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苓桂术甘汤运化并举干预β淀粉样蛋白代谢研究思路刍议

王莉兰 周春祥

王莉兰, 周春祥. 苓桂术甘汤运化并举干预β淀粉样蛋白代谢研究思路刍议[J]. 南京中医药大学学报, 2022, 38(9): 790-796. doi: 10.14148/j.issn.1672-0482.2022.0790
引用本文: 王莉兰, 周春祥. 苓桂术甘汤运化并举干预β淀粉样蛋白代谢研究思路刍议[J]. 南京中医药大学学报, 2022, 38(9): 790-796. doi: 10.14148/j.issn.1672-0482.2022.0790
WANG Li-lan, ZHOU Chun-xiang. Discussion on Research Ideas of Intervention of β-Amyloid Metabolism with Linggui Zhugan Decoction to Regulate Spleen's Governing Transportation and Transformation[J]. Journal of Nanjing University of traditional Chinese Medicine, 2022, 38(9): 790-796. doi: 10.14148/j.issn.1672-0482.2022.0790
Citation: WANG Li-lan, ZHOU Chun-xiang. Discussion on Research Ideas of Intervention of β-Amyloid Metabolism with Linggui Zhugan Decoction to Regulate Spleen's Governing Transportation and Transformation[J]. Journal of Nanjing University of traditional Chinese Medicine, 2022, 38(9): 790-796. doi: 10.14148/j.issn.1672-0482.2022.0790

苓桂术甘汤运化并举干预β淀粉样蛋白代谢研究思路刍议

doi: 10.14148/j.issn.1672-0482.2022.0790
基金项目: 

国家自然科学基金面上项目 81774021

国家自然科学基金面上项目 82074504

详细信息
    作者简介:

    王莉兰, 女,硕士研究生,E-mail: 1292451174@qq.com

    周春祥,1964年生,南京中医药大学教授、博士生导师,伤寒教研室主任,国家中医药管理局伤寒重点学科带头人,南京明基医院中医部部长。兼任中国中医药研究促进会经方分会副会长、世界自然医学会副主席、南京自然医学会会长、世界中医联合会教育指导委员会理事等。主要从事中药复方抗炎免疫研究,先后主持科技部十一五科技支撑项目1项,国家自然科学基金面上项目5项,江苏省中医药管理局课题2项,江苏省学位委员会课题1项,部省级课题7项。申请国家发明专利9项,授权7项。发表论文160余篇,其中SCI收录6篇。曾获国家民委社会科学研究成果二等奖,南京市人民政府科技进步三等奖。为江苏省“青蓝工程"优秀青年骨干教师培养对象,江苏省“青蓝工程”中青年学术带头人培养对象

    通讯作者:

    周春祥, 男,教授,博士生导师, 主要从事中医药抗炎免疫研究,E-mail: chunxiangzhou@njucm.edu.cn

  • 中图分类号: R285

Discussion on Research Ideas of Intervention of β-Amyloid Metabolism with Linggui Zhugan Decoction to Regulate Spleen's Governing Transportation and Transformation

  • 摘要: 脑内过多的β淀粉样蛋白(Aβ)清除主要通过自噬-溶酶体系统、星形胶质细胞分泌的蛋白酶、小胶质细胞吞噬作用进行降解清除, 还可通过血脑屏障和/或脑淋巴引流系统转运排出, 脾主运化功能在Aβ降解和转运过程中起着重要作用。大量实验证据表明, 温脾化饮法的代表方苓桂术甘汤可能影响Aβ代谢途径的关键结构和功能。在阐述Aβ代谢途径相关机制及分析苓桂术甘汤药理作用的基础上, 探讨苓桂术甘汤“运化并举”实现Aβ清除的科学内涵, 以期开拓中医治疗阿尔茨海默病的思路。

     

  • 图  1  苓桂术甘汤“运化并举”防治AD示意图

    Figure  1.  Schematic diagram of Linggui Zhugan Decoction regulate spleen's governing transportation and transformation to prevention and treatment of AD

    图  2  Aβ的降解及转运途径示意图[13]

    Figure  2.  Schematic diagram of degradation and transport route of β-amyloid[13]

    图  3  脾“运化”Aβ的取象比类示意图

    Figure  3.  Schematic diagram of spleen's governing transportation and transformation analogue for β-amyloid metabolism

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出版历程
  • 收稿日期:  2022-04-11
  • 网络出版日期:  2022-09-19
  • 发布日期:  2022-09-10

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