 /
- 药理作用
Abstract: Gecko has a long history in Chinese medicine, and is still widely used in the treatment of various tumor diseases at present. In particular, it has the best therapeutic effect on digestive system tumors, and has the advantages of small side effects and so on. Therefore, Gecko is known as the "anti-tumor star". In recent years, scholars have conducted a lot of research reports on the material basis and pharmacological mechanism of gecko in the treatment of tumors, and some research achievements have been made. However, its components are complex and its mechanism of action is still unclear. Therefore, this paper systematically summarizes the herbal research, active components, clinical application and pharmacological action of gecko therapy for cancer, which provides a certain reference for the in-depth study of gecko therapy for cancer and the development of new drugs.
- Gecko /
- Anti-tumor /
- Herbal research /
- Active ingredient /
- Clinical application /
- Pharmacological action

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图 1 壁虎治疗胃癌的功效物质基础

Figure 1. The material basis of the efficacy of Gecko in the treatment of gastric cancer

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表 1 历代古籍文献中壁虎的功效主治

Table 1. Summary of efficiency of Gecko in ancient books

朝代	出处	主治
宋	《太平圣惠方》	治破伤风
宋	《圣济总录》	治历节
明	《本草纲目》	治中风瘫痪, 手足不举, 或历节风痛, 及风痓惊痫, 小儿疳痢, 血积成痞, 疠风瘰疬, 疗蝎螫
明	《本草汇言》	治风痫急惊。且入血分，如疬疡流注及疳积食痞，亦属血分凝结于经络……用此攻散凝结之血，所以兼主之也
清	《本经逢原》	治风疰惊痫诸病……且入血分，故又治血病、疮疡
清	《得配本草》	治中风惊痫, 疠风瘰, 治风癞

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表 2 壁虎中含有的主要有效成分

Table 2. Main active ingredients in Gecko

成分类别	成分名称
氨基酸	甘氨酸、谷氨酸、脯氨酸、丙氨酸、天门冬氨酸、精氨酸、丝氨酸、苯丙氨酸、亮氨酸、赖氨酸、缬氨酸、苏氨酸、异亮氨酸、组氨酸
微量元素	钡、磷、镁、铅、硒、铁、锰、铬、钛、铝、钙、铜、锆、钠、银、锶、锡、钾
核苷类	尿嘧啶、胞苷、次黄嘌呤、尿苷、次黄苷、鸟苷、胸苷、腺苷、尿嘧啶核苷、脱氧胸苷、次黄苷
糖类	守宫硫酸多糖、甘露糖、半乳糖、葡萄糖
多肽类	守宫硫酸糖肽、环肽(脯氨酸-亮氨酸)、环肽(丙氨酸-脯氨酸)、环肽(甘氨酸-脯氨酸)、环肽(丙氨酸-缬氨酸)
蛋白类	守宫酸性蛋白、Hoxc10蛋白、守宫糖蛋白
其他成分	2-乙基-3, 5-二甲基吡嗪、异戊醛、三甲胺、1-辛烯-3-醇、正辛醛、壬醛、2-甲基萘、γ-辛内酯、2-庚酮、苯酚、5α-胆甾-3, 6-二酮、胆甾醇、十六烷酸单甘油酯、硬脂酸、组织胺类成分等

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