中医药对顺铂耳毒性的防治作用研究进展

安澜; 黄盈; 戴雨晨; 左真齐; 王超; 张超; 吴丽; 陈志鹏; 王宇彤

doi:10.14148/j.issn.1672-0482.2022.0452

中医药对顺铂耳毒性的防治作用研究进展

doi: 10.14148/j.issn.1672-0482.2022.0452

安澜^1,,
黄盈¹,
戴雨晨²,
左真齐¹,
王超¹,
张超²,
吴丽¹,
陈志鹏¹,
王宇彤^1, ,

1.
南京中医药大学药学院, 江苏南京 210023
2.
南京中医药大学医学院·整合医学学院, 江苏南京 210023

基金项目:

国家自然科学基金青年科学项目 81803456

国家重点研发计划-中医药现代化研究资助项目 2018YFC1706905

大学生创新创业训练计划资助项目 202010315058Y

南京中医药大学自然基金资助项目 NZY81803456

详细信息

作者简介:
安澜, 女, E-mail: anlan_18@163.com

通讯作者:
王宇彤, 女, 副教授, 主要从事中药新剂型与新技术研究, E-mail: wangyutong@njucm.edu.cn

中图分类号: R285.5
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- 文章访问数: 389
- HTML全文浏览量: 71
- PDF下载量: 26
- 被引次数: 0
出版历程
- 收稿日期: 2021-04-25
- 发布日期: 2022-05-10

A Review on Protective Effect of Traditional Chinese Medicine on Cisplatin-Induced Ototoxicity

1.
School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
2.
School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China

摘要

摘要: 顺铂是临床上广泛应用的抗肿瘤化疗药物, 耳毒性是其常见的毒副作用，患者常出现耳鸣、耳聋等症状, 预防与缓解顺铂耳毒性逐渐成为亟待解决的问题。研究表明, 中医药对顺铂产生的耳毒性有一定的预防和治疗作用。笔者从顺铂致耳毒性的中医认识、作用机制以及治疗策略综述了中医药对顺铂耳毒性的作用研究进展, 以期为寻找缓解化疗药物毒副作用的策略提供新的思路。
- 顺铂 /
- 中医药 /
- 耳毒性
Abstract: As a first-line chemotherapeutic drug, cisplatin displays wide ototoxicity. Tumor patients treated with cisplatin usually suffer from tinnitus and deafness, Preventing and relieving the ototoxicity caused by cisplatin has become an urgent problem to be solved. Reports have revealed the certain preventive and therapeutic effects of active components in traditional Chinese medicine on cisplatin ototoxicity. This review summarizes the recent researches on the protection of traditional Chinese medicine on cisplatin's ototoxicity, providing new insights for seeking strategies to alleviate the side effects of chemotherapy drugs.
- cisplatin /
- traditional Chinese medicine /
- ototoxicity

HTML全文

图 1 顺铂耳毒性的产生机制

Figure 1. Mechanism of cisplatin ototoxity

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表 1 用于逆转顺铂耳毒性的中药提取物

Table 1. Traditional Chinese medicine extracts for reducing cisplatin ototoxicity

名称	有效成分来源	原药材传统功效	缓解耳毒性的原理
银杏叶提取物	银杏科植物银杏Ginko biloba L.的干燥叶。	甘、苦、涩, 平。归心、肺经。活血化瘀, 通络止痛, 敛肺平喘, 化浊降脂。	缓解外部毛细胞损伤^[33]
石榴提取物	石榴科植物石榴Punica granatum L.的鲜品。	酸、涩、温。归大肠经。涩肠止泻, 止血, 驱虫。	缓解耳组织细胞损伤^[34]
三七总皂苷	五加科植物三七Panax notoginseng (Burk.) F. H. Chen的主根或根茎经加工制成的总皂苷。	甘、微苦, 温。归肝、胃经。散瘀止血, 消肿定痛。	抑制活性氧产生, 减少促凋亡蛋白表达^[35]

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表 2 用于逆转顺铂耳毒性的中药活性成分

Table 2. Active ingredients of traditional Chinese medicine for reducing cisplatin ototoxicity

名称	有效成分来源	原药材传统功效	缓解耳毒性的原理
槲皮素	豆科植物槐Sophora japonica L.的干燥花蕾及花、景天科植物瓦松Orostachys fim briata (Turcz.) Berg.的干燥地上部分	槐花: 苦, 微寒。归肝、大肠经。凉血止血, 清肝泻火。瓦松: 酸、苦、凉。归肝、肺、脾经。凉血止血, 解毒, 敛疮。	缓解耳组织损伤^[42]
姜油酮	姜科植物姜Zingiber officinale Rose.的干燥根茎	辛, 热。归脾、胃、肾、心、肺经。温中散寒, 回阳通脉, 温肺化饮。	降低炎症相关因子的mRNA表达; 降低氧化应激相关因子表达^[43]
银杏内酯B	银杏科植物银杏Ginkgo biloba L.的干燥叶	甘、苦、涩, 平。归心、肺经。活血化瘀, 通络止痛, 敛肺平喘, 化浊降脂。	减少活性氧的产生; 抑制线粒体的凋亡^[44]
连翘脂苷	木犀科植物连翘Forsythia suspensa (Thunb.) Vahl的干燥果实	苦, 微寒。归肺、心、小肠经。清热解毒, 消肿散结, 疏散风热。	减少促氧化、促炎、促凋亡因子蛋白表达^[45-48]
人参皂苷Rg1	五加科植物人参Panax ginseng C. A. Mey.的干燥根及根茎	甘、微苦, 微温。归脾、肺、心、肾经。大补元气, 复脉固脱, 补脾益肺, 生津养血, 安神益智。	减轻耳组织损伤; 抑制耳蜗组织细胞凋亡^[49]
川芎嗪	伞形科植物川芎Ligusticum chuanxiong Hort.的干燥根茎。	辛, 温。归肝、胆、心包经。活血行气, 祛风止痛。	抑制耳组织细胞凋亡; 减弱耳组织细胞损伤^[50-51]
大蒜素	百合科植物大蒜Allium sativum L.的鳞茎	辛, 温。归脾、胃、肺经。解毒消肿, 杀虫, 止痢。	抑制促凋亡蛋白的表达与活化; 降低耳蜗组织的氧化应激水平^{[16, 52-53]}
葛根素	豆科植物野葛Pueraria lobata (Willd.) Ohwi的根茎	甘、辛, 凉。归脾、胃、肺经。解肌退热, 生津止渴, 透疹, 升阳止泻, 通经活络, 解酒毒。	降低毛细胞内Ca²⁺水平, 降低毛细胞损失率^[54]
姜黄素衍生物EF24	姜科植物姜黄Curcuma longa L.的干燥根茎	辛、苦、温。归脾、肝经。破血行气, 通经止痛。	缓解听觉诱发电位阈值偏移^[55]
原花青素	葡萄科植物葡萄Vitis vinifera L.的干燥种子、银杏科植物银杏Ginkgo biloba L.的干燥叶	甘、苦、涩, 平。归心、肺经。活血化瘀, 通络止痛, 敛肺平喘, 化浊降脂。	降低活性氧含量; 调节凋亡相关蛋白的表达与活化^[56]
和厚朴酚	木兰科植物厚朴Magnolia officinalis Rehd. et Wils.或凹叶厚朴Magnolia offinalis Rehd. et Wils. var. biloba Rehd. et Wils.的干燥干皮、根皮及枝皮	苦、辛, 温。归脾、胃、肺、大肠经。燥湿消痰, 下气除满。	激活耳蜗中去乙酰化修饰酶SIRT3, 减少ROS产生, 改善线粒体功能^[11]

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