臭牡丹化学成分及药理作用的研究进展

赵河; 成飞; 秦优; 张水寒

doi:10.14148/j.issn.1672-0482.2022.0361

臭牡丹化学成分及药理作用的研究进展

doi: 10.14148/j.issn.1672-0482.2022.0361

赵河^{1, 2,},
成飞²,
秦优²,
张水寒^2, ,

1.
湖南中医药大学研究生院, 湖南长沙 410208
2.
湖南省中医药研究院中药研究所, 湖南长沙 410013

基金项目:

中医药公共卫生服务补助专项财社〔2017〕66号

中央本级重大增减支项目 2060302

详细信息

作者简介:
赵河, 男, 硕士研究生，E-mail: 924347015@qq.com

通讯作者:
张水寒, 女，研究员, 主要从事中药资源及综合开发利用研究，E-mail: zhangshuihan0220@126.com

中图分类号: R284
计量
- 文章访问数: 331
- HTML全文浏览量: 177
- PDF下载量: 40
- 被引次数: 0
出版历程
- 收稿日期: 2021-12-22
- 网络出版日期: 2022-04-13
- 发布日期: 2022-04-10

Research Progress on Chemical Constituents of Clerodendrum bungei Steud. and Its Pharmacological Activities

ZHAO He^{1, 2
,},
CHENG Fei²,
QIN You²,
ZHANG Shui-han^{2
, ,}

1.
Graduate School, Hunan University of Chinese Medicine, Changsha 410208, China
2.
Institute of Chinese Materia Medica, Hunan Academy of Chinese Medicine, Changsha 410013, China

摘要

摘要: 臭牡丹Clerodendrum bungei Steud.为马鞭草科大青属植物臭牡丹全草, 为民间常用中草药, 具有消肿解毒、活血散瘀之功效。通过对臭牡丹化学成分、药理作用及临床应用进行文献综述，总结出臭牡丹中含有苯乙醇苷类、萜类、甾醇类等多类化学成分; 作用广泛，具有抗肿瘤、镇痛、抑菌及抗炎等诸多药理作用；临床上具有治疗荨麻疹、癌症及改善月经不调等作用。为臭牡丹的深入研究和开发利用提供参考。
- 臭牡丹 /
- 苯乙醇苷类 /
- 萜类 /
- 抗肿瘤 /
- 镇痛
Abstract: Clerodendrum bungei Steud. is a plant of verbenaceae family, which is commonly used as folk herbal medicine. It has the effect of promoting blood circulation, disperses blood stasis, detoxification and detoxification. In this paper, the chemical constituents, pharmacological action and clinical application of Clerodendrum bungei Steud. were reviewed. It was concluded that Clerodendrum bungei Steud. contains phenylethanol glycosides, terpenoids, sterols and other chemical constituents. Clerodendrum bungei Steud. has a wide range of pharmacological effects, such as anti-tumor, analgesic, antibacterial and anti-inflammatory. Its clinical treatment of urticaria, cancer and improve menstrual irregularities. It provides reference for further research, development and utilization of Clerodendrum bungei Steud..
- Clerodendrum bungei Steud. /
- phenylethanol glycoside /
- terpenoids /
- anti-tumor /
- analgesia

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图 1 臭牡丹中苯乙醇苷类化合物结构

Figure 1. Structure of phenylethanol glycosides in Clerodendrum bungei Steud.

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图 2 臭牡丹中二萜类化合物的结构

Figure 2. Composition structure of diterpenoids in Clerodendrum bungei Steud.

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图 3 臭牡丹中三萜类化合物结构

Figure 3. Structure of triterpenoids in Clerodendrum bungei Steud.

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图 4 臭牡丹中甾醇类化合物结构

Figure 4. Structure of sterols in Clerodendrum bungei Steud.

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图 5 臭牡丹中黄酮类化合物结构

Figure 5. Structure of flavonoids in Clerodendrum bungei Steud.

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表 1 臭牡丹中苯乙醇苷类化合物

Table 1. Phenylethanol glycosides in Clerodendrum bungei Steud.

编号	成分	分子式	相对分子量	文献来源
1	类叶升麻苷(Acteoside)	C₂₉H₃₆O₁₅	624.58	[15]
2	异类叶升麻苷(Isoacteoside)	C₂₉H₃₆O₁₅	624.21	[15]
3	Campeneoside Ⅰ	C₃₀H₃₈O₁₆	654.22	[15]
4	Campeneoside Ⅱ	C₂₉H₃₆O₁₆	640.20	[15]
5	去咖啡酰基类叶升麻苷(Decaffeoylacteosode)	C₂₀H₃₀O₁₂	462.17	[15]
6	乙酰麦角甾苷(6-O-Acetylacteoside)	C₃₁H₃₈O₁₆	666.22	[19]
7	Isocampneoside Ⅱ	C₂₉H₃₆O₁₆	640.20	[20]
8	Oxoacteoside	C₂₉H₃₄O₁₆	638.38	[20]
9	Oxoisoacteoside	C₂₉H₃₄O₁₆	638.18	[20]
10	车前草苷C(Plantainoside C)	C₃₀H₁₈O₁₅	638.22	[21]
11	米团花苷A(Leucosceptoside A)	C₃₀H₃₈O₁₅	638.61	[21]
12	异地黄苷(Isomartynoside)	C₃₁H₄₀O₁₅	652.64	[21]
13	Darendoside B	C₂₁H₃₂O₁₂	476.47	[21]
14	Kankanoside G	C₂₉H₃₄O₁₆	608.21	[21]
15	地黄苷(Martynoside)	C₃₂H₄₂O₁₄	650.26	[22]
16	肉苁蓉苷C(Cistanoside C)	C₃₀H₃₈O₁₅	638.22	[15]
17	吉奥诺苷C(Jionoside C)	C₂₉H₃₆O₁₃	592.59	[15]
18	肉苁蓉苷D(Cistanoside D)	C₃₁H₄₀O₁₅	652.24	[15]
19	肉苁蓉苷F(Cistanoside F)	C₂₁H₂₈O₁₃	488.15	[15]
20	Cistanoside fisomer-1	C₂₁H₂₈O₁₃	488.15	[20]
21	Cistanoside fisomer-2	C₂₁H₂₈O₁₃	488.15	[20]
22	3', 4'-di-O-Acetylmartynoside	C₃₅H₄₄O₁₅	707.27	[21]
23	Acetylmartynoside B	C₃₅H₄₄O₁₇	736.71	[21]
24	Acetylmartynoside A	C₃₅H₄₄O₁₇	736.71	[21]
25	3'-O-Acetylmartyonside	C₃₃H₄₂O₁₄	662.26	[21]
26	2'-O-Acetylmartynoside	C₃₃H₄₂O₁₄	662.26	[21]
27	Phlomisethanoside	C₂₇H₃₄O₁₄	582.55	[21]
28	Darendoside A	C₁₉H₂₈O₁₁	432.42	[21]
29	去氢洋丁香酚苷(Dehydroacteoside)	C₂₉H₃₄O₁₅	622.19	[20]
30	连翘脂苷A(Forsythoside A)	C₂₉H₃₆O₁₅	624.21	[23]
31	Crenatoside isomer	C₂₉H₃₄O₁₅	622.19	[19]
32	Osmanthuside	C₂₉H₃₆O₁₃	592.22	[19]
33	Trichotomoside	C₄₇H₅₆O₁₈	908.35	[21]
34	Bunginoside A	C₃₉H₄₆O₁₆	770.28	[22]
35	Clerodendronoside	C₃₀H₁₈O₂	590.24	[15]

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表 2 臭牡丹中二萜类化合物

Table 2. Diterpenoids in Clerodendrum bungei Steud.

编号	成分	分子式	相对分子量	文献
36	臭牡丹酮A(Bungone A)	C₂₈H₁₈O₃	306.13	[24]
37	臭牡丹酮B(Bungone B)	C₂₁H₄₀O₄	366.14	[24]
38	11, 12, 16S-Trihydroxy-7-oxo-17(15→16), 18(4→3)-diabeo-abieta- 3, 8, 11, 13-tetraen-18-oic acid	C₂₀H₂₄O₆	360.16	[22]
39	19-Hydroxyteuvincenone F	C₂₀H₁₈O₆	354.11	[25]
40	Teuvincenone F	C₂₀H₁₈O₅	338.12	[25]
41	钩大青酮(Uncinatone)	C₂₀H₂₂O₄	326.15	[25]
42	Bungnate A	C₂₂H₂₄O₇	400.15	[21]
43	15-Dehydrocyrtophyllone A	C₂₁H₂₄O₅	356.16	[21]
44	15-Dehydro-17-hydroxycyrtophyllone A	C₂₁H₂₄O₆	372.16	[21]
45	12, 16-Epoxy-11, 14, 17-trihydroxy-6-methoxy-17(15→16)-abeo-abieta- 5, 8, 11, 13-tetraene-7-one	C₂₁H₂₆O₆	374.17	[21]
46	茎含大青酮(Cyrtophyllone A)	C₂₁H₂₆O₅	358.18	[21]
47	Villosin C	C₂₀H₂₄O₆	360.16	[21]
48	Mandarone E	C₂₀H₂₀O₄	324.14	[21]
49	12, 16-Epoxy-11, 14-dihydroxy-6-methoxy-17(15→16)-abeo-abieta- 5, 8, 11, 13, 15-pentaene-3, 7-dione	C₂₁H₂₂O₆	370.14	[21]
50	3β-(β-D-Glucopyranosyl)isopimara-7, 15-diene-11α, 12α-diol	C₂₆H₄₂O₈	482.29	[26]
51	16-O-β-D-Glucopyranosyl-3β-20-epoxy-3-hydroxyabieta-8, 11, 13-triene	C₂₇H₄₀O₉	508.27	[26]
52	11, 16-Dihydroxy-12-O-β-D-glucopyranosyl-17(15→16)	C₂₆H₃₄O₁₁	522.21	[25]
53	Bungnate B	C₂₇H₃₈O₁₀	522.25	[21]
54	19-O-β-D-Carboxyglucopyranosyl-12-O-β-D-glucopyranosyl-11, 16-dihydroxyabieta-8, 11, 13-triene	C₃₂H₄₈O₁₅	672.30	[25]
55	12-O-β-D-Glucopyranosyl-3, 11, 16-trihydroxyabieta-8, 11, 13-triene	C₂₆H₄₀O₉	496.27	[27]
56	3, 12-O-β-D-Diglucopyranosyl-11, 16-dihydroxyabieta-8, 11, 13-triene	C₃₂H₅₀O₁₄	658.32	[27]
57	Ajugaside A	C₃₂H₅₀O₁₄	658.73	[27]

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表 3 臭牡丹中三萜类化合物

Table 3. Triterpenoids in Clerodendrum bungei Steud.

编号	成分	分子式	相对分子量	文献来源
58	算盘子酮(Glochidone)	C₃₀H₄₆O	422.35	[28]
59	算盘子酮醇(Glochidonol)	C₃₀H₄₈O₂	440.70	[28]
60	算盘子二醇(Glochidiol)	C₃₀H₅₀O₂	442.71	[28]
61	赪桐酮(Clerodone)	C₃₀H₅₀O	426.39	[29]
62	α-香树脂醇(α-Amyrin)	C₃₀H₅₀O	426.39	[12]
63	木栓酮(Friedelin)	C₃₀H₅₀O	426.39	[29]
64	蒲公英赛醇(Taraxerol)	C₃₀H₅₀O	426.39	[29]
65	白桦脂酸(Betulinic acid)	C₃₀H₄₈O₃	456.36	[29]

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表 4 臭牡丹中甾醇类化合物

Table 4. Sterols in Clerodendrum bungei Steud.

编号	成分	分子式	相对分子量	文献来源
66	β-谷甾醇(β-Sitosterol)	C₂₉H₅₀O	414.39	[28]
67	羊毛甾二烯醇(Lanosta-8, 24-dien-3-ol)	C₃₀H₅₀O	426.39	[29]
68	臭牡丹甾醇(Bungesterol)	C₂₉H₄₈O	412.37	[12]
69	赪酮甾醇(Clerosterol)	C₂₉H₄₈O	412.37	[12]
70	豆甾三烯3-醇(Stigma-7, 22, 25-trien-3-ol)	C₂₉H₄₆O	410.35	[29]
71	胡萝卜苷(Daucosterol)	C₃₅H₆₀O₆	576.44	[29]
72	赤桐甾醇葡糖苷(Clerosterol glucopyranoside)	C₃₅H₅₈O₆	574.42	[32]

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表 5 臭牡丹中黄酮类化合物

Table 5. Flavonoids in Clerodendrum bungei Steud.

编号	成分	分子式	相对分子量	文献来源
73	柚皮素-7-O-葡萄糖苷(Naringenin7-O-β-D-glucopyranoside)	C₂₁H₂₂O₁₀	434.12	[12]
74	芸香柚皮苷(Narirutin)	C₂₇H₃₂O₁₄	580.18	[12]
75	香蜂草苷(Didymin)	C₂₈H₃₄O₁₄	594.19	[12]
76	柚皮素(Naringenin)	C₁₅H₁₂O₅	272.07	[12]
77	4'-O-Methylscutellarein	C₁₆H₁₂O₆	300.06	[12]
78	芹菜素(5, 7, 4'-Trihydroxyflavone)	C₁₅H₁₀O₅	270.05	[29]
79	5, 6, 7, 4'-四羟基黄酮(5, 6, 7, 4'-Tetrahydroxyflavanone)	C₁₅H₁₀O₆	286.05	[19]
80	5, 7, 8, 4'-四羟基黄酮(5, 7, 8, 4'-Tetrahydroxyflavanone)	C₁₅H₁₀O₆	286.05	[19]
81	5, 7-二羟基-4'-甲氧基黄烷酮(5, 7-Dihydroxy-4'-trimethoxyflavanone)	C₁₂H₁₆O₅	284.07	[19]
82	二氢杨梅素(Dihydromyricetin)	C₁₅H₁₂O₈	320.05	[19]
83	杨梅素(Myricetin)	C₁₅H₁₀O₈	318.04	[19]

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表 6 臭牡丹中挥发油类化合物

Table 6. Volatile oil compounds in Clerodendrum bungei Steud.

编号	成分	分子式	相对分子量	文献来源
84	桉油烯醇(Spathulenol)	C₁₅H₂₄O	220.35	[11]
85	乙酸橙花叔醇酯(Nerolidyl acetate)	C₁₇H₂₈O₂	264.40	[11]
86	(E, Z)-2, 13-十八烷二烯-1-醇[(Z, E)-2, 13-Octadecadien-1-ol]	C₁₈H₃₄O	266.46	[11]
87	反式-3-己烯醇(cis-3-Hexenol)	C₆H₁₂O	100.15	[11]
88	1-辛烯-3-醇(1-Octen-3-ol)	C₈H₁₆O	128.21	[11]
89	芳樟醇L(Linalool L)	C₁₀H₁₈O	154.25	[11]
90	氧化石竹烯(Caryophyllene oxide)	C₁₅H₂₄O	220.35	[11]
91	安息香酸丁酯(Benzoic acid butylester)	C₁₁H₁₄O₂	178.22	[11]
92	乙酸松油脂(α-Terpinyl acetate)	C₁₂H₂₀O₂	196.28	[11]
93	乙酸龙脑酯(Bornyl acetate)	C₁₂H₂₀O₂	196.28	[11]
94	植酮(6, 10, 14-Trimethyl-2-pentadecanone)	C₁₈H₃₆O	268.48	[11]
95	肉豆蔻醚(Myristicin)	C₁₁H₁₂O₃	192.21	[11]
96	橙花叔醇(Nerolidol)	C₁₅H₂₆O	222.37	[11]
97	3-甲基丁醛(3-Methylbutanal)	C₅H₁₀O	86.13	[40]
98	苯甲醛(Benzaldehyde)	C₇H₆O	106.12	[40]
99	叶绿醇(3, 7, 11, 15-Tetramethyll-2-hexadecen-1-ol)	C₂₀H₄₀O	296.53	[40]
100	苯乙醛(Benzene acetaldehyde)	C₈H₈O	120.15	[40]
101	十四烷醛(Tetradecanal)	C₁₄H₂₈O	212.37	[40]
102	棕榈酸甲酯(Hexadecanoic acid methylester)	C₁₇H₃₄O₂	270.45	[40]
103	α-紫罗兰酮(α-Lonone)	C₁₃H₂₀O	192.29	[40]
104	β-紫罗兰酮(β-Lonone)	C₁₃H₂₀O	192.29	[40]
105	2, 4-二叔丁基苯酚(2, 4-Di-tert-butylphenol)	C₁₄H₂₂O	206.32	[40]
106	香叶醇(Geraniol)	C₁₀H₁₈O	154.25	[40]
107	β-环柠檬醛(β-Cyclocitral)	C₁₀H₁₆O	152.23	[40]
108	十八烷酸(cis-Vaccenic acid)	C₁₈H₃₄O₂	282.46	[40]
109	二十烷醇(1-Eicosanol)	C₂₀H₄₂O	298.55	[40]
110	二十五烷(n-Pentacosane)	C₂₅H₅₂	352.41	[40]
111	正二十九烷(n-Nonacosane)	C₂₉H₆₀	408.47	[40]

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表 7 臭牡丹中其他类化合物

Table 7. Other compounds in Clerodendrum bungei Steud.

编号	成分	分子式	相对分子量	文献来源
112	Bungei A	C₁₆H₁₈O₄	274.12	[32]
113	反式氧化芳樟醇(trans-Linalooloxide)	C₁₀H₁₈O₂	170.13	[29]
114	正二十八烷酸(Octacosanoic acid)	C₂₈H₅₆O₂	424.43	[29]
115	Malyngic acid	C₁₈H₃₂O₅	328.22	[29]
116	12S^, 13R^-Dihydroxy-9-oxo-octadeca-10E-enoic acid	C₁₈H₃₂O₅	328.22	[22]
117	山橘脂酸(Glycosmisic acid)	C₂₀H₂₀O₇	372.12	[22]
118	Neroplomacrol	C₁₅H₂₂O₂	238.19	[22]
119	Butylitaconic acid	C₉H₁₄O₄	186.09	[22]
120	Hexylitaconic acid	C₁₁H₁₈O₄	214.12	[22]
121	对羟基苯甲酸(p-Hydroxybenzoic acid)	C₇H₆O₃	138.03	[22]
122	甲基麦芽酚(Maltol)	C₆H₆O₃	126.03	[12]
123	香草酸(Vanillic acid)	C₉H₁₀O₃	166.06	[12]
124	5-O-Ethylcleroindicin D	C₁₀H₁₆O₄	200.01	[32]
125	Cleroindicin A	C₈H₁₆O₃	160.11	[32]
126	Leroindicin C	C₈H₁₂O₃	156.08	[32]
127	Cleroindicin E	C₈H₁₄O₃	158.09	[32]
128	Cleroindicin F	C₉H₁₄O₂	154.10	[32]
129	Clerobungin A	C₁₀H₁₄O₄	198.09	[41]
130	(+)-Rengyolone	C₈H₁₀O₃	154.06	[41]
131	1, 3, 6, 8-Tetrahydroxyanthracene-9, 10-dione	C₁₄H₈O₆	272.21	[42]
132	丁二酸(Succinic acid)	C₄H₆O₄	118.03	[19]
133	没食子酸(Gallic acid)	C₇H₆O₅	170.02	[19]
134	原儿茶酸(Protocatechuic acid)	C₇H₆O₄	154.03	[19]
135	5, 7-二羟基色原酮(5, 7-Dihydroxychromone)	C₉H₆O₄	178.03	[19]
136	咖啡酸(Caffeic acid)	C₉H₈O₄	180.04	[19]
137	3, 4-二羟基苯甲醛(Catechaldehyde)	C₇H₆O₃	138.03	[19]

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表 8 臭牡丹抗肿瘤作用及机制

Table 8. Antitumor effect and mechanism of Clerodendrum bungei Steud.

肿瘤类型	给药成分	细胞/动物模型	作用结果	作用机制/靶点	文献来源
肺癌	臭牡丹萜类	A549细胞	抑制肿瘤细胞的迁移, 对肿瘤细胞侵袭也有一定作用	-	[7]
	臭牡丹苯乙醇苷类	A549细胞	显著的抑制肿瘤细胞的增殖、迁移和侵袭	-	[7]
	臭牡丹总黄酮类	A549细胞/ Lewis肺癌小鼠	降低肿瘤细胞的侵袭能力，抑制肿瘤细胞增殖；抑制Lewis肺癌小鼠实体瘤	上调p53和Bax mRNA的表达和P13K/Akt信号通路中的Bax和Bcl-2蛋白的表达	[7, 43-44]
	臭牡丹复方 (保肺饮)	CD133⁺细胞移植大鼠	抑制炎症反应，抑制肿瘤细胞的增殖	抑制TGF-β1、IL-4、IL-10水平蛋白表达	[46]
肝癌	臭牡丹含药血清	MHCC97-H细胞	随着给药时间增加肿瘤细胞稀疏杂乱，折光率增强，细胞凋亡率升高	G₂/M期细胞比例相应增加，S期细胞比例降低	[48]
	臭牡丹水提醇沉物	H22荷瘤小鼠	肿瘤细胞凋亡率升高	P13K/Akt信号通路中的Bax/Bcl-2蛋白的表达升高	[37]
	臭牡丹总黄酮	HepG2细胞	抑制肿瘤细胞增殖、诱导肿瘤细胞凋亡	调控Wnt/β-catenin信号通路	[47]
胃癌	臭牡丹总黄酮	SGC7901细胞	抑制胃癌细胞增殖、迁移和侵袭，有明显的浓度依赖性	Keap1-Nrf2-ARE信号通路	[49]
其他肿瘤细胞	臭牡丹单体萜类	黑色素瘤细胞B16/ 胃癌细胞HCG-27/ 肾脏上皮细胞HEK-293/子宫癌HeLa细胞	细胞毒作用, 可抑制肿瘤细胞增殖	诱导细胞周期阻滞在G₂/M期	[25]

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参考文献(72)

[1]	王大萱, 黄仁琼. 臭牡丹生药学研究[J]. 四川中草药研究, 1993(S35): 15-25. https://www.cnki.com.cn/Article/CJFDTOTAL-ZMYZ201211021.htm WANG DX, HUANG RQ. Study on pharmacognosy of Clerodendrum bungei Steud. [J]. Research of Sichuan Traditi Chin Med, 1993(S35): 15-25. https://www.cnki.com.cn/Article/CJFDTOTAL-ZMYZ201211021.htm
[2]	张宏达, 黄云辉, 缪汝槐, 等. 种子植物系统学[M]. 北京: 科学出版社, 2004. ZHANG HD, HUANG YH, MIU RH, et al. Systematics of Spermatophyta[M]. Beijing: Science press, 2004.
[3]	WANG Y, WANG HP, WANG JP, et al. Characterization of the complete chloroplast genome of Clerodendrum bungei steud. (Lamiaceae)[J]. Mitochondrial DNA B Resour, 2021, 6(7): 1939-1940. doi: 10.1080/23802359.2021.1937359
[4]	张建新, 张婷婷, 龙昌莲, 等. 重金属镉胁迫下臭牡丹的生理响应及富集研究[J]. 安徽农业大学学报, 2018, 45(4): 703-709. https://www.cnki.com.cn/Article/CJFDTOTAL-ANHU201804022.htm ZHANG JX, ZHANG TT, LONG CL, et al. Physiological response and bioconcentration of Clerodendrum bungei steud. to cadmium[J]. J Anhui Agric Univ, 2018, 45(4): 703-709. https://www.cnki.com.cn/Article/CJFDTOTAL-ANHU201804022.htm
[5]	崔乐怡, 张婷婷, 龙昌莲, 等. 重金属镉胁迫臭牡丹根系及其土壤生化指标的变化[J]. 贵州农业科学, 2018, 46(6): 28-31. doi: 10.3969/j.issn.1001-3601.2018.06.007 CUI LY, ZHANG TT, LONG CL, et al. Biochemical indexes variation of root system and soil of Clerodendrum bungei under cadmium stress[J]. Guizhou Agric Sci, 2018, 46(6): 28-31. doi: 10.3969/j.issn.1001-3601.2018.06.007
[6]	张建新, 闵佳丽, 俞沁媛, 等. 铝锰复合胁迫下臭牡丹抗逆性及其DNA损伤的研究[J]. 生态环境学报, 2017, 26(11): 1856-1864. https://www.cnki.com.cn/Article/CJFDTOTAL-TRYJ201711005.htm ZHANG JX, MIN JL, YU QY, et al. Research of the stress resistance and DNA damage of Clerodendrum bungei steud. under single and combined treatment of Al and Mn[J]. Ecol Environ Sci, 2017, 26(11): 1856-1864. https://www.cnki.com.cn/Article/CJFDTOTAL-TRYJ201711005.htm
[7]	余娜, 唐林, 谢壮鑫, 等. 臭牡丹不同提取物的抗肿瘤活性筛选及其对裸鼠移植瘤中EMT相关蛋白的影响[J]. 中药药理与临床, 2020, 36(4): 124-131. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYYL202004024.htm YU N, TANG L, XIE ZX, et al. The antineoplastic activity screening of different extracts from Clerodendrum bungei steud and their effects on EMT-related proteins in nude mice with transplanted tumor[J]. Pharmacol Clin Chin Mater Med, 2020, 36(4): 124-131. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYYL202004024.htm
[8]	张蜀艳, 蒲建萍, 李政, 等. 臭牡丹提取物体外抑菌及免疫毒理学研究[J]. 中国免疫学杂志, 2019, 35(14): 1694-1698, 1707. doi: 10.3969/j.issn.1000-484X.2019.14.007 ZHANG SY, PU JP, LI Z, et al. In vitro bacteriostasis and immunotoxicology study of extracts from Clerodendrum bungei steud. [J]. Chin J Immunol, 2019, 35(14): 1694-1698, 1707. doi: 10.3969/j.issn.1000-484X.2019.14.007
[9]	江茜, 王英. 臭牡丹对神经病理性痛的镇痛作用及其机制探讨[C]//中华医学会疼痛学分会. 中华医学会疼痛学分会第十二届学术年会论文集. 南京: 中华医学会疼痛学分会第十二届学术年会, 2016: 104. JIANG Q, WANG Y. Analgesic effect and mechanism of Clerodendrum bungei Steud. on neuropathic pain[C]//Pain Society of Chinese Medical Association. Proceedings of the 12th Annual conference of Pain Science Society of Chinese Medical Association. Nanjing: The 12th Annual conference of Pain Science Society of Chinese Medical Association, 2016: 104.
[10]	郭峰, 赵如娜, 李太美, 等. 6种植物乙醇提取物对桔小实蝇成虫的毒杀和产卵驱避作用的初步研究[J]. 植物检疫, 2021, 35(1): 39-43. https://www.cnki.com.cn/Article/CJFDTOTAL-ZWJY202101009.htm GUO F, ZHAO RN, LI TM, et al. Preliminary study on contact toxicity and oviposition deterrent effect of six plant ethanol extracts against Bactrocera dorsalis Hendel adults[J]. Plant Quar, 2021, 35(1): 39-43. https://www.cnki.com.cn/Article/CJFDTOTAL-ZWJY202101009.htm
[11]	LU XX, HU NN, DU YS, et al. Chemical compositions and repellent activity of Clerodendrum bungei Steud. essential oil against three stored product insects[J]. Daru, 2021, 29(2): 469-475. doi: 10.1007/s40199-021-00398-5
[12]	陈思勤, 朱克俭, 程晓燕, 等. 臭牡丹化学成分及其药理作用研究进展[J]. 湖南中医杂志, 2012, 28(2): 141-142. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZO201202084.htm CHEN SQ, ZHU KJ, CHENG XY, et al. Research Progress on Chemical Constituents of Clerodendrum bungei Steud. and Pharmacological Activities[J]. Hunan J Tradit Chin Med, 2012, 28(2): 141-142. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZO201202084.htm
[13]	ZHENG JN, ZHUO JY, NIE J, et al. Phenylethanoid glycosides from Callicarpa kwangtungensis Chun attenuate TNF-α-induced cell damage by inhibiting NF-κB pathway and enhancing Nrf2 pathway in A549 cells[J]. Front Pharmacol, 2021, 12: 693983. doi: 10.3389/fphar.2021.693983
[14]	TIAN XY, LI MX, LIN T, et al. A review on the structure and pharmacological activity of phenylethanoid glycosides[J]. Eur J Med Chem, 2021, 209: 112563. doi: 10.1016/j.ejmech.2020.112563
[15]	李友宾, 李军, 李萍, 等. 臭牡丹苯乙醇苷类化合物的分离鉴定[J]. 药学学报, 2005, 40(8): 722-727. doi: 10.3321/j.issn:0513-4870.2005.08.010 LI YB, LI J, LI P, et al. Isolation and characterization of phenylethanoid glycosides from clerodendron bungei[J]. Acta Pharm Sin, 2005, 40(8): 722-727. doi: 10.3321/j.issn:0513-4870.2005.08.010
[16]	魏敏, 曹莉婷, 惠玲, 等. 毛蕊花糖苷抗肿瘤机制研究进展[J]. 中医药导报, 2020, 26(15): 125-128. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZB202015033.htm WEI M, CAO LT, HUI L, et al. Research progress on the anti-tumor mechanism of verbascoside[J]. Guid J Tradit Chin Med Pharm, 2020, 26(15): 125-128. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZB202015033.htm
[17]	WU WJ, WU G, CAO DY. Acteoside presents protective effects on cerebral ischemia/reperfusion injury through targeting CCL2, CXCL10, and ICAM1[J]. Cell Biochem Biophys, 2021, 79(2): 301-310. doi: 10.1007/s12013-020-00965-8
[18]	QIAO ZG, TANG JX, WU W, et al. Acteoside inhibits inflammatory response via JAK/STAT signaling pathway in osteoarthritic rats[J]. BMC Complement Altern Med, 2019, 19(1): 264. doi: 10.1186/s12906-019-2673-7
[19]	HUANG XL, WAN D, SHU J, et al. α-Glucosidase inhibitory activity-guided identification of compounds from Clerodendrum bungei steud by HPLC-ESI- QTOF-MS/MS[J]. Digit Chin Med, 2019, 2(1): 41-49. doi: 10.1016/j.dcmed.2019.05.005
[20]	邓清平, 侯光菡. DPPH-HPLC-QTOF-MS/MS快速筛选和鉴定臭牡丹中抗氧化活性成分[J]. 华中师范大学学报(自然科学版), 2018, 52(6): 816-821. https://www.cnki.com.cn/Article/CJFDTOTAL-HZSZ201806012.htm DENG QP, HOU GH. Rapid screening and identification of antioxidants from Clerodendrum bungei by DPPH-HPLC-QTOF-MS/MS[J]. J Centr China Norm Univ Nat Sci, 2018, 52(6): 816-821. https://www.cnki.com.cn/Article/CJFDTOTAL-HZSZ201806012.htm
[21]	LIU Q, HU HJ, LI PF, et al. Diterpenoids and phenylethanoid glycosides from the roots of Clerodendrum bungei and their inhibitory effects against angiotensin converting enzyme and α-glucosidase[J]. Phytochemistry, 2014, 103: 196-202. doi: 10.1016/j.phytochem.2014.02.015
[22]	张贵杰, 代禄梅, 张斌, 等. 臭牡丹的化学成分研究[J]. 中国中药杂志, 2017, 42(24): 4788-4793. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGZY201724020.htm ZHANG GJ, DAI LM, ZHANG B, et al. Studies on chemical constituents of Clerodendrum bungei[J]. China J Chin Mater Med, 2017, 42(24): 4788-4793. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGZY201724020.htm
[23]	余娜, 朱克俭, 谢谊. 臭牡丹地上部分抗肿瘤活性的筛选[J]. 湖南中医杂志, 2017, 33(11): 147-150. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZO201711060.htm YU N, ZHU KJ, XIE Y. Screening for compounds with antitumor activity in the aerial part of Clerodendrum bungei[J]. Hunan J Tradit Chin Med, 2017, 33(11): 147-150. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZO201711060.htm
[24]	FAN TP, MIN ZD, ⅡNUMA M. Two novel diterpenoids from Clerodendrum bungei[J]. Chem Pharm Bull, 1999, 47(12): 1797-1798. doi: 10.1248/cpb.47.1797
[25]	LIU SS, ZHU HL, ZHANG SW, et al. Abietane diterpenoids from Clerodendrum bungei[J]. J Nat Prod, 2008, 71(5): 755-759. doi: 10.1021/np0703489
[26]	SUN L, WANG ZZ, DING G, et al. Isolation and structure characterization of two new diterpenoids from Clerodendrum bungei[J]. Phytochem Lett, 2014, 7: 221-224. doi: 10.1016/j.phytol.2013.12.006
[27]	KIM SK, CHO SB, MOON HI. Anti-complement activity of isolated compounds from the roots of Clerodendrum bungei Steud. [J]. Phytother Res, 2010, 24(11): 1720-1723. doi: 10.1002/ptr.3254
[28]	高黎明, 魏小梅, 何仰清. 臭牡丹化学成分的研究[J]. 中国中药杂志, 2003, 28(11): 1042-1044. doi: 10.3321/j.issn:1001-5302.2003.11.015 GAO LM, WEI XM, HE YQ. Studies on chemical constituents in of Clerodendrum bungei[J]. China J Chin Mater Med, 2003, 28(11): 1042-1044. doi: 10.3321/j.issn:1001-5302.2003.11.015
[29]	姜林锟. 臭牡丹茎的化学成分及白桦脂酸与甘草次酸的修饰合成[D]. 贵阳: 贵州大学, 2009. JIANG LK. Chemical constituents of the stem of Clerodendrum bungei and modified synthesis of betulinic acid and glycyrrhetinic acid[D]. Guiyang: Guizhou University, 2009.
[30]	JIANG WK, LI X, DONG S, et al. Betulinic acid in the treatment of tumour diseases: Application and research progress[J]. Biomed Pharmacother, 2021, 142: 111990. doi: 10.1016/j.biopha.2021.111990
[31]	ZHOU ZQ, CHOI JW, SHIN JY, et al. Betulinic acid ameliorates the severity of acute pancreatitis via inhibition of the NF-κB signaling pathway in mice[J]. Int J Mol Sci, 2021, 22(13): 6871. doi: 10.3390/ijms22136871
[32]	YANG H, HOU AJ, MEI SX, et al. Constituents of Clerodendrum bungei[J]. J Asian Nat Prod Res, 2002, 4(3): 165-169. doi: 10.1080/1028602021000000053
[33]	李萌茹, 周玉枝, 杜冠华, 等. 中药黄酮类化合物抗衰老作用及其机制研究进展[J]. 药学学报, 2019, 54(8): 1382-1391. https://www.cnki.com.cn/Article/CJFDTOTAL-YXXB201908006.htm LI MR, ZHOU YZ, DU GH, et al. Research progress about the anti-aging effect and mechanism of flavonoids from traditional Chinese medicine[J]. Acta Pharm Sin, 2019, 54(8): 1382-1391. https://www.cnki.com.cn/Article/CJFDTOTAL-YXXB201908006.htm
[34]	WANG S, ZHANG X, LIU MY, et al. Chrysin inhibits foam cell formation through promoting cholesterol efflux from RAW₂₆₄_{. 7} macrophages[J]. Pharm Biol, 2015, 53(10): 1481-1487. doi: 10.3109/13880209.2014.986688
[35]	RAVULA AR, TEEGALA SB, KALAKOTLA S, et al. Fisetin, potential flavonoid with multifarious targets for treating neurological disorders: An updated review[J]. Eur J Pharmacol, 2021, 910: 174492. doi: 10.1016/j.ejphar.2021.174492
[36]	冯纪南, 黄海英, 余瑞金, 等. 臭牡丹黄酮类化合物提取及其抗氧化作用[J]. 光谱实验室, 2013, 30(6): 3215-3220. doi: 10.3969/j.issn.1004-8138.2013.06.110 FENG JN, HUANG HY, YU RJ, et al. Extraction of flavonoid compound from Clerodendrum bungei. and it's antioxodant property[J]. Chin J Spectrosc Lab, 2013, 30(6): 3215-3220. doi: 10.3969/j.issn.1004-8138.2013.06.110
[37]	胡琦, 朱定耀, 谭小宁, 等. 臭牡丹提取物对H22荷瘤小鼠体内抑瘤作用及对相关蛋白表达的影响[J]. 药物评价研究, 2019, 42(7): 1309-1313. https://www.cnki.com.cn/Article/CJFDTOTAL-YWPJ201907009.htm HU Q, ZHU DY, TAN XN, et al. Anti-tumor effect of Clerodendron bungei extract on H22 tumor-bearing mice and its effect on expression of related proteins[J]. Drug Eval Res, 2019, 42(7): 1309-1313. https://www.cnki.com.cn/Article/CJFDTOTAL-YWPJ201907009.htm
[38]	NWANADE CF, WANG M, WANG TH, et al. Botanical acaricides and repellents in tick control: Current status and future directions[J]. Exp Appl Acarol, 2020, 81(1): 1-35. doi: 10.1007/s10493-020-00489-z
[39]	KHALED-GASMI W, HAMOUDA AB, CHAIEB I, et al. Natural repellents based on three botanical species essential oils as an eco-friendly approach against aphids[J]. S Afr N J Bot, 2021, 141: 133-141. doi: 10.1016/j.sajb.2021.05.001
[40]	李培源, 霍丽妮, 邓超澄, 等. 臭牡丹挥发油化学成分的GC-MS分析[J]. 广西中医药, 2010, 33(4): 56-57. https://www.cnki.com.cn/Article/CJFDTOTAL-GXZY201004030.htm LI PY, HUO LN, DENG CC, et al. Experimental study on chemical constituents of the volatile oil from different parts of Clerodendrum bungei[J]. Guangxi J Tradit Chin Med, 2010, 33(4): 56-57. https://www.cnki.com.cn/Article/CJFDTOTAL-GXZY201004030.htm
[41]	ZHU HC, HUAN LJ, CHEN CM, et al. A pair of unprecedented cyclohexylethanoid enantiomers containing unusual trioxabicyclo[4.2.1]nonane ring from Clerodendrum bungei[J]. Tetrahedron Lett, 2014, 55(14): 2277-2279. doi: 10.1016/j.tetlet.2014.02.088
[42]	张立文. 臭牡丹有效成分的提取及其细胞保护和抗炎机制研究[D]. 长沙: 中南大学, 2013. ZHANG LW. Study of cytoprotection and anti-inflammatory of effective extracting of Clerodendrum bungei[D]. Changsha: Central South University, 2013.
[43]	余娜, 朱克俭, 马思静, 等. 臭牡丹总黄酮通过调控Wnt/β-catenin通路影响A549细胞上皮间质转化研究[J]. 中草药, 2018, 49(3): 663-670. https://www.cnki.com.cn/Article/CJFDTOTAL-ZCYO201803023.htm YU N, ZHU KJ, MA SJ, et al. Effects of total flavonoids of Clerodendrum bungei on epithelial-mesenchymal transition(EMT) of A549 cells by regulating Wnt/β-catenin signal pathway[J]. Chin Tradit Herb Drugs, 2018, 49(3): 663-670. https://www.cnki.com.cn/Article/CJFDTOTAL-ZCYO201803023.htm
[44]	谭小宁, 李勇敏, 余娜, 等. 臭牡丹黄酮类化合物通过调控CXCR4对A549转移能力的影响[J]. 湖南中医杂志, 2019, 35(9): 131-133. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZO201909065.htm TAN XN, LI YM, YU N, et al. Flavonoids in Clerodendrum bungei affects the metastasis of A549 cells by regulating CXCR4[J]. Hunan J Tradit Chin Med, 2019, 35(9): 131-133. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZO201909065.htm
[45]	陈思勤, 朱克俭, 李勇敏, 等. 臭牡丹总黄酮抑制小鼠Lewis肺癌实体瘤及其与p53、bcl-2、bax表达相关性研究[J]. 世界中医药, 2016, 11(6): 946-949. doi: 10.3969/j.issn.1673-7202.2016.06.002 CHEN SQ, ZHU KJ, LI YM, et al. Inhibition effect of Clerodendrum bungei flavonoinds on lewis rats' lung tumor and its correlation to the expression of p53, bcl-2, and bax gene[J]. World Chin Med, 2016, 11(6): 946-949. doi: 10.3969/j.issn.1673-7202.2016.06.002
[46]	刘天舒, 戎宽, 谭小宁, 等. 臭牡丹复方对肺癌大鼠血清中TGF-β₁、IL-4、IL-10水平的影响[J]. 湖南中医杂志, 2017, 33(2): 129-131. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZO201702056.htm LIU TS, RONG K, TAN XN, et al. Effect of compound Clerodendrum bungei on serum levels of transforming growth factor-beta 1, interleukin-4, and interleukin-10 in mice with lung cancer[J]. Hunan J Tradit Chin Med, 2017, 33(2): 129-131. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZO201702056.htm
[47]	胡琦, 谭小宁, 余娜, 等. 臭牡丹总黄酮介导Wnt/β-catenin信号转导诱导人肝癌细胞HepG2的凋亡[J]. 世界中医药, 2016, 11(6): 954-957. doi: 10.3969/j.issn.1673-7202.2016.06.004 HU Q, TAN XN, YU N, et al. Research on the medicate effect of clerodendron bungei flavornoids on Wnt/β-catenin in inducing the apoptosis of HepG2[J]. World Chin Med, 2016, 11(6): 954-957. doi: 10.3969/j.issn.1673-7202.2016.06.004
[48]	胡琦, 蒋佳红, 李游, 等. 臭牡丹含药血清对人肝癌MHCC97-H细胞周期和凋亡的影响[J]. 湖南中医药大学学报, 2019, 39(12): 1444-1448. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZX201912005.htm HU Q, JIANG JH, LI Y, et al. Effects of drug-containing serum of Clerodendrum bungei on cell cycle and apoptosis of human hepatocellular carcinoma MHCC97-H[J]. J Hunan Univ Chin Med, 2019, 39(12): 1444-1448. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZX201912005.htm
[49]	孟鑫, 李振想, 姜孝奎. 臭牡丹总黄酮通过Keap1/Nrf2/ARE信号通路对胃癌SGC7901细胞增殖、迁移和侵袭的影响[J]. 现代肿瘤医学, 2019, 27(22): 3967-3972. doi: 10.3969/j.issn.1672-4992.2019.22.007 MENG X, LI ZX, JIANG XK. Effects of total flavone of Clerodendrum bungei on proliferation, migration and invasion of gastric cancer SGC7901 cells by Keap1/Nrf2/ARE signaling pathway[J]. J Mod Oncol, 2019, 27(22): 3967-3972. doi: 10.3969/j.issn.1672-4992.2019.22.007
[50]	SIKORSKY TV, ERMOLENKO EV, GLORIOZOVA TA, et al. Mini review: Anticancer activity of diterpenoid peroxides[J]. Vietnam J Chem, 2020, 58(3): 273-280. doi: 10.1002/vjch.202000014
[51]	BAN YF, XIA TS, JING R, et al. Vitex diterpenoids: Structural diversity and pharmacological activity[J]. Curr Pharm Des, 2020, 26(1): 138-159. doi: 10.2174/1381612825666191216151703
[52]	曾丹, 刘莉, 谭眉灵, 等. 臭牡丹大黄素对臭氧应激小鼠模型TLR4/MyD88/NF-κB信号通路的调节作用[J]. 中药新药与临床药理, 2018, 29(5): 581-585. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYXY201805010.htm ZENG D, LIU L, TAN ML, et al. Effect of emodin from Clerodendrum bungei on TLR4/my D88/NF-κB signaling pathway in mice with ozone stress[J]. Tradit Chin Drug Res Clin Pharmacol, 2018, 29(5): 581-585. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYXY201805010.htm
[53]	ZHANG D, QIN XQ, LIU C, et al. The protective effect of Clerodendrum bungei extracts on airway inflammation in mice induced by ozone exposure[J]. Cell Biol Int, 2008, 32(3): S42.
[54]	寇小妮, 解新科, 郝明霞, 等. 臭牡丹大黄素对急性肝衰竭小鼠生化指标及肝细胞内质网应激的影响[J]. 中国中医急症, 2019, 28(10): 1712-1715, 1720. doi: 10.3969/j.issn.1004-745X.2019.10.006 KOU XN, XIE XK, HAO MX, et al. Effects of emodin from Clerodendrum bungei steud on biochemical indicators and hepatocyte endoplasmic Reticulum stress in mice with acute liver failure[J]. J Emerg Tradit Chin Med, 2019, 28(10): 1712-1715, 1720. doi: 10.3969/j.issn.1004-745X.2019.10.006
[55]	江茜, 王英, 黄诚. 臭牡丹通过促炎细胞因子和NF-κB缓解大鼠神经病理性疼痛[J]. 中国疼痛医学杂志, 2018, 24(5): 336-342. doi: 10.3969/j.issn.1006-9852.2018.05.005 JIANG Q, WANG Y, HUANG C. Cytokines and NF-κB mediate the analgesic effect of Clerodendrum bungei steud on spared nerve injury induced neuropathic pain in rats[J]. Chin J Pain Med, 2018, 24(5): 336-342. doi: 10.3969/j.issn.1006-9852.2018.05.005
[56]	邹晓琴, 欧阳娟, 黄诚. 臭牡丹根提取物对神经病理性痛的镇痛作用[J]. 时珍国医国药, 2013, 24(1): 12-14. doi: 10.3969/j.issn.1008-0805.2013.01.006 ZOU XQ, OUYANG J, HUANG C. Effect of Clerodendron bungei steud roots extract on neuropathic pain in rats[J]. Lishizhen Med Mater Med Res, 2013, 24(1): 12-14. doi: 10.3969/j.issn.1008-0805.2013.01.006
[57]	江茜, 王英, 夏阳阳, 等. 臭牡丹对SNI诱导的神经病理性痛大鼠脊髓和背根神经节COX-2表达的作用[J]. 时珍国医国药, 2018, 29(5): 1058-1060. https://www.cnki.com.cn/Article/CJFDTOTAL-SZGY201805010.htm JIANG Q, WANG Y, XIA YY, et al. Effects of Clerodendron bungei steud on COX-2 expression in spinal cord and dorsal root ganglion of rats with neuropathic pain induced by SNI[J]. Lishizhen Med Mater Med Res, 2018, 29(5): 1058-1060. https://www.cnki.com.cn/Article/CJFDTOTAL-SZGY201805010.htm
[58]	邹晓琴, 刘立, 黄诚. 臭牡丹对神经病理性痛机械痛敏和脊髓背角谷氨酸的作用[J]. 赣南医学院学报, 2014, 34(6): 825-828. doi: 10.3969/j.issn.1001-5779.2014.06.001 ZOU XQ, LIU L, HUANG C. Effect of clerodendron bungei steud on the mechanical allodynia and glutamate in spinal cord in rats with neuropathic pain[J]. J Gannan Med Univ, 2014, 34(6): 825-828. doi: 10.3969/j.issn.1001-5779.2014.06.001
[59]	潘立卫, 罗泽萍, 陈俏燕. 臭牡丹叶化学成分及提取物抑菌作用研究[J]. 大众科技, 2018, 20(10): 18-20. doi: 10.3969/j.issn.1008-1151.2018.10.006 PAN LW, LUO ZP, CHEN QY. Studies on the chemical constituents of Clerodendrum bungei leaf and their antibacterial effects[J]. Pop Sci Technol, 2018, 20(10): 18-20. doi: 10.3969/j.issn.1008-1151.2018.10.006
[60]	YIN LG, LIN N, WEI Q, et al. Antifungal activity of extracts from Clerodendrum bungei leaves against two species of phytopathogens[J]. Agric Sci Technol, 2008, 9(1): 143-145.
[61]	刘建新, 李燕, 连磊凡, 等. 臭牡丹根正丁醇提取物的体外抗菌实验的研究[J]. 时珍国医国药, 2015, 26(8): 1849-1850. https://www.cnki.com.cn/Article/CJFDTOTAL-SZGY201508020.htm LIU JX, LI Y, LIAN LF, et al. Study on antibacterial activity of n-butanol extract from the root of Clerodendron bungei steud. in vitro[J]. Lishizhen Med Mater Med Res, 2015, 26(8): 1849-1850. https://www.cnki.com.cn/Article/CJFDTOTAL-SZGY201508020.htm
[62]	段军仓, 王有鹏, 王飞, 等. 臭牡丹总黄酮对PDGF诱导下血管平滑肌细胞增殖、迁移及表型转换的影响及机制[J]. 中药材, 2020, 43(9): 2258-2263. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYCA202009035.htm DUAN JC, WANG YP, WANG F, et al. Effects and mechanism of total flavonoids from Clerodendron bungei steud. on proliferation, migration and phenotypic transformation of vascular smooth muscle cells induced by PDGF[J]. J Chin Med Mater, 2020, 43(9): 2258-2263. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYCA202009035.htm
[63]	黄卫华, 钟文敏, 王德胜, 等. 臭牡丹乙醇提取物对小鼠睡眠功能和自发活动的影响[J]. 中国医院用药评价与分析, 2017, 17(10): 1313-1314, 1318. https://www.cnki.com.cn/Article/CJFDTOTAL-YYPF201710006.htm HUANG WH, ZHONG WM, WANG DS, et al. Effect of ethanol extract of Clerodendrum bungei on the sleep function and spontaneous activity in mice[J]. Eval Anal Drug Use Hosp China, 2017, 17(10): 1313-1314, 1318. https://www.cnki.com.cn/Article/CJFDTOTAL-YYPF201710006.htm
[64]	袁骏. 臭牡丹的临床运用[J]. 四川中医, 1996, 14(6): 14. https://www.cnki.com.cn/Article/CJFDTOTAL-SCZY199606011.htm YUAN J. Clinical application of Clerodendron bungei steud. [J]. Sichuan J Tradit Chin Med, 1996, 14(6): 14. https://www.cnki.com.cn/Article/CJFDTOTAL-SCZY199606011.htm
[65]	潘立文, 丁昭莉, 赵桂刚, 等. 治疗类风湿关节炎傣药概述[J]. 中国中医药信息杂志, 2019, 26(2): 137-140. doi: 10.3969/j.issn.1005-5304.2019.02.032 PAN LW, DING ZL, ZHAO GG, et al. Research status of Dai medicine for treatment of rheumatoid arthritis[J]. Chin J Inf Tradit Chin Med, 2019, 26(2): 137-140. doi: 10.3969/j.issn.1005-5304.2019.02.032
[66]	何兰, 曾雯, 张宁静, 等. 基于数据挖掘探讨蒋益兰治疗原发性支气管肺癌的用药规律[J]. 中医药导报, 2020, 26(15): 162-165. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZB202015042.htm HE L, ZENG W, ZHANG NJ, et al. Study on the medication rule of professor JIANG Yi-lan in the treatment of primary pulmonary carcinoma based on data mining[J]. Guid J Tradit Chin Med Pharm, 2020, 26(15): 162-165. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZB202015042.htm
[67]	周春吉, 周胜强, 刘芳. 基于中医传承辅助系统分析刘祖贻治疗恶性肿瘤用药规律[J]. 中国中医药信息杂志, 2019, 26(10): 105-109. doi: 10.3969/j.issn.1005-5304.2019.10.023 ZHOU CJ, ZHOU SQ, LIU F. Medication laws of LIU zuyi in treatment of malignant tumor based on TCM inheritance support system[J]. Chin J Inf Tradit Chin Med, 2019, 26(10): 105-109. doi: 10.3969/j.issn.1005-5304.2019.10.023
[68]	潘玉秀, 林艳芳. 中傣医结合治疗163例痛经临床疗效观察[J]. 中国民族医药杂志, 2012, 18(11): 16-17. doi: 10.3969/j.issn.1006-6810.2012.11.009 PAN YX, LIN YF. Clinical observation of 163 cases dysmenorrhea treated by combination of Chinese and Dai medicine[J]. J Med Pharm Chin Minor, 2012, 18(11): 16-17. doi: 10.3969/j.issn.1006-6810.2012.11.009
[69]	玉罕, 岩罕单. 傣药宾亮(红花臭牡丹)的应用和研究概况[J]. 中国民族医药杂志, 2018, 24(4): 47-48. doi: 10.3969/j.issn.1006-6810.2018.04.028 YU H, YAN HD. The application and research situation of Dai medicine Bin-liang (Clerodendrum bungei Steud. )[J]. J Med Pharm Chin Minor, 2018, 24(4): 47-48. doi: 10.3969/j.issn.1006-6810.2018.04.028
[70]	李群, 张勇. 臭牡丹根伍用小剂量环磷酰胺治疗慢性肾炎16例[J]. 现代生物医学进展, 2009, 9(13): 2543-2545. https://www.cnki.com.cn/Article/CJFDTOTAL-SWCX200913046.htm LI Q, ZHANG Y. Treatment of 16 cases of chronic nephritis by root of blerodendron bungei steud associated with low-dose of cyclophosphamide[J]. Prog Mod Biomed, 2009, 9(13): 2543-2545. https://www.cnki.com.cn/Article/CJFDTOTAL-SWCX200913046.htm
[71]	王伯成, 杨如乐. 牡丹诃麦汤治疗顽固性咳嗽128例[J]. 浙江中医杂志, 2013, 48(2): 154. doi: 10.3969/j.issn.0411-8421.2013.02.055 WANG BC, YANG RL. Treatment of 128 cases of intractable cough with Peony Kemal Decoction[J]. Zhejiang J Tradit Chin Med, 2013, 48(2): 154. doi: 10.3969/j.issn.0411-8421.2013.02.055
[72]	邹晓琴, 欧阳娟, 黄诚. 臭牡丹的药理作用研究进展[J]. 赣南医学院学报, 2013, 33(2): 318-320. doi: 10.3969/j.issn.1001-5779.2013.02.077 ZOU XQ, OUYANG J, HUANG C. Research progress on pharmacological effects of Clerodendron Bungei Steud. [J]. J Gannan Med Univ, 2013, 33(2): 318-320. doi: 10.3969/j.issn.1001-5779.2013.02.077