天然黄酮类化合物对芳香烃受体的调控作用研究进展

杨玲娟; 宋蒙蒙; 狄留庆; 丁康

doi:10.14148/j.issn.1672-0482.2021.0958

天然黄酮类化合物对芳香烃受体的调控作用研究进展

doi: 10.14148/j.issn.1672-0482.2021.0958

1.
江苏省生产力促进中心，江苏南京 210042
2.
南京中医药大学药学院，江苏南京 210023
3.
南京中医药大学附属南京市中医院, 江苏南京 210001

基金项目:

江苏省中医药科技发展计划项目 YB2020029

江苏省中医药老专家学术经验继承工作项目 2019-SSPSC-DK

南京中医药大学自然科学基金 XZR2020045

详细信息

作者简介:
杨玲娟, 女，副研究员，E-mail: 67230512@qq.com

通讯作者:
丁康，男，副主任中医师，主要从事中医药防治溃疡性结肠炎研究，E-mail：fsyy00237@njucm.edu.cn

中图分类号: R284
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- 被引次数: 0
出版历程
- 收稿日期: 2020-10-09
- 网络出版日期: 2021-12-21
- 刊出日期: 2021-11-10
- 发布日期: 2021-11-15

Recent Progress of Natural Flavonoids as Ligand on Aryl Hydrocarbon Receptor

1.
Productivity Centre of Jiangsu Province, Nanjing, 210042, China
2.
School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China
3.
Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, 210001, China

摘要

摘要: 黄酮类成分广泛存在于植物、中草药中，具有多种药理学活性，近年来的研究表明，它可以通过调控多种信号通路发挥其抗炎、抗氧化、化学预防等作用。笔者聚焦在药物代谢、免疫调节、化学预防中具有重要作用的芳香烃受体，在系统综述芳香烃受体功能及调控模式基础上，总结了不同黄酮类化合物对芳香烃受体的激动或拮抗作用，并对常见黄酮成分通过芳香烃受体发挥其抗肿瘤、抗溃疡性结肠炎、抗特异性皮炎的独特作用机制进行了介绍，并展望了黄酮类化合物在上述疾病治疗中潜在前景和局限性。
- 黄酮 /
- 芳香烃受体 /
- 配体
Abstract: Flavonoids are widely existed in plants and herbs, which have a variety of pharmacological activities. Recent studies have shown that they can exert anti-inflammatory, antioxidant, and chemopreventive effects by regulating various signaling pathways. In this paper, we focused on the aryl hydrocarbon receptor, which plays an important role in drug metabolism, immunomodulation, and chemoprevention. After a systematic review of the functions and regulation modes of aryl hydrocarbon receptor, we summarized the agonistic or antagonistic effects of different flavonoids on aryl hydrocarbon receptor and elaborated their anti-tumor, anti-ulcerative colitis, and anti-atopic dermatitis effects by activating aryl hydrocarbon receptor through unique mechanisms. Furthermore, the potential prospects and limitations of flavonoids in the treatment of the above diseases were also presented.
- flavonoids /
- aryl hydrocarbon receptor /
- ligands

HTML全文

表 1 黄酮类化合物对AHR的激动/拮抗作用

类型	中文名	英文名	细胞系/组织	激动	拮抗	参考文献
黄酮	金合欢素芹菜素黄芩苷白杨素芫花素黄酮木犀草素木犀草素-7, 3'-二葡萄糖苷野黄芩素桔皮素五羟黄酮 4, 7'-二甲氧基-5-羟基黄酮 4', 5, 7-三甲氧基黄酮 3', 4', 5, 7-四甲氧基黄酮	Acacetin Apigenin Baicalin Chrysin Genkwanin Flavone Luteolin Luteolin 7, 3'-diglucoside Scutellarein Tangeretin Tricetin 4, 7'-Dimethoxy-5-hydroxyflavone 4', 5, 7-Trimethoxyflavone 3', 4', 5, 7-Tetramethoxyflavone	Caco2 YAMC DLN HepG2 AHR-Lucia H1L6.1c2 3T3-L1(AHR) HCT116 MDA-MB-231 肝组织(大鼠) 心肌组织(小鼠)	+ + + + - + + + + - + + - +	- + + + - + + - - + - - - -	[31] [32] [33-34] [35-36] [37] [38] [32] [37] [31]
黄酮醇	漆黄素黄酮醇高良姜素棉黄素番石榴苷淫羊藿素异鼠李素山柰酚桑色素杨梅素槲皮素槲皮苷刺槐乙素芦丁柽柳素 3, 6, 2', 3'-四羟基黄酮 3, 6, 2', 4'-四羟基黄酮	Fisetin Flavonol Galangin Gossypetin Guaijaverin Icaritin Isorhamnetin Kaempferol Morin Myricetin Quercetin Quercitrin Robinetin Rutin Tamarixetin 3, 6, 2', 3'-Tetrahydroxyflavone 3, 6, 2', 4'-Tetrahydroxyflavone	LNCaP CWR22Rv1 Caco2 H1L6.1c2 3T3-L1(AHR) PBMEC/C1-2 HepG2 AHR-Lucia	+ + + + + + + + + + + - + + + + +	- + - - - - - + + + + + - + + - +	[36] [39] [39] [36, 39]
二氢黄酮醇	花旗松素二氢杨梅素	Taxifolin Dihydromyricetin	Caco2 HepG2	+ +	- -	[39] [40]
黄烷酮	山姜素圣草酚黄烷酮橙皮素橙皮苷异黄腐醇柚皮素柚皮苷柚皮素二甲醚樱花素 6-异戊二烯基柚皮素 8-异戊二烯基柚皮素	Alpinetin Eriodictyol Flavanone Hesperitin Hesperidin Isoxanthohumol Naringenin Naringin Naringenin Trimethyl Ether Sakuranetin 6-Prenylnaringenin 8-Prenylnaringenin	HepG2 MCF-7 HepG2 AHR-Lucia H1L6.1c2 Caco2 YAMC PBMEC/C1-2 EL-4	+ - + + + - - + - - + +	- + + + - - +/- + - - - -	[36] [32] [32] [32] [41]
查尔酮	小豆蔻明	Cardamonin	HepG2 AHR-Lucia, THP-1
异黄酮	鹰嘴豆芽素A 大豆黄素刺芒柄花素染料木素葛根素樱黄素 4, 7'-二甲氧基-5-羟基异黄酮 4', 5, 7-三甲氧基异黄酮 3', 4', 5, 7-四甲氧基异黄酮	Biochanin A Daidzein Formononetin Genistein Puerarin Prunetin 4, 7'-Dimethoxy-5-hydroxyisoflavone 4', 5, 7-Trimethoxyisoflavone 3', 4', 5, 7-Tetramethoxyisoflavone	Caco2 YAMC H1L6.1c2 MCF-7 HC-04 HepG2(AZ-AHR) Hepa-1c1c7 HepG2 AHR-Lucia	+ - + - - - - + -	- +/- - +/- - - - - -	[31] [36] [31-32] [41] [31] [31]

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